Osteoporosis and Melatonin

on Mar 17, 2021
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Melatonin for Osteoporosis

Osteoporosis and Melatonin: The Melatonin Series Continues

In this ongoing Melatonin Series on Earth Clinic, this next discussion is about osteoporosis.

Many supplements are purported to help osteoporosis, but one not currently listed on EC is melatonin. There are many studies regarding melatonin as it relates to osteoporosis so let's get started.

I'm not saying that melatonin is a replacement for these other supplements when it comes to osteoporosis, but it should definitely be a part of the armamentarium in the fight against this disease and is just one more important reason to consider melatonin as an overall health promoter against many diseases and health conditions.

What Is Osteoporosis?

Osteoporosis is a bone disease that occurs when the body loses too much bone, makes too little bone, or both. As a result, bones become weak and may break from a fall or, in serious cases, from sneezing or minor bumps. (1)

What Are The Risk Factors And Who Is At Risk?

Women are at higher risk than men, and here are some of the risk factors. Often, a fracture or a broken bone is the first sign of osteoporosis before any of the following risk factors are present:

* Estrogen deficiency from early menopause (before age 45, either natural or surgical) or no period for a long time (six months to a year)
* Personal history of fracture (broken bone) as an adult
* Family history of osteoporosis or bone fracture
* Small thin frame and/or low body weight
* Low intake of calcium (avoidance of dairy products)
* Low levels of vitamin D
* Immobilization or lack of exercise
* Cigarette smoking
* Excessive alcohol intake
* High caffeine intake
* Other medical problems that contribute to bone loss, including thyroid and parathyroid conditions, digestive issues, eating disorders, kidney disease, rheumatoid arthritis, asthma, cancer, and paralysis
* Use of certain medications that weaken bones, such as steroids, overuse of thyroid hormone, blood thinners, anticonvulsants, and diuretics. While osteoporosis can occur in anyone, it is more common in Caucasian and Asian women.

How Do Doctors Treat Osteoporosis?

Doctors have multiple drugs at their disposal to treat osteoporosis. Drugs such as the following Bisphosphonates:

  • Alendronate (Fosamax), a weekly pill
  • Risedronate (Actonel), a weekly or monthly pill
  • Ibandronate (Boniva), a monthly pill or quarterly intravenous (IV) infusion
  • Zoledronic acid (Reclast), an annual IV infusion

There is also:

  • Denosumab : Proloia / Xgeva
  • Romosozumab: One of the newest drugs for osteoporosis
  • Abaloparatide
  • Teriparatide


There are others, but these would be considered to be the leading group. The Bisphosphonates have some significant side effect issues as mentioned here:


Melatonin for Treatment of Osteoporosis

Previously we have discussed the use of melatonin for stroke prevention and treatment, Covid-19, Parkinson's Disease, the group of diseases that fall into the Cardiovascular Disease group, COPD and Memory.

As the title suggests, melatonin has shown benefit in fighting osteoporosis and is worth considering as part of a plan to combat osteoporosis. I won't rehash all of the benefits of melatonin that I have already mentioned in this Melatonin Series as they are many, but rather concentrate on showing studies that illustrate how melatonin can help people with osteoporosis.

In the following abstract, melatonin is shown to operate like most of the available prescription meds by inhibiting bone loss, but melatonin goes a step further and helps in new bone formation.


In the following mouse model of osteoporosis generated by giving the mice retinoic acid, melatonin was shown to prevent bone destruction while promoting bone formation.


In this following abstract, the title pretty much says it all, "Melatonin Suppresses Estrogen Deficiency-Induced Osteoporosis and Promotes Osteoblastogenesis by Inactivating the NLRP3 Inflammasome". This also happens to be one way that melatonin fights Covid-19.


In the following abstract, melatonin's ability to restore impaired osteogenic potential caused by osteoporosis is discussed.


Since diabetes is considered a potential risk factor for osteoporosis, the following study discusses how melatonin may stave off osteoporosis. The following study discusses how melatonin activates the Nrf2/HO1 pathway to help fight Diabetic osteoporosis. It also goes on to show that melatonin significantly reduces ferroptosis caused by high glucose levels:


The following study discusses how melatonin may be useful for preventing bone loss during space flight.


