Coronavirus
Natural Remedies

Melatonin Protocol for COVID-19

| Modified: Jun 30, 2020
Add New Post covid 19 natural remedies - corona

By Art Solbrig

April 20, 2020
Updated May 09, 2020 5:00 p.m. EST

One possible problem for moderate to severe Covid-19 patients is the potential for significant damage to the lungs and possibly other organs like the liver, based on what is being seen in patients.

At this point, treatment options to try and prevent, repair or ameliorate this damage is very limited and not necessarily a very high priority for doctors yet, but still important to the patient in the long run to maintain good health quality overall.

Toward that end, I would like to talk about one of my favorite supplements that I have previously mentioned on Earth Clinic that may help these patients have a more complete recovery of the lungs and possibly other organs: Melatonin.

Post-Intensive Care for COVID-19

The aftermath for patients with Covid-19 has not been discussed at length yet because it is not currently the highest priority for doctor's treating these patients.

Keeping them alive is obviously a primary concern right now, but preventing or ameliorating the significant amount of collateral damage caused by Covid-19 is very important also.

That subject, in time, will be quite popular as more people reach the recovery phase of Covid-19.

For many people who fall into the "high risk groups", this information may be useful and timely to reduce your chances of succumbing to the disease if infected and if some scientists are right in their thinking that the virus can potentially mutate and return seasonally, similarly to the seasonal flu, then melatonin certainly seems like a very useful adjuvant treatment to keep in mind from this point forward!

If you survive the virus once and develop antibodies to it that will be very good, but if the virus mutates extensively, there is a chance that those antibodies may not be effective against the new strain similarly to vaccines for the flu, which sometimes work against the new strain and sometimes don't as witnessed by people who have gotten the flu shot and still got the flu.

Melatonin has shown itself to be protective of the major organs of the body in many studies, which includes the lungs among its many potential health benefits.

There are several forum members currently using melatonin, including myself, so this could be useful information for them as well as other members who are trying to be as prepared as possible to deal with Covid-19.

Below is a link to a recent article that discusses the potential utility of melatonin as it would relate to Covid-19. Melatonin is just at the beginning of testing in Covid-19 patients with initial positive results. This article mainly discusses the effects of melatonin as it might relate to Covid-19 and includes its antiviral and anti-ARDS qualities among many other qualities. The article describes melatonin as "having a high safety profile" and suggests it might be useful before, during and after the disease process has ended.

Doctors may have a bit more latitude in using melatonin compared to all of the prescription drugs that have been mentioned on this forum and across the internet since melatonin is an OTC supplement sold at drug stores and big box item stores and almost all online supplement suppliers.

COVID-19: Melatonin as a potential adjuvant treatment

Life Sci. 2020 Jun 1; 250: 117583.
Published online 2020 Mar 23. doi: 10.1016/j.lfs.2020.117583

Rui Zhang,a Xuebin Wang,a Leng Ni,a Xiao Di,a Baitao Ma,a Shuai Niu,a Changwei Liu,a,⁎ and Russel J. Reiterb,⁎⁎

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102583/

Abstract

This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis. The recent outbreak of COVID-19 has become a pandemic with tens of thousands of infected patients. Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology. This leads to a cytokine storm and subsequent progression to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and often death. Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile. There is significant data showing that melatonin limits virus-related diseases and would also likely be beneficial in COVID-19 patients. Additional experiments and clinical studies are required to confirm this speculation.


Here is a link to an article in the Washington Post that gives an idea of which organs can be impacted by Covid-19 which further illustrates why melatonin might be a very useful adjuvant treatment option which doctors can add to their arsenal against Covid-19. That arsenal is relatively small at this point, but hopefully will continue to expand.

Since the multiple health benefits associated with melatonin may apply in the case of this disease in multiple ways, it may be worth saving this post for future reference for yourself or a family member or friend to show to their doctor to see if it is something that will be compatible with all that they are taking and safe for you to take.

I cannot recommend melatonin to anyone as I am not a doctor, but your doctor can. I do use melatonin daily myself as I have previously stated on the forum for multiple reasons.

Health Benefits of Melatonin

Melatonin is mainly thought of as an over the counter sleep aid, but its abilities go far beyond being a common sleep aid for some people.

Not everyone can tolerate melatonin and that is another good reason to include your doctor in that decision making process.

The majority of people do tolerate melatonin well and it is naturally produced in the body by the pineal gland as daylight turns to night time. There are melatonin receptors found throughout the body suggesting that the body does have uses for it. Unfortunately melatonin production declines very significantly as we age and that may possibly be one contributing factor as to why older people do not fair as well as younger people with Covid-19.

Here is another article that discusses the potential for melatonin in respiratory diseases. If you want to read the full article, you will have to click on the blue rectangular button that says "Download full-text PDF" once you follow this link.

This very recent (March 20, 2020), brief and interesting link takes you to an opinion page where a doctor is discussing how melatonin might be used as adjunctive treatment for Covid-19 in patients with and without pneumonia and is relatively short and straight forward. He is advocating for use of melatonin "now" in Covid-19 patients. He feels that melatonin also would be an effective antiviral and antibacterial, but that is not yet known in Covid-19.

This is worth reading!


The same doctor from the article just above, Dr. Richard L. Neel M.D., MPH., has actually started treating Covid-19 patients with melatonin and vitamin C as this link explains.

I like what he is doing by practicing what he is preaching. His treated patient count is low at this point, but you have to start somewhere and a hospital seems a safe place to do that if you are already infected with Covid-19! A quick mention to the fact that there are a couple of ads at the 1/3 point and 2/3 point in the following article so please scroll past each ad to make sure you read the whole article, its interesting. This is a good read.


One more update about Dr. Neel. He says he has treated 10 patients now giving them 80 mgs of melatonin per day. Click here.

One of my supplement experiments involved taking 70 mgs of melatonin per day so I already have an idea of what 80 mgs will be like for me. Another good read and not long.

Melatonin Levels Decline Sharply As We Age

Source: grivas tb, savvidou od. melatonin the “light of night

We're reporting our experience in a scientific journal, so hopefully, it could help save some COVID-19 patients, especially the elderly, who are reportedly left to die in some cities in Italy and Spain, so that doctors could allocate their resources to younger patients. If this information could save a few of these lives, it shall have been worth all that we've gone through convincing our local colleagues about it."

