Cardiovascular Disease (CVD) and Melatonin

on Feb 26, 2021| Modified on Dec 02, 2023
Melatonin for Heart Disease

Cardiovascular Disease, or CVD, is a common and growing health issue. It is estimated that nearly half of Americans have some form of heart disease, according to this brief article link:

Given that information, it is clear that people should have a prevention plan to avoid ever having CVD in the first place, and hopefully, this post will help in that effort.

In my experience, the simpler and the fewer supplements required, the better the chances of following a specific health plan.

This remedy's simplicity suggests that it will be easy to stick with and will likely bring other health benefits with it.

What Is Cardiovascular Disease?

CVD is a broad term that covers multiple health issues, including heart disease, heart attack, stroke, heart failure, arrhythmia, and heart valve problems.

What Are The Risk Factors for CVD?

The following abstract link gives some insight into some of the known risk factors for CVD other than PD.

Further, it discusses how melatonin may help work against these risk factors and against CVD itself. Multiple disease states increase your chances of getting or having CVD.

In the study links below, the value of melatonin in CVD will be discussed.

Melatonin has multiple positive health effects that show the potential to alleviate some of the health issues associated with CVD. Melatonin is itself a potent scavenger of reactive oxygen species (ROS), reactive nitrogen species (RNS), peroxynitrite (ONOO-), and H2o2 which, in excess, can all cause damage to normal cells throughout the body and the vasculature.

Melatonin is also a potent antiinflammatory. It also upregulates the body's potent antioxidant system while activating the Nrf2 pathway, increasing the body's total antioxidant capacity (TAC).

Melatonin can neutralize up to 10 oxygen radicals, while vitamin E and vitamin C can only neutralize one radical. Melatonin or its metabolites are also able to cross the blood-brain barrier (BBB) and repair a perturbed or damaged BBB. Melatonin can also enter all body tissues to get to most places that are damaged and then exert its multitude of positive health effects to effect repairs as needed—all this while having an excellent safety profile.

This study link below goes into greater detail about the many positive health effects of melatonin in the body beyond the heart and vasculature. It discusses how melatonin can act to return the body toward homeostasis via its antioxidative, antiinflammatory, metal chelating, mitochondrial protective effects, and radical scavenging effects, to name just a few.

The following study link covers the potential of melatonin in heart failure, an area of medicine that could use bolstering via melatonin's multiple actions.

The following article discusses the value of melatonin in multiple cardiovascular issues that could fall into the category of CVD, which is a broad range of the anti-health problems that melatonin seems adept at working against.

This following link to a very brief abstract clearly states that melatonin can interact directly with the heart via melatonin receptors in the heart via melatonin receptors M1 and M2 receptors to exert its protective effects directly in the heart while further offering protective effects against specific drugs known to cause heart damage.

There are many ways the heart can be damaged by other diseases or chemicals, such as diabetes. Melatonin has shown the ability to protect against some of this damage, especially mitochondrial damage throughout the body.

These subsequent two links discuss the damage that can be imparted on the heart in diabetes and how melatonin may help offset some of this damage:

The following abstract link discusses how melatonin can lower elevated heart rate and shows that melatonin reduces the development of endothelial dysfunction and atherosclerosis, which are considered a crucial pathophysiological disorder of increased heart rate pulsatile blood flow.

The following article discusses the protective effects of melatonin in myocardial infarction (heart attack).

The following two articles discuss the role of melatonin and its multiple protective mechanisms of action related to myocardial ischemia/reperfusion injury that occurs after oxygen-rich blood is restored after a blockage or partial blockage of a blood vessel to the heart.

In this next link, melatonin's potential to express anti-hypertrophic effects in cardiac hypertrophy ( left ventricular enlargement) is discussed.

The following mouse study illustrates the utility of melatonin in myocardial infarction. While it is just a mouse study, it offers insights into melatonin's specific mechanisms in increasing cardiomyocyte production and heart regeneration.


The above studies help define some of the ways that melatonin is likely to be heart-protective and CVD preventative.

Many more studies add confirmation to these multiple heart health effects of melatonin, so these are only a few of many studies. Still, the point being that melatonin continues to show its value in multiple areas of human and animal health and is worth having a melatonin discussion with your doctor about possibly implementing melatonin into your health regimen moving forward.

