Coronavirus
Natural Remedies

Melatonin Protocol for COVID-19

| Modified: Sep 20, 2020
Add New Post covid 19 natural remedies - corona

By Art Solbrig

April 20, 2020
Updated May 09, 2020 5:00 p.m. EST

One possible problem for moderate to severe Covid-19 patients is the potential for significant damage to the lungs and possibly other organs like the liver, based on what is being seen in patients.

At this point, treatment options to try and prevent, repair or ameliorate this damage is very limited and not necessarily a very high priority for doctors yet, but still important to the patient in the long run to maintain good health quality overall.

Toward that end, I would like to talk about one of my favorite supplements that I have previously mentioned on Earth Clinic that may help these patients have a more complete recovery of the lungs and possibly other organs: Melatonin.

Post-Intensive Care for COVID-19

The aftermath for patients with Covid-19 has not been discussed at length yet because it is not currently the highest priority for doctor's treating these patients.

Keeping them alive is obviously a primary concern right now, but preventing or ameliorating the significant amount of collateral damage caused by Covid-19 is very important also.

That subject, in time, will be quite popular as more people reach the recovery phase of Covid-19.

For many people who fall into the "high risk groups", this information may be useful and timely to reduce your chances of succumbing to the disease if infected and if some scientists are right in their thinking that the virus can potentially mutate and return seasonally, similarly to the seasonal flu, then melatonin certainly seems like a very useful adjuvant treatment to keep in mind from this point forward!

If you survive the virus once and develop antibodies to it that will be very good, but if the virus mutates extensively, there is a chance that those antibodies may not be effective against the new strain similarly to vaccines for the flu, which sometimes work against the new strain and sometimes don't as witnessed by people who have gotten the flu shot and still got the flu.

Melatonin has shown itself to be protective of the major organs of the body in many studies, which includes the lungs among its many potential health benefits.

There are several forum members currently using melatonin, including myself, so this could be useful information for them as well as other members who are trying to be as prepared as possible to deal with Covid-19.

Below is a link to a recent article that discusses the potential utility of melatonin as it would relate to Covid-19. Melatonin is just at the beginning of testing in Covid-19 patients with initial positive results. This article mainly discusses the effects of melatonin as it might relate to Covid-19 and includes its antiviral and anti-ARDS qualities among many other qualities. The article describes melatonin as "having a high safety profile" and suggests it might be useful before, during and after the disease process has ended.

Doctors may have a bit more latitude in using melatonin compared to all of the prescription drugs that have been mentioned on this forum and across the internet since melatonin is an OTC supplement sold at drug stores and big box item stores and almost all online supplement suppliers.

COVID-19: Melatonin as a potential adjuvant treatment

Life Sci. 2020 Jun 1; 250: 117583.
Published online 2020 Mar 23. doi: 10.1016/j.lfs.2020.117583

Rui Zhang,a Xuebin Wang,a Leng Ni,a Xiao Di,a Baitao Ma,a Shuai Niu,a Changwei Liu,a,⁎ and Russel J. Reiterb,⁎⁎

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7102583/

Abstract

This article summarizes the likely benefits of melatonin in the attenuation of COVID-19 based on its putative pathogenesis. The recent outbreak of COVID-19 has become a pandemic with tens of thousands of infected patients. Based on clinical features, pathology, the pathogenesis of acute respiratory disorder induced by either highly homogenous coronaviruses or other pathogens, the evidence suggests that excessive inflammation, oxidation, and an exaggerated immune response very likely contribute to COVID-19 pathology. This leads to a cytokine storm and subsequent progression to acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) and often death. Melatonin, a well-known anti-inflammatory and anti-oxidative molecule, is protective against ALI/ARDS caused by viral and other pathogens. Melatonin is effective in critical care patients by reducing vessel permeability, anxiety, sedation use, and improving sleeping quality, which might also be beneficial for better clinical outcomes for COVID-19 patients. Notably, melatonin has a high safety profile. There is significant data showing that melatonin limits virus-related diseases and would also likely be beneficial in COVID-19 patients. Additional experiments and clinical studies are required to confirm this speculation.


Here is a link to an article in the Washington Post that gives an idea of which organs can be impacted by Covid-19 which further illustrates why melatonin might be a very useful adjuvant treatment option which doctors can add to their arsenal against Covid-19. That arsenal is relatively small at this point, but hopefully will continue to expand.

Since the multiple health benefits associated with melatonin may apply in the case of this disease in multiple ways, it may be worth saving this post for future reference for yourself or a family member or friend to show to their doctor to see if it is something that will be compatible with all that they are taking and safe for you to take.

I cannot recommend melatonin to anyone as I am not a doctor, but your doctor can. I do use melatonin daily myself as I have previously stated on the forum for multiple reasons.

Health Benefits of Melatonin

Melatonin is mainly thought of as an over the counter sleep aid, but its abilities go far beyond being a common sleep aid for some people.

Not everyone can tolerate melatonin and that is another good reason to include your doctor in that decision making process.

The majority of people do tolerate melatonin well and it is naturally produced in the body by the pineal gland as daylight turns to night time. There are melatonin receptors found throughout the body suggesting that the body does have uses for it. Unfortunately melatonin production declines very significantly as we age and that may possibly be one contributing factor as to why older people do not fair as well as younger people with Covid-19.

Here is another article that discusses the potential for melatonin in respiratory diseases. If you want to read the full article, you will have to click on the blue rectangular button that says "Download full-text PDF" once you follow this link.

This very recent (March 20, 2020), brief and interesting link takes you to an opinion page where a doctor is discussing how melatonin might be used as adjunctive treatment for Covid-19 in patients with and without pneumonia and is relatively short and straight forward. He is advocating for use of melatonin "now" in Covid-19 patients. He feels that melatonin also would be an effective antiviral and antibacterial, but that is not yet known in Covid-19.

This is worth reading!


The same doctor from the article just above, Dr. Richard L. Neel M.D., MPH., has actually started treating Covid-19 patients with melatonin and vitamin C as this link explains.

I like what he is doing by practicing what he is preaching. His treated patient count is low at this point, but you have to start somewhere and a hospital seems a safe place to do that if you are already infected with Covid-19! A quick mention to the fact that there are a couple of ads at the 1/3 point and 2/3 point in the following article so please scroll past each ad to make sure you read the whole article, its interesting. This is a good read.


One more update about Dr. Neel. He says he has treated 10 patients now giving them 80 mgs of melatonin per day. Click here.

One of my supplement experiments involved taking 70 mgs of melatonin per day so I already have an idea of what 80 mgs will be like for me. Another good read and not long.

Melatonin Levels Decline Sharply As We Age

Source: grivas tb, savvidou od. melatonin the “light of night

We're reporting our experience in a scientific journal, so hopefully, it could help save some COVID-19 patients, especially the elderly, who are reportedly left to die in some cities in Italy and Spain, so that doctors could allocate their resources to younger patients. If this information could save a few of these lives, it shall have been worth all that we've gone through convincing our local colleagues about it."

