Hi Art -- I told my cousin - long suffering with long covid fatigue and brain fog -6 months at least- - about the new supplements shown in studies to show positive benefits. Last week and again this week he called to tell me - he could hardly believe he was that same person, pre our conversation. He was already taking arginine and coq10 before, but he changed over to ubiquinol and doubled to twice a day as well. He also added and took ALA along with the ubiquinol, as the studies suggest- taken together boosts the effects of each taken separately. He also takes (only) 5 mg melatonin as he does not tolerate it that well.
Thanks to you and all contributors for being the community of helpful info, sharing anecdotal successes and spreading protocols that might help others as in this case of my cousin - who can't thank me enough for bringing Art's information to him.
As promised, I will update this thread on long Covid(LC) as studies become available regarding LC.
In this new study (November 2022), the researchers discuss the multiple beneficial effects of Melatonin as a potential treatment to help deal with various LC symptoms. Something that is not mentioned in this study is that type 2 diabetes mellitus (T2DM) is being seen in post covid patients now and melatonin has previously shown benefit for T2DM. In any case they cover many side effects and how melatonin is likely to offer benefit via its multiple methods of action, which include antiapoptotic effects, antioxidant & radical scavenging effects, anti inflammatory effects and immunomodulatory effects Here is a link to the new study :
Here are some very relevant quotes from the study :
' This methoxyindole is found in all forms of life that express aerobic respiration; melatonin's primary function is cytoprotection, displaying anti-inflammatory, antioxidant, and immunostimulant effects [29, 30] which together endow it with highly potent neuroprotective properties . The anti-inflammatory action of melatonin involves a variety of mechanisms . One of them is Sirtuin-1 induction, which decreases the polarization of macrophages toward a proinflammatory profile . Suppression of nuclear factor (NF)-κB activation [34, 35] and stimulation of nuclear erythroid 2-related factor 2 are also detected after exposure to melatonin . Melatonin reduces proinflammatory cytokines (tumor necrosis (TN)F-α, interleukin (IL)-1β, IL-6, and IL-8) and increases anti-inflammatory cytokines such as IL-10 [33, 37]. '
' The antioxidant and scavenging effects of melatonin on free radicals in both the cytoplasm and the cell nucleus are mainly independent of receptors . To fulfill this, melatonin not only acts as a free radical scavenger but also gives rise to a cascade of molecules with high antioxidant activity. It also acts as an indirect antioxidant, enhancing the production of antioxidant enzymes while inhibiting that of prooxidant enzymes . In addition, some antiapoptotic and cytoprotective effects are seen under ischemia, presumably due to melatonin's stabilizing activity of the mitochondrial membrane . '
' Thus, melatonin can reduce the damage resulting from sepsis mediated by COVID-19 through different mechanisms, I.e., by reversing the Warburg-type metabolism and transforming proinflammatory M1 macrophages into anti-inflammatory M2 macrophages , by mitigating the production of HIF-1α , by suppressing NF-κB , and by inhibiting NLRP3 inflammasome . Circulating secreted phospholipase-A2 (Group IIA) correlated with the severity of COVID-19 disease ; hence, cyclooxygenase inhibition by melatonin [48, 49] is another potential mechanism by which the methoxyindole may inhibit viral infection. '
' It may well be true that higher doses of melatonin would be more beneficial in the COVID pandemic condition. For example, in a retrospective cross-sectional study of a closed population of 110 old adult patients treated with a mean melatonin daily dose of 46 mg for at least 12 months prior to the availability of COVID-19 vaccination, there was no death in the face of a lethality rate of 10.5% in the local population of elders suffering acute COVID-19 disease . Indeed, animal studies support the use of high doses of melatonin to prevent infection in murine COVID-19 models . From several animal studies, the human equivalent dose HED) of melatonin was calculated by allometry for a 75 kg adult . Allometry is commonly employed for determining initial doses used in Phase I human clinical drug trials . '
' As stated above, the deficits in attention, memory, verbal processing, and problem-solving seen in patients complaining of brain fog resemble MCI, the initial phase of Alzheimer's disease (AD) . The underlying neuroinflammation in this condition (Figure 1) could be effectively controlled by melatonin, as shown by studies in cell lines linked to AD, in which melatonin reverses abnormalities in the Wnt/β-catenin, insulin, and Notch signaling pathways, proteostasis disruption and abnormal autophagic integrity (reviewed in Refs. [67, 68, 69, 70, 71]). '
' The beneficial effects of melatonin on fibromyalgia (associated commonly with ME/CFS) were first described in one of our laboratories . Since then, several studies have confirmed the initial findings (for a summary, see ref. ). A common pathogenic mechanism is suggested by the similarities among ME/CFS, fibromyalgia, and post-COVID syndrome. The multiplicity of pathophysiological abnormalities in ME/CFS patients opens the possibility of numerous potential therapeutic targets . The several abnormalities described comprise increased oxidative stress, mitochondrial dysfunction, dysregulated bioenergetics, a proinflammatory state, the disruption of gut mucosal barriers, and autonomic nervous system disturbances related to autoimmunity  (Figure 2). The possible therapeutic options targeting these pathways include melatonin, coenzyme Q10, curcumin, molecular hydrogen, and N-acetylcysteine . Among them, melatonin is the only compound that addresses all mentioned potential targets .'
