This is a very important update regarding an RCT for melatonin and Covid-19!
I haven't updated this thread in awhile and now seems like a good time to do that. This very recent (June/2021) human study (RCT) shows that even a relatively low dose of melatonin (9 mg) divided into three doses throughout the day, reduces symptoms and speeds recovery in hospitalized Covid-19 patients. Here is a link to the full study which seems very impressive considering the very low dose that was used in these hospitalized Covid-19 patients. Keep in mind that Dr. Neel is using a dose of 1 mg of melatonin per kilogram of body weight, which is much higher than the 9 mg dose used in this study. In an 80 kilogram person ( 176 lbs), 1 mg per kg would equal a daily dose of 80 mg in divided doses.
Some of the highlights of this study:
1. Nobody died in the standard of care group or the standard of care plus melatonin group.
2. Meantime to release from the hospital was 8.15 days in the standard of care group and 4.65 days in the standard of care group plus Melatonin. (p-value = 0.021)
3. Patients in the melatonin group showed a return to baseline health sooner than control patients (15.09 ± 8.69 vs. 29.60 ± 21.12; p = 0.004).
4. There were no adverse events in the melatonin group.
5. Labored or difficult breathing (dyspnea) was significantly less in the melatonin group. ( p-value = 0.049)
6. Fatigue was significantly less in the melatonin group (p-value - 0.02)
7. Cough was significantly less in the melatonin group. ( p-value = .045)
8. The inflammatory marker CRP was significantly lower in the melatonin group (p-value = 0.045)
As you can see from these results melatonin plus standard of care was significantly better than standard of care alone. The downside here is the small size of the study group, but this still tends to confirm the very good results that Dr. Neel has reported in the over 1000 Covid-19 patients he has successfully treated using a significantly higher dose of melatonin (1 mg kg/bw/day) than this study which used just 9 mg/day. This is the first melatonin / Covid-19 study (RCT) that I have seen completed.
The Manila study has not completed yet, but that is an important study because they are only treating patients who already have Covid-19 pneumonia.I know I have said it before, but I am going to keep saying it, please don't throw your melatonin away just because you have been vaccinated! If the virus continues to mutate rapidly as it has shown it can, this is a good reason to keep melatonin on hand, even if it makes you sleepy the next day. Getting any rest is useful in a disease that is noted for causing sleep problems. People who have been vaccinated still have gotten Covid-19 and died.
When I first started writing this article about Melatonin/Covid-19, it was with the intent of using melatonin as an aid in recovery from long-lasting effects of Covid-19 that were just beginning to be seen in people who had supposedly recovered from Covid-19 and I thought that at the rapid rate that the disease was expanding, this would soon be a health issue that would need to be dealt with in the near future and melatonin seemed ideal to the task. Shortly after I started writing, I came across Dr. Neel's reports and realized that melatonin would not only be useful in long-term Covid-19 recovery but was also likely to work rapidly at reversing the disease process.
In any case, the reason I started writing was for the long term effects that I felt certain would become a problem in short order and it appears that time has arrived where patients who have supposedly cleared from the infection are having longer term health effects and these effects are now being reported and written about. Here is such an article that describes these multiple health issues that are now cropping up months after patients have supposedly recovered.
This problem is becoming so common that they even have names for it now such as "long haulers" or "post Covid-19 syndrome". In my opinion, melatonin is still relevant in trying to deal with these health issues which doctors have little experience dealing with, just as when Covid-19 first showed up, so if you are thinking they will be able to help with these symptoms, you may be very disappointed.
Keep your melatonin handy!
I mentioned in another thread that I would report if I got Covid-19 because that would indicate that melatonin does not work as a prophylactic as I am taking 106 mg+ per evening.
Well, last night at 8:00pm I started feeling off with pain in my chest, shoulders, back and upper legs. By 9:00pm, I was having severe chills and decided to take my daily melatonin a little earlier than normal, but I also decided to bump my dose up to around 125 mg and immediately went to bed. I put 4 blankets on and still felt cold so I pulled the blankets over my head to try and warm up faster, but when I put my face under the covers, it felt sort of like when you open up an oven door when you have had a turkey cooking for hours and that heat hits your face, so I pulled the blankets back down to uncover my head as I clearly had a fever, but was too cold to get up and take my temperature. I slept restlessly and each time I woke up, I felt worse with more pain in my joints, shoulders, legs and my hands and fingers felt like I had severe arthritis. My chest and back hurt even more than earlier and I could not take a deep breath without significant pain. I can say with complete certainty, I have never felt anything like this before. I also noticed I was getting little indications that my legs wanted to cramp up, but I could not get myself to get up and get the mag oil spray from the bathroom, I was just too cold!