Here is a link to that article: https://lifestyle.inquirer.net/361003/high-dose-melatonin-3-other-drugs-seen-as-effective-against-covid-19/


The following link discusses repurposing of existing drugs including melatonin. It is quite lengthy if you are pressed for time and don't have time to read it, here is a quote from the article:

https://www.nature.com/articles/s41421-020-0153-3

"Inflammatory pathways play essential roles in viral infections56,57. As a biogenic amine, melatonin (N-acetyl-5-methoxytryptamine) (Z = –1.72 and GSEA score = 2) plays a key role in various biological processes, and offers a potential strategy in the management of viral infections58,59. Viral infections are often associated with immune-inflammatory injury, in which the level of oxidative stress increases significantly and leaves negative effects on the function of multiple organs60. The antioxidant effect of melatonin makes it a putative candidate drug to relieve patients' clinical symptoms in antiviral treatment, even though melatonin cannot eradicate or even curb the viral replication or transcription61,62. In addition, the application of melatonin may prolong patients' survival time, which may provide a chance for patients' immune systems to recover and eventually eradicate the virus. As shown in Fig. 5e, melatonin indirectly targets several HCoV cellular targets, including ACE2, BCL2L1, JUN, and IKBKB. Eplerenone (Z = –1.59), an aldosterone receptor antagonist, is reported to have a similar anti-inflammatory effect as melatonin. By inhibiting mast-cell-derived proteinases and suppressing fibrosis, eplerenone can improve survival of mice infected with encephalomyocarditis virus63."


The following 2 links, while not related to Covid-19, takes you to two abstracts of a study where melatonin was used at a dose of 70 mg per day in children with Duchenne muscular dystrophy for 9 months to good effect. I'm adding this one just to show that melatonin is relatively safe in children who might get Covid-19, even at 70 mg/day. They used it everyday for 9 months, whereas it may only have to be used for a much shorter time period in Covid-19 patients.

https://www.ncbi.nlm.nih.gov/pubmed/20210854

https://www.ncbi.nlm.nih.gov/pubmed/21515247


This article adds further confirmation to the idea of melatonin for C-19:

https://www.melatonin-research.net/index.php/MR/article/view/79/502

One of the important points the authors are making is that melatonin seems to attenuate the serious viral activity response by your body while your body builds an effective and measured attack instead of an over response of a cytokine storm. It takes the body time to generate appropriate antibodies and melatonin seems to help by essentially calming the bodies over response until the body is able to generate enough antibodies and effectively destroy the virus. This tends to confirm what Dr. Neel is seeing in his patients of very significantly reduced symptoms in 24 hours.

An important quote from that article :

... "For the hosts, melatonin improves the defense system by upregulating the expression of antioxidant enzymes such as SOD, CAT, and glutathione peroxidase(163), effects that reduce the oxidative tissue damage caused by the pathogens. Most importantly, melatonin redirects the host immune response, i.e., by controlling the potentially over reactive innate response and promoting the adaptive immune response."


Summary

I am not recommending melatonin, just putting the information out on Earth Clinic so anyone interested can discuss it with their doctor or health care professional and to also make sure it is compatible with everything you may be taking.

I hope that you will be able to get enough information from this post to see that what Dr. Neel is suggesting is a non-invasive way to assist in the treatment of Covid-19 and possibly in the interim period where you might be told to stay home and rest and then go to the emergency room if you have trouble breathing.

Remember, there are drugs which are working to various degrees, but will we be able to get them and how long will we have to wait before we are tested and accepted as a patient in the hospital to receive those treatments if they are available?

If melatonin is as effective as Dr. Neel and the Philippines have seen so far, melatonin may be a consideration between you and your doctor during that period while you are waiting for your breathing to become difficult enough to be allowed into the hospital.

If it works as they have seen so far, perhaps that trip to the hospital may never be needed! Dr. Neel is talking about positive effects in as little as one day.

Some of the drugs that are being tested for Covid-19 have significant side effects and judging by what is already known about melatonin, it may even help to ameliorate the severity of some of those effects while also helping to alleviate symptoms of the disease itself. His hope, as he mentioned is that melatonin may prevent a patient from ever needing to go on a ventilator in the first place.

Given that some hospitals don't want to accept you in until you are having a hard time breathing, to me, if I feel I am getting sick in any way, I will continue to take the melatonin that I am already taking plus the difference to get up to his dosing schedule in the hope that I never even have to go to the hospital!

These are just more reasons why I refer to melatonin as one of my favorites!

Melatonin Dosage for Lung and Organ Damage Caused by COVID-19

To briefly summarize what Dr. Neel and the hospital in the Philippines are doing to combat the damage caused by Covid-19, Dr Neel is giving his adult patients 80 mg of melatonin each day.

He has them take that 80 mg in 4 equally divided doses so that they take 20 mg at each dose and they take that dose 4 times per day spread out through the day.

The hospital is doing similar, but with a slightly lower dose because they are using a dose range of 36 to 72 mg per day and they are dividing the dose into 4. They don't say why they are using a lower dose, but it may be because they are dealing with children and younger people as well as adults whereas Dr. Neel has so far only treated adults. Another factor may be that in general, Filipinos are a smaller people.

Where to Buy Melatonin

You can find melatonin at most pharmacies, health food stores, grocery stores, and of course, online.

Here are a few links to Amazon:

NOW Supplements, Melatonin, 10 mg, 100 Veg Capsules

Natrol Fast Dissolve - 10 mg - 100 Count - $12.99

Puritan's Pride Melatonin 10 mg 120 Capsules (3-Pack)- $23.00


I would also like to mention that I recently restocked my melatonin supply and they came very quickly compared to my zinc picolinate order and my vitamin D and C orders! Since I have been taking melatonin for years, much of this is information about melatonin I was aware of and why I looked for a possible connection in the first place.

I was not aware of its potential use as adjuvant treatment for Covid-19. Melatonin's ability to help protect the lungs and other major organs could be a very useful adjuvant treatment in trying to protect the body as a whole from most of the potential damage which Covid-19 has shown the ability to inflict on people infected with SARS CoV-2 and act as a potent antioxidant and also act as a potent antiinflammatory, all well known melatonin attributes and this is a very big thing for Covid-19 patients to help protect almost all of the organs that Covid-19 is now thought to involve in addition to the lungs.

A drug that can safely destroy the virus is extremely important, but ameliorating or preventing the damage caused by the virus is important now and later for the patient!

I am sorry for the length of this article, but since melatonin has not previously been discussed for this purpose on this forum, I wanted to include as much pertinent information as possible to give some background.

Related Links:

Coronavirus


40 User Reviews

Posted by Art (California) on 09/10/2020 634 posts
5 out of 5 stars

This recent report (August 26,2020) of an 87 year old who was treated with HDM and treated early, survived with no complications!

Here is a link to the brief article:

https://devinenews.com/hooker-87-beats-covid/

Although it is just one case, 87 years old is a definite high risk case and he survived with High Dose Melatonin, along with vitamin D, zinc and vitamin C. Melatonin has shown synergy with these vitamins in recent studies. These four supplements are noted for having very good safety profiles and are all commonly available over the counter and are inexpensive. Simple, easy and effective and can be started earlier than the drugs being prescribed for Covid-19 in most cases.

This bodes well for the elderly!

Art


Posted by Art (California) on 09/02/2020 634 posts
5 out of 5 stars

Here is the latest very promising report on Dr. Neels melatonin / Covid-19 protocol as used in a Texas convalescent facility. As many of you already know, these convalescent facilities are fairing very poorly with many patient deaths being the norm! This convalescent facility didn't waste anytime implementing Dr. Neels protocol once they had their first two cases die from Covid-19. They started using HDM right away and had no more deaths from Covid-19! One patient died afterward from another health issue. This is very important because this is a senior population with health issues and age that put them at increased risk of succumbing to Covid-19.The rest lived.