Here is a link to that article: https://lifestyle.inquirer.net/361003/high-dose-melatonin-3-other-drugs-seen-as-effective-against-covid-19/


The following link discusses repurposing of existing drugs including melatonin. It is quite lengthy if you are pressed for time and don't have time to read it, here is a quote from the article:

https://www.nature.com/articles/s41421-020-0153-3

"Inflammatory pathways play essential roles in viral infections56,57. As a biogenic amine, melatonin (N-acetyl-5-methoxytryptamine) (Z = –1.72 and GSEA score = 2) plays a key role in various biological processes, and offers a potential strategy in the management of viral infections58,59. Viral infections are often associated with immune-inflammatory injury, in which the level of oxidative stress increases significantly and leaves negative effects on the function of multiple organs60. The antioxidant effect of melatonin makes it a putative candidate drug to relieve patients' clinical symptoms in antiviral treatment, even though melatonin cannot eradicate or even curb the viral replication or transcription61,62. In addition, the application of melatonin may prolong patients' survival time, which may provide a chance for patients' immune systems to recover and eventually eradicate the virus. As shown in Fig. 5e, melatonin indirectly targets several HCoV cellular targets, including ACE2, BCL2L1, JUN, and IKBKB. Eplerenone (Z = –1.59), an aldosterone receptor antagonist, is reported to have a similar anti-inflammatory effect as melatonin. By inhibiting mast-cell-derived proteinases and suppressing fibrosis, eplerenone can improve survival of mice infected with encephalomyocarditis virus63."


The following 2 links, while not related to Covid-19, takes you to two abstracts of a study where melatonin was used at a dose of 70 mg per day in children with Duchenne muscular dystrophy for 9 months to good effect. I'm adding this one just to show that melatonin is relatively safe in children who might get Covid-19, even at 70 mg/day. They used it everyday for 9 months, whereas it may only have to be used for a much shorter time period in Covid-19 patients.

https://www.ncbi.nlm.nih.gov/pubmed/20210854

https://www.ncbi.nlm.nih.gov/pubmed/21515247


This article adds further confirmation to the idea of melatonin for C-19:

https://www.melatonin-research.net/index.php/MR/article/view/79/502

One of the important points the authors are making is that melatonin seems to attenuate the serious viral activity response by your body while your body builds an effective and measured attack instead of an over response of a cytokine storm. It takes the body time to generate appropriate antibodies and melatonin seems to help by essentially calming the bodies over response until the body is able to generate enough antibodies and effectively destroy the virus. This tends to confirm what Dr. Neel is seeing in his patients of very significantly reduced symptoms in 24 hours.

An important quote from that article :

... "For the hosts, melatonin improves the defense system by upregulating the expression of antioxidant enzymes such as SOD, CAT, and glutathione peroxidase(163), effects that reduce the oxidative tissue damage caused by the pathogens. Most importantly, melatonin redirects the host immune response, i.e., by controlling the potentially over reactive innate response and promoting the adaptive immune response."


Summary

I am not recommending melatonin, just putting the information out on Earth Clinic so anyone interested can discuss it with their doctor or health care professional and to also make sure it is compatible with everything you may be taking.

I hope that you will be able to get enough information from this post to see that what Dr. Neel is suggesting is a non-invasive way to assist in the treatment of Covid-19 and possibly in the interim period where you might be told to stay home and rest and then go to the emergency room if you have trouble breathing.

Remember, there are drugs which are working to various degrees, but will we be able to get them and how long will we have to wait before we are tested and accepted as a patient in the hospital to receive those treatments if they are available?

If melatonin is as effective as Dr. Neel and the Philippines have seen so far, melatonin may be a consideration between you and your doctor during that period while you are waiting for your breathing to become difficult enough to be allowed into the hospital.

If it works as they have seen so far, perhaps that trip to the hospital may never be needed! Dr. Neel is talking about positive effects in as little as one day.

Some of the drugs that are being tested for Covid-19 have significant side effects and judging by what is already known about melatonin, it may even help to ameliorate the severity of some of those effects while also helping to alleviate symptoms of the disease itself. His hope, as he mentioned is that melatonin may prevent a patient from ever needing to go on a ventilator in the first place.

Given that some hospitals don't want to accept you in until you are having a hard time breathing, to me, if I feel I am getting sick in any way, I will continue to take the melatonin that I am already taking plus the difference to get up to his dosing schedule in the hope that I never even have to go to the hospital!

These are just more reasons why I refer to melatonin as one of my favorites!

Melatonin Dosage for Lung and Organ Damage Caused by COVID-19

To briefly summarize what Dr. Neel and the hospital in the Philippines are doing to combat the damage caused by Covid-19, Dr Neel is giving his adult patients 80 mg of melatonin each day.

He has them take that 80 mg in 4 equally divided doses so that they take 20 mg at each dose and they take that dose 4 times per day spread out through the day.

The hospital is doing similar, but with a slightly lower dose because they are using a dose range of 36 to 72 mg per day and they are dividing the dose into 4. They don't say why they are using a lower dose, but it may be because they are dealing with children and younger people as well as adults whereas Dr. Neel has so far only treated adults. Another factor may be that in general, Filipinos are a smaller people.

Where to Buy Melatonin

You can find melatonin at most pharmacies, health food stores, grocery stores, and of course, online.

Here are a few links to Amazon:

NOW Supplements, Melatonin, 10 mg, 100 Veg Capsules

Natrol Fast Dissolve - 10 mg - 100 Count - $12.99

Puritan's Pride Melatonin 10 mg 120 Capsules (3-Pack)- $23.00


I would also like to mention that I recently restocked my melatonin supply and they came very quickly compared to my zinc picolinate order and my vitamin D and C orders! Since I have been taking melatonin for years, much of this is information about melatonin I was aware of and why I looked for a possible connection in the first place.

I was not aware of its potential use as adjuvant treatment for Covid-19. Melatonin's ability to help protect the lungs and other major organs could be a very useful adjuvant treatment in trying to protect the body as a whole from most of the potential damage which Covid-19 has shown the ability to inflict on people infected with SARS CoV-2 and act as a potent antioxidant and also act as a potent antiinflammatory, all well known melatonin attributes and this is a very big thing for Covid-19 patients to help protect almost all of the organs that Covid-19 is now thought to involve in addition to the lungs.

A drug that can safely destroy the virus is extremely important, but ameliorating or preventing the damage caused by the virus is important now and later for the patient!

I am sorry for the length of this article, but since melatonin has not previously been discussed for this purpose on this forum, I wanted to include as much pertinent information as possible to give some background.

Related Links:

Coronavirus



33 User Reviews

Posted by Art (California) on 06/24/2020 521 posts
5 out of 5 stars

Here is the latest update (6/23/2020) from Dr. Neel. It appears that he now has about 100 patients based on what he says in his update and he gives a brief idea of how things are going for his Covid-19 patients and his results are holding up very well as his patient base continues to expand (Texas appears to be having a significant increase in Covid-19 cases) and no deaths to report among his Covid-19 patients!

