Coronavirus
Natural Remedies

Melatonin Protocol for COVID-19

| Modified: Jan 27, 2021
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covid 19 natural remedies - corona

By Art Solbrig

April 20, 2020
Updated May 09, 2020 5:00 p.m. EST

One possible problem for moderate to severe Covid-19 patients is the potential for significant damage to the lungs and possibly other organs like the liver, based on what is being seen in patients.

At this point, treatment options to try and prevent, repair or ameliorate this damage is very limited and not necessarily a very high priority for doctors yet, but still important to the patient in the long run to maintain good health quality overall.

Toward that end, I would like to talk about one of my favorite supplements that I have previously mentioned on Earth Clinic that may help these patients have a more complete recovery of the lungs and possibly other organs: Melatonin.

Post-Intensive Care for COVID-19

The aftermath for patients with Covid-19 has not been discussed at length yet because it is not currently the highest priority for doctor's treating these patients.

Keeping them alive is obviously a primary concern right now, but preventing or ameliorating the significant amount of collateral damage caused by Covid-19 is very important also.

That subject, in time, will be quite popular as more people reach the recovery phase of Covid-19.

For many people who fall into the "high risk groups", this information may be useful and timely to reduce your chances of succumbing to the disease if infected and if some scientists are right in their thinking that the virus can potentially mutate and return seasonally, similarly to the seasonal flu, then melatonin certainly seems like a very useful adjuvant treatment to keep in mind from this point forward!

If you survive the virus once and develop antibodies to it that will be very good, but if the virus mutates extensively, there is a chance that those antibodies may not be effective against the new strain similarly to vaccines for the flu, which sometimes work against the new strain and sometimes don't as witnessed by people who have gotten the flu shot and still got the flu.

Melatonin has shown itself to be protective of the major organs of the body in many studies, which includes the lungs among its many potential health benefits.

There are several forum members currently using melatonin, including myself, so this could be useful information for them as well as other members who are trying to be as prepared as possible to deal with Covid-19.

Below is a link to a recent article that discusses the potential utility of melatonin as it would relate to Covid-19. Melatonin is just at the beginning of testing in Covid-19 patients with initial positive results. This article mainly discusses the effects of melatonin as it might relate to Covid-19 and includes its antiviral and anti-ARDS qualities among many other qualities. The article describes melatonin as "having a high safety profile" and suggests it might be useful before, during and after the disease process has ended.

Doctors may have a bit more latitude in using melatonin compared to all of the prescription drugs that have been mentioned on this forum and across the internet since melatonin is an OTC supplement sold at drug stores and big box item stores and almost all online supplement suppliers.

COVID-19: Melatonin as a potential adjuvant treatment

Life Sci. 2020 Jun 1; 250: 117583.
Published online 2020 Mar 23. doi: 10.1016/j.lfs.2020.117583

Rui Zhang,a Xuebin Wang,a Leng Ni,a Xiao Di,a Baitao Ma,a Shuai Niu,a Changwei Liu,a,⁎ and Russel J. Reiterb,⁎⁎

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102583/

Abstract

This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis. The recent outbreak of COVID-19 has become a pandemic with tens of thousands of infected patients. Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology. This leads to a cytokine storm and subsequent progression to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and often death. Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile. There is significant data showing that melatonin limits virus-related diseases and would also likely be beneficial in COVID-19 patients. Additional experiments and clinical studies are required to confirm this speculation.


Here is a link to an article in the Washington Post that gives an idea of which organs can be impacted by Covid-19 which further illustrates why melatonin might be a very useful adjuvant treatment option which doctors can add to their arsenal against Covid-19. That arsenal is relatively small at this point, but hopefully will continue to expand.

Since the multiple health benefits associated with melatonin may apply in the case of this disease in multiple ways, it may be worth saving this post for future reference for yourself or a family member or friend to show to their doctor to see if it is something that will be compatible with all that they are taking and safe for you to take.

I cannot recommend melatonin to anyone as I am not a doctor, but your doctor can. I do use melatonin daily myself as I have previously stated on the forum for multiple reasons.

Health Benefits of Melatonin

Melatonin is mainly thought of as an over the counter sleep aid, but its abilities go far beyond being a common sleep aid for some people.

Not everyone can tolerate melatonin and that is another good reason to include your doctor in that decision making process.

The majority of people do tolerate melatonin well and it is naturally produced in the body by the pineal gland as daylight turns to night time. There are melatonin receptors found throughout the body suggesting that the body does have uses for it. Unfortunately melatonin production declines very significantly as we age and that may possibly be one contributing factor as to why older people do not fair as well as younger people with Covid-19.

Here is another article that discusses the potential for melatonin in respiratory diseases. If you want to read the full article, you will have to click on the blue rectangular button that says "Download full-text PDF" once you follow this link.

This very recent (March 20, 2020), brief and interesting link takes you to an opinion page where a doctor is discussing how melatonin might be used as adjunctive treatment for Covid-19 in patients with and without pneumonia and is relatively short and straight forward. He is advocating for use of melatonin "now" in Covid-19 patients. He feels that melatonin also would be an effective antiviral and antibacterial, but that is not yet known in Covid-19.

This is worth reading!


The same doctor from the article just above, Dr. Richard L. Neel M.D., MPH., has actually started treating Covid-19 patients with melatonin and vitamin C as this link explains.

I like what he is doing by practicing what he is preaching. His treated patient count is low at this point, but you have to start somewhere and a hospital seems a safe place to do that if you are already infected with Covid-19! A quick mention to the fact that there are a couple of ads at the 1/3 point and 2/3 point in the following article so please scroll past each ad to make sure you read the whole article, its interesting. This is a good read.


One more update about Dr. Neel. He says he has treated 10 patients now giving them 80 mgs of melatonin per day. Click here.

One of my supplement experiments involved taking 70 mgs of melatonin per day so I already have an idea of what 80 mgs will be like for me. Another good read and not long.

Melatonin Levels Decline Sharply As We Age

Source: grivas tb, savvidou od. melatonin the “light of night

We're reporting our experience in a scientific journal, so hopefully, it could help save some COVID-19 patients, especially the elderly, who are reportedly left to die in some cities in Italy and Spain, so that doctors could allocate their resources to younger patients. If this information could save a few of these lives, it shall have been worth all that we've gone through convincing our local colleagues about it."

Here is a link to that article: https://lifestyle.inquirer.net/361003/high-dose-melatonin-3-other-drugs-seen-as-effective-against-covid-19/


The following link discusses repurposing of existing drugs including melatonin. It is quite lengthy if you are pressed for time and don't have time to read it, here is a quote from the article:

https://www.nature.com/articles/s41421-020-0153-3

"Inflammatory pathways play essential roles in viral infections56,57. As a biogenic amine, melatonin (N-acetyl-5-methoxytryptamine) (Z = –1.72 and GSEA score = 2) plays a key role in various biological processes, and offers a potential strategy in the management of viral infections58,59. Viral infections are often associated with immune-inflammatory injury, in which the level of oxidative stress increases significantly and leaves negative effects on the function of multiple organs60. The antioxidant effect of melatonin makes it a putative candidate drug to relieve patients' clinical symptoms in antiviral treatment, even though melatonin cannot eradicate or even curb the viral replication or transcription61,62. In addition, the application of melatonin may prolong patients' survival time, which may provide a chance for patients' immune systems to recover and eventually eradicate the virus. As shown in Fig. 5e, melatonin indirectly targets several HCoV cellular targets, including ACE2, BCL2L1, JUN, and IKBKB. Eplerenone (Z = –1.59), an aldosterone receptor antagonist, is reported to have a similar anti-inflammatory effect as melatonin. By inhibiting mast-cell-derived proteinases and suppressing fibrosis, eplerenone can improve survival of mice infected with encephalomyocarditis virus63."


The following 2 links, while not related to Covid-19, takes you to two abstracts of a study where melatonin was used at a dose of 70 mg per day in children with Duchenne muscular dystrophy for 9 months to good effect. I'm adding this one just to show that melatonin is relatively safe in children who might get Covid-19, even at 70 mg/day. They used it everyday for 9 months, whereas it may only have to be used for a much shorter time period in Covid-19 patients.

https://www.ncbi.nlm.nih.gov/pubmed/20210854

https://www.ncbi.nlm.nih.gov/pubmed/21515247


This article adds further confirmation to the idea of melatonin for C-19:

https://www.melatonin-research.net/index.php/MR/article/view/79/502

One of the important points the authors are making is that melatonin seems to attenuate the serious viral activity response by your body while your body builds an effective and measured attack instead of an over response of a cytokine storm. It takes the body time to generate appropriate antibodies and melatonin seems to help by essentially calming the bodies over response until the body is able to generate enough antibodies and effectively destroy the virus. This tends to confirm what Dr. Neel is seeing in his patients of very significantly reduced symptoms in 24 hours.

An important quote from that article :

... "For the hosts, melatonin improves the defense system by upregulating the expression of antioxidant enzymes such as SOD, CAT, and glutathione peroxidase(163), effects that reduce the oxidative tissue damage caused by the pathogens. Most importantly, melatonin redirects the host immune response, i.e., by controlling the potentially over reactive innate response and promoting the adaptive immune response."


Summary

I am not recommending melatonin, just putting the information out on Earth Clinic so anyone interested can discuss it with their doctor or health care professional and to also make sure it is compatible with everything you may be taking.

I hope that you will be able to get enough information from this post to see that what Dr. Neel is suggesting is a non-invasive way to assist in the treatment of Covid-19 and possibly in the interim period where you might be told to stay home and rest and then go to the emergency room if you have trouble breathing.

Remember, there are drugs which are working to various degrees, but will we be able to get them and how long will we have to wait before we are tested and accepted as a patient in the hospital to receive those treatments if they are available?

If melatonin is as effective as Dr. Neel and the Philippines have seen so far, melatonin may be a consideration between you and your doctor during that period while you are waiting for your breathing to become difficult enough to be allowed into the hospital.

If it works as they have seen so far, perhaps that trip to the hospital may never be needed! Dr. Neel is talking about positive effects in as little as one day.

Some of the drugs that are being tested for Covid-19 have significant side effects and judging by what is already known about melatonin, it may even help to ameliorate the severity of some of those effects while also helping to alleviate symptoms of the disease itself. His hope, as he mentioned is that melatonin may prevent a patient from ever needing to go on a ventilator in the first place.

Given that some hospitals don't want to accept you in until you are having a hard time breathing, to me, if I feel I am getting sick in any way, I will continue to take the melatonin that I am already taking plus the difference to get up to his dosing schedule in the hope that I never even have to go to the hospital!

These are just more reasons why I refer to melatonin as one of my favorites!

Melatonin Dosage for Lung and Organ Damage Caused by COVID-19

To briefly summarize what Dr. Neel and the hospital in the Philippines are doing to combat the damage caused by Covid-19, Dr Neel is giving his adult patients 80 mg of melatonin each day.

He has them take that 80 mg in 4 equally divided doses so that they take 20 mg at each dose and they take that dose 4 times per day spread out through the day.

The hospital is doing similar, but with a slightly lower dose because they are using a dose range of 36 to 72 mg per day and they are dividing the dose into 4. They don't say why they are using a lower dose, but it may be because they are dealing with children and younger people as well as adults whereas Dr. Neel has so far only treated adults. Another factor may be that in general, Filipinos are a smaller people.

Where to Buy Melatonin

You can find melatonin at most pharmacies, health food stores, grocery stores, and of course, online.