Here is a link to the latest article :

https://devinenews.com/lytle-area-facility-fights-back-quickly-as-covid-outbreak-strikes/

Art

Replied by Mary Lou
Ky
09/08/2020

Art,

I just tested positive for Covid and I am assuming my infection date was 9/4/2020. I didn't get the test results until 9/6/2020.

I'm 68 years old and in very good health. I do not take any medications and have never had a surgery. I currently (9/8/2020) have very mild symptoms, mostly sinus congestion, head cold feeling, mild headache and exhaustion.

I just ordered Melatonin and will place another order for sublingual melatonin as I believe I read that was preferred.

I've read all the articles that I could and the comments. Several of the lengthy ones I had to skip. I can't focus on complex explanations right now.

I see in the article about Country Life Assisted Living that they supplemented with Vitamin D3, Zinc, and Airborne Supplement with Vitamin C per collaboration with Dr. Richard Neel.

Could you provide the suggested doses using Vitamin D3, Zinc, and Vitamin C powder? (I have been alkalizing 2-3 times a day and supplementing additional Vitamin C powder, 1 gram and ¼ tsp baking soda almost every hour in between.) I've also added Quercetin (800 mg) with Bromelain (165 mg), and Astragalus Root (400 mg), and Lugol's Iodine.

I should get my Melatonin in a day or two.

Thank you so much for a quick reply.

Replied by Art
California
09/08/2020
634 posts

Mary Lou,

I did test melatonin in the sublingual form, but did not notice any difference and the report you are referring to occured around the same time that Dr. Neel reported a more difficult strain of Covid-19 in his patients that was requiring more time to see improvement and in some cases he was using even higher dosing. I suspect that report was reflecting the tougher strain that Dr. Neel had mentioned that also came with digestive issues that he previously had not seen in his covid patients. I believe this may have been the reason for the report of a delayed response in that family.

As far as dosing of zinc, vitamin D and vitamin C, unfortunately they did not state the dosing used, in the article.

One of Dr. Neel's patients in an earlier report mentioned 2,000 mg of vitamin C total per day.

The Italian study suggested a serum level of 40 to 60 ng/ml for a good response to vitamin D, but again vitamin D serum level has to be tested regularly in order to reach a specific level such as 40~60 ng/ml and the dose will vary from person to person as some people simply require higher dosing than others to reach a specific serum level. The reference range for vitamin D / 25 (OH) d serum level is 30 ng/ml ~ 100 ng/ml and would need to be tested by your doctor to get there.

Art

Mary Lou
Ky
09/11/2020

Art,

Thank you for your reply.

I'm on day 9 of the virus and was just able to start Melatonin the evening of Day 7. I'm glad there was no noticeable difference using sublingual Melatonin as I couldn't find any that didn't have a lot of additives.

I used the Vitamin C protocol from another page on Earth Clinic of 1000 mg every hour, with Zinc, Quercetin, and then added D two days ago. Also, few other supplements- some of which are listed in my previous post.

I had about 3 days of very bad flu-like symptoms that changed to mild sinus congestion and head cold.

Right now (day 9) I feel pretty good, (actually almost normal) except for being extremely tired and feeling very weak.

I plan on retesting the first of October and will remain in self-quarantine until then.

Can you suggest how long to continue the Vitamin C and Melatonin protocols? Today I reduced the Vitamin C to every 2 hours.

Also, I am having the best nights sleep I've had in a long, long time!

Replied by Art
California
09/12/2020
634 posts

Mary Lou,

Glad to hear your sleep has improved and even gladder to hear you have fared very well with your bout of Covid!

I think what Dr. Neel is doing is waiting until you test negative and then slowly reduce your melatonin dose until you get down to around 5 mg/night.

I believe the reason he is in no rush to take his patients off of melatonin too quickly is because Covid-19 has shown damage to almost all major organs in autopsies and studies suggest that melatonin can repair much of the damage that you can't see and is not readily apparent to the patient or doctor. This damage if left unchecked may cause health issues years down the road. I think the damage has the best chance of being repaired while it is relatively fresh.

Art


Posted by Art (California) on 08/26/2020 634 posts
5 out of 5 stars

In this latest update from Dr. Neel, he mentions that although the amount of new cases in his area of Texas have slowed a bit, the current strain affecting his area is definitely more difficult to treat than the previous strain he was working against. He has shown a willingness to raise the melatonin dosing level to help deal with this current strain because with this strain it has taken 3 days to start to see improvement whereas with the previous strain he was seeing improvement in just one day.

One thing he didn't mention is the number of patients he has treated as of today(8/26/2020). The last time he mentioned the number, he said over 400 patients treated. He still not has reported any deaths as of this update. Here is a link to the update:

https://devinenews.com/masks-to-melatonin-how-it-works-why-it-works/

Art


Posted by Art (California) on 08/25/2020 634 posts

Since it appears that Covid-19 is going to be here longer than anticipated by the administration, I am continuing to update this thread as I find relevant information regarding this infection. It is worth noting that overall, since the administration has taken over keeping track of Covid-19, from the CDC, in mid July, the number of new cases for the US have been declining steadily. On July 24th, there were 78,586 new cases that day and it has steadily declined from that day forward. Can this even be correct considering the elevated new cases in California, Texas, Florida and New York?

This recent study (June/2020) is in agreement with the idea of using melatonin against Covid-19, but their hypothesized dose rate is approximately 8 times greater than what Dr. Neel is using on average (1mg per kilogram/day) at 8 mg/kg/day and higher for severe cases! To put that in perspective, if you weigh about 175 lbs or 80 kilos, you would have to take about 640 mg of melatonin per day for severe Covid-19 infection!!!

https://www.melatonin-research.net/index.php/MR/article/view/83/562

I'm a fan of melatonin, but that is the highest dosing I have ever heard of in humans and even greater than what Dr. Shallenberger is using in his stage 4 cancer patients!!

Art


Posted by Art (California) on 08/15/2020
5 out of 5 stars

Here is another upcoming melatonin / Covid-19 study that is going to be done in Spain using 60 mg / day and what makes this study different is that they are injecting those 60 mgs of melatonin and this will be a randomized, placebo controlled, double blind study which is also a first when it comes to melatonin / Covid-19. I don't think they have a randomized, placebo controlled, double blind study for Hydroxychloroquine yet :

https://www.docwirenews.com/abstracts/clinical-trial-to-test-the-efficacy-of-melatonin-in-covid-19/

Art


Posted by Art (California) on 08/02/2020 634 posts
5 out of 5 stars

Below is a link to an article about a 4 year old boy in Texas who got sick shortly after his father tested positive for Covid-19.

Of note related to this story is that 4 to 7 year olds are at or very near the peak of natural melatonin levels seen in humans suggesting that melatonin can not prevent infection, but it can apparently reverse it in short order based on this and many other reports! This could be useful information for all of those people who have kids or grandkids! Here is a link to that article :

https://devinenews.com/local-4-year-old-battles-103-9-fever-days-after-dad-tests-positive-for-covid-19/

Art

Replied by Anon
Anon
08/02/2020

Or the boy's ability to produce melatonin has been compromised.