Since I am not a doctor, I can not recommend melatonin or dosing of melatonin for any health condition. I can say that I am still taking 106+ mg of melatonin/night for over 4 1/2 months now after previously taking it at lower dosing for years.

Dr. Neel continues to recommend 1 mg of melatonin for every kilogram of body weight for the treatment of his over 1,000 Covid-19 patients, and he is experiencing great success at that dose in his patients.

My intent in the dose I am currently taking is to afford the multiple health effects that melatonin seems to offer in many human health areas, such as those listed in the next paragraph.

In this ongoing melatonin series, we have already shown that melatonin is beneficial for stroke prevention and recovery, Covid-19, COPD / Emphysema, Parkinson's disease, Memory, and now we are showing the cardiovascular benefits of this remarkable molecule called melatonin. This melatonin series does not end here, as will be shown in future additions to this series! The following links briefly mention some of the known health benefits associated with the use of melatonin, such as cancer.

As always, it is imperative that you seek the advice of your doctor or healthcare professional before starting or testing melatonin to make sure it is safe for you at the dose you want to take and that it is not contraindicated with any of your current medications, supplements, vitamins, and other alternatives. I am just showing studies that help to clarify all of the potential benefits that melatonin offers.

About The Author

Art Solbrig is a researcher who has been reading scientific studies and testing natural remedies for over 30 years searching for useful studies and alternatives that apply positively to human health issues and natural treatments using minerals, vitamins, amino acids, essential oils, herbs, homeopathy, colloidal silver, combination treatments and other alternatives to improve the quality of life of others by writing about his findings and test results in places like Earth Clinic. He documents and writes about many of his experiences in helping others. Art is a native of sunny California.

Related Links:

Effective Natural Remedies for Heart Attack Recovery
Melatonin Cures
Top Natural Treatments for Heart Disease (Cardiovascular Disease)

High Dose Melatonin

Posted by Baldev (Mumbai Maharashtra India) on 04/27/2022 185 posts

Hi Art,

I remember in one of your posts you mentioned that you take the maximum dose of Melatonin in the night. I had recently some concern with my heart and have refused to take the doctor's protocol of alopathic medicines.

I have started on Melatonin and am comfortable with that, presently I have reached to 20Mg in the night. I tried taking during the day too but I feel zomby so I am avoiding during the day. My age is 83+yrs wt.52kg and active person exercising practically every day. Three days a week try to play nine holes of golf, and practically have a drink every evening. I want your help to make a sort of protocol of Melatonin that how much I could take in the night and if it is necessary to take during the day how much minimum I should try to take without it affecting me to drive to the club, whether alcohol does adversely effect with Melatonin. All these doubts are there in mind. Presently whatever I am doing it"s giving me a good feeling and I am happy with the situation. If any thing else I should add it will be great.

Your help will be highly appreciated

Thanks and God Bless You


Replied by Art
2220 posts


You said,

>>> ' Presently whatever I am doing it"s giving me a good feeling and I am happy with the situation. ' <<<

To me that sounds wonderful at 83 years of age! If it ain't broke, maybe you shouldn't try to fix it.


(Mumbai Maharashtra India)
185 posts

Hi Art,

No, I think I have not been able to express myself correctly. Problem is there I have a cardiac history. In 1999 I was advised to go through triple bypass surgery because my three arteries were blocked 99%, 95%and 90% and I had no symptoms but I got my angiogram done just to check because I had retired from active flying duties. I was told that my coletrals were vey well formed and so I was passing my medical exams every six months.

I have come so far, I changed life style followed Ted"s advice. Once in a while I do get in to the problem get admitted in the ICU get stabalised come back follow my regimen ( not any thing in particular) . Once I read your article on Melatonin I started taking it, then I had on 10th April while playing golf some angina type feeling in the chest, on 11th I got admitted in ICU t.hey kept me there for four days and asked me to go through the surgical procedure, which I refused and back home. This is my background and want to pursue Melatonin treatment, if you can help in that I will be grateful.

