Osteoporosis and Melatonin

on Mar 17, 2021| Modified on Sep 07, 2023
Melatonin for Osteoporosis

Osteoporosis and Melatonin: The Melatonin Series Continues

In this ongoing Melatonin Series on Earth Clinic, this next discussion is about osteoporosis.

Many supplements are purported to help osteoporosis, but one not currently listed on EC is melatonin. There are many studies regarding melatonin as it relates to osteoporosis so let's get started.

I'm not saying that melatonin is a replacement for these other supplements when it comes to osteoporosis, but it should definitely be a part of the armamentarium in the fight against this disease and is just one more important reason to consider melatonin as an overall health promoter against many diseases and health conditions.

What Is Osteoporosis?

Osteoporosis is a bone disease that occurs when the body loses too much bone, makes too little bone, or both. As a result, bones become weak and may break from a fall or, in serious cases, from sneezing or minor bumps. (1)

What Are The Risk Factors And Who Is At Risk?

Women are at higher risk than men, and here are some of the risk factors. Often, a fracture or a broken bone is the first sign of osteoporosis before any of the following risk factors are present:

* Estrogen deficiency from early menopause (before age 45, either natural or surgical) or no period for a long time (six months to a year)
* Personal history of fracture (broken bone) as an adult
* Family history of osteoporosis or bone fracture
* Small thin frame and/or low body weight
* Low intake of calcium (avoidance of dairy products)
* Low levels of vitamin D
* Immobilization or lack of exercise
* Cigarette smoking
* Excessive alcohol intake
* High caffeine intake
* Other medical problems that contribute to bone loss, including thyroid and parathyroid conditions, digestive issues, eating disorders, kidney disease, rheumatoid arthritis, asthma, cancer, and paralysis
* Use of certain medications that weaken bones, such as steroids, overuse of thyroid hormone, blood thinners, anticonvulsants, and diuretics. While osteoporosis can occur in anyone, it is more common in Caucasian and Asian women.

How Do Doctors Treat Osteoporosis?

Doctors have multiple drugs at their disposal to treat osteoporosis. Drugs such as the following Bisphosphonates:

  • Alendronate (Fosamax), a weekly pill
  • Risedronate (Actonel), a weekly or monthly pill
  • Ibandronate (Boniva), a monthly pill or quarterly intravenous (IV) infusion
  • Zoledronic acid (Reclast), an annual IV infusion

There is also:

  • Denosumab : Proloia / Xgeva
  • Romosozumab: One of the newest drugs for osteoporosis
  • Abaloparatide
  • Teriparatide


There are others, but these would be considered to be the leading group. The Bisphosphonates have some significant side effect issues as mentioned here:


Melatonin for Treatment of Osteoporosis

Previously we have discussed the use of melatonin for stroke prevention and treatment, Covid-19, Parkinson's Disease, the group of diseases that fall into the Cardiovascular Disease group, COPD and Memory.

As the title suggests, melatonin has shown benefit in fighting osteoporosis and is worth considering as part of a plan to combat osteoporosis. I won't rehash all of the benefits of melatonin that I have already mentioned in this Melatonin Series as they are many, but rather concentrate on showing studies that illustrate how melatonin can help people with osteoporosis.

In the following abstract, melatonin is shown to operate like most of the available prescription meds by inhibiting bone loss, but melatonin goes a step further and helps in new bone formation.


In the following mouse model of osteoporosis generated by giving the mice retinoic acid, melatonin was shown to prevent bone destruction while promoting bone formation.


In this following abstract, the title pretty much says it all, "Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome". This also happens to be one way that melatonin fights Covid-19.


In the following abstract, melatonin's ability to restore impaired osteogenic potential caused by osteoporosis is discussed.


Since diabetes is considered a potential risk factor for osteoporosis, the following study discusses how melatonin may stave off osteoporosis. The following study discusses how melatonin activates the Nrf2/HO1 pathway to help fight Diabetic osteoporosis. It also goes on to show that melatonin significantly reduces ferroptosis caused by high glucose levels:


The following study discusses how melatonin may be useful for preventing bone loss during space flight.