To me that is awesome news compared to all other major drugs being trialed and tested, as even the best of these are showing patients still dying, but at a lesser rate. Importantly, he once again reiterates the importance of vitamin D based on the Italian vitamin D statistical analysis as it relates to Covid-19 patients. In this latest update you can see that Dr. Neel is becoming even more focused in treating his covid-19 patients quickly and has had no major complications or deaths!

Dr. Neel also mentions the study trial in Manila that will treat 350 Covid-19 patients who also have pneumonia. It seems pretty bold to focus on Covid-19 patients with pneumonia, as this group has a significantly higher death rate!

Here is a link to his latest update:

https://devinenews.com/cases-come-back-with-a-vengeance-melatonin-offers-hope-as-full-scale-clinical-trials-start-on-covid-19/

Art

Replied by Art
California
06/25/2020
521 posts

Below is a link to a nurse who had Covid-19 and Dr. Neel is her doctor. She gives an idea of what Dr. Neel is like as her doctor :

https://devinenews.com/medina-county-woman-shares-what-her-battle-with-covid-was-like/

Art

Replied by Art
California
06/29/2020
521 posts

Here is a link to a new abstract that suggests that melatonin is useful for restoring the glutathione redox system as well as working against Covid-19!

https://pubmed.ncbi.nlm.nih.gov/32597503/

Art


Posted by Art (California) on 06/17/2020 521 posts
5 out of 5 stars

GREAT NEWS!!! The latest from Dr. Neel is that over 50 of his Covid-19 patients have recovered using his high dose melatonin protocol!!! https://devinenews.com/50-covid-patients-recover-under-dr-neels-care/ Art


Posted by Art (California) on 06/17/2020 521 posts
5 out of 5 stars

This new article explains how melatonin inhibits the cytokine storm that is proving to be a serious problem from Covid-19 : https://www.sciencedirect.com/science/article/pii/S2590098620300312?via%3Dihub Art


Posted by Art (California) on 06/14/2020 521 posts

The new study link below shows that melatonin use reduced the risk of testing positive for Covid-19! https://pubmed.ncbi.nlm.nih.gov/32533957/?from_term=melatonin&from_sort=date&from_size=20&from_pos=2 What will it take for mainstream medicine to start considering something that will actually work instead of the repurposed drugs that result in not much of anything good? Art


Posted by Art (California) on 06/12/2020 521 posts
5 out of 5 stars

Apparently, the Doctors Hospital in Manila, Philippines has gotten funding to do a clinical trial of high dose melatonin (HDM) in 350 patients with "Covid-19 and pneumonia or other Covid-19 related high risk features" based on their experience of successfully treating their Covid-19 patients with HDM. They still have not publicly released their Covid-19 patient data that they said they were going to publish in a scientific journal, but they did manage to get funding for this study based on their initial experience with HDM and the study is being funded by their Department of Science and Technology (DOST). They also mentioned that melatonin is being used in other countries for Covid-19. They further stated that the trial will last at least 4 months which suggest that the results will be available near halloween. https://news.abs-cbn.com/news/06/12/20/dost-allots-p98-million-for-melatonin-clinical-trials-to-treat-covid-19 Art


Posted by Art (California) on 06/02/2020 521 posts
5 out of 5 stars

Why melatonin for Covid-19? Melatonin also protects endothelial cells as well as red blood cells being damaged by excess oxidative stress as seen in Covid-19 which can lead to blood clots, while also being the most potent antioxidant in the body ( more powerful than glutathione) that helps to neutralize the significantly elevated levels of ROS that is seen in patients that damages endothelial cells, a potent antiinflammatory agent, an upregulator of the gene expression of the bodies own potent antioxidants, catalase, superoxide dismutase and glutathione peroxidase. Melatonin also scavenges reactive oxygen species/hydroxyl radicals, reactive nitrogen species and peroxynitrite. Melatonin is also protective of all major organs in the body that the virus has shown itself to damage. Melatonin is an excellent protector of the lungs which is very important in Covid-19 to help protect against the cytokine storm. Melatonin acts as an anticoagulant which is very useful in Covid-19 as it has shown itself to cause blood clots. Melatonin also lowers the inflammatory cytokine IL-6, chemokine IL-8, IL-17, inflammatory mediator TNF-alpha, NF Kappa b and IL-1b which are all elevated in Covid-19. There is much more that melatonin does to fight Covid-19, such that if one was trying to create a good drug to fight the effects of the virus, melatonin could possibly be it. Art


Posted by Art (California) on 05/28/2020 521 posts
5 out of 5 stars

Apparently the combination of melatonin and vitamin D may have synergy against Covid-19 health issues according to the following new study. Is anybody surprised? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227533/ I am glad that they released this study, because it is already known that high dose vitamin D lowers native melatonin levels in humans, so having more of both will nullify this issue and likely speed the healing process. I wonder what they will find if they add vitamin C? You just know that this combination is likely to be more effective than any of the drugs which they are continuing to test despite dismal results in Covid-19. EC has the answers and governments and their scientists continue to look in all the wrong places! Art

Replied by Steve East
EC's Facebook
05/31/2020

But melatonin is related to the body's sleep modes ...how can that stop a virus? The body has its OWN inbuilt protocols for resisting infection and disease ... you can't ameliorate an infection using stuff that doesn't deal directly with that infection where it matters ... in the cells! In the case of virus, it's Zinc that prevents viral replication and it's Quercetin that puts it there! Now its taken that if you have LOW levels of vitamin D .... then you are a sitting duck ... and the majority of the vulnerable have that due to inability to get out in the sun coupled to a surfeit of toxic drugs courtesy of doctors making profits! HIGH Vitamin D is protective meaning that its renders infection much harder to gain a foothold ... it is NOT however a treatment once you have that virus ... that needs ultra high levels of Vitamin C ... known as LVC coupled to Zinc supplemented ... Zinc Picolinate is the best absorbed!

Art
California
05/31/2020
521 posts
5 out of 5 stars

Hi, Steve, Yes, melatonin does affect sleep, but it does way more than that! Melatonin does not stop the virus, but it reduces the the innate immune response which is what can trigger the potentially deadly cytokine storm and inhibits the potential for pneumonia and thus eliminates the need for a ventilator, three important actions associated with death in Covid-19. Melatonin also is protective of all major organs of the body which in autopsies have all been shown to have been attacked by the virus, including the brain, liver,kidneys, pancreas, spleen, eyes, skin, lungs and heart. Dr. Neel is able to turn his patients around in just 24 hours after starting them on HDM! By not attacking the virus directly, the body can then use its adaptive immune response to create antibodies that will fight the virus as the body is supposed to do. Kill the virus too fast and the body may not be able to generate enough antibodies before the virus is eradicated and this is important in case the virus comes back each year as other Coronaviruses have and scientists are indicating is very possible. By having adequate antibodies in your system, the body should be able to eradicate the virus on its own next time around. In hydroxychloroquine studies that used zinc and azithromycin, the zinc has not shown effectiveness even though hydroxy is supposed to act as an ionophore to help the zinc to have better cell access. Yes, people still died with this combination! Art