Posted by Art (California) on 08/02/2020 634 posts

Melatonin and What Type May Be Best for Covid-19:

Previously I had stated that when it comes to Covid-19, the type of melatonin should not be an issue, but Dr. Neel had stated that he was using the type of melatonin that dissolves in the mouth or under the tongue (sublingual).

I thought the only significance of that type was that he felt it would be possible to give to patients already on a ventilator and that was it, but this recent report suggests that there may be more to sublingual melatonin than that! Other sublingual supplements are often said to have better bioavailability in their sublingual forms over regular capsules or pills. Perhaps this is also true for melatonin in its sublingual form? Melatonin on its own has poor bioavailability. Roughly, oral melatonin only offers a maximum of 15% bioavailability at best. So this offers some creedence that even a small increase in bioavailability may have significant ramifications when it comes to melatonin?

https://pubmed.ncbi.nlm.nih.gov/10883420/#:~:text=Subjects were administered, in a, absolute bioavailability of approximately 15%.

Given that information, the following report from a Covid-19/Melatonin patient makes a little more sense and I may need to rethink the use of sublingual melatonin on the chance that it is better absorbed by the human body???

https://devinenews.com/family-of-8-hit-hard-by-coronavirus/

Perhaps type of melatonin does matter??? Since I have been taking melatonin in the capsule form, I may have to get a bottle of sublingual melatonin to see if I respond differently to it? This may take a little bit of time since I have other experiments already in my queue.

Art


Posted by Art (California) on 07/26/2020 634 posts

Very recently I found out that some 10 mg melatonin capsules also contain vitamin B6. This will not work for high dose melatonin (HDM) treatment as it can deliver to much B6 and this can be unsafe and unhealthful to take in that much B6 everyday! The B6 is added for the purpose of increasing the absorption of melatonin. Stay away from these types of melatonin that contain extra B6 as they should not be used for HDM.

Art


Posted by Nancy11 (Florida) on 07/23/2020 3 posts

H2o2 use and melatonin:

I have just got over a median case of covid. I have copd and my breathing has worsened since, I just started taking or doing the hp protocol today. I have noticed in your article that melatonin fights off h2o2, so would it be advisable to say I should just do the melatonin to try to recover my lung capacity, I am not on any meds at this time.

Replied by Art
California
07/24/2020
634 posts

Nancy11,

This is going to be a long answer.

To briefly answer your question, yes, I would lean toward "melatonin only", at least until you find that your breathing difficulty has improved significantly back toward your normal. This should help allow your lungs to heal to the extent that melatonin is capable of doing.

Once and if you improve from the melatonin supplementation, then you can consider whether you want to add H2O2 to the mix. Melatonin is likely to work against H2O2 as it is a radical and melatonin neutralizes radicals and melatonin can enter any tissues in the body and is proven to significantly affect the lungs.

More on this below and a possible workaround.This is a tough question for me, because I look at H2O2 as a very potent oxidant that can potentially lead to excess oxidative stress and I see that as the reason it would very likely be effective at destroying SARS CoV-2 that exists in the lungs via inhalation of H2O2, but once the virus is destroyed in the lungs, do you really need to keep inhaling a potent oxidant (H2O2) into COPD lungs that already have elevated levels of H2O2 as shown in existing studies?

I know there is plenty of anecdotal evidence that suggests H2O2 inhalation may be beneficial for COPD and in one sense that seems likely as it will very likely kill bacteria in the lungs that may thrive in the lungs of people with COPD and help to feed the disease process.

On the other hand, studies have shown that exhaled H2O2 is elevated in people with stable COPD compared to controls and is almost 3 times higher in COPD patients whose condition is exacerbated as opposed to stable.

This data could mean that the body is able to produce enough H2O2 for COPD lungs on its own, or it may turn out that even though the body produces more H2O2 in the lungs as the disease severity increases, it is not able to produce enough to reach maximum efficacy.

I have not seen data to confirm that additional inhalation of H2O2 will be beneficial, though the anecdotal evidence suggests it may be.

So inhaling H2O2 will add even more H2O2 to the already elevated levels in patients lungs with COPD and this is where the anecdotal evidence and the science seem to part ways as the science so far does not seem to support the inhalation of H2O2 in patients with COPD.

Oxidative stress is elevated in COPD as is inflammation and these two work together in a vicious cycle to increase each other as elevated oxidative stress increases inflammatory cytokines and mediators which also creates more oxidative stress ultimately creating an environment that is conducive to disease progression.

If you could look inside your lungs to see how they are reacting to inhaled H2O2, that would be very useful, but that is not possible and with no practical way to know if there is enough or too much H2O2 in the lungs, the melatonin may help with this aspect of H2O2 inhalation.

Melatonin, on the other hand, has many studies that show that it is beneficial for COPD patients and two of the effective mechanisms of action are its potent radical scavenging and very potent antioxidant activities as well as its inhibition of inflammatory cytokines which may have the potential to break that vicious cycle that can be quite active in COPD.

Another consideration is knowing that melatonin level drops when the disease is in an exacerbated state, exactly when more melatonin would likely be needed! Melatonin levels also decline with age.

Melatonin is the most potent antioxidant in the human body because it elevates the gene expression Superoxide Dismutase (SOD), Glutathione Peroxidase (GPx), Glucose-6- Phosphate Dehydrogenase (G6PD) and Catalase (CAT) while increasing Glutathione. Melatonin doesn't stop there though. It is also a potent scavenger of Peroxynitrite (ONOO) which is elevated in COPD and has negative effects, it scavenges Reactive Oxygen Species (ROS) / Hydroxyl Radicals, Reactive Nitrogen Species and H2O2 which are all mostly elevated and damaging in COPD and help extend disease progression.

Melatonin is also able to do something that other antioxidants like vitamin C and E can't.

Vitamins C and E can each neutralize one oxygen radical while melatonin can neutralize as many as 10 oxygen radicals because each time it reduces one oxygen radical, melatonin becomes a different metabolite of itself and each of these metabolites can in turn neutralize another oxygen radical.

Add in the antiinflammatory qualities of melatonin and it is a potent molecule to use against Covid-19 and COPD!So given all of the above, for myself, if I wanted to try one or both of these and if I believed they both had potential to help people with COPD, I would discuss it with my doctor to see if he thought that either one or both might be helpful for me and would be compatible with my current medications. If he or she approved the use of both, then I would consider an appropriate plan of attack.

I suggest that anyone reading this also get their doctors approval before trying to implement such a regimen.

Given that melatonin is likely to work against H2O2 by neutralizing it directly or indirectly through the upregulation of Catalase or other antioxidants which will also neutralize it, I might consider a rotating approach where I use one for a day or two followed by using the other for a day a day or two. This could possibly allow the H2O2 to work while the next phase allows melatonin to give the lungs a break and neutralize the elevated radical levels in the lungs as well as lower the elevated inflammatory levels in the lungs.

H2O2 is highly likely to do some damage in the lungs and the idea being that melatonin may nullify or repair some of this damage while helping to work against COPD through its known multiple actions against COPD.

So that is my idea of how I might use these two substances under my doctor's supervision based on my experience with both substances and the available studies I was able to find. I did not include any study links in this post because it is long enough already.

Art

Freda
Canada
07/25/2020

Hi Art

Would you recommend melatonin for severe Copd and not inhaling H202? Thanks.