The following study comes to this conclusion regarding Melatonin and Osteoporosis:
>>> ' The osteoblast-inducing, bone-enhancing effects of melatonin and improvement in the quality of life suggest that melatonin is a safe and effective bone loss therapy. '<<<


It is worth reminding here that melatonin production declines with age, as noted on the following graph. This is very important when you consider all of the health conditions that studies show that melatonin is useful for. This adds credence to the whole idea of supplementing with melatonin as a preventative or treatment as we age.

This next abstract discusses how melatonin can help reduce the risk of osteoporosis in people with Multiple Sclerosis.


The following RCT is very interesting. It shows how melatonin works well with other natural supplements that are often used for Osteoporosis and Osteopenia, such as vitamin D, vitamin K-2, and strontium. Here is a quote from the study:

>>> 'These findings provide both clinical and mechanistic support for the use of MSDK for the prevention or treatment of osteopenia, osteoporosis, or other bone-related diseases. ' <<<


The following rat study is interesting because it demonstrates how melatonin has synergy with Calcium Carbonate to reduce and possibly reverse osteoporosis in these rats. Here is a quote from the study:

>>> 'Melatonin and calcium carbonate can significantly improve antioxidative ability in rats with osteoporosis, increase bone density, elevate serum calcium level and reduce bone mineral loss, thus preventing and treating osteoporosis, and the combination displays more remarkable effects.' <<<


This next abstract is important because it points out that melatonin can also have oral health benefits, as pointed out in a previous post on oral health, all why working against Osteoporosis and Osteopenia.



I could go on for pages highlighting the many Melatonin studies showing benefits for Osteoporosis and Osteopenia, but the above should be more than enough to show how helpful melatonin is for the purpose.

The above studies go into substantial detail explaining how beneficial melatonin is for the purpose and how it is synergistic with other known supplements that are often used to fight osteoporosis. When you combine this information with the previous articles in this Melatonin Series, you might start to get an inkling of why I choose to take high dose melatonin (HDM) every day at 106 mg+ per night so that I can try and avail myself of all of the health benefits that melatonin appears to offer.

As always, I can not recommend melatonin or dosing because I am not a doctor, but I can highlight these relevant studies so that others can clearly see the benefit of HDM. You should consult your doctor or healthcare professional before testing or taking melatonin for any reason to be safe.


Where to Buy Melatonin

Melatonin is an inexpensive supplement and easy to find at pharmacies, grocery stores, and local health food stores.

Here are a few links to Amazon:

NOW Supplements, Melatonin, 10 mg, 100 Veg Capsules

Natrol Fast Dissolve - 10 mg - 100 Count - $12.99

Puritan's Pride Melatonin 10 mg 120 Capsules (3-Pack)- $23.00

Got a question for Art or feedback about melatonin for Osteoporosis? Please submit it here!

About The Author

Art Solbrig is a researcher who has been reading scientific studies and testing natural remedies for over 30 years searching for useful studies and alternatives that apply positively to human health issues and natural treatments using minerals, vitamins, amino acids, essential oils, herbs, homeopathy, colloidal silver, combination treatments and other alternatives to improve the quality of life of others by writing about his findings and test results in places like Earth Clinic. He documents and writes about many of his experiences in helping others. Art is a native of sunny California.

Article Update

2 User Reviews
5 star (2) 

Posted by Art (California) on 03/05/2023 2145 posts

To further update this thread on osteoporosis, osteopenia and melatonin, this October 2022 review on postmenopausal osteoporosis and melatonin delves a little deeper into how melatonin works against osteoporosis :


Here are some very relevant quotes from the review :

' Recent studies have indicated that serum melatonin levels are closely associated with the occurrence and development of osteoporosis in postmenopausal women. Exogenous melatonin could also improve bone mass and increase skeletal strength. '

' Melatonin directly affects bone remodeling by promoting osteogenesis and suppressing osteoclastogenesis. Melatonin also regulates the biological rhythm of bone tissue, which benefits its osteogenic effect. Additionally, melatonin participates in the modulation of the bone microenvironment. Melatonin attenuates the damage induced by oxidative stress and inflammation on osteoblasts and prevents osteolysis from reactive oxygen species and inflammatory factors. '