Here are a few links to Amazon:

NOW Supplements, Melatonin, 10 mg, 100 Veg Capsules

Natrol Fast Dissolve - 10 mg - 100 Count - $12.99

Puritan's Pride Melatonin 10 mg 120 Capsules (3-Pack)- $23.00


I would also like to mention that I recently restocked my melatonin supply and they came very quickly compared to my zinc picolinate order and my vitamin D and C orders! Since I have been taking melatonin for years, much of this is information about melatonin I was aware of and why I looked for a possible connection in the first place.

I was not aware of its potential use as adjuvant treatment for Covid-19. Melatonin's ability to help protect the lungs and other major organs could be a very useful adjuvant treatment in trying to protect the body as a whole from most of the potential damage which Covid-19 has shown the ability to inflict on people infected with SARS CoV-2 and act as a potent antioxidant and also act as a potent antiinflammatory, all well known melatonin attributes and this is a very big thing for Covid-19 patients to help protect almost all of the organs that Covid-19 is now thought to involve in addition to the lungs.

A drug that can safely destroy the virus is extremely important, but ameliorating or preventing the damage caused by the virus is important now and later for the patient!

I am sorry for the length of this article, but since melatonin has not previously been discussed for this purpose on this forum, I wanted to include as much pertinent information as possible to give some background.

Related Links:

Coronavirus


48 User Reviews

Posted by Mama to Many (TN) on 01/23/2021
5 out of 5 stars

Hi guys!

I am happy to report that I and my family are on the other side of Covid, at least til our immunity wanes.

We were doing a variety of Coronavirus preventatives around my house. My husband and I have taken coconut oil daily since last March. My husband and daughter have taken astragalus root that whole time as well. We take vitamin D intermittently, and even in winter my husband and kids get lots of outside time. I have been taking 15 mg of melatonin at night for quite a while.

Then we got Covid.

None of us had a cough. Several of us lost sense of smell. Adults had significant fatigue. One child had a fever for one day. Several of us had sinus burning pain and eye pain. Headaches were common. I never registered a fever but felt flu like for a couple of days.

At the very first sign of illness, especially since we realized we had probably been exposed to COVID, I put everyone on the appropriate amount of melatonin (1gm/kg body weight every 24 hours, divided into four doses.) We also took 50 mcg of zinc, 1-2 grams of vitamin C, vitamin D and 2 quercetin capsules. We ate a lot soup and drank tea with honey. Appetites were not amazing, so I just focused on fluids. I had just gotten an amazing deal and stocked up on organic orange juice, too, so that was handy. Everyone rested as much as needed.

We did use some tylenol, ibuprofen and alka seltzer (never at the same time! ) for fever and aches. Alka seltzer seemed to work the best but I did NOT give it to children. Covid is new and aspirin has a history of causing Reye's Syndrome for some children with some viruses (like flu and chicken pox.)

It may be my imagination but I think I could feel the melatonin wearing off. When I was close to redosing time I would notice that I was feeling worse. I did take an extra dose or two in the middle of the night sometimes.

My mother in law, who is in poor health and lives with us, never had any symptoms. I gave her the same protocol that we took ourselves, in hopes of nipping it in the bud if she began with symptoms, which she never did.

I had some concerns about high dose melatonin (HDM) and its blood thinning properties. I am a bleeder because I have chronic low platelets. I didn't have any bleeding trouble with the HDM. My 9 year old is prone to nosebleeds but they did not increase in frequency during HDM. I don't recall him having any at all during that time. My mother in law is on xeralto and didn't have any trouble with HDM. This is descriptive though, not prescriptive.

While astragalus, melatonin, and coconut oil were part of our preventatives, they didn't prevent the disease. But perhaps they made symptoms lighter? I don't know.

I do think the earlier treating any illness begins, the better. It seems the viruses might get less of a foothold.

I think an over taxed immune system puts one at greater risk for getting a bad case of anything. Good nutrition, stress management, enough sleep, fresh air and exercise are all important for that. But honestly that can be really difficult for many people to accomplish. I'm just making an observation.

I have known some hale and hearty people get seriously sick. A naturopathic local doctor who was doing tons of preventatives and being super careful still got covid and got pretty sick.

I don't think there needs to be guilt associated with getting sick, for some failure of preventatives. We are humans and sickness happens to most everyone. When we are sick sometimes we have time to regroup our priorities, read a book we have wanted to read, and then take care of others when we are well.

At the end of the day, I am thankful we made it through relatively unscathed. I would use the same remedies again.

This is only one story of so many covid stories. It isn't a recommendation for anyone, but a “this is what seemed to work for us” story.

~Mama to Many~

Charity
faithville, Us
01/24/2021

Love your testimony of good results and tips for others who get caught in the covid storm. I wanted to add that when I was young I had no appetite and felt sick a lot. I started taking B vitamins and noticed that I felt like eating a horse and that was interestin. I finally gained weight and had to figure it out and cut back on how many B vitamins I was eating. 2021 is war and victory and war is always a great reset of all that we thought mattered. Sort of a housecleaning.

Blessings, Charity

Tessa
Okanagan
01/24/2021

Thanks Mama to Many for your update.

Not only was the information on what you and your family took very valuable in itself, but I appreciate how you mention people shouldn't feel guilty for getting ill - regardless of what preventatives they may take. No one benefits from the shaming/blaming game. Thank you for the compassion you always show to others.

And I'm so very happy that your family is feeling better!

Take care,

Tessa (from cold Canada)

Replied by Art
California
01/23/2021
779 posts

M to M,

I'm glad that you and your family had a relatively easy go of Covid-19!

To be clear on Dr. Neel's dosing schedule, it is ""1 mg of melatonin per kilogram of body weight"", not 1 gm.

Art

Replied by Mama to Many
TN
01/23/2021

Thanks for the clarification Art. That's what we used. I'm just awful at my abbreviations.

We also used 50 mg of zinc not mcg. 🤦‍♀️

Replied by HisJewel
NC
01/24/2021

Praise the Lord, Mama to Many!

That was in awesome family venture. I am so happy for you and your family.

To me one the biggest battles I see families facing since 2020 is a purposeful effect to help one another stay well.

I came to NC to help an elderly Aunt. It has been trying venture to me to get me well and keep her well. I know the Lord has help us.

I happy to say she got the first part of her COVID Vaccine shot. She wanted it so bad, she has Faith in it. So I am happy for her. She's a tuff cookie and still fussing.

Thank God for family and Caring neighbors, and for our EC family.

HisJewel

Replied by aspen-spitfire
AL
01/27/2021

Thank you so much for this testimony. It is super useful.


Posted by Bill (Philippines) on 01/22/2021
5 out of 5 stars

Here's some more useful and surprising safety info in support of using melatonin for COVID-19.

It has already been recommended that melatonin dosage should be 1 mg/kg/day by Dr Neel. But, in the following research study, it is recommending 8 mg/kg/day divided into 5 sub-doses for COVID-19. The research study below also surprisingly says that melatonin at 8 mg/kg/day is "in the ranges used to treat septic patients clinically and is devoid of any adverse effect; thus, it is safe".

See below:

https://doi.org/10.32794/mr11250062

I find that dose of 8 mgs/kg/day very interesting. That also tells me that melatonin is very safe indeed at just 1mg/kg/day.

I've also found 12 research reviews on PubMed assessing and strongly recommending melatonin as a protocol for COVID-19 patients. These studies are all begging for permission from the FDA for melatonin to be studied for use in US hospitals. But the FDA/NIH are still not interested in doing the necessary research to prove that melatonin works against COVID-19. What's more, the FDA has known about melatonin's usefulness against COVID-19 since April/May 2019 when Dr Neel and others loudly informed the FDA of its hugely beneficial effects. I guess the FDA might be thinking that a successful, simple and cheap COVID-19 therapeutic like melatonin at this time might well hinder the ongoing vast sales of western vaccines all over the world. After all, if you have a successful and cheap natural therapeutic like melatonin that can revert your COVID-19 to ordinary, harmless flu then we wouldn't really need those vaccines. Right?

Art
California
01/23/2021
779 posts

Hi Bill,

Unfortunately Dr. Neel's work with HDM is largely ignored by the FDA, doctors, main stream media and scientists in general. There are a few studies showing the safety of melatonin at high dose for years, but my experience is that some people simply do not tolerate melatonin very well, so as far ultra high dosing, I would reserve that for stage 4 cancers and other serious diseases that move relatively quickly like ALS.

One thing that Dr. Neel's work seems to show is that melatonin also seems to prevent some of the serious after effects of Covid-19 that are showing up in people months after supposedly being clear of the virus. This is something that apparently "standard treatment" can not claim.

I still feel that HDM and Xlear Nasal Spray are a very good combination to work against Covid-19 in a timely manner while minimizing symptoms very significantly and shortening the time to being symptom free. Dr. Neel said that only a handful of his over 1,000 HDM patients even needed to go to the hospital. The great majority have treated themselves at home with Dr. Neel's guidance.

They are even thinking that melatonin may have preventative effects at a high enough dose. In my current melatonin test I have been taking 106 mg per night for over 3 1/2 months with no issues that I am aware of, but I knew from previous testing that I tolerated HDM fairly well.

On a related note, the Manila trial of HDM seems like it should be close to completion, but they took longer to recruit patients than anticipated and consequently their results have been delayed. I am anxiously awaiting their results!

Art


Posted by Payton (Beesands) on 01/09/2021

I just read this review of Melatonin. Can liposomal melatonin be used at the same dosage as high dose melatonin?

Replied by Art
California
01/10/2021
779 posts

Hi Payton,

Liposomal melatonin is fairly expensive and Dr. Neel has not used it in his patients, so he has no data to show if it is more effective than regular melatonin for Covid-19. More importantly, he has no data on how to dose the liposomal form of melatonin.

On Amazon, many of these liposomal melatonin products are $40 for one ounce.

https://www.amazon.com/Biopure-Liposomal-Melatonin-Phospholipid-Natural/dp/B01MPZU9BG/ref=sr_1_6?dchild=1&keywords=liposomal+melatonin&qid=1610306110&sr=8-6


Posted by Jacob (Harrisburg, Pennsylvania ) on 01/01/2021
5 out of 5 stars

Ever since I read about Dr. Neel's success with melatonin on this site, I began taking bigger doses of melatonin every night at bedtime and kept a large reserve of different melatonin brands for myself and my friends and family. So when I contracted covid at the beginning of December and I found out I had it I immediately started taking about 30mg 5 or 6 times a day.

I also increased my vitamin d, c, and zinc intake daily as well.

Before I knew I had the virus, I had a pretty bad headache, a bit of a fever, and had some chills and heat flashes. My stomach was slightly bubbly as well. That was the first 2 days. By the afternoon of the second day I found out I had covid. So that is when I started taking megadoses of melatonin. My headache and fever started to leave.

The next morning, I woke up virtually symptom free. I could feel it just a little bit in my lungs and would occasionally cough up a little bit of phlegm but that was it. I continued with megadosing melatonin and taking extra c, d, and zinc for the next 2 weeks or maybe a little bit longer.

Then I tapered everything down gradually until I got back to my normal routine. Now I just take 20-30 mg a night before bed. I really believe that the melatonin increase basically made me asymptomatic almost immediately.

I used several different brands of dissolvable lozenges that were between 2.5 and 12 mgs a lozenge.

Art
California
01/01/2021
779 posts
5 out of 5 stars

Wow, Jacob, that is amazing! I am very glad that your recovery was so quick and smooth!

Thank you for coming back and giving this update as it is useful for any of the members who may get Covid.

Your results pretty much mirror what Dr. Neel has seen in his over 1,000 Covid-19 patients. Once full dosing is initiated, improvements are generally seen to begin the very next day. In the symposium he recently attended about using melatonin as a treatment for Covid-19, the doctors who attended were asked what if any dose may act as a preventative. Their answer was that is not yet known about melatonin, but they felt that if there is a dose that may act to prevent Covid-19 from getting started, it would be 20mg minimum.