Replied by Mama To Many
Tn
07/24/2020

Dear Art,

I really appreciate this post on Melatonin, H202 and COPD. It is timely for me. We are getting ready to move my mother in law into our home and she has COPD, in addition to other health problems.

By the way, I continue to take Melatonin at night for sleep and it has definitely helped me!

Thank you!

~Mama to Many~

Replied by Art
California
07/25/2020
634 posts

Hi M to M!

Thank you for saying so! I know you are probably already aware of the following, but I am putting it in for others who may not be. COPD is common, so it is worth putting this info up. Some people refer to it as emphysema, but that is an older term and COPD seems more common now as a blanket term. There are some similarities with chronic bronchitis.I'm not sure about the H2O2 for COPD simply for lack of studies to add confirmation to the anecdotal evidence, but the anecdotal evidence is compelling.

In COPD patients who are stable, the amount of H2O2 in the exhaled air is approximately 7 times that of normal controls while patients who are in an exacerbated state are almost 3 times higher than stable patients and about 21 times higher than control patients.

So H2O2 inhalation will add to these already significantly elevated H2O2 levels. This brief abstract discusses H2O2 exhalation levels in people with COPD:

https://www.atsjournals.org/doi/10.1164/ajrccm.154.3.8810624

Melatonin clearly has studies that show it benefits COPD as does NAC, which is purported to significantly reduce exacerbations at two 600 mg doses per day.

Generally elevated oxidative stress is considered to possibly be the single most important factor driving COPD disease progression, so these two seem quite useful and melatonin is the most potent antioxidant in the human body as I described in the original post. Maximum radical scavenging is desirable.HDM made it possible for me to get rid of a cough that I had had for months that was not getting better, only worse. With HDM it started to lessen in two days and was gone by the third day.Vitamin C is synergistic with melatonin and adds to both its antioxidant abilities as well as its antiinflammatory qualities.Quercetin is also useful for COPD and quercetin is also synergistic with melatonin increasing its antiinflammatory activity.

Vitamin D reduces the number of acute exacerbations also and it is almost always good to be vitamin D replete for overall health, especially with so many people being insufficient or deficient. Getting into the upper half of the reference range for 25 OH d is worth looking into at whatever vitamin D dose is needed to get there. Simply put, some people require more vitamin D to achieve a specific 25 OH d level. The 25 OH d reference range is 30 ng/ml ~ 100 ng/ml

Some essential oils such as eucalyptus are thought to be helpful with COPD also. Not everyone can tolerate melatonin. Does your mother in law have Afib?

Art

Replied by Art
California
07/25/2020
634 posts

Freda,

I answered this question in the original reply I made to Nancy and there is further information re: COPD in my reply to Mama to Many.

Art

Replied by Mama To Many
Tn
07/25/2020

Dear Art,

Thank you for the information!

Yes, as a matter of fact, my mother in law does have A-fib!

She is actually taking a small amount of melatonin right now. She has been in a nursing home for 9 months and when her sleeping pill prescription ended, they asked if they could give her melatonin instead. Well, I was sure happy about that! I don't know how much yet.

I actually didn't realize that COPD is what they used to call emphysema. But it makes sense.

Thank you again!

~Mama to Many~

Replied by Missm
New York
07/26/2020

I had Covid in March and coughed almost five months without cure. I discovered that quitting all dairy immediately caused my coughing to stop! But still left with difficulty breathing, runny nose.
I found that NAC 600 mg twice a day has really helped.

Then I do a steam as I do not own a nebulizer with Theranaturals glutathione, one capsule and one drop of eucalyptus essential oil. This glutathione is made for nebulizers. Eucalyptus is beneficial for lungs.

I do not do HP.

You could try above.

Covid takes a long time to recover.


Posted by Art (California) on 07/22/2020 634 posts
5 out of 5 stars

Dr. Neel has treated over 400 Covid-19 patients now, as of July 22, 2020!

Since his patient load has increased very considerably, so has his knowledge and understanding of the use of HDM (High Dose Melatonin) in Covid-19 patients. This seems like one of his most informative updates so far!

Dr. Neel is now seeing patients who are in multiple higher risk categories and treating some of them is no walk in the park. Dr Neel is now using even higher doses of melatonin in these harder to treat patients at dosing that is closer to what Dr. Shallenberger uses in almost all of his non cancer patients and similar to what Dr. Reiter has used in some of his studies. Dr. Shallenberger uses much higher dosing in his cancer patients though.

Dr. Neel also mentions that he is now seeing many more young patients than in the previous 3 months. He also mentions that people with asthma are having a harder time with Covid-19 than his patients who don't have asthma. He is also seeing more young patients who are developing gastrointestinal issues. He does not mention any deaths in this latest update.

He also mentions that he is seeing at least one strain of virus that seems to be more virulent. The information he includes with this latest update does not seem to bode too well for the supposedly soon to be available vaccinations, if the virus is mutating significantly. Here is the link to this latest update:

Art


Posted by Art (California) on 07/20/2020 634 posts
5 out of 5 stars

July update From One of Dr. Neel's Patients Describing Her Experience

This is an update from one of Dr. Neel's patients describing her experience using high dose melatonin (HDM) to treat her Covid-19 case. She adds confirmation to what Dr. Neel has been saying about the rapid onset of action by HDM (High Dose Melatonin).

Also of interest in this update is the fact that Dr. Neel appears willing to go slightly above his proposed dosing schedule of 1 mg of melatonin per kilogram if he deems it necessary.

This is essentially one patient's play by play of her experience with Covid-19 and HDM:

https://devinenews.com/ms-ovalle-shares-battle-with-covid-and-what-got-her-through-it/

Art


Posted by Art (California) on 06/24/2020 634 posts
5 out of 5 stars

Here is the latest update (6/23/2020) from Dr. Neel. It appears that he now has about 100 patients based on what he says in his update and he gives a brief idea of how things are going for his Covid-19 patients and his results are holding up very well as his patient base continues to expand (Texas appears to be having a significant increase in Covid-19 cases) and no deaths to report among his Covid-19 patients!

To me that is awesome news compared to all other major drugs being trialed and tested, as even the best of these are showing patients still dying, but at a lesser rate. Importantly, he once again reiterates the importance of vitamin D based on the Italian vitamin D statistical analysis as it relates to Covid-19 patients. In this latest update you can see that Dr. Neel is becoming even more focused in treating his covid-19 patients quickly and has had no major complications or deaths!

Dr. Neel also mentions the study trial in Manila that will treat 350 Covid-19 patients who also have pneumonia. It seems pretty bold to focus on Covid-19 patients with pneumonia, as this group has a significantly higher death rate!