I woke up at 8:00 am and with the time change, that would have been 10 hours since I first noticed I was sick. In all of my life, I have never had a cold or flu come on so quickly as I felt perfectly normal at 7:00 pm last night. I finally got up at 9:00 am and had a lot of congestion in my chest and surprisingly, for me, was able to cough most or all of it up. Usually, when I have that amount of congestion, it means I am going to be coughing for a month or longer. I decided to take a long shower and during the shower, I noticed that I felt almost normal except for the chest pain when I would try and take a deep breath. By the time I got out of the shower, I felt really good, but I decided it might be better for me to go back to bed rather than go for my walk.
I don't know for sure that this was covid as I had no test, but I feel as certain as I can that it was. I've never had symptoms quite like these before and the arthritic feeling hands is an absolute first. Sitting here typing, I also notice that it no longer hurts to take a deep breath and I feel normal! No more pain in my joints, no more chest pain, no more back pain, and no more congestion!
If this is covid, I will say that melatonin does not seem to prevent it, but neither does the vaccine. My understanding of the vaccine is that you can still get covid except it is supposed to be milder and not life-threatening or very similar to melatonin.
I am taking 20 mg doses throughout today and will likely continue that for possibly a week and then go back to my regular night dosing. I had previously mentioned that you should not throw your melatonin away just because you get a vaccine and I still feel that way because if you do get covid after being vaccinated, melatonin if used right away, looks likely to make that covid infection even milder.
I am glad I found Dr. Neel and his melatonin protocol because only having to put up with covid for 12 hours is wonderful! I think it is worth mentioning that I was not taking vitamin C or D, lysine, iodine or quercetin. I was taking zinc though.
I will update if things change as I know I will carry this virus for at least a week or more so I will stay on top of my melatonin dosing. Dr. Neel did mention that melatonin could work as a stand alone treatment for covid and my experience tends to confirm his statement.
I am not aware of any other treatment for covid that can reverse it so dramatically in just 12 hours!
Although there is so much more I can write about melatonin, I am only going to write one more post about it on EC because I think people just get tired of hearing about melatonin, no matter how many health issues it can be useful for.
I am happy to report that I and my family are on the other side of Covid, at least til our immunity wanes.
We were doing a variety of Coronavirus preventatives around my house. My husband and I have taken coconut oil daily since last March. My husband and daughter have taken astragalus root that whole time as well. We take vitamin D intermittently, and even in winter my husband and kids get lots of outside time. I have been taking 15 mg of melatonin at night for quite a while.
Then we got Covid.
None of us had a cough. Several of us lost sense of smell. Adults had significant fatigue. One child had a fever for one day. Several of us had sinus burning pain and eye pain. Headaches were common. I never registered a fever but felt flu like for a couple of days.
At the very first sign of illness, especially since we realized we had probably been exposed to COVID, I put everyone on the appropriate amount of melatonin (1gm/kg body weight every 24 hours, divided into four doses.) We also took 50 mcg of zinc, 1-2 grams of vitamin C, vitamin D and 2 quercetin capsules. We ate a lot soup and drank tea with honey. Appetites were not amazing, so I just focused on fluids. I had just gotten an amazing deal and stocked up on organic orange juice, too, so that was handy. Everyone rested as much as needed.
We did use some tylenol, ibuprofen and alka seltzer (never at the same time! ) for fever and aches. Alka seltzer seemed to work the best but I did NOT give it to children. Covid is new and aspirin has a history of causing Reye's Syndrome for some children with some viruses (like flu and chicken pox.)
It may be my imagination but I think I could feel the melatonin wearing off. When I was close to redosing time I would notice that I was feeling worse. I did take an extra dose or two in the middle of the night sometimes.