You do mention about your friends, so I want to be your friend so that I can communicate with you at the personal level and that's why I asked your number/email address.

I have a feeling, with your help I can continue healthy for more number of yrs playing golf.



2220 posts

Hi Baldev,

While the studies do confirm that melatonin is very beneficial for the heart and in warding off heart disease in general, there are no studies that suggest it can treat a very serious existing heart condition as you seem to have. You said you were admitted to the ICU for 4 days just 18 days ago! The fact that they kept you in ICU for 4 days seems to make it clear it is a serious condition.

This is well beyond the scope of seeking advice on an internet health forum. You need an experienced cardiologist to advise you on your best options and hopefully one of those options will include melatonin, but I am not a cardiologist and am not qualified to advise you how to deal with your serious heart issues. For that you need a real cardiologist with experience and training in that specialized field.

Regarding being my friend, I would tell any friend the same thing for such a serious condition. I'm sorry that I can't be of any help for you in this matter.


(Somewhere in Europe)
84 posts

Hi Baldev,

What was your diet when your arteries were blocked 99%, 95%, and 90%?

If my arteries were almost completely blocked, I would not wait. I would not postpone, or delay.

I would concentrate my attention on that issue. I would take action ASAP, even if I had very little or no symptoms.

Time is, or seems to be, of the essence. I would do something, anything, in order to unblock my arteries ASAP.

You are, or seem to be, playing with your life. No, I would not wait, delay, or postpone. This is not the time to waste time trying to experiment with Melatonin, play golf, and or do something else that is, or seems to be, unrelated.

Yes, you might need surgery. However, surgery is probably not the only option.

For starters, I would ask for an "ultrasonic carotid artery color Doppler ultrasound" - this is a harmless, non-invasive, non-carcinogenic test for the determination of the amount of plaque that can be seen in your carotid arteries.

I hope this helps.

Melatonin and Lisinopril Interaction

Posted by Joseph A. (Stockton, CA) on 02/26/2021 73 posts

I have formulas that have worked in treating Tardive Dyskinesia, things that treat Anxiety, etc., but big PHARMA makes Billions of dollars selling their products to the public, even with major side effects and even death. I will say that if you have heart disease, you most likely have hypertension, just like me, but I take lisinopril for hypertension and tried Melatonin for sleep, the reaction was “MY HEART STARTED POUNDING, AND POUNDING, MY BLOOD PRESSURE ROSE BY 90 POINTS, all because I used Melatonin, so be careful what you read about CVD and Melatonin if you're taking lisinopril. I research things that conventional medical doctors don’t, and won’t unless it’s by big PHARMA.

MD’s aren’t trained in alternative meds nor Nutrition, so when you tell them you want to use ——— for Severe Anxiety, their reply is "Don’t"!

Melatonin Dosage for CVD

1 User Review
5 star (1) 

Posted by Tina (US) on 02/26/2021

Hello Art,

Terrific article but….1 kg take 1 mg melatonin. I am 90 pounds and I would need to take 298 mg melatonin? That is nuts! I am sorry if My husband or I take over 10 we are groggy and can not wake easily in the am , and my husband weight 175.

This really makes no sense but all else is terrific. I cannot believe you can take 106 mg and over?!


Replied by Deirdre

Hi Tina,

No, your calculations are incorrect. Your dosage would be around 43 mg.

Here's our dosing calculations page.

P.S. I've done 50mg in a night a number of times, no problem.

Replied by GertJr

I take 50 mg fast dissolve melatonin and 20 mg timed release every single night and still can't sleep. Everyone is different.



Where do you find 50mg or 60 mg.? dr prescription?

The best I can find bulk is 15 mg, 400 tablets per bag on amazon.

Replied by Art
2220 posts

Hi Tina,

You give your weight as 90 lbs.

So first you need to convert your 90 lbs to kilograms.

So as you can see, 90 lbs converts to 40.8233 kilograms. So 40kg is your approximate weight, so 40 kg requires approximately 40 mg of melatonin per day to reach Dr. Neel's protocol level to fight Covid-19.

As to the next day tiredness, I had that too once I switched to high-dose melatonin, but over time that faded away. The majority of the tiredness was gone in two to three weeks, but still, a bit remained and that is all gone now as my body adjusted to the increased melatonin levels over a period of about 2 months. Now I have no daytime tiredness at all at nearly 5 months into HDM.