Here is a link to his latest update:

https://devinenews.com/cases-come-back-with-a-vengeance-melatonin-offers-hope-as-full-scale-clinical-trials-start-on-covid-19/

Art

Replied by Art
California
06/25/2020
634 posts

Below is a link to a nurse who had Covid-19 and Dr. Neel is her doctor. She gives an idea of what Dr. Neel is like as her doctor :

https://devinenews.com/medina-county-woman-shares-what-her-battle-with-covid-was-like/

Art

Replied by Art
California
06/29/2020
634 posts

Here is a link to a new abstract that suggests that melatonin is useful for restoring the glutathione redox system as well as working against Covid-19!

https://pubmed.ncbi.nlm.nih.gov/32597503/

Art


Posted by Art (California) on 06/17/2020 634 posts
5 out of 5 stars

GREAT NEWS!!! The latest from Dr. Neel is that over 50 of his Covid-19 patients have recovered using his high dose melatonin protocol!!! https://devinenews.com/50-covid-patients-recover-under-dr-neels-care/ Art


Posted by Art (California) on 06/17/2020 634 posts
5 out of 5 stars

This new article explains how melatonin inhibits the cytokine storm that is proving to be a serious problem from Covid-19 : https://www.sciencedirect.com/science/article/pii/S2590098620300312?via%3Dihub Art


Posted by Art (California) on 06/14/2020 634 posts

The new study link below shows that melatonin use reduced the risk of testing positive for Covid-19! https://pubmed.ncbi.nlm.nih.gov/32533957/?from_term=melatonin&from_sort=date&from_size=20&from_pos=2 What will it take for mainstream medicine to start considering something that will actually work instead of the repurposed drugs that result in not much of anything good? Art


Posted by Art (California) on 06/12/2020 634 posts
5 out of 5 stars

Apparently, the Doctors Hospital in Manila, Philippines has gotten funding to do a clinical trial of high dose melatonin (HDM) in 350 patients with "Covid-19 and pneumonia or other Covid-19 related high risk features" based on their experience of successfully treating their Covid-19 patients with HDM. They still have not publicly released their Covid-19 patient data that they said they were going to publish in a scientific journal, but they did manage to get funding for this study based on their initial experience with HDM and the study is being funded by their Department of Science and Technology (DOST). They also mentioned that melatonin is being used in other countries for Covid-19. They further stated that the trial will last at least 4 months which suggest that the results will be available near halloween. https://news.abs-cbn.com/news/06/12/20/dost-allots-p98-million-for-melatonin-clinical-trials-to-treat-covid-19 Art


Posted by Art (California) on 06/02/2020 634 posts
5 out of 5 stars

Why melatonin for Covid-19? Melatonin also protects endothelial cells as well as red blood cells being damaged by excess oxidative stress as seen in Covid-19 which can lead to blood clots, while also being the most potent antioxidant in the body ( more powerful than glutathione) that helps to neutralize the significantly elevated levels of ROS that is seen in patients that damages endothelial cells, a potent antiinflammatory agent, an upregulator of the gene expression of the bodies own potent antioxidants, catalase, superoxide dismutase and glutathione peroxidase. Melatonin also scavenges reactive oxygen species/hydroxyl radicals, reactive nitrogen species and peroxynitrite. Melatonin is also protective of all major organs in the body that the virus has shown itself to damage. Melatonin is an excellent protector of the lungs which is very important in Covid-19 to help protect against the cytokine storm. Melatonin acts as an anticoagulant which is very useful in Covid-19 as it has shown itself to cause blood clots. Melatonin also lowers the inflammatory cytokine IL-6, chemokine IL-8, IL-17, inflammatory mediator TNF-alpha, NF Kappa b and IL-1b which are all elevated in Covid-19. There is much more that melatonin does to fight Covid-19, such that if one was trying to create a good drug to fight the effects of the virus, melatonin could possibly be it. Art


Posted by Art (California) on 05/28/2020 634 posts
5 out of 5 stars

Apparently the combination of melatonin and vitamin D may have synergy against Covid-19 health issues according to the following new study. Is anybody surprised? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227533/ I am glad that they released this study, because it is already known that high dose vitamin D lowers native melatonin levels in humans, so having more of both will nullify this issue and likely speed the healing process. I wonder what they will find if they add vitamin C? You just know that this combination is likely to be more effective than any of the drugs which they are continuing to test despite dismal results in Covid-19. EC has the answers and governments and their scientists continue to look in all the wrong places! Art

Replied by Steve East
EC's Facebook
05/31/2020

But melatonin is related to the body's sleep modes ...how can that stop a virus? The body has its OWN inbuilt protocols for resisting infection and disease ... you can't ameliorate an infection using stuff that doesn't deal directly with that infection where it matters ... in the cells! In the case of virus, it's Zinc that prevents viral replication and it's Quercetin that puts it there! Now its taken that if you have LOW levels of vitamin D .... then you are a sitting duck ... and the majority of the vulnerable have that due to inability to get out in the sun coupled to a surfeit of toxic drugs courtesy of doctors making profits! HIGH Vitamin D is protective meaning that its renders infection much harder to gain a foothold ... it is NOT however a treatment once you have that virus ... that needs ultra high levels of Vitamin C ... known as LVC coupled to Zinc supplemented ... Zinc Picolinate is the best absorbed!

Art
California
05/31/2020
634 posts
5 out of 5 stars

Hi, Steve, Yes, melatonin does affect sleep, but it does way more than that! Melatonin does not stop the virus, but it reduces the the innate immune response which is what can trigger the potentially deadly cytokine storm and inhibits the potential for pneumonia and thus eliminates the need for a ventilator, three important actions associated with death in Covid-19. Melatonin also is protective of all major organs of the body which in autopsies have all been shown to have been attacked by the virus, including the brain, liver,kidneys, pancreas, spleen, eyes, skin, lungs and heart. Dr. Neel is able to turn his patients around in just 24 hours after starting them on HDM! By not attacking the virus directly, the body can then use its adaptive immune response to create antibodies that will fight the virus as the body is supposed to do. Kill the virus too fast and the body may not be able to generate enough antibodies before the virus is eradicated and this is important in case the virus comes back each year as other Coronaviruses have and scientists are indicating is very possible. By having adequate antibodies in your system, the body should be able to eradicate the virus on its own next time around. In hydroxychloroquine studies that used zinc and azithromycin, the zinc has not shown effectiveness even though hydroxy is supposed to act as an ionophore to help the zinc to have better cell access. Yes, people still died with this combination! Art

Karen S.
US
07/10/2020

Does taking the high dose melatonin cause drowsiness since its a sleep aide. I want to start taking it but am not sick at this time for prevention off Covid???? I have been exposed and want to be proactive and start on regimen before I do become ill.

Art
California
07/11/2020
634 posts

Karen S.,

Dr. Neel has never mentioned a preventative dose because melatonin is not likely to prevent Covid-19, only lessen the symptoms and help the body fight the virus off on its own without the deadly complications often seen in Covid-19 patients. Dr. Neel has only given melatonin to patients who have shown symptoms and tested positive for Covid-19 and these patients have turned their symptoms around in one day after starting HDM.

Many people have reported next morning drowsiness with melatonin, myself included. I don't necessarily consider that a negative for someone with Covid-19 as rest is likely good for someone with Covid-19 to help maintain a more effective immune system. Dr. Neel is currently recommending 1 milligram of melatonin for every kilogram that the patient weighs. So if a patient weighs 80 kilograms, then they would take 80 milligrams of melatonin.

That is the advice he is giving to other doctors who are wanting to use melatonin on their Covid-19 patients.

Art

Replied by Anon
Anon
07/11/2020

Someone posted that melatonin does cause next day drowsyness at first, but after you take it for a while it does not.

Replied by Gertjr
Madison
07/12/2020

You can always do the usual anti-virus things--vit C and D, lysine, chicken soup, healthy diet, plenty of water, sleep, fresh air and sunshine. Melatonin surely can't hurt and may help. Whenever I am exposed to anything, even stress, I try to fall back on the tried and true remedies.