Posted by Art (California) on 05/22/2020 521 posts
5 out of 5 stars

Here is the latest from Dr. Neel who now has at least 20 covid-19 patients and all are doing well on his high dose melatonin/vitamin C protocol. He now has patients calling him from across the country, including New York who he is advising on his protocol! This latest update is very hopeful and continues to show quick improvement in his patients and I would say it is one of his best updates yet! https://devinenews.com/dr-neel-sees-amazing-results-in-covid-19-patients-by-boosting-amount-of-melatonin/ Art

Replied by Meg
USofA
05/22/2020

Thank you Art. I found this quote from the devinenews article you posted very helpful: “As a Ph.D. student I was taught that a virus actively kills our cells during the course of the infection…..But now I know a virus is more like a provoking bully, a bully who continues to provoke cells in our lungs and our respiratory tract to commit suicide……We analyzed the molecular mechanism, how the virus does it, and matched it with scientific databases. Then, came to conclusion that melatonin can block the process that promotes suicide in lung cells,” Shneider said. Source: https://devinenews.com/dr-neel-sees-amazing-results-in-covid-19-patients-by-boosting-amount-of-melatonin/

Art
California
05/22/2020
521 posts

Meg, I agree and found that an interesting statement that goes against what many people think when it comes to viruses! I think that kind of thinking is helpful to looking at Covid-19 in a different light in order to come up with a better answer like melatonin. The current methods being deployed to fight SARS CoV-2 are proving to be only marginally effective at best, yet these methods continue to be the standard of care as people continue to die from Covid-19. Unfortunately the powers that be continue to ignore melatonin which according to Dr. Neel is easily more effective than any of the drugs currently being tested based on his experience with his Covid-19 patients. Art


Posted by Art (California) on 05/18/2020 521 posts

It has become well established that Diabetes is a significant risk factor when it comes to Covid-19 so it is good to know that melatonin can reduce many of the factors that are elevated in diabetes such as CRP, A1c, IL-6, Serum Ferritin, chemokine IL-8, ESR, Fibrinogen, oxidative stress, inflammation and Serum Ferritin. https://www.ncbi.nlm.nih.gov/pubmed/32416321 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140344/ Art


Posted by Art (California) on 05/17/2020 521 posts

One problem that seems to come with a cytokine storm and pneumonia, assuming you survive both, is significant damage to the lungs in terms of fibrosis and scarring as outlined in the article link below. Although not talked about a tremendous amount, this can become a long term problem well beyond when you are cleared of the virus. In some cases, possibly for the rest of your life if the damage turns into scarring. https://www.sciencenews.org/article/coronavirus-covid-19-some-patients-may-suffer-lasting-lung-damage So far, Dr. Neel and the doctor in Florida have not mentioned this problem in their patients who they have given high dose melatonin (HDM) to! In fact, so far, they have not seen many of the complications that other doctors who are treating Covid-19 patients have reported. What Dr. Neel is seeing in his HDM treated Covid-19 patients is rapid recovery with no apparent complications. This bodes well for the potential to entirely avoid these long term lung complications associated with Covid-19. No cytokine storm, no pneumonia, no lung complications, no ventilator are so far what Dr. Neel has reported in his patients! Just one more reason to consider HDM with your doctor's guidance should the need arise! Art


Posted by Art (California) on 05/17/2020 521 posts

Since I tend to look at melatonin plus vitamin C as a potential way to open up the economy in a somewhat safer way, I thought that the following videos, although not related to melatonin, might also add to the safety of "reopening". My apologies if it is old news here on EC. https://www.youtube.com/watch?v=wfc6QdBiRK8 https://www.youtube.com/watch?v=rhfh5XBzyFA Given that the current Covid-19 tests are notoriously inaccurate, this seems like it is likely to be more accurate with instantaneous results! Art


Posted by Art (California) on 05/14/2020 521 posts

Dr. Neel is now at 17 patients as of 5/13/2020 and reports that all are doing well using his melatonin protocol with vitamin C! Another doctor in Florida has reported similar results in her two Covid-19 patients! https://devinenews.com/dr-neel-continues-treating-covid-19-patients-all-across-the-country/ Sadly, the only scheduled trial for melatonin is only going to be using 2 mg / day of melatonin. I don't understand why they even bother at that dose! Art

Replied by Annette Garcia
United States
06/17/2020

Art, I really don't understand the high dosages listed above! I bought 10 mg melatonin because that was the highest I could find in my store. My husband and I took it for about a week but it is just too much. Feel groggy and sleepy the next day well past noon. I wouldn't be able to function if it was a higher dose! How is this possible?

mmsg
somewhere, europe
06/18/2020

Annette, the way I understand it is: if you are ill, higher dosing is appropriate. If not, and you are just taking it for prevention, why would you need high dosing? Personally, I always prefer the lowest dose of anything I try until a need for higher dosing shows up.

Art
California
06/17/2020
521 posts

This is a common issue that people experience, but for most, the "melatonin hangover" gradually goes away after a couple of weeks. What I have tried that has helped is taking the dose earlier in the evening. So if I feel groggy for about two hours after getting up in the morning, I might try taking my dose a couple of hours earlier. Failing that, you can consider just taking it if you get Covid-19. The extra rest may be helpful at that time and Dr. Neel has had very good success treating his patients who were already infected. I have experimented at multiple dosing levels up to 180 mg per night recently and I find the melatonin hangover goes away much sooner and now I seem to tolerate most dosing well. The highest dose I have heard of in a human study was 1,000 mg for thirty days, but I'm not sure why you would ever need such a high dose. I believe animal studies have gone higher and according to Dr. Reiter, he has never had an animal die at any dose. Art