' Based on the evidence in this review, melatonin will play a more important role in the diagnosis, prevention, and treatment of postmenopausal osteoporosis. '

' Melatonin is increasingly valued by patients and clinicians due to its antioxidant and antiaging properties. In our previous study, we determined that serum melatonin levels were obviously decreased in postmenopausal women with osteoporosis (Cao et al., 2022). '

' Melatonin is a mild osteogenic drug with few complications and has the potential and prospect of being an effective drug for the treatment of osteoporosis. '

' Therefore, serum melatonin measurements might become a new diagnostic standard for the prediction of the risk of postmenopausal osteoporosis. In fact, they could replace conventional dual energy X-rays, which would reduce economic costs and improve detection efficiency. '

' Melatonin treatment positive affected the increase in bone mineral density and the improvement in body mass index (Treister-Goltzman and Peleg, 2021). However, oral estrogen could inhibit nocturnal melatonin release in postmenopausal women (Okatani et al., 2000). '

Given the above, it is becoming very clear that melatonin is of significant value when it comes to osteoporosis and given its very good safety profile when compared to the latest class of drugs for osteoporosis, Bisphosphonates, it seems like a good choice.

Here is a list of Bisphosphonates which include Fosamax, Actonel, Boniva, Reclast and Aredia .

This link is for Fosamax side effects :


Here is a list of side effects :

Fosamax side effects

Get emergency medical help if you have signs of an allergic reaction to Fosamax: hives; wheezing, difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using Fosamax and call your doctor at once if you have:

  • chest pain, new or worsening heartburn;

  • difficulty or pain when swallowing;

  • pain or burning under the ribs or in the back;

  • severe heartburn, burning pain in your upper stomach, or coughing up blood;

  • new or unusual pain in your thigh, hip or groin;

  • jaw pain, numbness, or swelling;

  • severe joint, bone, or muscle pain; or

  • signs of low calcium levels - muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes).

Common Fosamax side effects may include:

  • heartburn, upset stomach;

  • stomach pain, nausea;

  • diarrhea, constipation; or

  • headaches; or

  • bone pain, muscle or joint pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.



Replied by Art
2145 posts

This new (May 2023) study adds further confirmation to the use of melatonin for Osteoporosis/Osteopenia : Https://pubmed.ncbi.nlm.nih.gov/37274021/

Here is a quote of what the study concluded :

' Melatonin was found to reverse the inhibitory effect of TNF-α on osteogenic differentiation and inflammation in BMSCs. Taken together, these findings indicated that melatonin may have therapeutic potential to be used for the treatment of osteoporosis. '


Melatonin Contraindications

Posted by Joseph A. (San Bruno, Ca) on 03/17/2021 73 posts

Melatonin interacts with lisinopril, which is a hypertension medicine.

Replied by Art
2145 posts

Hi Joseph,

I have a friend who is taking lisinopril and melatonin with no problems.

This article from Drugs.com. says,

No interactions were found between lisinopril and Melatonin Time Release. This does not necessarily mean no interactions exist. Always consult your healthcare provider.


Almost anyone can have a reaction to anything and that is why I said you should have your doctor or professional healthcare provider's approval and supervision if you plan to use melatonin for anything.

I do not know what you mean by: "fix what errors"?

Melatonin Dosage for Osteopenia

2 User Reviews
5 star (2) 

Posted by Luvbug (Atlanta) on 07/30/2023

Melatonin Dosage for Osteoporosis or Osteopenia

One post says they take HDM (high dose melatonin) of 106 mg+ at night but the Options to purchase melatonin below the post, only showed 10 mg capsules. I'm just confirming that 106mg+ of Melatonin is the appropriate dose and not a typo. Also any tips for finding the best melatonin would be appreciated . Thank you very much

Replied by Art
2145 posts


I wrote the article you are referring to and at the time that I wrote it, I was taking 106+ mg/day of melatonin. I was just making a statement about the dose I was taking and not recommending that others take such a high dose. I am now and have been taking 132 +mg/night of melatonin for about the past 9 months or so.

In the following study they used melatonin @ just 5 mg/day for patients with osteopenia, but they also used three other supplements with it, vitamin K2, Vitamin D and Strontium in the following doses :

' 5 mg melatonin, 450 mg strontium (citrate), 2000 IU vitamin D3 and 60μg vitamin K2, '

The study refers to this combination of supplements as MSDK.


