Thank you Art for sharing this article and study so informative. Blessings to you and all who work so hard to share this news.
You're welcome, Dianne!
As much as I have written about melatonin, I am still amazed at all of the benefits that humans, animals, plants and other life forms on the planet get from melatonin and the research is nowhere near complete on those benefits. Just its cancer fighting benefits alone are great and there are literally hundreds of scientific studies that prove it, yet oncologists almost never recommend melatonin to their patients even though it has synergy with both chemo and radiotherapy, while reducing the side effects associated with both treatments and being a potent cancer fighter and preventative itself.
So having a way for people who do not tolerate melatonin supplements to be able to increase their melatonin levels naturally can be very healthful for them.
Wow, very well done! Very informative. Thank you.
When I was dx with cancer I wanted onc's opinion on vitC IV's, melatonin and vitD. He got so uptight and said do not take anything but the chemo. I knew that was crazy.
For melatonin I didn't know alot at the time but read it might have anti-cancer properties/synergize chemo. Then heard a chemo nurse talking about how they needed to stop at wal mart to get some. I asked her why she was taking it thinking she would say "for sleep." Instead she told me they all take it for the anti-cancer benefit.
I hope alot more will find this site and make their own informed health decisions based on research and personal experiences found here.
Just appreciate your comments re: melatonin. I have stage 5 pd ( since omicron bti)--had achieved a strong stage 2 from dx 4 thru mostly plant therapies, TCM Acupuncture, appropriate
Diet, detox regularly with calcium bentonite clay--& had read of melatonin vs covid-19--
Which led me to several journals re: melatonin & parkinson's disease--WOW! Even biogenetic, which is what is needed for pt w/pd & bti Omicron (india has an omicron specific test).
BUT--you don't speak of precursors: is 5-HTP Enuff? 100 mg is sufficient to metab? mg
Melatonin? Should Tryptophan precede the 5-htp? mg?
Along with melatonin for PD, high dose vitamin B1/Thiamine Hydrochloride and Citicoline have shown benefit for PD. Here is a link to a multiple study review of Citicoline for PD that shows significant benefit in multiple areas of PD :
Here is a very relevant quote from the review :
>>> ' A total of 7 studies (2 crossover, 3 randomized controlled, and 2 open prospective studies) were included. Despite the varied outcome tools, this review found that patients with PD who were taking citicoline had significant improvement in rigidity, akinesia, tremor, handwriting, and speech. Citicoline allowed effective reduction of levodopa by up to 50%. Significant improvement in cognitive status evaluation was also noted with citicoline adjunctive therapy. ' <<<
These are three common supplements that have shown benefit in PD.
Here are two studies using melatonin to good effect in people with PD :
Melatonin Used In Parkinson's Disease Study
Here is a relevant quote from the study :
>>> ' Overall, melatonin supplementation for 12 weeks to patients with PD had favorable effects on the UPDRS part I score, PSQI, BDI, BAI, hs-CRP, TAC, GSH, insulin levels, HOMA-IR, total-, LDL-cholesterol, and gene expression of TNF-α, PPAR-γ and LDLR, but did not affect other metabolic profiles. ' <<<
Melatonin Returns Oxidative Stress Levels to Healthy Control Levels
Here is a relevant quote from the study of melatonin in people with Parkinson's Disease :
>>> ' At the end of the trial, in patients who received melatonin, we detected a significant diminution of lipoperoxides, nitric oxide metabolites, and carbonyl groups in plasma samples from PD patients compared with the placebo group. Conversely, catalase activity was increased significantly in comparison with the placebo group. Compared with the placebo group, the melatonin group showed significant increases of mitochondrial complex 1 activity and respiratory control ratio. The fluidity of the membranes was similar in the melatonin group and the placebo group at baseline and after three months of treatment. In conclusion, melatonin administration was effective in reducing the levels of oxidative stress markers and restoring the rate of complex I activity and respiratory control ratio without modifying membrane fluidity. This suggests that melatonin could play a role in the treatment of PD. ' <<<
I was reading a 2021 study discussing the use of melatonin in cancer and came upon another 4 ways to significantly increase melatonin levels without actually taking a melatonin supplement itself.
Here is a link to the study :
Here is a relevant quote from the study that explains 3 more ways to get significantly increased melatonin levels without taking a melatonin supplement :
>>> ' Volunteers were given juice extracted from 1 kg of orange or pineapple or two whole bananas, containing 302, 150, and 8.9 ng phytomelatonin, respectively. The study demonstrated that the serum melatonin concentration was significantly increased after 120 min of fruit consumption. For pineapple (146 versus 48 pg/mL p = 0.002), orange (151 versus 40 pg/mL, p = 0.005), and banana (140 versus 32 pg/mL, p = 0.008), and this definitely proves that fruits are a good source of phytomelatonin. Besides, the antioxidant capacity in the serum also markedly increased, suggested by the significant increases in two indicators; ferric reducing antioxidant power assay and oxygen radical antioxidant capacity . Likewise, a study conducted with young, middle-aged, and elderly participants showed that the ingestion of 200 mL of grape juice twice a day increased urinary 6-sulfatoxymelatonin, a major metabolite of melatonin commonly used as a biomarker, and total antioxidant capacity in the all three groups of individuals [36 ' <<<
So now we know that fresh orange and pineapple juice as well as bananas or grape juice can significantly increase melatonin levels in humans. In the case of fresh orange juice, a greater than 3x increase in the melatonin level was seen. So in total, we now have 5 ways to very significantly increase melatonin levels without the side effects reported for melatonin supplements! I'll drink to that....orange juice, that is!