My mother in law, who is in poor health and lives with us, never had any symptoms. I gave her the same protocol that we took ourselves, in hopes of nipping it in the bud if she began with symptoms, which she never did.
I had some concerns about high dose melatonin (HDM) and its blood thinning properties. I am a bleeder because I have chronic low platelets. I didn't have any bleeding trouble with the HDM. My 9 year old is prone to nosebleeds but they did not increase in frequency during HDM. I don't recall him having any at all during that time. My mother in law is on xeralto and didn't have any trouble with HDM. This is descriptive though, not prescriptive.
While astragalus, melatonin, and coconut oil were part of our preventatives, they didn't prevent the disease. But perhaps they made symptoms lighter? I don't know.
I do think the earlier treating any illness begins, the better. It seems the viruses might get less of a foothold.
I think an over taxed immune system puts one at greater risk for getting a bad case of anything. Good nutrition, stress management, enough sleep, fresh air and exercise are all important for that. But honestly that can be really difficult for many people to accomplish. I'm just making an observation.
I have known some hale and hearty people get seriously sick. A naturopathic local doctor who was doing tons of preventatives and being super careful still got covid and got pretty sick.
I don't think there needs to be guilt associated with getting sick, for some failure of preventatives. We are humans and sickness happens to most everyone. When we are sick sometimes we have time to regroup our priorities, read a book we have wanted to read, and then take care of others when we are well.
At the end of the day, I am thankful we made it through relatively unscathed. I would use the same remedies again.
This is only one story of so many covid stories. It isn't a recommendation for anyone, but a “this is what seemed to work for us” story.
~Mama to Many~
Here's some more useful and surprising safety info in support of using melatonin for COVID-19.
It has already been recommended that melatonin dosage should be 1 mg/kg/day by Dr Neel. But, in the following research study, it is recommending 8 mg/kg/day divided into 5 sub-doses for COVID-19. The research study below also surprisingly says that melatonin at 8 mg/kg/day is "in the ranges used to treat septic patients clinically and is devoid of any adverse effect; thus, it is safe".
I find that dose of 8 mgs/kg/day very interesting. That also tells me that melatonin is very safe indeed at just 1mg/kg/day.
I've also found 12 research reviews on PubMed assessing and strongly recommending melatonin as a protocol for COVID-19 patients. These studies are all begging for permission from the FDA for melatonin to be studied for use in US hospitals. But the FDA/NIH are still not interested in doing the necessary research to prove that melatonin works against COVID-19. What's more, the FDA has known about melatonin's usefulness against COVID-19 since April/May 2019 when Dr Neel and others loudly informed the FDA of its hugely beneficial effects. I guess the FDA might be thinking that a successful, simple and cheap COVID-19 therapeutic like melatonin at this time might well hinder the ongoing vast sales of western vaccines all over the world. After all, if you have a successful and cheap natural therapeutic like melatonin that can revert your COVID-19 to ordinary, harmless flu then we wouldn't really need those vaccines. Right?
Ever since I read about Dr. Neel's success with melatonin on this site, I began taking bigger doses of melatonin every night at bedtime and kept a large reserve of different melatonin brands for myself and my friends and family. So when I contracted covid at the beginning of December and I found out I had it I immediately started taking about 30mg 5 or 6 times a day.
I also increased my vitamin d, c, and zinc intake daily as well.
Before I knew I had the virus, I had a pretty bad headache, a bit of a fever, and had some chills and heat flashes. My stomach was slightly bubbly as well. That was the first 2 days. By the afternoon of the second day I found out I had covid. So that is when I started taking megadoses of melatonin. My headache and fever started to leave.
The next morning, I woke up virtually symptom free. I could feel it just a little bit in my lungs and would occasionally cough up a little bit of phlegm but that was it. I continued with megadosing melatonin and taking extra c, d, and zinc for the next 2 weeks or maybe a little bit longer.
Then I tapered everything down gradually until I got back to my normal routine. Now I just take 20-30 mg a night before bed. I really believe that the melatonin increase basically made me asymptomatic almost immediately.
I used several different brands of dissolvable lozenges that were between 2.5 and 12 mgs a lozenge.
Wow, Jacob, that is amazing! I am very glad that your recovery was so quick and smooth!
Thank you for coming back and giving this update as it is useful for any of the members who may get Covid.