' Considering the quantity of scientific/medical studies that have suggested melatonin use in the COVID-19 pandemic, the inability of melatonin to garner attention from public health authorities or the pharmaceutical industry is disheartening. More than 190 papers on pubmed.gov (accessed on 9 October 2022) have examined the use of melatonin as a safe and potentially effective therapy for the COVID-19 pandemic since its inception . This might be due to several factors, including the fact that no influential organization has promoted its therapeutic use for this condition. Melatonin is non-patentable and cheap; therefore, the pharmaceutical business has little motive to encourage its usage. Meanwhile, several potentially harmful and costly medications have been repackaged as therapies for this disease . '
' In critical situations, such as an Ebola outbreak or the COVID-19 pandemic, it is ethical to use all accessible and safe medicines, even if their usefulness has not been fully demonstrated, especially if the therapy has no major adverse side effects. From an analysis of 27 publications that were surveyed on the ability of drugs to successfully treat COVID-19, it was concluded that melatonin is at least twice as effective as remdesivir or tocilizumab in reducing the inflammatory markers of a coronavirus 2019 infection . Given the substantial number of deaths caused by SARS-CoV-2 infections throughout the world, it seems to us that it is immoral to not take advantage of any such safe therapy, especially if the vaccinations become less effective as the virus continues to evolve. At the very least, well-controlled and powered clinical trials are essential to further establish the current evidence that melatonin is safe and efficacious in treating COVID-19 and its sequelae. '
As you can see from the above study quotes, melatonin covers a lot of known symptoms seen in LC and should clearly be a main candidate for not only treating Covid-19, but very importantly, LC also!
I was recently talking with a friend who was relating how after he got over Covid-19 in 5 days, developed a strange cough where he didn't cough much, but when he would talk, he would get spasms that made him cough and also made it impossible to continue talking. He told me he had the cough for over 2.5 months and it was getting worse instead of better, because now his voice had become hoarse and he had more phlegm that was getting darker.
I had previously given him a bottle of colloidal silver (CS) to test for another health issue, so he decided to use the leftover CS in his cold process vaporizer and inhale directly from the output port of the vaporizer for 10 minutes, three times per day for a total of 30 minutes per day. He told me he replaced the CS in the vaporizer with new CS after each use and he did this for 3 days in a row and by the third day his cough started to diminish and was gone by the 5th or 6th day, but he only used the CS for the first three days.
He was very happy with the results and said he still had some CS left over which he was going to save until needed again. I told him that I was a little surprised that he was able to recover from such a long standing cough so quickly, but I was happy to hear it! He told me that before he used the CS, he would not have been able to have this conversation with me as all of the talking would have had him coughing up a storm.
Recently a friend was telling me about a problem that she had gotten shortly after getting Covid-19, which I would describe as a Long Covid issue as she did not have the problem prior to having Covid-19.
So she told me that a month or two after getting over Covid-19 she started having symptoms of overactive bladder (OAB). She said that once the symptoms started, they seemed to be increasing steadily and getting worse. Her symptoms were that she had to frequently urinate as well as not being able to sleep through the night because of frequent trips to the bathroom.
She also mentioned that another symptom was cramping in her calves, which she had not previously had and the cramping was becoming an everyday thing. Another problem that she mentioned was that it was becoming difficult to go anywhere because she was afraid she might not make it to a restroom on time. She said the urge could come on so fast, that she sometimes had a hard time making it to the bathroom at home in time.
All of this was causing her anxiety and she felt like she was no longer wanting to go out and socialize with her friends and family. She said this was leading her to a depressed state and she was noticing that with each passing day the combination of everything was making her feel weaker. She further told me that she was no longer going for her swimming exercises because she feared she might have an accident in the pool. She said she was feeling desperate and the thought of going to her doctor with a long covid symptom and knowing that doctors do not yet have options for their patients with long covid symptoms, was making her feel more distressed. She then asked me what I thought and if there was anything I could recommend for her to take.
I was kind of at a loss for words after she had told me everything, because I was trying to process everything she had told me while also seeing how the frequent urge to urinate had totally changed her life, and not in a good way. It isn't like there are tons of known remedies for long covid symptoms. We reviewed recent research together regarding OAB post Covid-19. The research seemed to confirm that what she was experiencing was very likely a post Covid symptom as discussed here :
Here is a relevant quote from the article :
- New retrospective research adds to the limited literature on the novel condition known as COVID-associated cystitis (CAC).
- Patients with COVID-19 are at nearly 3 times greater risk of developing new or worsening OAB symptoms than those who haven't been infected.