Thank you again for your update, Jacob!

Art

Jiggy
Harrisburg, Pennsylvania
01/15/2021

Glad I could share with you guys. One more thing I forgot to mention was I let the melatonin lozenges disolve under my tongue for maximum absorption. I read that taking tablets, pills, and capsules are not quite as effective because your digestive system doesn't absorb it as well. So putting a disolvable or sublingual form under your tongue gets the maximum amount in your system.

Replied by Amy
IA
01/03/2021

I am so sensitive to Melatonin. Maybe the MTHFR gene mut factor. But I'm on day 52 of covid, some days good but fatigue and breathlessness happens. Eating low histamine as I know it's inflammation.

Do you think I should up my melatonin even though as small as 5 mg keeps me awake and sometimes jittery. Would you if it were you? I have people saying to do 30 mg just to get over this.

Art
California
01/03/2021
779 posts

Hi Amy,

Some people simply can not tolerate melatonin and that may be the case with you based on how sensitive you say you are to it.

What you can consider and ask your doctor about is Xlear nasal spray which may be helpful. Here is a link to a post I wrote about it :

https://www.earthclinic.com/xlear-for-covid-recovery.html

This is a fairly non invasive approach that showed benefit in a few Covid-19 patients. There are currently 95 other Covid-19 remedies listed on EC. It may be worth looking at some of those here:

https://www.earthclinic.com/cures/coronavirus.html

Art

Lynn
California
01/23/2021

What happens when you take Melatonin?

I'm curious because a few years ago I realized I could not take Melatonin even at super low doses of .25 mg but can NOT remember what side effects it caused that made me quit using it.

Art
California
01/23/2021
779 posts

Hi Lynn,

Some side effects of melatonin that I am aware of are diarrhea/nausea, but there is often a delay to get to diarrhea that can vary from person to person to as little as a few days or as much as a few weeks. Other side effects are sleeplessness, vivid dreams, nightmares, daytime sleepiness which usually diminishes with daily use over time. Headache is another symptom that sometimes also goes away with daily use as the body adjusts to increased melatonin levels. Dizziness is another which for me was transient and went away completely with daily use. There are others, but these are the main ones that I am aware of. In studies, scientists and doctors consider these to be minor side effects and generally rate melatonin to have minor side effects and a very good safety profile.

I still feel that even though melatonin has a very good safety profile, I believe that some people are not able to tolerate it and should avoid using it, but the great majority of people are able to tolerate and use melatonin regularly.

Art


Posted by Annette (Lubbock, TX) on 12/21/2020
5 out of 5 stars

For anyone thinking the high melatonin dosage is crazy... you'll be fine!

Husband started with a sore throat late Friday night. I had him gargle with apple cider vinegar in water and we also took liposomal vitamin C, D3, echinacea, and Chanca Piedra. Applied some DoTerra OnGuard oil.

Saturday again with those things plus had him gargle with warm salt water, which he said helped.
Saturday night he ran fever so we slept in separate beds and I have tried keeping my distance and wearing a mask. Although probably not 100% of the time. Gave him baby aspirin.

Sunday we took the same things mentioned before and I added garlic for him. He has been sipping on water with lemon and Gaia herbs bronchial wellness tea as well as ginger tea. We scheduled to get tested. Rode in separate cars but tested together in the same room, at which time he had 100.4 fever.
He's positive. I'm negative.

Sunday 6pm 1st dosage of melatonin for us both. 20mg.
Took a second dosage at 1am. 20mg.
Another at 7am. 20mg.

I have been able to wake up a few times to go check on him. Tested his oxygen level and temperature. Normal.

I don't feel anymore sleepy than I do when I take 10mg. I had stopped talking melatonin last week because it's been giving me headaches. We had been taking it regularly. Natrol brand, 10mg time released. Husband had not stopped taking it. I currently feel just a light pressure (nothing terrible). Decided to drink some coffee and type this up.

I plan to continue 20 mg melatonin for us both at noon or 1pm today.
Oh! I've also been boiling water on the stove on and off all day with drops of Eucalyptus oil. We live in a pretty dry climate and with the heater running sinuses get really dry.

Art, I hope to keep updating. Let me know if you have any comments/ suggestions/ questions. Thanks for all the information you've provided!

Replied by Art
California
12/21/2020
779 posts

Hi Annette!

Thank you very much for your feedback on melatonin for Covid-19.

Your results seem to mirror what Dr. Neel has seen in his over 1,000 C-19 patients that he has treated with HDM. He reports rapid turnaround in symptoms very shortly after initiating HDM.

Regarding your husband taking 10 mg and still getting Covid-19, in the symposium that Dr. Neel recently attended, the general consensus among the doctors, researchers and scientists at the symposium, 20 mg was the suggested preventative dose.

Regarding the headache from taking melatonin, this is a known side effect, but in the people who I have talked to with this issue, like the "melatonin hangover", it tends to reduce as the body adjust to more melatonin in the system.

The question I have is, since you started the other supplements prior to HDM, did your husband notice any improvement from them or did he just see improvement once he brought his HDM dose up to par?

Thank you again, Annette for the feedback as it adds further confirmation to the effectiveness of HDM.

Art

Replied by Karen
ENGLAND
01/01/2021

So very grateful for this information, Art. I have just received a positive test so have ordered some HTP which seems to be the same product. It was confusing to buy over here to say the least. I will let you know how it goes. They arrive in two days as today is New Year.

Thank you again!

Karen

Art
California
01/01/2021
779 posts

Hi Karen,

If you mean 5HTP, it is not the same as melatonin and it does different things than melatonin. If you are in England, I believe that melatonin is by prescription only and it may be a problem trying to get a doctor to prescribe the high dose you would need? Perhaps an EC member from your side of the pond can suggest a source???

Art

M-L
Switzerland
01/21/2021

Hi Karen,

For people in Europe order at iherb.com. I am from Switzerland and here Melatonin is absolutely forbidden. You get a prescription only after 65 for only 0,5mg. I have ordered the Melatonin, in case somebody near me gets Covid. Fortunately we have not yet have to use it. Good luck M-L


Posted by Karen (ARKANSAS) on 12/09/2020
5 out of 5 stars

Thank you, Art, for this important and timely information about high dose melatonin. I was diagnosed with Covid the Tuesday before Thanksgiving and began your protocol of 80 mg/day in divided doses the following day. My symptoms (ongoing severe headache and other less painful symptoms) reduced very quickly. I had minor respiratory involvement which never fully developed.

My question is how long do I continue to use the high dosage? From reading through the information you provided, I'm thinking to reduce dosage and see if symptoms return or worsen? At first, I thought I should stay on it for a minimum of two months. Any clarification or thoughts will be appreciated.

Shout out to Earth Clinic for being Earth Clinic!!

Replied by Art
California
12/09/2020
779 posts

Hi Karen!

First and very importantly, thank you for coming back to EC to share with us how melatonin worked for you! I am very happy to hear that high dose melatonin(HDM) worked for you so well and quickly against Covid-19!

Can you give a little more specific information while it is still pretty fresh in your mind?

1. How long after your first symptoms did you start melatonin?

2. How long after your first dose of HDM did your symptoms start to improve?

3. How long did your symptoms last after you started HDM?

4. Is there any other information related to Covid-19 and melatonin you feel is worth sharing with our community?

To answer your question about HDM, I can only tell you what my plan is if I ever get Covid-19. I plan to start at the first symptom with or without a confirmed positive test for Covid-19 because HDM has also shown the potential to help with the flu. I will start at Dr. Neel's last dosing update of 1 mg of melatonin for every kilogram of body weight. So for a person who weighs 176 pounds or 80 kilos, the HDM dose would be 80 mg of melatonin per day. It sounds like patients who are showing severe symptoms or are fairly late stage, Dr. Neel might go higher on the dosing on an individual basis.

I will stay at 1 mg per kilogram of body weight / per day, well beyond the point of no symptoms because being symptom free does not guarantee that you are also virus free. The other reason I will do this is because the latest Covid-19 research is showing that people are developing Covid-19 complications months after supposedly being Covid-19 free and symptom free. The latest after effect related to Covid-19 in men is that of erectile dysfunction. Just a month or so ago it was found that 1 in 5 patients will develop a neuro conditions such as depression, anxiety or insomnia among others. The post Covid-19 issues regarding the lungs and heart are also being seen and can be life long.

In my opinion, this is where the body and organ protective effects of melatonin can really shine beyond just its ability to greatly lessen the effects and symptoms of Covid-19. The known effects of melatonin in humans suggest that melatonin may be able to mitigate some, if not all of the after effects of Covid-19 and possibly prevent these unwanted effects which show the potential to become life long health issues. So for me, I plan to take HDM for at least two months after being symptom free, unless I develop a problem taking HDM, in which case I will stop HDM if I have a problem with it. This two month period of HDM is for the purpose of possibly preventing the potential side effects of Covid-19.

Continued better health to you, Karen, and I look forward to your update!

Art


Posted by Art (California) on 12/09/2020 779 posts
5 out of 5 stars

Here is the latest update from Dr. Neel who has now treated over 1,000 Covid-19 patients with high dose melatonin (HDM) with only a handful of patients needing to be admitted to the hospital at all!

Generally, he uses a dose of 1 mg per kilogram of body weight, but other doctors are now reporting going as high as 6x higher than Dr. Neel, by using up to 6 mg per kilogram of bodyweight! Overall, this is the best update yet and is quite informative because Dr. Neel attended a symposium of melatonin researchers and doctors who shared their information that they have gathered over time in the treatment of their patients with HDM. Even Dr. Castillo who is involved in the Manila study of HDM in Covid-19 patients who also have pneumonia. His team is doing the world's first randomized, placebo controlled, double blind study of HDM to treat Covid-19 patients. Dr. Reiter also spoke at the symposium as did Dr. Brown of Canada talked about intravenous melatonin because oral melatonin is known to be absorbed at only 3% to 15% of the dose taken while intravenous melatonin has much higher bioavailability. Dr. Castillo also mentioned a "maintenance dose" which many people are wondering about. The general consensus of the doctors who spoke at the symposium was 20 mg /day.

There was more to the update, but this was clearly the most informative and exciting update yet! Here is a link to the article :

https://devinenews.com/dr-neel-introduced-as-worlds-leading-expert-in-treating-covid-19-with-melatonin-clinically/#more-21819

Art


Posted by Art (California) on 11/12/2020 779 posts

I just wanted to report this recent news update about melatonin as it relates to Covid-19 :

https://medicalxpress.com/news/2020-11-melatonin-covid-treatment.html

Art

Replied by Kristine
North Canton
11/17/2020

Art,

How does one take melatonin throughout the day without falling asleep? Melatonin knocks me out at night, I can't imagine taking it during the day and being functional.

Replied by Art
California
11/17/2020
779 posts

Hi Kristine,

I have answered this questions a few times and that answer would be in the link to the original post in my reply to you.

Melatonin is known for what is often referred to as the "melatonin hangover" which I assume you are referring to. For many people, this issue diminishes with regular use as the body adjusts to increased melatonin.

As far as I know, Dr. Neel only prescribes melatonin for Covid-19 when you get symptoms and test positive. Under those circumstances he starts his patients at 1 mg per kilogram of body weight. So essentially he does not give it to you until he knows you are sick. Once you are sick with Covid-19, you shouldn't be going anywhere outside of your home as you are contagious. That means you should be spending the majority of your time at home in bed resting and good sleep with Covid-19 is rare. So imo, actually getting more restful sleep is a good thing and melatonin is known for helping to get people to REM sleep where your body is able to do more repair than in non REM sleep.