Posted by Art (California) on 05/14/2020 521 posts

Dr. Neel is currently at 14 patients and according to him, all are doing very well. This is a far cry from what the reports are saying about the drugs that are currently being tested for Covid-19. With any of those drugs, people still die! It just seems odd that they will not even consider testing melatonin when they already know that none of the current drugs being tested are showing as good results or even just fair results. Melatonin, from hundreds of previous studies has already shown that its multiple methods of action are very likely to have a very significant impact against Covid-19, but the direction seems to remain testing drugs that are not doing much of anything against this virus. In the meantime, people continue to die. Melatonin has a better safety profile than any of the drugs being tested. Melatonin is available over the counter here in the US and production can be ramped up quickly if it proves to work because there are multiple manufacturers already making it. Here is an incomplete list of everything that they currently know Covid-19 can do to humans: 1. Heart attacks 2. Strokes 3. Neuronal damage 4. Liver damage 5. Kidney damage 6. Damage to the spleen 7. Skin damage 8. Heart damage 9. Lung damage 10. Pneumonia 11. Loss of taste and smell 12. Kawasaki or Kawasaki like disease 13. Seizures 14. Death 15. Damage to the eyes 16. Blood clots 17. Damage to the endothelium 18. Oxygen deprivation 19. Fibrosis 20. Damage to the brain 21. Cytokine storm 22. Covid-19 toes 23. Tissue damage throughout the body 24. Organ failure 25. Fever and oxidative stress Just about any of the above items would require significant treatment, but with Covid-19, you are almost guaranteed to get at least 5 of these symptoms, which means that it is like your body is fighting multiple diseases all at one time! Melatonin is known through studies to ameliorate symptoms related to this whole list. Furthermore, it is one of the most potent antioxidants in the human body and it upregulates gene expression of the most potent antioxidants of the body and has potent antiinflammatory qualities which are thought to potentially prevent the potential for a cytokine storm. Having this many things going on in the body at one time will certainly deplete the natural antioxidant defense system which means the elevated levels of ROS is going to be causing cellular damage throughout the body and melatonin will definitely bring that elevated ROS level down. Given the above, it seems like melatonin would be high on the list for potential drug candidates to treat and test against Covid-19, but such is not the case. I wonder why that is? Art

Replied by Bill
Philippines
05/15/2020

Hi Art... Concerning your question about why melatonin has not been already recognized as a successful treatment for COVID-19, it really depends on how much you trust the American drugs companies and the US medical system. For some while now, I've realized that the FDA, in cahoots with the power of the drugs companies, have insured that they are indeed the Lords of Medicine in every sense. To this end, the FDA has already ensured that all research must adhere to their own broken and perverted version of "the scientific method". In effect, this means that the FDA owns ALL the medical laws in America and in the West. These biased laws are, for the most part, mainly used to banish any competing opposition i.e. natural herbal therapies and nutraceuticals. For instance, did you know that melatonin has been ordained by the FDA -- and backed by a Federal Law -- to be a food and not a drug? And according to that law, a substance defined by the FDA as a food can never be used in modern medicine as a drug. Did you know that? That's according to the medical laws already on the statute books in America (and in other Western countries). And that's also why the FDA will never allow food or nutraceutical substances like Melatonin or BHT to see daylight in any US hospital.

Art
California
05/15/2020
521 posts
5 out of 5 stars

Wow, Bill! I was not aware of that point about the FDA! I was aware that the large pharmaceutical companies do what they can to eliminate any competition, even in a pandemic! It is a sad state of affairs for the citizens though, because they are the ones who get hurt in the end. I am glad that there are doctors like Dr. Neel who are willing to buck the system and use something like melatonin rather than push the current list of drugs for C-19 which seem mostly just marginally effective if at all and people still die, so that to me is not my idea of effective! We are fortunate that we have EC to share these ideas that we will likely never hear from our doctors! Thank you for EC, Deirdre and thank you for the information, Bill! Art

Art
California
05/16/2020
521 posts

Hi, Bill, Okay, but can you tell me what you really feel!!! I agree 100% with what you said, sadly. Here, it seems to always come down to money and or politics. I was hoping that the pandemic might change things, at least for a moment,but that is obviously not the case, but I certainly don't see a problem with asking other governments who seem to have a handle on Covid-19, what they are doing to make that happen, but that doesn't seem to be happening either. I think of the combination of melatonin and vitamin C (M+C) as a possible way to move forward in a safer manner as the government begins to reopen the economy because opening is assuredly going to cause an increase in new cases and deaths. Yes, more people will get sick at a faster rate with the reopening, but M+C shows the potential to lower that death rate significantly if Dr. Neels success with his C-19 patients is any indicator. Thank you for the comments and information! Art

Bill
Philippines
05/16/2020

Hi Art...I confess that I too am somewhat shocked by the hapless anti-COVID-19 strategies that mostly the western countries are using against COVID-19. These strategies are not working by any stretch of the imagination are they? And when you start sending people back to work when both the infection rate and the death rate are still high then how sensible is that? The governments are saying that they need everyone back at work and the FDA are saying "No, no -- more people will die". Well, they are both right in a way because it's like being stuck between a rock and a hard place. Because if people don't go back to work the national economy will die a horrible death and people will continue to die anyway and if people do go back to work then even more people will likely die. So what should we do? The answer is obvious. All the American and European government leaders should look around at other world nations that have used successful treatment therapies against COVID-19. Oh look, China has got it's death rate down to zero.....How did they do that? Maybe we should talk to them in a friendly way and see if they can help us out? Is America or Europe talking in a friendly way to China to see how they achieved a death rate of zero with a population of 1.3 billion? Not a cat in hell's chance. All the western leaders are all still plying their stupid political agendas, propaganda and misinformation for other lowly political reasons while their people -- their own citizens -- continue to die in high numbers in there own countries. This is particularly true for both the US and UK. And this is exactly what the drugs companies want. They want confusion and fear, because when their fast-tracked COVID-19 vaccines eventually become available in 18 months or so then every western country will be clamoring for a vaccine -- ANY vaccine. That is the really scary part. As far as I can see, there has been no significant research at all on the mutation rate of COVID-19. This is very important because if the mutation rate is too high then the vaccines will not work well. Why do I say this? In 2014, the US CDC actually apologized publicly for the fact for the previous years flu vaccine failed so badly. I mean heck, if our eminent vaccine companies can't even get the simple flu vaccine right then what chance those same vaccine companies getting a much more complex COVID-19 vaccine right? And what about the likely and obvious dangers of rushing through a COVID-19 vaccine in a tenth the time it would normally take to make a regular vaccine? All bad. I've also just read some interesting articles about how Iran who, without the help of any western drugs (because of the US embargo), has managed to quickly flatten her COVID-19 infection rate and rapidly reduce her own COVID-19 death rate. I think China helped Iran initially and now Iran is successfully running with the ball and is currently helping infected people from other countries in her own region because she now appears to have a successful therapeutic treatment for COVID-19. So if our western leaders want you to go back to work and get their economies up to speed again -- without a climbing COVID-19 death rate then, without any doubt, they will need to find a successful therapeutic COVID-19 treatment to achieve that. And what about hydroxychloroquine and remdesevir? I think Melatonin, at 20mg taken 4 times a day with 1000mgs vitamin C, would be far more effective than using both those failed drugs. Melatonin also has a high safety profile. That's my honest opinion from looking at the research.