- The likelihood of OAB symptoms may be higher in COVID-infected patients who have diabetes mellitus or are on chronic steroid therapy. '
In this next study they discuss how inevitably every form of incontinence has psychological consequences such as shame and insecurity, which is interesting because that was exactly what she was describing to me :
Here is a relevant quote from the article :
' Almost inevitably every form of incontinence has psychological consequences: shame and insecurity are often results of uncontrolled loss of urine. Among others, in the long term, they lead to the avoidance of social contacts and possibly to depression and isolation. '
I told her that studies are starting to show that a main issue that is being seen in many long covid symptoms is increased levels of oxidative stress that can further lead to inflammation. So I told her that I would suggest trying a potent antioxidant that is also a mild anti inflammatory with a very good safety profile and high tolerability because she would likely have to take a higher dose in order to be effective for her. She told me that she is very sensitive to many supplements and was concerned whether she would be able to tolerate a higher dose of any supplement.
I told her that all she could do was try and first see if she can tolerate it and then see if it would help with her OAB symptoms. I suggested that she try the Grape Seed Proanthocyanidin Extract (GSPE) that I use because it is a potent antioxidant and is generally very tolerable by friends that I have recommended it to as well as myself at even higher dosing. She agreed to order it and start it as soon as it arrived. I told her the bottle recommends taking 3 capsules per day and I suggested the same. She told me she would keep me updated. This is the product she used :
She started texting after starting on the GSPE, and she said she was only taking two caps per day instead of the label recommended 3 caps per day. So she was taking an 800 mg dose per day.
- In her first text, she said she was able to go 4 1/2 hours of sleep before having to get up and go to the bathroom. She said that previously she had to get up 4 to 5 times a night.
- Her next text said she was feeling a little less urgency to urinate.
- The next text said that she was starting to feel like she was regaining bladder control and because of that was starting to think about possibly getting back to her swimming exercises soon.
- Her next text said she was able to sleep from 11:30 pm until 6:30 am without having to get up once to go to the bathroom.
- Her next text said that her urgency level is down by about 50%.
- The next text said, 'Good news, went to bed at 9:30 pm and slept through til 5:00 am.
- Her next text said I feel that I am about 95% back to normal.
- In her next text she said that her leg cramping seems to be diminishing also.
- Her next text said she is looking forward to returning to her swimming exercises.
- Her next text said that the depression, anxiety, shame, and fear of going out socially are almost nonexistent now.
- Her last text said she is feeling back to normal now!
It is worth pointing out that these texts were received over a period of a week.
Although I see this friend fairly often, she never brought this health issue up until she was feeling desperate and all I saw was that she was always in a rush to get home.
In any case, I hope that this will be helpful for others who may have had Covid-19 and then experienced exacerbated OAB symptoms or experienced OAB symptoms for the first time.
Thought you might be interested in this article I just read on NPR.
Long COVID brain fog may originate in a surprising place, say scientists
(Camp Hill, PA)
Lysine, I read on here about Lysine, on amazon you can get lysine on amazon at https://amzn.to/3TzdqlO
This worked for me, I had a dry mouth, felt tired, head was off, ached. heart would race when I would try to walk. thought I was probably going to die from long haul, had it for months
I took that lysine and within a day it took away everything. been good since. I recommend this so much.
Maca for Long-Covid Memory Issues and Cognitive Impairment
After having Covid, I soon realized I had Long-Covid. Scary-bad Alzheimer's-level memory issues. It was deeply concerning.
I started taking Maca for a multitude of issues like metabolism, depression, balancing my hormones, post-menopause, vaginal dryness, energy, etc...
After a month of supplementing with Maca, I noticed my memory and cognitive issues had greatly improved. Further research shows that Maca is also specifically indicated for cognitive function. My full memory function has returned.
Maca is know as the South American GinSeng, generally from Peru. It grows at the highest altitudes. Maca affects the pineal and pituitary glands. These glands regulate our hormones, metabolism, etc. It is an adaptogen, meaning it helps to manage stress.
Any fertility and libido issues it will balance, so be careful! I have knowledge of women with fertility issues becoming pregnant shortly after supplementing with Maca. Post-menopause women and male fertility issues are deeply supported by this herb.
There are different types of Maca. Red, black and Yellow.They are emphasized for different issues. I found an organic supplement on xoxo that combined all 3.
There are different high-potency Maca's on xoxo. You have to find and work with one that is comfortable for you. Too high potency can make you feel jittery.
I generally took about 3 at breakfast and lunch. You don't want to take it too late as it can keep you up at night ... for great sex ;)
As I mentioned when I wrote this article about how to treat Long Covid (LC), I would add newer studies adding further information on combating LC as they become available. In that line of thinking, one of the most common Covid-19 and LC symptoms is Anosmia or the loss of smell. In this new study (Nov, 2022), it is shown that the common citrus fruit derived supplement, Hesperidin, reduced Covid-19 and LC symptoms, including anosmia :
Here is a relevant quote from the study :
' During the third wave of the COVID-19 pandemic, only 30% of initially symptomatic nonhospitalized and nonvaccinated subjects were asymptomatic about 18 days after symptom onset. Anosmia affected 50% of subjects and was the most frequently persisting symptom in 30%. Hesperidin therapy is safe and may help reduce a composite of selected COVID-19 symptoms, including fever, cough, shortness of breath, and anosmia. Further trials with this agent are encouraged. This research has previously been published as a preprint . '