Here are two relevant quotes from the study :

' MSDK treatment increased BMD in lumbar spine (4.3%) and left femoral neck (2.2%), with an upward trend for total left hip (p=0.069). MSDK increased serum P1NP levels and reduced bone turnover (CTx:P1NP). Psychometric analyses indicated that mood and sleep quality improved for the MSDK group. MSDK-exposed human mesenchymal stem cells (hMSCs) and human peripheral blood monocytes (hPBMCs) plated in transwells or layered demonstrated increases in osteoblastogenesis, decreases in osteoclastogenesis, increases in OPG (TNFRSF11B) and decreases in RANKL (TNFSF11) levels. '

' These findings provide both clinical and mechanistic support for the use of MSDK for the prevention or treatment of osteopenia, osteoporosis or other bone-related diseases. '

Also worthy of mention is that this study was a one year study and that would be a minimum study period for a disease such as osteopenia or osteoporosis because that would normally be the earliest to see measurable results.

I think all of the supplements used are very good for osteoporosis, however, in my opinion the doses were fairly modest, but seem like good starting doses. This combination of supplements proved to be effective in the study and in my opinion is part of a group of many supplements that are beneficial for osteopenia and osteoporosis.

Even the common osteoporosis prescription drug Fosamax requires 3 years to increase spinal density 6% to 8%, whereas these supplements, at modest dosing, were able to increase spinal bone mineral density 4.3% in just one year. Fosamax comes with the potential for these side effects :


While the study supplement combination is likely to offer other health benefits such as improved mood and sleep quality as mentioned in the study above.

As regards dosing for people taking high dose melatonin, there are suppliers offering 60 mg of melatonin per capsule such as this :


As far as a specific brand to recommend, I do not have one.


(New York)

Would not recommend strontium. On dexa scans strontium skews results. You think you have gained bone density but you have not. You should do further reading on this.

What helps is natural calcium from food - no calcium supplements as these end up like concrete in heart.

K2 many studies done, and this is a must to take calcium from food and deposits in bones.

Mineral supplements without calcium.


Why is there bone loss? Lack of Estrogen.

I know many women post menopausal doing low dose estrogen and progesterone to prevent bone loss.

Big pharma wants you to take nasty drugs. You can protect yourself with above!

Search The Calcium Lie on Vimeo.

You need minerals and estrogen.

2145 posts


Strontium Citrate (SC) showed good results for osteoporosis in conjunction with several of the other supplements (melatonin, vitamin D and vitamin K2) in the study I linked to in the article. Here is a link to that study again :


Here is a relevant quote from the RCT :

' This one-year double blind randomized control trial assessed the effects of nightly melatonin, strontium (citrate), vitamin D3 and vitamin K2 (MK7; MSDK) on bone mineral density (BMD) and quality of life (QOL) in postmenopausal osteopenic women (ages 49-75). Compared to placebo, MSDK treatment increased BMD in lumbar spine (4.3%) and left femoral neck (2.2%), with an upward trend for total left hip (p=0.069). MSDK increased serum P1NP levels and reduced bone turnover (CTx:P1NP). Psychometric analyses indicated that mood and sleep quality improved for the MSDK group. MSDK-exposed human mesenchymal stem cells (hMSCs) and human peripheral blood monocytes (hPBMCs) plated in transwells or layered demonstrated increases in osteoblastogenesis, decreases in osteoclastogenesis, increases in OPG (TNFRSF11B) and decreases in RANKL (TNFSF11) levels. In transwell osteoblasts, MSDK increased pERK1/2 (MAPK1/MAPK3) and RUNX2 levels; decreased ERK5 (MAPK7); and did not affect the expression of NFκB (NFKB1) and β1integrin (ITGB1). In layered osteoblasts, MSDK also decreased expression of the metabolic proteins PPARγ (PPARG) and GLUT4 (SLC2A4). In adipose-derived human MSCs, MSDK induced osteoblastogenesis. These findings provide both clinical and mechanistic support for the use of MSDK for the prevention or treatment of osteopenia, osteoporosis or other bone-related diseases.'