Posted by Trina Peterson (United States) on 05/13/2020
5 out of 5 stars

Cautionary about melatonin… maybe. Just a funny story about my parent's recent experience after I sent my mom this link and some melatonin, just in case they got sick. My dad was gardening with my brother-in-law for a couple of days, and he seemed really out of it. They had a pow-wow to talk about what was going on with my dad. He was super dingy and lethargic, started to be grumpy and kinda goofy, hoarse sleepy voice. It was a marked change; he is a very active grandfather and sharp-minded. He nodded out while having a fourth cup of coffee. Mike says, "Steve, what's wrong with you, are you smoking a lot of pot or taking pain meds?"… Dad says, "no, just the herbs and my anti-rejection meds, Melody (my mom) was giving me!" Mikes ask what it was. "Melatonin." My mom says. "20mg 4 x a day." He's like, "What! 5mg, and I pass out." It turns out my mom skimmed reading the article and didn't realize it wasn't a preventative; it was only to be taken if he was to get sick. We now have a new story about how Grandma was dosing Grandpa. They are adorable and well. I hope we all make it through this new life. Good luck, and thanks for all the info!

Replied by Art
California
05/13/2020
521 posts

Trina, I'm glad you posted about your mom and dad's experience. This is why I say to include your doctor in a decision to use melatonin for this purpose and to also make sure it will be compatible with any medications that you may be taking. Dr Neel has not yet mentioned a dose to take before actually being sick, only after symptoms appear and you test positive. Some people are more sensitive than others to melatonin. Another point that your mom may have missed is that the actual dose range that Dr. Neel is using is between 50~100 mg / day depending on the size of the person and the severity of symptoms. Well, it sounds like if your dad ever has to use it, he will be getting plenty of rest! Art


Replied by Megan
Canada
05/12/2020

They are getting it, thanks to you, Art! You published on April 20 and finally news publications are picking up on it 20 days later. Thank YOU!!!

Art
California
05/12/2020
521 posts

Megan, Thank you for saying so. My interest is in sharing the information and hoping people realize that melatonin looks likely to do more than any drug the governments are currently testing for Covid-19! You would think with Dr. Neels results so far that researchers would be all over melatonin, but such is not the case. At least we have the information here on EC to add it to our tool box of Covid-19 tools! Art


Posted by Art (Califormia) on 05/11/2020 521 posts

I got excited for a moment when I saw this future study that said it was going test melatonin against Covid-19 in patients and then I read a little further and saw the dosing schedule they are going to be using just two milligrams of melatonin vs placebo. I think I can save them time and money and just say don't bother, because 2 mg of melatonin at best might improve your sleep and that's about it! https://clinicaltrials.gov/ct2/show/NCT04353128 Art


Posted by Art (California) on 05/11/2020 521 posts

This new article from "Psychology Today" discusses melatonin and Covid-19. https://www.psychologytoday.com/us/blog/sleep-newzzz/202005/could-melatonin-help-protect-against-covid-19 Here is a quote from the article: ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: ' This capacity of melatonin, to target this inflammasome that is so critical to the most serious and life-threatening complications of COVID-19, along with melatonin's high degree of safety and benefits for sleep, is drawing attention from scientists as a therapy to de-escalate the immune response to coronavirus, potentially reducing the severity of COVID-19. ' ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: Oddly, Psychology Today magazine is aware of the potential of melatonin for Covid-19, but our scientists that are specifically working on Covid-19 are silent??? I don't really understand how so many government agencies in so many different countries can be searching relentlessly for potential ways to fight this virus, but they just skip over a molecule that through research is known to block, inhibit or ameliorate many of the known bad effects of Covid-19??? Art


Posted by Art (California) on 05/10/2020 521 posts
5 out of 5 stars

Let's discuss the bad first 😩😩😩 and the good second! Covid-19 was originally thought to zero in on the lungs and the ACE-2 receptors located there. More recently it has been found that C-19 is attracted to ACE-2 receptors in other areas of the body and the virus is now known to attack much more than the lungs! C-19 autopsied patients are showing that it is attacking the heart, kidneys, liver, lungs, brain, skin, endothelium and is causing blood clotting which is causing heart attacks and strokes in patients who are otherwise asymptomatic and not considered to be in the high risk groups. Yes, the virus is causing much more damage system wide than initially thought. C-19 is causing a 4 times increase in Kawasaki disease reports in New York. The disease is attacking the vascular system and causing very elevated oxidative stress levels as well as significantly elevated inflammation. It also seems to be causing significantly more problems in black people who are not necessarily in the at risk groups, but possibly should be. C-19 is causing heart attacks, strokes, heart damage, pneumonia, liver damage, lung damage, organ failure, Kawasaki or Kawasaki like disease, rash up to full body coverage, blood clotting in different areas of the body that can potentially result in the need for amputation, neuronal damage, intestinal issues and death and this is an incomplete list! Yes, this disease is very serious indeed, even for those not to be considered in the high risk groups. Many of the heart attack and stroke victims are much younger than these two conditions are generally associated with, with no previous symptoms and doctors are only finding out these patients have C-19 when they start working on them and see the damage that is known to be associated with C-19 and that is when they are tested and confirmed to have C-19. Yes, this is one f'd up disease that is considerably worse than initially thought and it seems like new troubling aspects of this disease are being discovered each week if not almost daily !!! Now let's discuss the good! 😂😂😂 The good news is that melatonin works against this disease process at multiple levels of disease progression and at every place in the body where the disease has been found because melatonin can readily penetrate body tissues (including its metabolites) and easily cross the BBB to express its very potent antioxidant and antiinflammatory effects as well as other positive effects. Melatonin is a protector of all major organs and is protective of endothelial cells as well as the skin. Melatonin has anti-clotting abilities. Melatonin has shown itself to "upregulate the gene expression" of some of the bodies own very potent antioxidants such as Catalase(CAT), Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx) and glucose-6-phosphate dehydrogenase (G6PD) and this aspect of melatonin is very important because it is very likely that all of these natural antioxidant defense mechanisms of the body are being depleted very significantly trying to fight this disease because of the multiple areas of the body being affected simultaneously, so melatonin boosting their production can help to level the playing field giving the body more than a fighting chance to defeat this virus. Since it has been proven in autopsy that C-19 is attacking multiple areas of the body simultaneously, it is as though the body is fighting multiple diseases all at the same time!Never show up to a gang fight with just yourself! Melatonin's boosting of the body's potent antioxidant system is absolutely needed to deal with something worse than it would normally ever have to deal with in moderate and severe patients. Add to this melatonin's potent and broad antiinflammatory abilities and things are starting to look hopeful! To add a little more brightness to that light at the end of the tunnel, melatonin itself is a highly potent scavenger of Reactive Oxygen Species (ROS), Reactive Nitrogen Species(RNS), hydroxyl radicals, Hydrogen Peroxide(H2O2) and Peroxynitrite (ONOO). All of these radicals are thought to be highly active in C-19 and doing a lot of damage. One melatonin molecule can scavenge up to 10 oxygen radicals while many other antioxidants can only scavenge and neutralize one oxygen radical 1:1. Melatonin inhibits NADPH Oxidase which is a very bad player that ends up generating ROS in large amounts and damaging almost all cells in its path. Now let's add in the vitamin C that Dr. Neel is using alongside melatonin in his C-19 patients. Vitamin C is synergistic with the antioxidant and antiinflammatory aspects of melatonin! Together they are better than either one alone and vitamin C pales in comparison to the broad ranging effects that are melatonin, but adding it to melatonin makes melatonin more potent. That light at the end of the tunnel is looking brighter! 💡🔦💡🔦💡🔦💡 A couple of points I would like to make. Originally some people thought that inhalation of food grade hydrogen peroxide via a nebulizer or ultrasonic vaporizer would be sufficient to kill the virus and it likely will in the lungs if you use HP as early as possible, but HP is an oxidant and Catalase will come along and neutralize it soon enough, turning it into water and oxygen, which means HP will not have staying power and more importantly, it suggests that HP will never make it past the lungs to other areas of the body where the virus may be thriving. So I would not want to rely on HP alone. Though I am a believer and user of silver nanoparticles (AgNPs), although inhaled AgNPs are likely to have staying power in the lungs before being absorbed into the blood I do not believe that by itself it will be enough. It will require drinking the AgNPs also and that combination with melatonin and vitamin C, may just be what it will take to put this virus down as quickly as possible, in my opinion. Although I think melatonin and vitamin C may be sufficient, I think that the addition of AgNPs will speed the process considerably! Art