Lastly, Covid-19 is deadly in some people, so would I really be worried about if I felt tired or not in order to take melatonin? My answer is no and that should be the least of my worries with a known deadly disease! Keep in mind that melatonin has a better safety profile than any drug currently being used to treat Covid-19 and melatonin has shown in one study to improve outcomes for patients on a ventilator. No other Covid-19 specific drug that I am aware of can do that!

So for people who are "very worried" about feeling tired if they take melatonin for Covid-19, perhaps the answer is to skip melatonin and go with something like Hydroxychloroquine, Remdesivir or Favipiravir which all do poorly in late stage Covid-19 disease and nobody is really even talking about these drugs any more for Covid-19 because the available studies and results for them are nothing to get excited about.

Art

Kristine
North Canton
11/19/2020

Thank you for explaining. I was hoping to take it as a preventative measure and was wondering how to do that. I will start it at the first sign of illness (if/when I become infected) along with coconut oil, which DOES work on cold and seasonal flu viruses. I can only hope that coconut oil will work on the coronavirus too. Thanks, again, for your response.

Replied by GertJr
Madison
11/18/2020

Art, can you take high dose melatonin prophylactically? My DinL was just sent home with sniffles and headache, was told to get tested. She got the test, but it's 5 days for result. Should she start high dose now? Or wait until it's positive? I'd say now, since covid is a virus. She's a little bitty thing, maybe 105 pounds, but her overall diet is not great.

Replied by Art
California
11/18/2020
779 posts

GertJr,

I'm not a doctor so I can't tell anyone else what to do or take.

Dr. Neel is recommending to other doctors and his patients, 1 mg of melatonin for each kilogram of body weight. If she weighs 105 lbs, that is equivalent to just under 48 kilos.

For myself, I would start at the first symptom and stop if the test comes back negative, but I am not recommending that anyone do what I do.

Art

Replied by GertJr
Madison
11/19/2020

Thanks, Art. That's what I told her to do. She already had melatonin, so just took enough to add up to that amount and divvied it up into 4 doses. She started that yesterday as soon as she got home (sent home from work, stopped to get tested) and is, today, up and about like nothing happened. They're harvesting around us, so lots of dust in the air and she thinks she was just reacting to that. Probably.


Posted by Art (California) on 10/21/2020 779 posts

This new study abstract goes a very long way in confirming the value of melatonin in Covid-19 patients who receive melatonin after intubation. It shows that melatonin applied after intubation is significantly associated with patient survival. This is very good news because it shows that even when melatonin is applied late in the disease process, it can be effective. Dr. Neel has shown in over 400 patients that early treatment with melatonin can resolve the disease process fairly quickly. So this piece of the puzzle is quite useful in further showing the effectiveness of melatonin for Covid-19!

https://pubmed.ncbi.nlm.nih.gov/33083812

The full study is not available yet.

Art

Replied by Bill
Philippines
10/21/2020

Just a post in support of Art's last post on Melatonin. I also think it's worth mentioning that the Chinese researchers quickly confirmed the efficacy and safety of Melatonin for COVID-19 as far back as March this year and, unlike the Western researchers and the FDA, they wasted no time implementing its rapid use in their hospitals. Here is the Chinese research:

https://pubmed.ncbi.nlm.nih.gov/32217117/

China has also donated and shipped large amounts of drugs/herbs to the Philippines (where I live). They shipped Lianhua Qingwen (a COVID-19 anti-viral) and Melatonin as well as other drug/herbal combinations to be used in Filipino hospitals. The Philippine researchers have also wasted no time confirming the efficacy and safety of Melatonin which can easily be purchased from any Asian retailer website like Alibaba and Lazada.

Unfortunately, as Art and I have discovered, Chinese anti-viral herbs like Lianhua Qingwen capsules are not being sold on Amazon (banned by Jeff Bezos?) but they are sold on eBay. So now Amazon has been politicized in support of all that China-hate from all western govts, which is a great shame.

It also appears to me that the perpetration of all that China-hate propaganda in the western media seems to be way more important (sic) than western researchers actually knuckling down and making the effort to find a successful and consistent therapeutic anti-viral cure (with a 95% cure rate) for COVID-19 in order to save lives in the West. That's the way to go, not vaccines. And China is already there with her integrated medicine approach (but this has not being accurately reported or recognized in the West because of all the continual China-hate propaganda emanating from western, govt-led media who are so successfully blurring, distorting or just not reporting all the facts).


Posted by Art (California) on 10/19/2020 779 posts

Today (10/19/2020) Dr. Mercola posted an article essentially confirming what we here on EC have known for month about high dose melatonin. Hopefully an article from Dr. Mercola who has a good sized following will get even more exposure of melatonin for Covid-19!

Here is a link to his article:

Art


Posted by Mary Lou (Ky) on 10/18/2020

Art,

10/18/2020, Sunday.

As promised, I'm coming back to relay my experience with Covid and using Melatonin. However, I will make two separate posts. This one will be a continuation of the post for Covid related diarrhea.

This is the 3rd week of diarrhea. I implemented your suggestions of 50mg Zinc and ¼ cup blackberries a day. I restarted my COVID protocol which included 80mg of Melatonin. I also added Psyllium Husk (5 capsules, 3 times a day). I stopped the High Dose of Zinc and the Psyllium on Saturday. I felt I needed to give the Psyllium a rest and you'd suggested a short term of the High Dose of Zinc.

I did implement your suggestions with Magnesium, Zinc, and Melatonin from your Restful Sleep post.

I was seeing a slight improvement with stools being a little more formed and duration decreasing a little by Thursday/Friday.

Previous to this week there was no diarrhea during the day or evening. This week (depending on what I ate) I would have a very loose movement or two 30 minutes to an hour after eating.

Today the diarrhea is back to mostly liquid and the duration was about 3 hours. Then this afternoon, within a few minutes of drinking water or coffee, I'm back on the commode.

I'm testing Activated Charcoal today and moving to Turmeric. I may have started my doses too close together at the beginning and the Charcoal may have offset the Turmeric.

I work, so taking all these supplements at the right times is challenging. That's one reason I wanted to stop Psyllium.

I will continue to take my Covid Protocol.

Do you have any other suggestions?

Replied by Jasmine
NC
11/13/2020

Mary Lou, how are you feeling now?

Replied by Art
California
11/14/2020
779 posts

Yes, I am wondering how Mary Lou is doing also? She hasn't updated yet.

Art

Mary Lou
Ky
12/31/2020

Jasmine, Art,

Thank you for inquiring. My last post was 10/29 so I will resume at that post to keep the info in some logical order.

Replied by Carol
Claycomb
11/19/2020

I do not have COVID 19 but have had bowel problems for a very long time due to so much anti biotic use over the years for COPD. Recently I switched over to Lauricidin ( a concentrated coconut oil pellet) that I slowly worked up from a 6 count pellet in a scoop to a full scoop., 3xs a day at meals. I can't tell you how much better I feel. Don't have to always keep the bathroom in my sights when going out. Bowels are returning to normal. The micro biome is where we all need to start in our desire to be healthy. Hope this sheds some light on your situation. Carol

Replied by Mary Lou
Ky
12/31/2020

3 Month Update:

Again, Jasmine and Art, thank you for inquiring about my status. Carol, thank you for your suggestion.

I found out that the diarrhea was indeed caused by Melatonin. As I posted in October 29th, I stopped all supplements except Melatonin. I was taking 80 mg, and then 40 mg of Melatonin daily from about 9/12/2020 to 10/29/2020.

In Art's post about Ulcerative Colitis and IBD he stated, "The 5 mg dose is a good place to start as some people cannot tolerate melatonin " When I read that In October, I stopped Melatonin too. Within 24 hours there was a dramatic change in my bowel habits – not back to normal but enough of a change to know I'd found the cause of the diarrhea.

However, due to nearly (5) weeks of diarrhea and stomach turmoil, it was nearly another (5) weeks before my bowel movements returned to normal.

I tested 5mg of Melatonin a couple of nights ago, because I had been sleeping so much better when I was taking it. I found out that I'm still Melatonin intolerant as diarrhea returned for a couple of days.

Several folks in my office tested positive for Covid in November so I re-tested even through I didn't have symptoms. I still tested positive. However, I didn't have to quarantine as our Kentucky Health Department told me there is a 90-day rule and I was about day 87. It basically states, that if there are no new symptoms, then the virus is “residual” in your system and not contagious. (I may have my terminology incorrect, but you get the gist of it.)

Bottom line, I've been feeling very good lately. I still have a little cough occasionally in the morning. I clear my throat/lungs and it's gone. I've always had a little sinus issue.

I'm back on most of my supplements and have added

Colloidal Silver, 30 Mg, ½ tsp 3x Day - I'm on my 2nd bottle and will stop after the 3rd

1 Tbsp Coconut Oil in coffee at least once a day;

Lysine, ¼ tsp, twice a day;

Black Seed Oil, 1 tsp/day

Hemp Seed Oil, 1 Tbsp/day

My questions now are:

1. Is there something else for sleep in place of Melatonin?

a. I'm still taking Magnesium, Zinc, and D at night and DHEA in the morning.

2. Is there a protocol/suggestion for what supplements are good to take on a daily basis for optimal health? And how much of each. (My pantry is full of supplements and I feel like I'm taking too many and maybe too much of some and not enough of others.)

Thank you for all you and Earth Clinic do to help us.

JGNY
NY
01/01/2021

I recently started taking gaba for sleep, but I also include a little melatonin. Have you tried theanine or niacin? For the virus, I would increase the cs. I make my own and drink several ounces a day. :)

Art
California
12/31/2020
779 posts

Hi Mary Lou.

Thank you for coming back to update on your progress!

Yes, melatonin can cause diarrhea and while it is not a common side effect, it can happen. Here is a quote from my very last reply to you :

>>>I suggest you stop taking vitamin c, magnesium and melatonin as each one of these can cause diarrhea.<<<

..............................

In your case, the diarrhea did not come on for well over a week, which generally would suggest that you tolerate melatonin as in cases of diarrhea related to melatonin use are usually seen right away, at or near the first dose. This may be a good thing for you in case you get Covid-19 again. The antibodies appear to last for months, but apparently it varies with each patient. If you were, to get Covid-19 again, you could still try melatonin at the very beginning and stick with the melatonin until you develop diarrhea again and then stop taking melatonin. Your previous experience will be a very good guide for you!

You may have missed a post I wrote about a specific nasal spray called Xlear, but if you contract Covid-19 again somewhere down the road, I think the combination of melatonin and Xlear, may get you over it quickly and before diarrhea becomes an issue. Here is a link to that post about Xlear :

https://www.earthclinic.com/xlear-for-covid-recovery.html

Now regarding your question about a possible alternative sleep aid to melatonin, I have used Valerian Root Extract (VRE) and it is helpful for sleep. The zinc and magnesium should work well with it. A word of caution regarding VRE, It smells bad, and may be off putting for some people, so again it comes down to trial and error.

Your second question is more involved and would require much more information about what issues you are having that require supplementing.

Thank you again for the update, Mary Lou!

Art

Johanna
NY
01/01/2021

Mary-Lou, have you tried buying a different brand of melatonin? It's possible you bought a bad batch. I would buy another bottle and brand from the local health food store and see if it's any different. Just my initial thought.

Mary Lou
Ky
01/04/2021

Art,

Thank you for a quick reply. And thank you for the suggestion of Valerian. I had taken it some time ago and will start again. I did get a weighted blanket, and after a "getting used to" period, I think it has helped some.

As far as the 2ne question about the supplements, I don't have any current issues to address. I just like to take supplements to maintain good health.

I usually take a multi-vitamin with minerals, extra D, extra C, and extra Zinc. I've added a few other supplements since I've had Covid - Iodine, lysine, Hemp Seed Oil, and MSM.