My purpose for discussing multiple supplements is to look for the best effects possible to improve osteoporosis. If you do not feel comfortable with one of them, you don't have to use it. In my friend that could not do the injections for osteoporosis, her doctor approved her use of the supplements including SC.


Melatonin Dosage for Osteopenia
Posted by Elaine (Millerstown, PA) on 03/17/2021

Good afternoon, I was just diagnosed with osteopenia.

I just finished reading your interesting article on melatonin. I know you can't prescribe, but could you suggest a dosage that I could begin with? Any recommendation would be helpful as I do not have medical coverage right now.

Replied by Cynthia
(Killen, Alabama)

Elaine, not sure if this will answer your question, but I was taking 30mg for chronic cough after covid. I have used 3-6mg off and on for 30yrs, but found 30mg worked very different as to have a non drowsy effect on me. After 1 week of 30mg no cough at all, and so for here in the south now post nasal drip from allergies YAY. Try working your way up over a few days and see if you can tolerate higher dosage. Best Wish


Cynthia, I just realized that I never responded to your reply. Thank you so much for your reply!!!! I have osteopenia and I am 65. Again, I am so sorry that I did not reply. I am not very tech savvy. God bless.

Replied by Art
2145 posts

Hi Elaine,

Unfortunately, not being a doctor, I can not give dosing suggestions, I can only tell others what I am using and what some doctors are using or suggesting. Dr. Neel is using 1 mg of melatonin for every kilogram of body weight for his Covid -19 patients. I am using 106 mg of melatonin per night as a preventative. Dr. Shallenberger said he suggests 180 mg of melatonin in his patients and suggests over 300 mg per day for his stage 4 cancer patients.

In Cynthia's post in this thread, she cites her use of melatonin at 30 mg/day to get rid of a lingering Covid-19 cough in a week. She suggests starting low and working your way up on dosage to make sure you can tolerate higher dosing. At my current dose, I had a similar response to a cough I got from the flu that had been lingering for months and it was gone in about 3 days after starting HDM (High Dose Melatonin). I have worked my way up on dosing when I first started melatonin to make sure I could tolerate HDM similarly to what Cynthia described.

In a 2020 study, they used 10 mg of melatonin in Parkinson's Disease patients that produced modest benefits in patients.

In Manila's Doctors Hospital, they used dosages of 60 to 72 mg to treat Covid-19 patients successfully, but Filipinos are generally smaller people so their dose may be fairly close to what Dr. Neel is using for his over 1,000 Covid-19 patients.

In another post in this thread, Dana reports a study where they used just 3 mg of melatonin per night to get a positive response in COPD patients.

I always keep in mind that some people can not tolerate melatonin as reported on EC by others, but the majority of people are able to tolerate melatonin as shown in multiple studies.



Art, I just realized that I NEVER responded to your reply. Thank you so much for your reply...I guess better late than never. I am taking 20 - 30 mg of melatonin at night. My naturopathic chiropractor, however, told me that it interferes with one's hormones, etc. and he definitely does not advise the use of melatonin. Well... I am taking it and I am able to sleep almost the entire night waking only once, not three and four times a night! I had not had a good night's sleep in almost two decades. :(

Also, I am 65 and I was diagnosed with osteopenia. Again I am so sorry for responding just now. I am not real tech savvy.

God bless you!

2145 posts


Thank you for the feedback on melatonin and your sleep!

It is very good to hear that melatonin is improving your sleep so much. Good sleep is important for maintaining health and wellbeing.

Newer studies are clearly showing that melatonin has health benefits that your chiropractor may not be aware of. Ask him if he can link you to a newer study that definitively shows that melatonin interferes with your hormones. I would like to read it.


Melatonin Feedback

1 User Review
5 star (1) 

Posted by Anne (Guilliers, France) on 03/18/2021

Hi Art.

I've really appreciated your new melatonin piece. I use a tiny dose every night 1.8 which over time has improved my mood, too. I hope you don't mind me using your thread to point out i5 is low progesterone that most women suffer, not low estrogen. This is a common but crucially important mistake that needs correcting everywhere we can.

