Osteoporosis and Melatonin

on Mar 17, 2021
Melatonin Studies
Posted by Art (California) on 04/08/2022 1463 posts
5 out of 5 stars

I just wanted to update this thread on the use of Melatonin for Osteoporosis/Osteopenia because a new study came out that adds further confirmation to the relationship between melatonin and osteoporosis :


Here is a very relevant quote from the study :

>>> ' This study confirmed that bone density positively correlates with the melatonin level in human blood. In the animal model, melatonin supplementation reverses postmenopausal osteoporosis. We explored the internal mechanism of melatonin treatment of osteoporosis. Melatonin promotes an increase in intracellular calcium ion concentrations through the STIM1/ORAI1 pathway to induce osteoblast proliferation. ' <<<


Melatonin Feedback
Posted by SaraB (CA) on 05/10/2021

I agree! I've been very influenced by Dr. Lee, the "original" expert on Progesterone and the other hormones. I still use it because I believe our environment and foods are keeping us in a perpetual state of estrogen dominance.

Melatonin Feedback
Posted by Art (California) on 03/18/2021 1463 posts

Hi Anne,

EC is a community that is all about sharing and indexing natural health ideas to help everyone with their health issues, so your input and feedback is definitely appreciated!


Melatonin Feedback
Posted by Anne (Guilliers, France) on 03/18/2021

Hi Art.

I've really appreciated your new melatonin piece. I use a tiny dose every night 1.8 which over time has improved my mood, too. I hope you don't mind me using your thread to point out i5 is low progesterone that most women suffer, not low estrogen. This is a common but crucially important mistake that needs correcting everywhere we can.

Progesterone is a precursor to estrogen and hardly ever mentioned. Look up Dr. John Lee pioneer in the study of natural progesterone. Our bodies are actually so overloaded with estrogen from what we eat and outside sources (Xeno estrogen) that it leads to varying problems like bone weakness, thyroid problems, overweight, diabetes. Our hormones are completely out of balance which obviously is disruptive to our endocrine system. I could go on but this is your post about melatonin and just wanted to point this out in the hope it will be read and picked up by the many people who are affected by it.

Thank you. Anne

Melatonin Feedback
Posted by Art (California) on 03/17/2021 1463 posts

Hi BellaPaolina,

Thank you very much for the compliment and I am glad you enjoyed the melatonin series, but it has reached the end of the road with this current post!

I am glad both you and your husband are tolerating HDM and like the both of you, I am also using HDM as a preventative against many potential health issues that melatonin has shown benefit for beyond what I have written on EC. To me it is an amazing molecule in that sense.

Regarding being sick, I just updated that thread today and overall I am very happy with the outcome. There were quite a few posts today so you will have to scroll back a bit to find it.

Again, thank you, BellaPaolina for your compliment and feedback!


Melatonin Contraindications
Posted by Art (California) on 03/17/2021 1463 posts

Hi Joseph,

I have a friend who is taking lisinopril and melatonin with no problems.

This article from Drugs.com. says,

No interactions were found between lisinopril and Melatonin Time Release. This does not necessarily mean no interactions exist. Always consult your healthcare provider.


Almost anyone can have a reaction to anything and that is why I said you should have your doctor or professional healthcare provider's approval and supervision if you plan to use melatonin for anything.

I do not know what you mean by: "fix what errors"?

Melatonin Dosage for Osteopenia
Posted by Art (California) on 03/17/2021 1463 posts

Hi Elaine,

Unfortunately, not being a doctor, I can not give dosing suggestions, I can only tell others what I am using and what some doctors are using or suggesting. Dr. Neel is using 1 mg of melatonin for every kilogram of body weight for his Covid -19 patients. I am using 106 mg of melatonin per night as a preventative. Dr. Shallenberger said he suggests 180 mg of melatonin in his patients and suggests over 300 mg per day for his stage 4 cancer patients.

In Cynthia's post in this thread, she cites her use of melatonin at 30 mg/day to get rid of a lingering Covid-19 cough in a week. She suggests starting low and working your way up on dosage to make sure you can tolerate higher dosing. At my current dose, I had a similar response to a cough I got from the flu that had been lingering for months and it was gone in about 3 days after starting HDM (High Dose Melatonin). I have worked my way up on dosing when I first started melatonin to make sure I could tolerate HDM similarly to what Cynthia described.

In a 2020 study, they used 10 mg of melatonin in Parkinson's Disease patients that produced modest benefits in patients.

In Manila's Doctors Hospital, they used dosages of 60 to 72 mg to treat Covid-19 patients successfully, but Filipinos are generally smaller people so their dose may be fairly close to what Dr. Neel is using for his over 1,000 Covid-19 patients.

In another post in this thread, Dana reports a study where they used just 3 mg of melatonin per night to get a positive response in COPD patients.

I always keep in mind that some people can not tolerate melatonin as reported on EC by others, but the majority of people are able to tolerate melatonin as shown in multiple studies.


Melatonin Feedback
Posted by BellaPaolina (Texas) on 03/17/2021
5 out of 5 stars

A big thank you for Art. Your melatonin series has been a pleasure to read, and we hope you continue writing many more posts on the subject. My husband and I are taking 50 mg melatonin each every night as a preventivate against age-related woes- and hope very gradually to reach the 160 mg/night dosage that Dr. Schallenberg is taking since 1980.

Please continue illustrating the earth clinic readers with your very interesting posts.

How are you feeling after your COVID 19 experience?

Melatonin Contraindications
Posted by Joseph A. (San Bruno, Ca) on 03/17/2021 75 posts

Melatonin interacts with lisinopril, which is a hypertension medicine.

Melatonin Dosage for Osteopenia
Posted by Cynthia (Killen, Alabama) on 03/17/2021

Elaine, not sure if this will answer your question, but I was taking 30mg for chronic cough after covid. I have used 3-6mg off and on for 30yrs, but found 30mg worked very different as to have a non drowsy effect on me. After 1 week of 30mg no cough at all, and so for here in the south now post nasal drip from allergies YAY. Try working your way up over a few days and see if you can tolerate higher dosage. Best Wish

Melatonin Dosage for Osteopenia
Posted by Elaine (Millerstown, PA) on 03/17/2021
5 out of 5 stars

Good afternoon, I was just diagnosed with osteopenia.

I just finished reading your interesting article on melatonin. I know you can't prescribe, but could you suggest a dosage that I could begin with? Any recommendation would be helpful as I do not have medical coverage right now.