Cardiovascular Disease (CVD) and Melatonin

on Feb 26, 2021
High Dose Melatonin
Posted by Baldev (Mumbai Maharashtra India) on 04/27/2022 189 posts

Hi Art,

I remember in one of your posts you mentioned that you take the maximum dose of Melatonin in the night. I had recently some concern with my heart and have refused to take the doctor's protocol of alopathic medicines.

I have started on Melatonin and am comfortable with that, presently I have reached to 20Mg in the night. I tried taking during the day too but I feel zomby so I am avoiding during the day. My age is 83+yrs wt.52kg and active person exercising practically every day. Three days a week try to play nine holes of golf, and practically have a drink every evening. I want your help to make a sort of protocol of Melatonin that how much I could take in the night and if it is necessary to take during the day how much minimum I should try to take without it affecting me to drive to the club, whether alcohol does adversely effect with Melatonin. All these doubts are there in mind. Presently whatever I am doing it"s giving me a good feeling and I am happy with the situation. If any thing else I should add it will be great.

Your help will be highly appreciated

Thanks and God Bless You


Melatonin Dosage for CVD
Posted by Mike (Colorado) on 03/17/2021


Where do you find 50mg or 60 mg.? dr prescription?

The best I can find bulk is 15 mg, 400 tablets per bag on amazon.

Melatonin Research for CVD
Posted by Art (California) on 03/03/2021 1658 posts
5 out of 5 stars

The following article link below was just released today regarding melatonin and Cardiovascular Disease (CVD) which adds further confirmation to the idea that melatonin is very useful as a treatment to help prevent or treat CVD!

This article breaks it all down by each aspect of CVD and how melatonin interplays with each aspect and is very straightforward in its approach. Here is a link to the full article :

Here is a direct quote from the article that is interesting:

>>> ' Despite contradictions between the studies the majority of data claims that melatonin is a promising supplement with hardly any adverse effects. ' <<<


Melatonin Dosage for CVD
Posted by niceshott7 (Florida) on 03/01/2021
5 out of 5 stars

Melatonin is available in 60 mg dosage and often used for cancer prevention and treatment with its master antioxidant properties.

Melatonin and Lisinopril Interaction
Posted by Joseph A. (Stockton, CA) on 02/26/2021 75 posts

I have formulas that have worked in treating Tardive Dyskinesia, things that treat Anxiety, etc., but big PHARMA makes Billions of dollars selling their products to the public, even with major side effects and even death. I will say that if you have heart disease, you most likely have hypertension, just like me, but I take lisinopril for hypertension and tried Melatonin for sleep, the reaction was “MY HEART STARTED POUNDING, AND POUNDING, MY BLOOD PRESSURE ROSE BY 90 POINTS, all because I used Melatonin, so be careful what you read about CVD and Melatonin if you're taking lisinopril. I research things that conventional medical doctors don’t, and won’t unless it’s by big PHARMA.

MD’s aren’t trained in alternative meds nor Nutrition, so when you tell them you want to use ——— for Severe Anxiety, their reply is "Don’t"!

Melatonin Dosage for CVD
Posted by Art (California) on 02/26/2021 1658 posts

Hi Tina,

You give your weight as 90 lbs.

So first you need to convert your 90 lbs to kilograms.

So as you can see, 90 lbs converts to 40.8233 kilograms. So 40kg is your approximate weight, so 40 kg requires approximately 40 mg of melatonin per day to reach Dr. Neel's protocol level to fight Covid-19.

As to the next day tiredness, I had that too once I switched to high-dose melatonin, but over time that faded away. The majority of the tiredness was gone in two to three weeks, but still, a bit remained and that is all gone now as my body adjusted to the increased melatonin levels over a period of about 2 months. Now I have no daytime tiredness at all at nearly 5 months into HDM.

I can't say it will be the same for everyone and there will always be people who simply can not tolerate melatonin, but I was highly motivated to make it work so I could afford myself all of the potential health benefits that melatonin may offer. There are many more potential health benefits that melatonin can offer, well beyond the many health benefits I have written about on EC. So I am quite interested in those health benefits.

I can't speak for others, but the less I have to see doctors, the better!


Melatonin Dosage for CVD
Posted by GertJr (Madison ) on 02/26/2021

I take 50 mg fast dissolve melatonin and 20 mg timed release every single night and still can't sleep. Everyone is different.

Melatonin Dosage for CVD
Posted by Deirdre (CT) on 02/26/2021

Hi Tina,

No, your calculations are incorrect. Your dosage would be around 43 mg.

Here's our dosing calculations page.

P.S. I've done 50mg in a night a number of times, no problem.

Melatonin Dosage for CVD
Posted by Tina (US) on 02/26/2021

Hello Art,

Terrific article but….1 kg take 1 mg melatonin. I am 90 pounds and I would need to take 298 mg melatonin? That is nuts! I am sorry if My husband or I take over 10 we are groggy and can not wake easily in the am , and my husband weight 175.

This really makes no sense but all else is terrific. I cannot believe you can take 106 mg and over?!