The following study comes to this conclusion regarding Melatonin and Osteoporosis:
>>> ' The osteoblast-inducing, bone-enhancing effects of melatonin and improvement in the quality of life suggest that melatonin is a safe and effective bone loss therapy. '<<<


It is worth reminding here that melatonin production declines with age, as noted on the following graph. This is very important when you consider all of the health conditions that studies show that melatonin is useful for. This adds credence to the whole idea of supplementing with melatonin as a preventative or treatment as we age.

This next abstract discusses how melatonin can help reduce the risk of osteoporosis in people with Multiple Sclerosis.


The following RCT is very interesting. It shows how melatonin works well with other natural supplements that are often used for Osteoporosis and Osteopenia, such as vitamin D, vitamin K-2, and strontium. Here is a quote from the study:

>>> 'These findings provide both clinical and mechanistic support for the use of MSDK for the prevention or treatment of osteopenia, osteoporosis, or other bone-related diseases. ' <<<


The following rat study is interesting because it demonstrates how melatonin has synergy with Calcium Carbonate to reduce and possibly reverse osteoporosis in these rats. Here is a quote from the study:

>>> 'Melatonin and calcium carbonate can significantly improve antioxidative ability in rats with osteoporosis, increase bone density, elevate serum calcium level and reduce bone mineral loss, thus preventing and treating osteoporosis, and the combination displays more remarkable effects.' <<<


This next abstract is important because it points out that melatonin can also have oral health benefits, as pointed out in a previous post on oral health, all why working against Osteoporosis and Osteopenia.



I could go on for pages highlighting the many Melatonin studies showing benefits for Osteoporosis and Osteopenia, but the above should be more than enough to show how helpful melatonin is for the purpose.

The above studies go into substantial detail explaining how beneficial melatonin is for the purpose and how it is synergistic with other known supplements that are often used to fight osteoporosis. When you combine this information with the previous articles in this Melatonin Series, you might start to get an inkling of why I choose to take high dose melatonin (HDM) every day at 106 mg+ per night so that I can try and avail myself of all of the health benefits that melatonin appears to offer.

As always, I can not recommend melatonin or dosing because I am not a doctor, but I can highlight these relevant studies so that others can clearly see the benefit of HDM. You should consult your doctor or healthcare professional before testing or taking melatonin for any reason to be safe.


Where to Buy Melatonin

Melatonin is an inexpensive supplement and easy to find at pharmacies, grocery stores, and local health food stores.

Here are a few links to Amazon:

NOW Supplements, Melatonin, 10 mg, 100 Veg Capsules

Natrol Fast Dissolve - 10 mg - 100 Count - $12.99

Puritan's Pride Melatonin 10 mg 120 Capsules (3-Pack)- $23.00

Got a question for Art or feedback about melatonin for Osteoporosis? Please submit it here!

About The Author

Art Solbrig is a researcher who has been reading scientific studies and testing natural remedies for over 30 years searching for useful studies and alternatives that apply positively to human health issues and natural treatments using minerals, vitamins, amino acids, essential oils, herbs, homeopathy, colloidal silver, combination treatments and other alternatives to improve the quality of life of others by writing about his findings and test results in places like Earth Clinic. He documents and writes about many of his experiences in helping others. Art is a native of sunny California.

Melatonin Contraindications

Posted by Joseph A. (San Bruno, Ca) on 03/17/2021 55 posts

Melatonin interacts with lisinopril, which is a hypertension medicine.

Replied by Art
933 posts

Hi Joseph,

I have a friend who is taking lisinopril and melatonin with no problems.

This article from Drugs.com. says,

No interactions were found between lisinopril and Melatonin Time Release. This does not necessarily mean no interactions exist. Always consult your healthcare provider.


Almost anyone can have a reaction to anything and that is why I said you should have your doctor or professional healthcare provider's approval and supervision if you plan to use melatonin for anything.

I do not know what you mean by: "fix what errors"?

Melatonin Dosage for Osteopenia

1 User Review
5 star (1) 

Posted by Elaine (Millerstown, PA) on 03/17/2021
5 out of 5 stars

Good afternoon, I was just diagnosed with osteopenia.

I just finished reading your interesting article on melatonin. I know you can't prescribe, but could you suggest a dosage that I could begin with? Any recommendation would be helpful as I do not have medical coverage right now.