Are you permitted to recommend a Multi-vitamin brand that is good? There are so many to choose from.

So my 2nd question was, basicially, what Supplements are good to take to continue to maintain good health? Is there a post or a list of basic "good" stuff to take to maintain health?

Art
California
01/04/2021
779 posts

Hi Mary Lou.

Generally I prefer to take supplements on an as needed basis. It sounds like you are taking some good supplements already, but a B vitamin multi such as B-50 might be a worthwhile addition to your current regimen.

Art


Posted by Art (California) on 10/02/2020
5 out of 5 stars

Everyone is now aware of the fact that the president and his wife have Covid-19 and apparently there are several of his staff who also have it.

Trump always talked about how hydroxychloroquine was the solution to the problem, but he is not taking it! Nope, he's taking melatonin! ABC news just reported that.

Does anyone besides me find it odd that his administration never once mentioned that melatonin might be useful to fight Covid-19 and yet it is what they are giving him???

Art

Replied by Tina
Princeton, Nj
10/03/2020

Hi Art,

I'm not surprised at him using melatonin. Like many things about this administration, it's one rule for them and another for the hoi polloi. Maybe now some people will realize that masks work.

Replied by Anon
Not Canada
10/03/2020

Maybe he made them read EarthClinic yesterday.

Replied by Anon
Not Canada
10/05/2020
Replied by Ct
San Francisco, Ca
10/05/2020

Trump did finish a two-week trial of hydroxychloroquine in May, probably as a prophylactic because it showed promising results in early studies. Of course we now are aware of more possible therapeutics such as melatonin and vitamin D due to more research. But he's not advocating the use of a particular drug now, after HCQ has become politicized.

Replied by Debra
Crystal City
12/04/2020

Considering the fact that the media turned his statement about Hydroxy into a political debate, I doubt that he would ever admit to anything he was taking. Here, a local doctor put all of his nursing home patients on Hydroxy (after a resident was diagnosed and passed away), and no one else at the facility caught Covid. I hated that anything was rejected - especially when no one could offer anything else. It's a 60 year old drug that is safe. Just my opinion.


Posted by Art (California) on 09/10/2020 779 posts
5 out of 5 stars

This recent report (August 26,2020) of an 87 year old who was treated with HDM and treated early, survived with no complications!

Here is a link to the brief article:

https://devinenews.com/hooker-87-beats-covid/

Although it is just one case, 87 years old is a definite high risk case and he survived with High Dose Melatonin, along with vitamin D, zinc and vitamin C. Melatonin has shown synergy with these vitamins in recent studies. These four supplements are noted for having very good safety profiles and are all commonly available over the counter and are inexpensive. Simple, easy and effective and can be started earlier than the drugs being prescribed for Covid-19 in most cases.

This bodes well for the elderly!

Art


Posted by Art (California) on 09/02/2020 779 posts
5 out of 5 stars

Here is the latest very promising report on Dr. Neels melatonin / Covid-19 protocol as used in a Texas convalescent facility. As many of you already know, these convalescent facilities are fairing very poorly with many patient deaths being the norm! This convalescent facility didn't waste anytime implementing Dr. Neels protocol once they had their first two cases die from Covid-19. They started using HDM right away and had no more deaths from Covid-19! One patient died afterward from another health issue. This is very important because this is a senior population with health issues and age that put them at increased risk of succumbing to Covid-19.The rest lived.

Here is a link to the latest article :

https://devinenews.com/lytle-area-facility-fights-back-quickly-as-covid-outbreak-strikes/

Art

Replied by Mary Lou
Ky
09/08/2020

Art,

I just tested positive for Covid and I am assuming my infection date was 9/4/2020. I didn't get the test results until 9/6/2020.

I'm 68 years old and in very good health. I do not take any medications and have never had a surgery. I currently (9/8/2020) have very mild symptoms, mostly sinus congestion, head cold feeling, mild headache and exhaustion.

I just ordered Melatonin and will place another order for sublingual melatonin as I believe I read that was preferred.

I've read all the articles that I could and the comments. Several of the lengthy ones I had to skip. I can't focus on complex explanations right now.

I see in the article about Country Life Assisted Living that they supplemented with Vitamin D3, Zinc, and Airborne Supplement with Vitamin C per collaboration with Dr. Richard Neel.

Could you provide the suggested doses using Vitamin D3, Zinc, and Vitamin C powder? (I have been alkalizing 2-3 times a day and supplementing additional Vitamin C powder, 1 gram and ¼ tsp baking soda almost every hour in between.) I've also added Quercetin (800 mg) with Bromelain (165 mg), and Astragalus Root (400 mg), and Lugol's Iodine.

I should get my Melatonin in a day or two.

Thank you so much for a quick reply.

Replied by Art
California
09/08/2020
779 posts

Mary Lou,

I did test melatonin in the sublingual form, but did not notice any difference and the report you are referring to occured around the same time that Dr. Neel reported a more difficult strain of Covid-19 in his patients that was requiring more time to see improvement and in some cases he was using even higher dosing. I suspect that report was reflecting the tougher strain that Dr. Neel had mentioned that also came with digestive issues that he previously had not seen in his covid patients. I believe this may have been the reason for the report of a delayed response in that family.

As far as dosing of zinc, vitamin D and vitamin C, unfortunately they did not state the dosing used, in the article.

One of Dr. Neel's patients in an earlier report mentioned 2,000 mg of vitamin C total per day.

The Italian study suggested a serum level of 40 to 60 ng/ml for a good response to vitamin D, but again vitamin D serum level has to be tested regularly in order to reach a specific level such as 40~60 ng/ml and the dose will vary from person to person as some people simply require higher dosing than others to reach a specific serum level. The reference range for vitamin D / 25 (OH) d serum level is 30 ng/ml ~ 100 ng/ml and would need to be tested by your doctor to get there.

Art

Replied by Mary Lou
Ky
09/11/2020

Art,

Thank you for your reply.

I'm on day 9 of the virus and was just able to start Melatonin the evening of Day 7. I'm glad there was no noticeable difference using sublingual Melatonin as I couldn't find any that didn't have a lot of additives.

I used the Vitamin C protocol from another page on Earth Clinic of 1000 mg every hour, with Zinc, Quercetin, and then added D two days ago. Also, few other supplements- some of which are listed in my previous post.

I had about 3 days of very bad flu-like symptoms that changed to mild sinus congestion and head cold.

Right now (day 9) I feel pretty good, (actually almost normal) except for being extremely tired and feeling very weak.

I plan on retesting the first of October and will remain in self-quarantine until then.

Can you suggest how long to continue the Vitamin C and Melatonin protocols? Today I reduced the Vitamin C to every 2 hours.

Also, I am having the best nights sleep I've had in a long, long time!

Replied by Art
California
09/12/2020
779 posts

Mary Lou,

Glad to hear your sleep has improved and even gladder to hear you have fared very well with your bout of Covid!

I think what Dr. Neel is doing is waiting until you test negative and then slowly reduce your melatonin dose until you get down to around 5 mg/night.

I believe the reason he is in no rush to take his patients off of melatonin too quickly is because Covid-19 has shown damage to almost all major organs in autopsies and studies suggest that melatonin can repair much of the damage that you can't see and is not readily apparent to the patient or doctor. This damage if left unchecked may cause health issues years down the road. I think the damage has the best chance of being repaired while it is relatively fresh.

Art

Replied by Mary Lou
Ky
10/09/2020

Art,

Thank you for the quick replies. I hope you can offer suggestions now about a diarrhea issue that I believe is a result of the COVID.

About a week after I was released from quarantine I started having diarrhea (very liquid and sometimes explosive). It usually starts first thing in the morning and lasts for only about 1-2½ hours. Then I'd be good the rest of the day - sometimes a little drained feeling. Other than that I feel very good.

I'm thinking the diarrhea is from having COVID. I'm ending week 5 from the date I first experienced COVID symptoms. I have not been re-tested for COVID.

I tried posted EC remedies – ACV, Activated Charcoal, and Turmeric. None of these had any effect. I added Psyllium Husks and am beginning to see some slow, v-e-r-y slow, change in the firmness of the loose stools and for the most part they are no longer explosive. Diarrhea lasts about a hour now, and I've had loose stools in the afternoon for 2-3 days (which is a new occurrence)

I had reduced Melatonin to 40 mg a day and have returned to 60-80mg (depends if I can get all doses in). I take 1000 mg of Vitamin C two times a day. During the time I had symptoms, I took 1000 mg of Vitamin C 6-7 times a day.

Any suggestions on this issue would be greatly appreciated.

Katherine
Vacaville
12/03/2020

Mary Lou,

I had similar symptoms after what could have been COVID, but didn't get tested. I read on Curezone that we need 150 mcg of iodine a day, some for digestion. The recommendation was to take 100mcg of 5% Lugol's solution a day (16 drops) if you have problems with gut or thyroid AND for COVID. I did and my loose stool was instantly stopped and so was whatever I had (upper and lower respiratory symptoms). It wasn't even minutes. I will continue to take that amount until I get myself iodine saturated.

I also take co factors: Vit c, Selenium 55-400mcg, zinc 25 mg-higher and copper. (I haven't taken the copper yet). I also take a good probiotic.

Replied by Art
California
10/09/2020
779 posts

Hi Mary Lou,

First I would like to say thank you for coming back and updating on your use of melatonin for Covid-19 as this information is very useful for other members to help know what is useful!

Yes, I think you lessened your dose to soon. As for the diarrhea, Dr. Neel mentioned that in his more recent patients he was seeing gastrointestinal issues regularly and he felt it my be a different strain of Covid-19 than he had previously been seeing. You can try zinc at 50 mg/day for a short course to see if it is enough to regain normal digestion. Dr. Neel added antibiotics in some cases where he suspected bacterial infection.

You can also consider blackberries for the diarrhea.

If you have time, could you give us an idea of your experience with melatonin for Covid-19 and the dosing that you used throughout the treatment period? Thank you!

Art

Replied by Mary Lou
Ky
10/09/2020

Thank you again, Art.

I will come back and fill in my usage of Melatonin for Covid, but for this post, would you elaborate on using blackberries? For example, try 1/4 cup once a day...

I will start Zinc tonight. Do you recommend 50 mg at once or divided morning and evening, or ....?

Replied by Art
California
10/09/2020
779 posts

Hi Mary Lou,

Regarding the blackberries, that seems like a reasonable dose to start with and see how you do with it. Regarding the zinc, I split my dose as the zinc is useful for sleep so I take half of the daily dose about an hour before bed with the other two supplements as I mentioned in my post about pursuit of restful sleep here:

https://www.earthclinic.com/art-solbrig-insomnia-protocol.html

Good luck and I look forward to your update!

Art

Replied by Mary Lou
Ky
10/18/2020

Art,

10/18/2020, Sunday.

As requested and promised, this is my post on my COVID experience and using Melatonin. I don't know that it will be sufficient evidence to support any one protocol, but maybe it will help someone.

I've tried to re-create the two weeks that I had COVID as best I can. I was not interested in documenting it at the time, but started after a few days.

My first symptoms were about 6 days after I believe I was infected. On Thursday, 9/3/2020, I had the worse sinus and head cold symptoms I'd had in my life. That was the day I was told I had been in contact with a person who tested positive.

I had been taking a COVID preventative protocol for about a week. These included Alkalizing, Vitamin C, D, Zinc, Querticin.

The next two days I felt better in the morning and worse in the evening.

By Day Four, I felt more flu like symptoms. Very severe head cold and sinus congestion, an occasional cough, and very tired. I went back to earthclinic.com for additional suggestions and the EC staff pointed me to your Melatonin posts. I ordered some.