Posted by Art (California) on 05/22/2020 634 posts
5 out of 5 stars

Here is the latest from Dr. Neel who now has at least 20 covid-19 patients and all are doing well on his high dose melatonin/vitamin C protocol. He now has patients calling him from across the country, including New York who he is advising on his protocol! This latest update is very hopeful and continues to show quick improvement in his patients and I would say it is one of his best updates yet! https://devinenews.com/dr-neel-sees-amazing-results-in-covid-19-patients-by-boosting-amount-of-melatonin/ Art

Replied by Meg
USofA
05/22/2020

Thank you Art. I found this quote from the devinenews article you posted very helpful: “As a Ph.D. student I was taught that a virus actively kills our cells during the course of the infection…..But now I know a virus is more like a provoking bully, a bully who continues to provoke cells in our lungs and our respiratory tract to commit suicide……We analyzed the molecular mechanism, how the virus does it, and matched it with scientific databases. Then, came to conclusion that melatonin can block the process that promotes suicide in lung cells,” Shneider said. Source: https://devinenews.com/dr-neel-sees-amazing-results-in-covid-19-patients-by-boosting-amount-of-melatonin/

Art
California
05/22/2020
634 posts

Meg, I agree and found that an interesting statement that goes against what many people think when it comes to viruses! I think that kind of thinking is helpful to looking at Covid-19 in a different light in order to come up with a better answer like melatonin. The current methods being deployed to fight SARS CoV-2 are proving to be only marginally effective at best, yet these methods continue to be the standard of care as people continue to die from Covid-19. Unfortunately the powers that be continue to ignore melatonin which according to Dr. Neel is easily more effective than any of the drugs currently being tested based on his experience with his Covid-19 patients. Art


Posted by Art (California) on 05/18/2020 634 posts

It has become well established that Diabetes is a significant risk factor when it comes to Covid-19 so it is good to know that melatonin can reduce many of the factors that are elevated in diabetes such as CRP, A1c, IL-6, Serum Ferritin, chemokine IL-8, ESR, Fibrinogen, oxidative stress, inflammation and Serum Ferritin. https://www.ncbi.nlm.nih.gov/pubmed/32416321 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140344/ Art


Posted by Art (California) on 05/17/2020 634 posts

One problem that seems to come with a cytokine storm and pneumonia, assuming you survive both, is significant damage to the lungs in terms of fibrosis and scarring as outlined in the article link below. Although not talked about a tremendous amount, this can become a long term problem well beyond when you are cleared of the virus. In some cases, possibly for the rest of your life if the damage turns into scarring. https://www.sciencenews.org/article/coronavirus-covid-19-some-patients-may-suffer-lasting-lung-damage So far, Dr. Neel and the doctor in Florida have not mentioned this problem in their patients who they have given high dose melatonin (HDM) to! In fact, so far, they have not seen many of the complications that other doctors who are treating Covid-19 patients have reported. What Dr. Neel is seeing in his HDM treated Covid-19 patients is rapid recovery with no apparent complications. This bodes well for the potential to entirely avoid these long term lung complications associated with Covid-19. No cytokine storm, no pneumonia, no lung complications, no ventilator are so far what Dr. Neel has reported in his patients! Just one more reason to consider HDM with your doctor's guidance should the need arise! Art


Posted by Art (California) on 05/17/2020 634 posts

Since I tend to look at melatonin plus vitamin C as a potential way to open up the economy in a somewhat safer way, I thought that the following videos, although not related to melatonin, might also add to the safety of "reopening". My apologies if it is old news here on EC. https://www.youtube.com/watch?v=wfc6QdBiRK8 https://www.youtube.com/watch?v=rhfh5XBzyFA Given that the current Covid-19 tests are notoriously inaccurate, this seems like it is likely to be more accurate with instantaneous results! Art


Posted by Art (California) on 05/14/2020 634 posts

Dr. Neel is now at 17 patients as of 5/13/2020 and reports that all are doing well using his melatonin protocol with vitamin C! Another doctor in Florida has reported similar results in her two Covid-19 patients! https://devinenews.com/dr-neel-continues-treating-covid-19-patients-all-across-the-country/ Sadly, the only scheduled trial for melatonin is only going to be using 2 mg / day of melatonin. I don't understand why they even bother at that dose! Art

Replied by Annette Garcia
United States
06/17/2020

Art, I really don't understand the high dosages listed above! I bought 10 mg melatonin because that was the highest I could find in my store. My husband and I took it for about a week but it is just too much. Feel groggy and sleepy the next day well past noon. I wouldn't be able to function if it was a higher dose! How is this possible?

mmsg
somewhere, europe
06/18/2020

Annette, the way I understand it is: if you are ill, higher dosing is appropriate. If not, and you are just taking it for prevention, why would you need high dosing? Personally, I always prefer the lowest dose of anything I try until a need for higher dosing shows up.

Art
California
06/17/2020
634 posts

This is a common issue that people experience, but for most, the "melatonin hangover" gradually goes away after a couple of weeks. What I have tried that has helped is taking the dose earlier in the evening. So if I feel groggy for about two hours after getting up in the morning, I might try taking my dose a couple of hours earlier. Failing that, you can consider just taking it if you get Covid-19. The extra rest may be helpful at that time and Dr. Neel has had very good success treating his patients who were already infected. I have experimented at multiple dosing levels up to 180 mg per night recently and I find the melatonin hangover goes away much sooner and now I seem to tolerate most dosing well. The highest dose I have heard of in a human study was 1,000 mg for thirty days, but I'm not sure why you would ever need such a high dose. I believe animal studies have gone higher and according to Dr. Reiter, he has never had an animal die at any dose. Art


Posted by Art (California) on 05/14/2020 634 posts

Dr. Neel is currently at 14 patients and according to him, all are doing very well. This is a far cry from what the reports are saying about the drugs that are currently being tested for Covid-19. With any of those drugs, people still die! It just seems odd that they will not even consider testing melatonin when they already know that none of the current drugs being tested are showing as good results or even just fair results. Melatonin, from hundreds of previous studies has already shown that its multiple methods of action are very likely to have a very significant impact against Covid-19, but the direction seems to remain testing drugs that are not doing much of anything against this virus. In the meantime, people continue to die. Melatonin has a better safety profile than any of the drugs being tested. Melatonin is available over the counter here in the US and production can be ramped up quickly if it proves to work because there are multiple manufacturers already making it. Here is an incomplete list of everything that they currently know Covid-19 can do to humans: 1. Heart attacks 2. Strokes 3. Neuronal damage 4. Liver damage 5. Kidney damage 6. Damage to the spleen 7. Skin damage 8. Heart damage 9. Lung damage 10. Pneumonia 11. Loss of taste and smell 12. Kawasaki or Kawasaki like disease 13. Seizures 14. Death 15. Damage to the eyes 16. Blood clots 17. Damage to the endothelium 18. Oxygen deprivation 19. Fibrosis 20. Damage to the brain 21. Cytokine storm 22. Covid-19 toes 23. Tissue damage throughout the body 24. Organ failure 25. Fever and oxidative stress Just about any of the above items would require significant treatment, but with Covid-19, you are almost guaranteed to get at least 5 of these symptoms, which means that it is like your body is fighting multiple diseases all at one time! Melatonin is known through studies to ameliorate symptoms related to this whole list. Furthermore, it is one of the most potent antioxidants in the human body and it upregulates gene expression of the most potent antioxidants of the body and has potent antiinflammatory qualities which are thought to potentially prevent the potential for a cytokine storm. Having this many things going on in the body at one time will certainly deplete the natural antioxidant defense system which means the elevated levels of ROS is going to be causing cellular damage throughout the body and melatonin will definitely bring that elevated ROS level down. Given the above, it seems like melatonin would be high on the list for potential drug candidates to treat and test against Covid-19, but such is not the case. I wonder why that is? Art