I can't say it will be the same for everyone and there will always be people who simply can not tolerate melatonin, but I was highly motivated to make it work so I could afford myself all of the potential health benefits that melatonin may offer. There are many more potential health benefits that melatonin can offer, well beyond the many health benefits I have written about on EC. So I am quite interested in those health benefits.

I can't speak for others, but the less I have to see doctors, the better!


Replied by niceshott7

Melatonin is available in 60 mg dosage and often used for cancer prevention and treatment with its master antioxidant properties.

Melatonin Research for CVD

2 User Reviews
5 star (2) 

Posted by Art (California) on 03/03/2021 2220 posts

The following article link below was just released today regarding melatonin and Cardiovascular Disease (CVD) which adds further confirmation to the idea that melatonin is very useful as a treatment to help prevent or treat CVD!

This article breaks it all down by each aspect of CVD and how melatonin interplays with each aspect and is very straightforward in its approach. Here is a link to the full article :

Here is a direct quote from the article that is interesting:

>>> ' Despite contradictions between the studies the majority of data claims that melatonin is a promising supplement with hardly any adverse effects. ' <<<


Replied by Art
2220 posts

To update this article on CVD and melatonin, this new study (April 2022) shows that in myocardial infarction(MC) (heart attack), even if you haven't been taking melatonin regularly, if it is given within 3 hours after the MC, it can have positive health effects over the near term and long term compared to not getting melatonin :

Here are some relevant quotes from the study :

' This pilot study demonstrated that compared to placebo, melatonin administration was associated with better outcomes in AMI patients undergoing primary percutaneous coronary intervention. '

' At 2 years of follow-up, 13 (13.8%) patients suffered the primary endpoint (3 deaths and 10 readmissions due to heart failure), 3 patients in the melatonin group and 10 in the placebo group. '

' The hypothesis-generating analysis found a relation between treatment effect and ischemia time and the authors concluded that melatonin administration within 3 h of ischemia onset reduces myocardial infarct size by approximately 40%. '

' The results of this pilot study indicate that treatment with intravenous melatonin in patients with AMI undergoing primary percutaneous coronary intervention is associated with a reduced incidence of death or readmission due to heart failure. '

This is the first study that I have seen using melatonin in people that have just had a heart attack and the results are quite impressive! The attached graph clearly shows that melatonin significantly improved longer term survival with just one dose given within 3 hours after MC. What this study doesn't show is what would have happened had the patients continued to take melatonin for the full study length of 800 days beyond the single dose given at the hospital.


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2220 posts

This new animal study (January 2023) shows that melatonin works to reduce aortic wall thickness in the tested animals fed a high fat diet :!/

Here is what the study concluded :

' The administration of HFD to Wistar rats led to pathomorphological and morphometric changes in their abdominal aorta, which constitute the main diagnostic criteria of endothelial dysfunction. Melatonin supplementation regressed vascular wall remodeling and restored its functional capacity. '

Aortic wall thickening is a common component of cardiovascular disease (CVD) and reducing that thickening and restoring capacity is a huge step in reversing CVD. So this study adds further corroboration to the value of melatonin in fighting CVD.


2220 posts

While many studies show multiple methods by which melatonin helps prevent or treat cardiovascular disease, this study link below suggests that melatonin also helps reduce vascular calcifications :

This is a quote from the study :

' Our results indicate that MT can potentially be used in the therapy of vascular calcification and ageing by targeting exosomal miR-204/miR-211. '

If you are wondering why reducing vascular calcifications (VCs) is important, according to the following article, VCs can increase your risk for heart attack, stroke, dementia, renal insufficiency and inadequate blood supply to arms and legs :


Replied by Frances
(Cabarlah, Qld.)

There are informative books, youtube videos, articles about melatonin. After research by Dr Shallenberger, Prof. Dr. R Reiter and John Lieurance, I started taking high-dose melatonin for a couple of medical conditions. I need a GP prescription and compounding chemist/pharmicist to get the melatonin. Shallenberger mentions two sources in the USA.