Day 5 was very bad “flu” like symptoms. I started taking 1000mg of Vitamin C extra times during the day. The highest fever I had as 99.1.

Day 6 still the same. I started taking 1000mg Vitamin C every hour.

Day 7 I received my order of Melatonin and added 40mg that evening to my current protocol. After the first dose of 20mg at 4:00 p.m., I was so sleepy I took a 3 hour nap. After the 2nd dose at 9 p.m., I slept till about 10 a.m. the next day. I had already started to feel a little better today.

Day 8 I added the full 80mg Melatonin today. It didn't knock me out like the two yesterday. I coughed more today than I had since this started. The worse symptom was weakness, tiredness and being shaky on my feet.

Day 9 I felt fairly good, but shaky, a little dizzy, weak, tired, and coughing a little less. I reduced Vitamin C to every 2 hours.

Day 10 I didn't feel like getting up in the morning. I was more congested. I reduced Vitamin C to every 3 hours as I was having light diarrhea and thought I was saturated with Vitamin C.

Day 11 I felt fairly good except for a little cough in the morning to clear my lungs and still tired and sleeping a lot.

Day 12 I felt fairly good today. I still had a little cough in the morning to clear my lungs. I actually walked about 2 blocks before wearing out. I was still sleeping a lot.

Day 13 I felt fairly good today too. I still had a little cough, congestion, and weakness.

Day 14 I considered myself healed at this point.

Over the next couple of days, I cut back on the melatonin.

Day 25 This was about a week and a half later and later severe diarrhea started. At first I thought it was food poisoning. When that didn't clear, I started back on my COVID treatment protocol including 80 mg of Melatonin.

At first the diarrhea only happened first thing in the morning and lasted 1-3 hours. It started severe, explosive, and liquid. I stayed on the BRAT diet and/or ate light. After (2) weeks, I ate other things and sometimes had diarrhea after lunch or dinner, but only 1-3 movements, then I was usually good.

I started back to work on 10/05/2020 feeling good except for the diarrhea.

I tried most of the popular EC remedies for diarrhea. Charcoal, Turmeric, and ACV didn't help. I added Psyllium and it helped just a little. Last week I upped Zinc to 50mg and ate ¼ cup blackberries.

I felt I needed a break from all the supplements on Friday, 10/16/2020. So Friday night and Saturday I stopped the psyllium and a lot of the supplements. Today, Sunday, 10/18/2020, the diarrhea was back full blown and for about 3 hours.

I wrote a previous post on the diarrhea only and am hoping for more help with that.

Here is my COVID protocol that I implemented over the 14 days I had symptoms:

  • Alkalizing with ACV/baking soda
  • Iodine 12.5 mg
  • Querticin 80mg with Bromelain 165mg
  • Zinc 25 mg
  • Vitamin C 3000- 10,000
  • Melatonin 80 mg
  • Multi-vitamin
  • B-Complex

I am back on the Full COVID protocol. I had some NAC so I added that too.

I will take Turmeric this week to hopefully help with the diarrhea.

I will say the Melatonin and Art's insomnia protocol has helped me sleep better than I have in years with not as many bathroom trips during the night.

Replied by Art
California
10/18/2020
779 posts

Hi Mary Lou,

Thank you for the great feedback on your Covid-19 / melatonin experience!

Based on what you wrote, it appears that your Covid-19 "preventative protocol" was insufficient to actually stop or reverse the virus progression in your system as suggested by your steady system increase during those first 7 days.

My opinion of your preventative protocol is that most of those components are synergistic with melatonin and can improve the outcome of the melatonin treatment, but without melatonin they are insufficient and I feel that your experience adds confirmation to this theory.

From what I have seen so far with most things being tested for Covid-19, the sooner they are initiated, the better the outcome. Unfortunately you weren't able to actually take melatonin until a week had passed and this allowed the virus to multiply unabated that first week and the increased viral load seems to be confirmed by that continuing increase and worsening of your symptoms in that first week.

Studies of Covid-19 show that increased viral load equates to worsened symptoms and sometimes death, while lower viral loads equate to moderate to being asymptomatic and living.

On the 7th day, your first day of taking melatonin, you already had very significant symptoms and you only took a 40 mg dose of melatonin and that allowed you to get good sleep which is actually very good! Some people say that melatonin can make them feel tired the day after they take it, but it is a good thing to sleep and reach REM sleep where your body is able to do a lot of needed repair work.

Consequently, even though you only took 40 mg of melatonin the night before, you already felt a smidgen better the next morning which was a first! This is exactly what Dr. Neel has been reporting in his patients with noticeable improvement the day after the first dose. Dr. Neel recommends to other doctors to give their patients 1 mg of melatonin for every kilogram of body weight.

I don't know what you weigh, but 80 mg is probably close enough to that dosing schedule to work as Dr. Neel has been reporting in over 400 Covid-19 patients treated successfully so far.

On the 8th day, you actually took your first full 80 mg dose of melatonin that you planned to take. You noticed increased coughing and again, this can be a good indication because one of the first things that melatonin does is reduce inflammation in the lungs and with reduced inflammation and consequently reduced swelling in the lungs, the body will attempt to start clearing fluid and mucus buildup which would represent as increased coughing that should be more productive than previous coughing.

The symptoms on day 8 are to be expected.

Day 9, your second day at the full 80 mg dose again showed symptom improvement and that was to be expected.

You stated, >>> ' I felt fairly good, but shaky, a little dizzy, weak, tired, and coughing a little less. I reduced Vitamin C to every 2 hours.' <<<

Again, you are showing improvement at just your second day of full dosing!

One thing that has been shown by Dr. Neel and studies is that vitamin C has synergy with melatonin, so it may have been a bit premature to reduce the vitamin C dose, but that is unknown for certain in your case. Remember that your original preventative formula mostly has synergy with melatonin.

Day 10 you reported reducing your vitamin C dose even further after getting a little diarrhea. This is where the way the post I wrote on this subject gets a little harder to follow.

You see, whenever I got new information regarding using melatonin for Covid-19, I can not add that information to the original post, so I have to add it as a "reply" to the original post so if you don't read the whole original post "and" all of the replies to that post, you will not get all of the information needed.

In one of my replies I said that in later cases of Covid-19, Dr. Neel is seeing gastrointestinal issues that he did not see in his first 200 patients or so and he surmised that these gastro issues were likely related to a mutation of the viral strain. His solution to the problem was to add an antibiotic to try and kill whatever bacteria was causing the gastro issues, but you were probably not even aware of that update. Now if you were going to try to use some type of natural antibiotic to treat the diarrhea, it would probably be things along the line of garlic, Olive Leaf Extract, Grapefruit Seed Extract, Colloidal Silver etc.

Really just a personal choice based on what you prefer.Day 11 went fairly well with tiredness, a light cough to clear the lungs and more sleepiness which would all be expected on your third day at full dose melatonin. No mention of diarrhea.Day 12 sounds really good and again no mention of diarrhea.Day 13 sounds similar to day 12 and no mention of diarrhea.

Day 14 you said, >>> ' I considered myself healed at this point. ' <<<

On this point I would completely disagree. Your symptoms may have abated, but this in no way means that you are no longer sick! I think that many people think that if they have no symptoms, then they are no longer sick.

You are only on your 7th day of melatonin at full dose and you started a week later than you should have which essentially gave the virus a head start. Chances are you would have still tested positive at that point and to let up at that critical point is a mistake imo.

For myself in a similar situation, I would have continued with everything for at least a week more and I would probably gone even longer than that with the melatonin. Here is why. In the beginning of the original post I am talking about all of the damage that Covid-19 has shown in autopsies to many of the major organs and melatonin has shown the potential in other studies to help prevent or lessen this damage which can in time become long term or possibly life long damage.

It is my opinion, based on melatonin studies, that much of this damage can be prevented or reduced with longer use of melatonin after all symptoms have cleared. No mention of diarrhea.

From day 14, you skip to day 25 and I assume that you are relatively okay during these 11 days.By day 25 you have cut back on everything and are now trying different things to control the diarrhea.

I believe that the ACV with baking soda is a bad idea as you do not want to raise stomach pH as one of the purposes of stomach acid is to kill bacteria that enters the stomach with your food and imo can possibly be a reason for the diarrhea.

Eleven days with no symptoms suggests that you had the virus under control, but reducing stomach acid via your alkalizing method does not seem like a good idea imo.Unless I missed something, none of the things you have been taking seem to have strong antibacterial effects, except curcumin, but it is not well absorbed and would likely require a high dose, but I have no knowledge of using curcumin in this way.

The supplements I mentioned above, do have antibiotic effects as do others. Generally, but not always, diarrhea is caused by a bacteria and in your case you do not know the exact cause at this point, but if you went to a doctor, he might put you on an antibacterial regimen to try and kill any bacteria that might be causing the diarrhea.

ACV by itself might be helpful because of its low pH, but likely insufficient for full blown diarrhea and by adding baking soda to the ACV, you are significantly raising the pH of the ACV and possibly your stomach acid depending on what dose you have been using thus nullifying the possible benefit of the ACV.

Ideally, a visit to the doctor to take and test a stool sample to find out if it is a bacteria and which bacteria and knowing which bacteria would be very useful. With that knowledge he would know the best antibiotic to use. Failing that, you have a decision to make to either go to the doctor or decide if you are going to try and use naturals supplements with antibiotic effects on the diarrhea.

I am not a doctor and can not tell you what to do regarding the diarrhea.This diarrhea situation is questionable at this point whether it is related to Covid-19 or not because you went well over a week with no symptoms or diarrhea and Dr. Neel's reports only discussed earlier onset diarrhea which you did recover from, but those reports are not overwhelming with information.

It is entirely possible that this current diarrhea is unrelated to Covid-19 as even you thought that it might be food poisoning.

Art

Replied by Bill
Philippines
10/18/2020

Mary Lou,

I think that most of the residual problems that you're having after your COVID-19 infection are perhaps mainly due to the inflammation caused by existing residual virus issues(acting in the intestines) that can always occur whenever you recover from any viral infection.Don't forget that most virus have the ability to hide from the immune system(eg Herpes virus, Epstein Barr) and COVID-19 is really no different.

In all the recent research that I've read on COVID-19, it is a fact that ALL cells in the human body have special inflammation ACE-2 receptors. And since the COVID-19 virus attaches to the cellular ACE-2 receptors and disrupts it, that therefore means that ANY tissue or organ can be seriously affected by inflammation whenever you are infected by COVID-19. I've also read much research that confirms that COVID-19 inflammation can cause cytokine storms, heart mycarditis, thick blood, arterial build up and occlusion(arterial blockages), pneumonia, kidney/liver/pancreas problems as well as causing problems in the intestines.

You can perhaps use a three pronged strategy against COVID-19 by supplementing the following:

1. Serious immune boosting all-round anti-viral neutraceuticals like Ted's lysine + Vitamin C protocol or quercetin + resveratrol, or niacinamide. These are just a few of my favorites.

2. Supplement neutraceuticals that directly attack the virus by stripping the oily outer coat from lipid coated viruses(like COVID-19), which then exposes the the virus protein as a foreign protein body, which the immune system then identifies as enemy non-host protein and so it is rapidly destroyed and removed by the immune system. Neutraceuticals that can strip the oily coat of the virus are: Virgin Coconut Oil(3 tablespoons a day), simple aspirin(taken 4 times a day at 3 hour intervals outside meals) and BHT(up to 500 mgs 3 times a day outside meals).There is also alot of conflicting research evidence on BHT mainly caused by all the "spoiler research" on BHT that has been put out by Big Pharma. The best and most honest research and recommendations I've found for supplementing BHT comes from Dr Steve Fowkes, an independent and honest researcher, who has been investigating BHT's beneficial anti-viral properties for over 20 years. See his free ebook -- called The BHT Book -- for more info on BHT.