Replied by Bill
Philippines
05/15/2020

Hi Art... Concerning your question about why melatonin has not been already recognized as a successful treatment for COVID-19, it really depends on how much you trust the American drugs companies and the US medical system. For some while now, I've realized that the FDA, in cahoots with the power of the drugs companies, have insured that they are indeed the Lords of Medicine in every sense. To this end, the FDA has already ensured that all research must adhere to their own broken and perverted version of "the scientific method". In effect, this means that the FDA owns ALL the medical laws in America and in the West. These biased laws are, for the most part, mainly used to banish any competing opposition i.e. natural herbal therapies and nutraceuticals. For instance, did you know that melatonin has been ordained by the FDA -- and backed by a Federal Law -- to be a food and not a drug? And according to that law, a substance defined by the FDA as a food can never be used in modern medicine as a drug. Did you know that? That's according to the medical laws already on the statute books in America (and in other Western countries). And that's also why the FDA will never allow food or nutraceutical substances like Melatonin or BHT to see daylight in any US hospital.

Art
California
05/15/2020
634 posts
5 out of 5 stars

Wow, Bill! I was not aware of that point about the FDA! I was aware that the large pharmaceutical companies do what they can to eliminate any competition, even in a pandemic! It is a sad state of affairs for the citizens though, because they are the ones who get hurt in the end. I am glad that there are doctors like Dr. Neel who are willing to buck the system and use something like melatonin rather than push the current list of drugs for C-19 which seem mostly just marginally effective if at all and people still die, so that to me is not my idea of effective! We are fortunate that we have EC to share these ideas that we will likely never hear from our doctors! Thank you for EC, Deirdre and thank you for the information, Bill! Art

Art
California
05/16/2020
634 posts

Hi, Bill, Okay, but can you tell me what you really feel!!! I agree 100% with what you said, sadly. Here, it seems to always come down to money and or politics. I was hoping that the pandemic might change things, at least for a moment,but that is obviously not the case, but I certainly don't see a problem with asking other governments who seem to have a handle on Covid-19, what they are doing to make that happen, but that doesn't seem to be happening either. I think of the combination of melatonin and vitamin C (M+C) as a possible way to move forward in a safer manner as the government begins to reopen the economy because opening is assuredly going to cause an increase in new cases and deaths. Yes, more people will get sick at a faster rate with the reopening, but M+C shows the potential to lower that death rate significantly if Dr. Neels success with his C-19 patients is any indicator. Thank you for the comments and information! Art

Bill
Philippines
05/16/2020

Hi Art...I confess that I too am somewhat shocked by the hapless anti-COVID-19 strategies that mostly the western countries are using against COVID-19. These strategies are not working by any stretch of the imagination are they? And when you start sending people back to work when both the infection rate and the death rate are still high then how sensible is that? The governments are saying that they need everyone back at work and the FDA are saying "No, no -- more people will die". Well, they are both right in a way because it's like being stuck between a rock and a hard place. Because if people don't go back to work the national economy will die a horrible death and people will continue to die anyway and if people do go back to work then even more people will likely die. So what should we do? The answer is obvious. All the American and European government leaders should look around at other world nations that have used successful treatment therapies against COVID-19. Oh look, China has got it's death rate down to zero.....How did they do that? Maybe we should talk to them in a friendly way and see if they can help us out? Is America or Europe talking in a friendly way to China to see how they achieved a death rate of zero with a population of 1.3 billion? Not a cat in hell's chance. All the western leaders are all still plying their stupid political agendas, propaganda and misinformation for other lowly political reasons while their people -- their own citizens -- continue to die in high numbers in there own countries. This is particularly true for both the US and UK. And this is exactly what the drugs companies want. They want confusion and fear, because when their fast-tracked COVID-19 vaccines eventually become available in 18 months or so then every western country will be clamoring for a vaccine -- ANY vaccine. That is the really scary part. As far as I can see, there has been no significant research at all on the mutation rate of COVID-19. This is very important because if the mutation rate is too high then the vaccines will not work well. Why do I say this? In 2014, the US CDC actually apologized publicly for the fact for the previous years flu vaccine failed so badly. I mean heck, if our eminent vaccine companies can't even get the simple flu vaccine right then what chance those same vaccine companies getting a much more complex COVID-19 vaccine right? And what about the likely and obvious dangers of rushing through a COVID-19 vaccine in a tenth the time it would normally take to make a regular vaccine? All bad. I've also just read some interesting articles about how Iran who, without the help of any western drugs (because of the US embargo), has managed to quickly flatten her COVID-19 infection rate and rapidly reduce her own COVID-19 death rate. I think China helped Iran initially and now Iran is successfully running with the ball and is currently helping infected people from other countries in her own region because she now appears to have a successful therapeutic treatment for COVID-19. So if our western leaders want you to go back to work and get their economies up to speed again -- without a climbing COVID-19 death rate then, without any doubt, they will need to find a successful therapeutic COVID-19 treatment to achieve that. And what about hydroxychloroquine and remdesevir? I think Melatonin, at 20mg taken 4 times a day with 1000mgs vitamin C, would be far more effective than using both those failed drugs. Melatonin also has a high safety profile. That's my honest opinion from looking at the research.


Posted by Trina Peterson (United States) on 05/13/2020
5 out of 5 stars

Cautionary about melatonin… maybe. Just a funny story about my parent's recent experience after I sent my mom this link and some melatonin, just in case they got sick. My dad was gardening with my brother-in-law for a couple of days, and he seemed really out of it. They had a pow-wow to talk about what was going on with my dad. He was super dingy and lethargic, started to be grumpy and kinda goofy, hoarse sleepy voice. It was a marked change; he is a very active grandfather and sharp-minded. He nodded out while having a fourth cup of coffee. Mike says, "Steve, what's wrong with you, are you smoking a lot of pot or taking pain meds?"… Dad says, "no, just the herbs and my anti-rejection meds, Melody (my mom) was giving me!" Mikes ask what it was. "Melatonin." My mom says. "20mg 4 x a day." He's like, "What! 5mg, and I pass out." It turns out my mom skimmed reading the article and didn't realize it wasn't a preventative; it was only to be taken if he was to get sick. We now have a new story about how Grandma was dosing Grandpa. They are adorable and well. I hope we all make it through this new life. Good luck, and thanks for all the info!

Replied by Art
California
05/13/2020
634 posts

Trina, I'm glad you posted about your mom and dad's experience. This is why I say to include your doctor in a decision to use melatonin for this purpose and to also make sure it will be compatible with any medications that you may be taking. Dr Neel has not yet mentioned a dose to take before actually being sick, only after symptoms appear and you test positive. Some people are more sensitive than others to melatonin. Another point that your mom may have missed is that the actual dose range that Dr. Neel is using is between 50~100 mg / day depending on the size of the person and the severity of symptoms. Well, it sounds like if your dad ever has to use it, he will be getting plenty of rest! Art



NEXT