Progesterone is a precursor to estrogen and hardly ever mentioned. Look up Dr. John Lee pioneer in the study of natural progesterone. Our bodies are actually so overloaded with estrogen from what we eat and outside sources (Xeno estrogen) that it leads to varying problems like bone weakness, thyroid problems, overweight, diabetes. Our hormones are completely out of balance which obviously is disruptive to our endocrine system. I could go on but this is your post about melatonin and just wanted to point this out in the hope it will be read and picked up by the many people who are affected by it.

Thank you. Anne

Replied by Art
2145 posts

Hi Anne,

EC is a community that is all about sharing and indexing natural health ideas to help everyone with their health issues, so your input and feedback is definitely appreciated!


Replied by SaraB

I agree! I've been very influenced by Dr. Lee, the "original" expert on Progesterone and the other hormones. I still use it because I believe our environment and foods are keeping us in a perpetual state of estrogen dominance.

Melatonin Feedback
Posted by BellaPaolina (Texas) on 03/17/2021

A big thank you for Art. Your melatonin series has been a pleasure to read, and we hope you continue writing many more posts on the subject. My husband and I are taking 50 mg melatonin each every night as a preventivate against age-related woes- and hope very gradually to reach the 160 mg/night dosage that Dr. Schallenberg is taking since 1980.

Please continue illustrating the earth clinic readers with your very interesting posts.

How are you feeling after your COVID 19 experience?

Replied by Art
2145 posts

Hi BellaPaolina,

Thank you very much for the compliment and I am glad you enjoyed the melatonin series, but it has reached the end of the road with this current post!

I am glad both you and your husband are tolerating HDM and like the both of you, I am also using HDM as a preventative against many potential health issues that melatonin has shown benefit for beyond what I have written on EC. To me it is an amazing molecule in that sense.

Regarding being sick, I just updated that thread today and overall I am very happy with the outcome. There were quite a few posts today so you will have to scroll back a bit to find it.

Again, thank you, BellaPaolina for your compliment and feedback!


Melatonin Studies

1 User Review
5 star (1) 

Posted by Art (California) on 04/08/2022 2145 posts

I just wanted to update this thread on the use of Melatonin for Osteoporosis/Osteopenia because a new study came out that adds further confirmation to the relationship between melatonin and osteoporosis :


Here is a very relevant quote from the study :

>>> ' This study confirmed that bone density positively correlates with the melatonin level in human blood. In the animal model, melatonin supplementation reverses postmenopausal osteoporosis. We explored the internal mechanism of melatonin treatment of osteoporosis. Melatonin promotes an increase in intracellular calcium ion concentrations through the STIM1/ORAI1 pathway to induce osteoblast proliferation. ' <<<


Replied by Betty

Your Melatonin studies are great, Art!

I was reading a book today and it mentioned melatonin being an adaptogen. How cool is that!?! I wondered what class it would be considered, now I know.

2145 posts

Hi Betty,

I have never heard melatonin referred to as an adaptogen, but I guess when you consider its multitude of effects to try and return us to homeostasis, I guess that makes perfect sense. It is often described as a hormone, but even Dr. Reiter said he wasn't sure of the accuracy of that description.

I meant to ask you if your brother has any peripheral neuropathy symptoms?

How are your visits with the TCM practitioner(?) going ?



I didn't see anywhere how much to take. Do you know? Thanks, Edy

Replied by Betty

Good question. He has never mentioned neuropathy. I will have to ask and report back.

TCM is going great. Needles freak me out but I have adjusted :) He puts them head to toe on my front side concentrating on abdomen I believe more (can't confirm but have been meaning to ask). I feel really good for a few days and appetite is so much better during those days. I go 2x per week. My right side is sluggish (the needle tapping is more intense) so why we concentrate on correcting balance right to left side (blue blood/red blood) also. RBC's have gotten better on last labs. I have to say the Hemo Him is still rough stuff on my digestion even with food.

Donnie Yance's book referred to melatonin as one of the many adaptogens he considers in treatment plans. That just popped out to me and had to tell you.

Hope all is well your way!

Thank you for asking about my brother and myself.

Replied by KS
(Glenview, IL)

So, what sources and doses for Melatonin are recommended? I couldn't extract that from the highly technical paper.