Replied by Ragaa Shabib
Jordan
05/11/2020

What brands of nanoparticle silver are good ones?

Art
California
05/12/2020
521 posts

Ragaa Shabib, The only two products I have seen that appear to be AgNps or silver nanoparticles are MesoSilver and MediSilver : https://www.amazon.com/MediSILVER-AMBER-Traditional-Colloidal-Silver/dp/B00ADQ5VWS https://www.amazon.com/s?k=mesosilver&ref=nb_sb_noss_1 I'm not recommending either one, just saying they appear to be AgNPs. As far as I know, everything else is likely ionic silver as they are colorless unless you go to a chemical supplier who can probably get most anything you want, but probably at a higher price though. Art

Replied by Art
California
05/11/2020
521 posts
5 out of 5 stars

I no sooner got this list above this post complete and posted last night and I read the following article that shows that Covid-19 is negatively affecting the eyes too! Just when I thought this disease couldn't get any worse, it does! https://www.medpagetoday.com/infectiousdisease/covid19/85752 Art

Replied by Dave
California
05/11/2020

What would it take to get this to politicians?

Art
California
05/11/2020
521 posts

Dave, That is a really good question! I'm trying to spread the information around as much as possible about melatonin, but actually trying to get a politician to seriously look at and consider it is another story. What I have noticed is that the drugs that they are repurposing for use with Covid-19 patients are only marginally effective or not effective enough. Hydroxychloroquine is only marginally effective at best and Remdesivir, although touted by Fauci, is only marginally effective. This seems to be the case with most if not all of the drugs they are trying so far. It seems like more natural items like those presented here on EC are mostly ignored by scientists and the powers that be. The government is having to spend trillions of dollars to try and keep the economy going, but they don't seem interested in spending a few million dollars to trial supplements or vitamins of any kind. Our government seems so convoluted when it comes to Covid-19. Everyone seems to have their own agenda and alternatives, supplements, herbs and vitamins do not seem to be on anyone's agenda who might have the power to actually test them in patients. If I was in Fauci's or Trump's position, I would have a very small team of people scouring the internet everyday to find ideas that might sound promising and EC seems to be a very good place to start looking, but clearly that is not the case. They would rather pump their research dollars into drugs that are not really showing good results at all. Dr. Neel is, in one week, highly recommending that doctors use melatonin in their Covid-19 patients based on the very good safety profile of it, as well as a lot of research studies clearly suggesting that it is definitely worth trying and testing it. And then the very next week is already using it successfully in his patients. He's only been using it since the beginning of April and already has 14 patients on it. I think it is going to take doctors like him who are willing to suggest it to their patients. And if more doctors find similar results in their Covid-19 patients as Dr. Neel has, then the politicians will have no choice, but to start testing it in trials. In the meantime, we common folks are left to figure things out on our own! Art

Replied by Dimoune
Africa
05/11/2020

Art, If someone does not have access to melatonin, do you think drinking and nebulizing AgNP is a good alternative?

Art
California
05/11/2020
521 posts

Dimoune, Before I found out about melatonin for this purpose, my intent was to use the combination approach of inhaling and drinking with silver nanoparticles (AgNPs). The truth is that there is no clinical experience with AgNPs for Covid-19 or anything else, but the method of action seems likely to work, so I would have tried it right away myself and if I didn't think it was working or working well enough, I would have moved on to something else or added something else with the AgNPs just in case. Art


Posted by Art (California) on 05/07/2020 521 posts

This is a reminder for people in the USA who might think that things are getting under control as far as Covid-19 because Trump is encouraging governors to open their local economies. The following will hopefully explain why that may not be the best move at this time! There are currently 3,897,925 cases of Covid-19 in the world. Of that number, the US is accounting for a solid 33% of those cases, but the US only accounts for 4.25% of the world population. There are currently 269,519 dead from Covid-19. Of that number, the US is accounting for 28% and again that is 28% when we only represent 4.25% of the world population. The US is clearly way ahead of any other country in the world by a very wide margin in terms of cases and deaths! The next closest country in terms of cases is Spain with 256,855 cases whereas the US has 1,286,024 or over 5 times as many cases! In terms of deaths, the US currently has 76,672 deaths from Covid-19 while the UK (2nd) has 30,615 deaths or less than half of the US deaths! Compared to the rest of the world, the US is accounting for over 28% of the deaths, again, even though the US accounts for only 4.25% of the total population of the world! If that does not give Trump pause to push for opening the economy, what will??? Art

Replied by Kathleen
Madison
05/08/2020

Trump is not pausing. It's about the economy... and of course his re-election. The re-opening is happening, whether we think it's a good idea or not. One of the things that amazes me is that so many of us refuse to social distance and wear masks. The masks are about caring for others, in case we are carrying the virus without knowing it. The social distancing is caring for ourselves and for others. Yes, it's a pain, but what is that compared to slowing the progression of the virus, compared to saving lives? My parents' generation went through the Great Depression and WW2. Neither of these difficult times lasted for a just few months, and they couldn't quit because they were 'tired of it'. C'mon folks! We can do this!