3. Take supplements that act to suppress the inflammation caused by the out of control ACE-2 receptors. Tumeric and melatonin are perhaps the best supplements to take for this -- and you are already taking them.

To further improve your residual intestinal problems(severe diarrhea) I would just do one round of Milk of Magnesia at the normal, recommended laxative dose. Make sure you do this at the weekend so you are always near a toilet. After your intestines have been cleared out by MoM also make sure that you re-mineralize the blood electrolytes by taking the appropriate minerals. MoM causes the laxative or diarrhea effect because of its high alkalinity(pH 10). At that pH MoM will also kill any pathogens(incl viruses) or parasites in your intestines. By the way, taking MoM this way is also one of Ted from Bangkok's anti-pathogen remedies for problems in the intestines.

And after you have cleared out your intestines with MoM, you should continue your current anti-COVID protocol until you are fully recovered.

Replied by Mary Lou
Ky
10/19/2020

Thank you Art for your input.

I'm definitely staying on the whole Covid Protocol with Melatonin for another week or two.


Bill,

Thank you for your input. I have Lysine and Vitamin C so I'd like to add that. However, I can't find Ted's lysine and Vitamin C protocol. I've spent about over 30 minutes searching posts and don't know how to find the protocol.

Can you or EC post a link?

I am taking Quercetin but not Resveratrol.

Replied by Bill
Philippines
10/20/2020

Mary Lou,

Here is a link to Ted from Bangkok's lysine anti-viral remedy. This link deals with H1N1, which is similar to the COVID-19 virus. The post also contains a list of other remedies against such viruses that also includes using Hydrogen Peroxide, MMS, Aspirin etc:

https://ted.earthclinic.com/cures/h1n1-swine-flu7.html

Replied by Mary Lou
Ky
10/29/2020

1 Month Update

Art and Bill,

This is my 4th week and the diarrhea was worse near the end of last week, this past weekend and the beginning of the week.

I've went back on the full Covid Protocol for 2-3 weeks and just stopped a lot of the supplements on Tuesday, 10/27

I went to the elders of my church and was anointed and prayed for according to scriptures.

I felt God directing me to look at all the supplements I was taking.

This may have gone from a Covid related diarrhea to a supplement induced diarrhea as its gotten worse over the last week.

I know that both Vitamin C and Turmeric can cause diarrhea. Also, in Art's post about Ulcerative Colitis and IBD you stated, "The 5 mg dose is a good place to start as some people cannot tolerate melatonin ".

I've already stopped Vitamin C, Turmeric, Quercetin, extra Zinc and extra D.

I'm still taking 80 mg of Melatonin, a Multi, (1) zinc, (1) D.

I added DHEA, Colloidal Silver, and (3) tbsp. of VCO this week. I added Lysine a couple of days then stopped because I didn't want to add an additional supplement until I got a better handle on what is causing the irritation.

The diarrhea is a little better since I stopped most of the supplements, not so liquid, but not formed at all and still urgent.

After the first couple of hours in the morning I'm usually good until I eat something. Then I have a very loose, urgent movement or two or three and I'm usually good till the next meal.

However, my stomach is aching almost constantly.

I'm to the point of a hard decision. I don't want damage from Covid. However, I think I've taken the protocol long enough. I can't go on with this diarrhea. I had to leave work early twice this week due to the diarrhea and/or exhaustion from it and the stomach pain.

Since, I read Art's post on Ulcerative Colitis, I'm going to stop Melatonin for the rest of today and then pick up tomorrow night with only the evening doses per Art's“restful sleep” protocol and add Zinc at night - to see if I've built up intolerance to it.

If diarrhea continues, I will stop all supplements for several days to see if any others are contributing to the issue.

I would like to resume a preventative protocol, but at this time, I want to concentrate on stopping this diarrhea.

Both your suggestions are greatly appreciated.

Replied by Art
California
10/29/2020
779 posts

Hi Mary Lou.

Last time we spoke, I mentioned that you had a decision to make regarding the diarrhea, either go to the doctor or continue trying to fight it with natural substances. You have now tried the latter and the effort has not been successful. You can not continue with the diarrhea as this is preventing your body from absorbing nutrients from food you are eating, so this now leaves the doctor option so that he/she can determine the cause of the diarrhea.

In case the doctor is not able to see you immediately, you can try Pepto Bismol tablets, not the liquid, to help you last until your doctor appointment. Take as directed on the box. The doctor can take a stool sample and also test you to see if you now test negative for Covid-19. From what you have written, it sounds as though the diarrhea is your only symptom, but this is serious and needs to be stopped as soon as possible. A word of warning, the bismuth in Pepto Bismol tablets will turn your stool a blackish green color, so do not be alarmed about that.

I suggest you stop taking vitamin c, magnesium and melatonin as each one of these can cause diarrhea.

Please come back and update us on how it is going for you.

Art

Replied by GertJr
Madison
10/30/2020

Art, I think you're right about the diarrhea. Anecdotally, person in my office flies to sporting events every weekend. He is one who never covers his coughs. This past week, many of us in the office have had strange stomach pain, joint pain, fatigue and diarrhea. I'm betting we've been exposed to covid and, since we are very aware of supplements/rest/nutrition, we're fighting it off. Maybe a minor infection at this point. But how would we know without testing? And none of us want to be tested because that would shut down our department and we're essential and would have to work anyway unless seriously ill. We do not encounter the public much, so it's purely internal other than at home. And, since we're conscientious about not infecting others, I think we'll be okay. But, sucks for us to have one person bring it in.


Posted by Art (California) on 08/26/2020 779 posts
5 out of 5 stars

In this latest update from Dr. Neel, he mentions that although the amount of new cases in his area of Texas have slowed a bit, the current strain affecting his area is definitely more difficult to treat than the previous strain he was working against. He has shown a willingness to raise the melatonin dosing level to help deal with this current strain because with this strain it has taken 3 days to start to see improvement whereas with the previous strain he was seeing improvement in just one day.

One thing he didn't mention is the number of patients he has treated as of today(8/26/2020). The last time he mentioned the number, he said over 400 patients treated. He still not has reported any deaths as of this update. Here is a link to the update:

https://devinenews.com/masks-to-melatonin-how-it-works-why-it-works/

Art


Posted by Art (California) on 08/25/2020 779 posts

Since it appears that Covid-19 is going to be here longer than anticipated by the administration, I am continuing to update this thread as I find relevant information regarding this infection. It is worth noting that overall, since the administration has taken over keeping track of Covid-19, from the CDC, in mid July, the number of new cases for the US have been declining steadily. On July 24th, there were 78,586 new cases that day and it has steadily declined from that day forward. Can this even be correct considering the elevated new cases in California, Texas, Florida and New York?

This recent study (June/2020) is in agreement with the idea of using melatonin against Covid-19, but their hypothesized dose rate is approximately 8 times greater than what Dr. Neel is using on average (1mg per kilogram/day) at 8 mg/kg/day and higher for severe cases! To put that in perspective, if you weigh about 175 lbs or 80 kilos, you would have to take about 640 mg of melatonin per day for severe Covid-19 infection!!!

https://www.melatonin-research.net/index.php/MR/article/view/83/562

I'm a fan of melatonin, but that is the highest dosing I have ever heard of in humans and even greater than what Dr. Shallenberger is using in his stage 4 cancer patients!!

Art


Posted by Art (California) on 08/15/2020
5 out of 5 stars

Here is another upcoming melatonin / Covid-19 study that is going to be done in Spain using 60 mg / day and what makes this study different is that they are injecting those 60 mgs of melatonin and this will be a randomized, placebo controlled, double blind study which is also a first when it comes to melatonin / Covid-19. I don't think they have a randomized, placebo controlled, double blind study for Hydroxychloroquine yet :

https://www.docwirenews.com/abstracts/clinical-trial-to-test-the-efficacy-of-melatonin-in-covid-19/

Art


Posted by Art (California) on 08/02/2020 779 posts
5 out of 5 stars

Below is a link to an article about a 4 year old boy in Texas who got sick shortly after his father tested positive for Covid-19.

Of note related to this story is that 4 to 7 year olds are at or very near the peak of natural melatonin levels seen in humans suggesting that melatonin can not prevent infection, but it can apparently reverse it in short order based on this and many other reports! This could be useful information for all of those people who have kids or grandkids! Here is a link to that article :

https://devinenews.com/local-4-year-old-battles-103-9-fever-days-after-dad-tests-positive-for-covid-19/

Art

Replied by Anon
Anon
08/02/2020

Or the boy's ability to produce melatonin has been compromised.


Posted by Art (California) on 08/02/2020 779 posts

Melatonin and What Type May Be Best for Covid-19:

Previously I had stated that when it comes to Covid-19, the type of melatonin should not be an issue, but Dr. Neel had stated that he was using the type of melatonin that dissolves in the mouth or under the tongue (sublingual).

I thought the only significance of that type was that he felt it would be possible to give to patients already on a ventilator and that was it, but this recent report suggests that there may be more to sublingual melatonin than that! Other sublingual supplements are often said to have better bioavailability in their sublingual forms over regular capsules or pills. Perhaps this is also true for melatonin in its sublingual form? Melatonin on its own has poor bioavailability. Roughly, oral melatonin only offers a maximum of 15% bioavailability at best. So this offers some creedence that even a small increase in bioavailability may have significant ramifications when it comes to melatonin?

https://pubmed.ncbi.nlm.nih.gov/10883420/#:~:text=Subjects were administered, in a, absolute bioavailability of approximately 15%.

Given that information, the following report from a Covid-19/Melatonin patient makes a little more sense and I may need to rethink the use of sublingual melatonin on the chance that it is better absorbed by the human body???

https://devinenews.com/family-of-8-hit-hard-by-coronavirus/

Perhaps type of melatonin does matter??? Since I have been taking melatonin in the capsule form, I may have to get a bottle of sublingual melatonin to see if I respond differently to it? This may take a little bit of time since I have other experiments already in my queue.

Art


Posted by Art (California) on 07/26/2020 779 posts

Very recently I found out that some 10 mg melatonin capsules also contain vitamin B6. This will not work for high dose melatonin (HDM) treatment as it can deliver to much B6 and this can be unsafe and unhealthful to take in that much B6 everyday! The B6 is added for the purpose of increasing the absorption of melatonin. Stay away from these types of melatonin that contain extra B6 as they should not be used for HDM.

Art


Posted by Nancy11 (Florida) on 07/23/2020 3 posts

H2o2 use and melatonin:

I have just got over a median case of covid. I have copd and my breathing has worsened since, I just started taking or doing the hp protocol today. I have noticed in your article that melatonin fights off h2o2, so would it be advisable to say I should just do the melatonin to try to recover my lung capacity, I am not on any meds at this time.

Replied by Art
California
07/24/2020
779 posts

Nancy11,

This is going to be a long answer.

To briefly answer your question, yes, I would lean toward "melatonin only", at least until you find that your breathing difficulty has improved significantly back toward your normal. This should help allow your lungs to heal to the extent that melatonin is capable of doing.

Once and if you improve from the melatonin supplementation, then you can consider whether you want to add H2O2 to the mix. Melatonin is likely to work against H2O2 as it is a radical and melatonin neutralizes radicals and melatonin can enter any tissues in the body and is proven to significantly affect the lungs.

More on this below and a possible workaround.This is a tough question for me, because I look at H2O2 as a very potent oxidant that can potentially lead to excess oxidative stress and I see that as the reason it would very likely be effective at destroying SARS CoV-2 that exists in the lungs via inhalation of H2O2, but once the virus is destroyed in the lungs, do you really need to keep inhaling a potent oxidant (H2O2) into COPD lungs that already have elevated levels of H2O2 as shown in existing studies?