Replied by Cynthia
(Killen, Alabama)

Elaine, not sure if this will answer your question, but I was taking 30mg for chronic cough after covid. I have used 3-6mg off and on for 30yrs, but found 30mg worked very different as to have a non drowsy effect on me. After 1 week of 30mg no cough at all, and so for here in the south now post nasal drip from allergies YAY. Try working your way up over a few days and see if you can tolerate higher dosage. Best Wish

Replied by Art
933 posts

Hi Elaine,

Unfortunately, not being a doctor, I can not give dosing suggestions, I can only tell others what I am using and what some doctors are using or suggesting. Dr. Neel is using 1 mg of melatonin for every kilogram of body weight for his Covid -19 patients. I am using 106 mg of melatonin per night as a preventative. Dr. Shallenberger said he suggests 180 mg of melatonin in his patients and suggests over 300 mg per day for his stage 4 cancer patients.

In Cynthia's post in this thread, she cites her use of melatonin at 30 mg/day to get rid of a lingering Covid-19 cough in a week. She suggests starting low and working your way up on dosage to make sure you can tolerate higher dosing. At my current dose, I had a similar response to a cough I got from the flu that had been lingering for months and it was gone in about 3 days after starting HDM (High Dose Melatonin). I have worked my way up on dosing when I first started melatonin to make sure I could tolerate HDM similarly to what Cynthia described.

In a 2020 study, they used 10 mg of melatonin in Parkinson's Disease patients that produced modest benefits in patients.

In Manila's Doctors Hospital, they used dosages of 60 to 72 mg to treat Covid-19 patients successfully, but Filipinos are generally smaller people so their dose may be fairly close to what Dr. Neel is using for his over 1,000 Covid-19 patients.

In another post in this thread, Dana reports a study where they used just 3 mg of melatonin per night to get a positive response in COPD patients.

I always keep in mind that some people can not tolerate melatonin as reported on EC by others, but the majority of people are able to tolerate melatonin as shown in multiple studies.


Melatonin Feedback

1 User Review
5 star (1) 

Posted by Anne (Guilliers, France) on 03/18/2021

Hi Art.

I've really appreciated your new melatonin piece. I use a tiny dose every night 1.8 which over time has improved my mood, too. I hope you don't mind me using your thread to point out i5 is low progesterone that most women suffer, not low estrogen. This is a common but crucially important mistake that needs correcting everywhere we can.

Progesterone is a precursor to estrogen and hardly ever mentioned. Look up Dr. John Lee pioneer in the study of natural progesterone. Our bodies are actually so overloaded with estrogen from what we eat and outside sources (Xeno estrogen) that it leads to varying problems like bone weakness, thyroid problems, overweight, diabetes. Our hormones are completely out of balance which obviously is disruptive to our endocrine system. I could go on but this is your post about melatonin and just wanted to point this out in the hope it will be read and picked up by the many people who are affected by it.

Thank you. Anne

Replied by Art
933 posts

Hi Anne,

EC is a community that is all about sharing and indexing natural health ideas to help everyone with their health issues, so your input and feedback is definitely appreciated!


Replied by SaraB

I agree! I've been very influenced by Dr. Lee, the "original" expert on Progesterone and the other hormones. I still use it because I believe our environment and foods are keeping us in a perpetual state of estrogen dominance.

Melatonin Feedback
Posted by BellaPaolina (Texas) on 03/17/2021
5 out of 5 stars

A big thank you for Art. Your melatonin series has been a pleasure to read, and we hope you continue writing many more posts on the subject. My husband and I are taking 50 mg melatonin each every night as a preventivate against age-related woes- and hope very gradually to reach the 160 mg/night dosage that Dr. Schallenberg is taking since 1980.

Please continue illustrating the earth clinic readers with your very interesting posts.

How are you feeling after your COVID 19 experience?

Replied by Art
933 posts

Hi BellaPaolina,

Thank you very much for the compliment and I am glad you enjoyed the melatonin series, but it has reached the end of the road with this current post!

I am glad both you and your husband are tolerating HDM and like the both of you, I am also using HDM as a preventative against many potential health issues that melatonin has shown benefit for beyond what I have written on EC. To me it is an amazing molecule in that sense.

Regarding being sick, I just updated that thread today and overall I am very happy with the outcome. There were quite a few posts today so you will have to scroll back a bit to find it.

Again, thank you, BellaPaolina for your compliment and feedback!