Art
California
05/08/2020
521 posts

Hi Kathleen, Yes, apparently the economy is more important than human lives, but that is truly short sighted thinking as this virus has proven quite adept at spreading from human to human so once the economy opens again and people are back in relatively closed spaces together with many other people, the virus will begin its voracious spread again. Trump said the other day on the news that Covid-19 has been "some of his best work", but the stats for the US show that we are leading the world in number of cases at a whopping 33% of the total cases in the world! We are also leading the world in number of deaths with America accounting for 28% of the total deaths from Covid-19 in the world! All of that, yet we only account for 4.25% of the world population. We have more than 5 times the cases of the next closest country to us, Spain. We have greater than double the number of deaths than the next closest country, the UK! If this is some of Trump's best work......? Once the economy reopens, those numbers will climb much faster and put the US even further apart from the crowd.! I guess we really are expendable when it comes to money! On the other hand, if you are living from paycheck to paycheck and don't get back to work soon, you could lose everything you have and end up homeless or you can go back to work and possibly end up dead. It is a no win situation for many people! Art


Posted by Art (California) on 05/06/2020 521 posts
5 out of 5 stars

Here is a link to a biomedical scientist who agrees that melatonin should be used in Covid-19 patients, just as Dr. Neel is doing. https://devinenews.com/biomed-scientist-believes-melatonin-can-help-fight-covid-and-post-infection-complications/ and new information regarding melatonin: https://www.tandfonline.com/doi/full/10.1080/08830185.2020.1756284?scroll=top&needAccess=true& Art


Posted by Art (California) on 05/02/2020 521 posts
5 out of 5 stars

I ended up doing three evenings of melatonin at 80 mgs per evening in four 20 mg doses per night and it seems I was able to tolerate it with no apparent problems. I didn't really notice anything while taking it except that a cough I have had since the first week of February after catching a Flu/cold the day after Superbowl is gone. It was a choking cough when I would talk and would seem to worsen each day starting in the early evening. More recently it was starting first thing in the morning and worsening as the day went on. I was considering trying a lot of things for it, but I didn't because I figured it would just go away on its own. I should have known better because I have had a cough like this at least five times in my life and each time it took 6 months to a year to go away on its own. It is different than the productive coughs I have had because this one is like a spasm when I talk. I found that I kept talking softer and softer so I wouldn't get the spasm and cough to try and relieve the cough. There was no apparent phlegm at all once the cold was gone. Well, I am very happy to say that it appears that cough is now just a bad memory! The day after my melatonin experiment, I thought the cough might be gone, but now I know it's gone and I can talk at normal level again! Okay, I've always referred to melatonin as one of my favorite supplements, but it just went up a notch for me! That flu, in hindsight, had quite a few aspects that are considered Covid-19 symptoms, but at the time, February third, I was not aware of Covid-19 so I didn't really give it much thought then. Now I realize I had a sore throat for 3 to 4 days accompanied by fatigue, headache, bodyache and fever which I didn't bother measuring and that was followed with a cold and in total it took me a month to get over everything except that horrible nagging cough! I hope eventually that my doctor can do an antibody test to determine if it was Covid-19. That's the update for today! Art


Posted by Art (California) on 04/30/2020 521 posts

In yesterday's MedCram video (62) as well as today's video (63), Dr. Seheult goes into greater detail about the damage being done to the endothelium as well as the effects of this damage at same and downstream points, one of which is the reduction of Angiotensin 1,7 and the runaway oxidation that ensues. Today's video goes into more detail about the downstream effects of the damage to the endothelium as well as the massive generation of ROS. Melatonin is also a signaling molecule that upregulates gene expression of antioxidant enzymes while itself being a potent ROS, RNS and hydroxyl radical scavenger while having antiinflammatory effects when systemic inflammation becomes elevated. Melatonin has shown itself to be a protector of the endothelium which this video shows is damaged as part of the disease process resulting in downstream damage in this cascade of events. Melatonin also helps prevent reduction of Angiotensin 1,7 which would be useful in diminishing disease progression. Dr. Seheult describes how Covid-19 greatly reduces angiotensin 1,7. If that isn't enough, melatonin is also an inhibitor of NADPH Oxidase! This video series is continuing to show how melatonin has shown many pathways by which it can negatively impact the disease process of Covid-19. Dr. Seheult and MedCram are generating a very lengthy list about known aspects of the method of action of this disease. What would make a great video at this point is one that compares their list to the known activities of melatonin! MELATONIN VS COVID-19! https://youtu.be/DtPwfihjyrY https://youtu.be/Aj2vB_VITXQ


Posted by Art (California) on 04/28/2020 521 posts
5 out of 5 stars

Based on yesterday's MedCram video, there is a lot of C-19 related damage to cells throughout the body including endothelial damage plus blood clotting which is resulting in hyper elevated levels of reactive oxygen species and inflammation and ultimately stroke or heart attack in C-19 patients of relatively young age who may also be symptomless right up to the stroke or heart attack. Among all of the things that melatonin is known for, such as: increaser of the bodies own potent antioxidant system, oxidant neutralization and radical scavenging, cardiovascular protectant, anti-inflammatory, anti-clotting/anticoagulating, anti-ARDS activity, anti-ALI activity, endothelial protectant and blood thinning are part of its healthful effects. In my opinion, this video adds to the case for melatonin in multiple ways to help ameliorate many of these viral-related activities that are resulting in stroke and heart attacks in the relatively young, sometimes before any symptoms are apparent! His comments on hydroxychloroquine did not sound very promising. Link to Video: https://www.youtube.com/watch?time_continue=4&v=22Bn8jsGI54&feature=emb_title Art


Posted by Kristie (Tennessee ) on 04/28/2020
5 out of 5 stars

Art, Thank you for sharing this!

Replied by Art
California
04/28/2020
521 posts

You're welcome, Kristie! I hope you find it useful. Art


Posted by Art (California) on 04/27/2020 521 posts

So I went another night (3 nights) at 80 mg and I slept through the night which is unusual for me. I woke up a little earlier than usual and feel rested. So this seems to be the pattern from taking 80 mg per evening, uninterrupted sleep through the night and waking a little earlier than normal. I can live with this so I am about as prepared as can be now to use melatonin if I get Covid-19. Art

Replied by Sithina
Sri Lanka
04/29/2020

Is is milligrams or micrograms?

Art
California
04/30/2020
521 posts

Sithina, Dr. Neel is using about 80 milligrams total per day divided into four (4) 20 mg doses in his adult patients, but I believe he actually has a range of from 50 milligrams to 100 milligrams, depending on patient's size and severity of symptoms. The doctors Hospital in Manila has reported using a dose range of 36 to 72 milligrams/day in their patients. Both locations are giving that dose divided into four doses per day to achieve the daily dose Thank you for bringing up the dosing as I wouldn't want his protocol to be mistaken on something as critical as dosing! Art



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