I know there is plenty of anecdotal evidence that suggests H2O2 inhalation may be beneficial for COPD and in one sense that seems likely as it will very likely kill bacteria in the lungs that may thrive in the lungs of people with COPD and help to feed the disease process.

On the other hand, studies have shown that exhaled H2O2 is elevated in people with stable COPD compared to controls and is almost 3 times higher in COPD patients whose condition is exacerbated as opposed to stable.

This data could mean that the body is able to produce enough H2O2 for COPD lungs on its own, or it may turn out that even though the body produces more H2O2 in the lungs as the disease severity increases, it is not able to produce enough to reach maximum efficacy.

I have not seen data to confirm that additional inhalation of H2O2 will be beneficial, though the anecdotal evidence suggests it may be.

So inhaling H2O2 will add even more H2O2 to the already elevated levels in patients lungs with COPD and this is where the anecdotal evidence and the science seem to part ways as the science so far does not seem to support the inhalation of H2O2 in patients with COPD.

Oxidative stress is elevated in COPD as is inflammation and these two work together in a vicious cycle to increase each other as elevated oxidative stress increases inflammatory cytokines and mediators which also creates more oxidative stress ultimately creating an environment that is conducive to disease progression.

If you could look inside your lungs to see how they are reacting to inhaled H2O2, that would be very useful, but that is not possible and with no practical way to know if there is enough or too much H2O2 in the lungs, the melatonin may help with this aspect of H2O2 inhalation.

Melatonin, on the other hand, has many studies that show that it is beneficial for COPD patients and two of the effective mechanisms of action are its potent radical scavenging and very potent antioxidant activities as well as its inhibition of inflammatory cytokines which may have the potential to break that vicious cycle that can be quite active in COPD.

Another consideration is knowing that melatonin level drops when the disease is in an exacerbated state, exactly when more melatonin would likely be needed! Melatonin levels also decline with age.

Melatonin is the most potent antioxidant in the human body because it elevates the gene expression Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Glucose-6- Phosphate Dehydrogenase (G6PD) and Catalase (CAT) while increasing Glutathione. Melatonin doesn't stop there though. It is also a potent scavenger of Peroxynitrite (ONOO) which is elevated in COPD and has negative effects, it scavenges Reactive Oxygen Species (ROS) / Hydroxyl Radicals, Reactive Nitrogen Species and H2O2 which are all mostly elevated and damaging in COPD and help extend disease progression.

Melatonin is also able to do something that other antioxidants like vitamin C and E can't.

Vitamins C and E can each neutralize one oxygen radical while melatonin can neutralize as many as 10 oxygen radicals because each time it reduces one oxygen radical, melatonin becomes a different metabolite of itself and each of these metabolites can in turn neutralize another oxygen radical.

Add in the antiinflammatory qualities of melatonin and it is a potent molecule to use against Covid-19 and COPD!So given all of the above, for myself, if I wanted to try one or both of these and if I believed they both had potential to help people with COPD, I would discuss it with my doctor to see if he thought that either one or both might be helpful for me and would be compatible with my current medications. If he or she approved the use of both, then I would consider an appropriate plan of attack.

I suggest that anyone reading this also get their doctors approval before trying to implement such a regimen.

Given that melatonin is likely to work against H2O2 by neutralizing it directly or indirectly through the upregulation of Catalase or other antioxidants which will also neutralize it, I might consider a rotating approach where I use one for a day or two followed by using the other for a day a day or two. This could possibly allow the H2O2 to work while the next phase allows melatonin to give the lungs a break and neutralize the elevated radical levels in the lungs as well as lower the elevated inflammatory levels in the lungs.

H2O2 is highly likely to do some damage in the lungs and the idea being that melatonin may nullify or repair some of this damage while helping to work against COPD through its known multiple actions against COPD.

So that is my idea of how I might use these two substances under my doctor's supervision based on my experience with both substances and the available studies I was able to find. I did not include any study links in this post because it is long enough already.

Art

Freda
Canada
07/25/2020

Hi Art

Would you recommend melatonin for severe Copd and not inhaling H202? Thanks.

Replied by Mama To Many
Tn
07/24/2020

Dear Art,

I really appreciate this post on Melatonin, H202 and COPD. It is timely for me. We are getting ready to move my mother in law into our home and she has COPD, in addition to other health problems.

By the way, I continue to take Melatonin at night for sleep and it has definitely helped me!

Thank you!

~Mama to Many~

Replied by Art
California
07/25/2020
779 posts

Hi M to M!

Thank you for saying so! I know you are probably already aware of the following, but I am putting it in for others who may not be. COPD is common, so it is worth putting this info up. Some people refer to it as emphysema, but that is an older term and COPD seems more common now as a blanket term. There are some similarities with chronic bronchitis.I'm not sure about the H2O2 for COPD simply for lack of studies to add confirmation to the anecdotal evidence, but the anecdotal evidence is compelling.

In COPD patients who are stable, the amount of H2O2 in the exhaled air is approximately 7 times that of normal controls while patients who are in an exacerbated state are almost 3 times higher than stable patients and about 21 times higher than control patients.

So H2O2 inhalation will add to these already significantly elevated H2O2 levels. This brief abstract discusses H2O2 exhalation levels in people with COPD:

https://www.atsjournals.org/doi/10.1164/ajrccm.154.3.8810624

Melatonin clearly has studies that show it benefits COPD as does NAC, which is purported to significantly reduce exacerbations at two 600 mg doses per day.

Generally elevated oxidative stress is considered to possibly be the single most important factor driving COPD disease progression, so these two seem quite useful and melatonin is the most potent antioxidant in the human body as I described in the original post. Maximum radical scavenging is desirable.HDM made it possible for me to get rid of a cough that I had had for months that was not getting better, only worse. With HDM it started to lessen in two days and was gone by the third day.Vitamin C is synergistic with melatonin and adds to both its antioxidant abilities as well as its antiinflammatory qualities.Quercetin is also useful for COPD and quercetin is also synergistic with melatonin increasing its antiinflammatory activity.

Vitamin D reduces the number of acute exacerbations also and it is almost always good to be vitamin D replete for overall health, especially with so many people being insufficient or deficient. Getting into the upper half of the reference range for 25 OH d is worth looking into at whatever vitamin D dose is needed to get there. Simply put, some people require more vitamin D to achieve a specific 25 OH d level. The 25 OH d reference range is 30 ng/ml ~ 100 ng/ml

Some essential oils such as eucalyptus are thought to be helpful with COPD also. Not everyone can tolerate melatonin. Does your mother in law have Afib?

Art

Replied by Art
California
07/25/2020
779 posts

Freda,

I answered this question in the original reply I made to Nancy and there is further information re: COPD in my reply to Mama to Many.

Art

Replied by Mama To Many
Tn
07/25/2020

Dear Art,

Thank you for the information!

Yes, as a matter of fact, my mother in law does have A-fib!

She is actually taking a small amount of melatonin right now. She has been in a nursing home for 9 months and when her sleeping pill prescription ended, they asked if they could give her melatonin instead. Well, I was sure happy about that! I don't know how much yet.

I actually didn't realize that COPD is what they used to call emphysema. But it makes sense.

Thank you again!

~Mama to Many~

Replied by Missm
New York
07/26/2020

I had Covid in March and coughed almost five months without cure. I discovered that quitting all dairy immediately caused my coughing to stop! But still left with difficulty breathing, runny nose.
I found that NAC 600 mg twice a day has really helped.

Then I do a steam as I do not own a nebulizer with Theranaturals glutathione, one capsule and one drop of eucalyptus essential oil. This glutathione is made for nebulizers. Eucalyptus is beneficial for lungs.

I do not do HP.

You could try above.

Covid takes a long time to recover.


Posted by Art (California) on 07/22/2020 779 posts
5 out of 5 stars

Dr. Neel has treated over 400 Covid-19 patients now, as of July 22, 2020!

Since his patient load has increased very considerably, so has his knowledge and understanding of the use of HDM (High Dose Melatonin) in Covid-19 patients. This seems like one of his most informative updates so far!

Dr. Neel is now seeing patients who are in multiple higher risk categories and treating some of them is no walk in the park. Dr Neel is now using even higher doses of melatonin in these harder to treat patients at dosing that is closer to what Dr. Shallenberger uses in almost all of his non cancer patients and similar to what Dr. Reiter has used in some of his studies. Dr. Shallenberger uses much higher dosing in his cancer patients though.

Dr. Neel also mentions that he is now seeing many more young patients than in the previous 3 months. He also mentions that people with asthma are having a harder time with Covid-19 than his patients who don't have asthma. He is also seeing more young patients who are developing gastrointestinal issues. He does not mention any deaths in this latest update.

He also mentions that he is seeing at least one strain of virus that seems to be more virulent. The information he includes with this latest update does not seem to bode too well for the supposedly soon to be available vaccinations, if the virus is mutating significantly. Here is the link to this latest update:

Art


Posted by Art (California) on 07/20/2020 779 posts
5 out of 5 stars

July update From One of Dr. Neel's Patients Describing Her Experience

This is an update from one of Dr. Neel's patients describing her experience using high dose melatonin (HDM) to treat her Covid-19 case. She adds confirmation to what Dr. Neel has been saying about the rapid onset of action by HDM (High Dose Melatonin).

Also of interest in this update is the fact that Dr. Neel appears willing to go slightly above his proposed dosing schedule of 1 mg of melatonin per kilogram if he deems it necessary.

This is essentially one patient's play by play of her experience with Covid-19 and HDM:

https://devinenews.com/ms-ovalle-shares-battle-with-covid-and-what-got-her-through-it/

Art


Posted by Art (California) on 06/24/2020 779 posts
5 out of 5 stars

Here is the latest update (6/23/2020) from Dr. Neel. It appears that he now has about 100 patients based on what he says in his update and he gives a brief idea of how things are going for his Covid-19 patients and his results are holding up very well as his patient base continues to expand (Texas appears to be having a significant increase in Covid-19 cases) and no deaths to report among his Covid-19 patients!

To me that is awesome news compared to all other major drugs being trialed and tested, as even the best of these are showing patients still dying, but at a lesser rate. Importantly, he once again reiterates the importance of vitamin D based on the Italian vitamin D statistical analysis as it relates to Covid-19 patients. In this latest update you can see that Dr. Neel is becoming even more focused in treating his covid-19 patients quickly and has had no major complications or deaths!

Dr. Neel also mentions the study trial in Manila that will treat 350 Covid-19 patients who also have pneumonia. It seems pretty bold to focus on Covid-19 patients with pneumonia, as this group has a significantly higher death rate!

Here is a link to his latest update:

https://devinenews.com/cases-come-back-with-a-vengeance-melatonin-offers-hope-as-full-scale-clinical-trials-start-on-covid-19/

Art

Replied by Art
California
06/25/2020
779 posts

Below is a link to a nurse who had Covid-19 and Dr. Neel is her doctor. She gives an idea of what Dr. Neel is like as her doctor :

https://devinenews.com/medina-county-woman-shares-what-her-battle-with-covid-was-like/

Art

Replied by Art
California
06/29/2020
779 posts

Here is a link to a new abstract that suggests that melatonin is useful for restoring the glutathione redox system as well as working against Covid-19!

https://pubmed.ncbi.nlm.nih.gov/32597503/

Art


Posted by Art (California) on 06/17/2020 779 posts
5 out of 5 stars

GREAT NEWS!!! The latest from Dr. Neel is that over 50 of his Covid-19 patients have recovered using his high dose melatonin protocol!!! https://devinenews.com/50-covid-patients-recover-under-dr-neels-care/ Art



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