Thank you Art for sharing this article and study so informative. Blessings to you and all who work so hard to share this news.
You're welcome, Dianne!
As much as I have written about melatonin, I am still amazed at all of the benefits that humans, animals, plants and other life forms on the planet get from melatonin and the research is nowhere near complete on those benefits. Just its cancer fighting benefits alone are great and there are literally hundreds of scientific studies that prove it, yet oncologists almost never recommend melatonin to their patients even though it has synergy with both chemo and radiotherapy, while reducing the side effects associated with both treatments and being a potent cancer fighter and preventative itself.
So having a way for people who do not tolerate melatonin supplements to be able to increase their melatonin levels naturally can be very healthful for them.
Along with melatonin for PD, high dose vitamin B1/Thiamine Hydrochloride and Citicoline have shown benefit for PD. Here is a link to a multiple study review of Citicoline for PD that shows significant benefit in multiple areas of PD :
Here is a very relevant quote from the review :
>>> ' A total of 7 studies (2 crossover, 3 randomized controlled, and 2 open prospective studies) were included. Despite the varied outcome tools, this review found that patients with PD who were taking citicoline had significant improvement in rigidity, akinesia, tremor, handwriting, and speech. Citicoline allowed effective reduction of levodopa by up to 50%. Significant improvement in cognitive status evaluation was also noted with citicoline adjunctive therapy. ' <<<
These are three common supplements that have shown benefit in PD.
Here are two studies using melatonin to good effect in people with PD :
Here is a relevant quote from the study :
>>> ' Overall, melatonin supplementation for 12 weeks to patients with PD had favorable effects on the UPDRS part I score, PSQI, BDI, BAI, hs-CRP, TAC, GSH, insulin levels, HOMA-IR, total-, LDL-cholesterol, and gene expression of TNF-α, PPAR-γ and LDLR, but did not affect other metabolic profiles. ' <<<
Here is a relevant quote from the study of melatonin in people with Parkinson's Disease :
>>> ' At the end of the trial, in patients who received melatonin, we detected a significant diminution of lipoperoxides, nitric oxide metabolites, and carbonyl groups in plasma samples from PD patients compared with the placebo group. Conversely, catalase activity was increased significantly in comparison with the placebo group. Compared with the placebo group, the melatonin group showed significant increases of mitochondrial complex 1 activity and respiratory control ratio. The fluidity of the membranes was similar in the melatonin group and the placebo group at baseline and after three months of treatment. In conclusion, melatonin administration was effective in reducing the levels of oxidative stress markers and restoring the rate of complex I activity and respiratory control ratio without modifying membrane fluidity. This suggests that melatonin could play a role in the treatment of PD. ' <<<
Just appreciate your comments re: melatonin. I have stage 5 pd ( since omicron bti)--had achieved a strong stage 2 from dx 4 thru mostly plant therapies, TCM Acupuncture, appropriate
Diet, detox regularly with calcium bentonite clay--& had read of melatonin vs covid-19--
Which led me to several journals re: melatonin & parkinson's disease--WOW! Even biogenetic, which is what is needed for pt w/pd & bti Omicron (india has an omicron specific test).
BUT--you don't speak of precursors: is 5-HTP Enuff? 100 mg is sufficient to metab? mg
Melatonin? Should Tryptophan precede the 5-htp? mg?