Your results pretty much mirror what Dr. Neel has seen in his over 1,000 Covid-19 patients. Once full dosing is initiated, improvements are generally seen to begin the very next day. In the symposium he recently attended about using melatonin as a treatment for Covid-19, the doctors who attended were asked what if any dose may act as a preventative. Their answer was that is not yet known about melatonin, but they felt that if there is a dose that may act to prevent Covid-19 from getting started, it would be 20mg minimum.
Thank you again for your update, Jacob!
For anyone thinking the high melatonin dosage is crazy... you'll be fine!
Husband started with a sore throat late Friday night. I had him gargle with apple cider vinegar in water and we also took liposomal vitamin C, D3, echinacea, and Chanca Piedra. Applied some DoTerra OnGuard oil.
Saturday again with those things plus had him gargle with warm salt water, which he said helped.
Saturday night he ran fever so we slept in separate beds and I have tried keeping my distance and wearing a mask. Although probably not 100% of the time. Gave him baby aspirin.
Sunday we took the same things mentioned before and I added garlic for him. He has been sipping on water with lemon and Gaia herbs bronchial wellness tea as well as ginger tea. We scheduled to get tested. Rode in separate cars but tested together in the same room, at which time he had 100.4 fever.
He's positive. I'm negative.
Sunday 6pm 1st dosage of melatonin for us both. 20mg.
Took a second dosage at 1am. 20mg.
Another at 7am. 20mg.
I have been able to wake up a few times to go check on him. Tested his oxygen level and temperature. Normal.
I don't feel anymore sleepy than I do when I take 10mg. I had stopped talking melatonin last week because it's been giving me headaches. We had been taking it regularly. Natrol brand, 10mg time released. Husband had not stopped taking it. I currently feel just a light pressure (nothing terrible). Decided to drink some coffee and type this up.
I plan to continue 20 mg melatonin for us both at noon or 1pm today.
Oh! I've also been boiling water on the stove on and off all day with drops of Eucalyptus oil. We live in a pretty dry climate and with the heater running sinuses get really dry.
Art, I hope to keep updating. Let me know if you have any comments/ suggestions/ questions. Thanks for all the information you've provided!
Here is the latest update from Dr. Neel who has now treated over 1,000 Covid-19 patients with high dose melatonin (HDM) with only a handful of patients needing to be admitted to the hospital at all!
Generally, he uses a dose of 1 mg per kilogram of body weight, but other doctors are now reporting going as high as 6x higher than Dr. Neel, by using up to 6 mg per kilogram of bodyweight! Overall, this is the best update yet and is quite informative because Dr. Neel attended a symposium of melatonin researchers and doctors who shared their information that they have gathered over time in the treatment of their patients with HDM. Even Dr. Castillo who is involved in the Manila study of HDM in Covid-19 patients who also have pneumonia. His team is doing the world's first randomized, placebo controlled, double blind study of HDM to treat Covid-19 patients. Dr. Reiter also spoke at the symposium as did Dr. Brown of Canada talked about intravenous melatonin because oral melatonin is known to be absorbed at only 3% to 15% of the dose taken while intravenous melatonin has much higher bioavailability. Dr. Castillo also mentioned a "maintenance dose" which many people are wondering about. The general consensus of the doctors who spoke at the symposium was 20 mg /day.
There was more to the update, but this was clearly the most informative and exciting update yet! Here is a link to the article :
Thank you, Art, for this important and timely information about high dose melatonin. I was diagnosed with Covid the Tuesday before Thanksgiving and began your protocol of 80 mg/day in divided doses the following day. My symptoms (ongoing severe headache and other less painful symptoms) reduced very quickly. I had minor respiratory involvement which never fully developed.
My question is how long do I continue to use the high dosage? From reading through the information you provided, I'm thinking to reduce dosage and see if symptoms return or worsen? At first, I thought I should stay on it for a minimum of two months. Any clarification or thoughts will be appreciated.
Shout out to Earth Clinic for being Earth Clinic!!
Everyone is now aware of the fact that the president and his wife have Covid-19 and apparently there are several of his staff who also have it.
Trump always talked about how hydroxychloroquine was the solution to the problem, but he is not taking it! Nope, he's taking melatonin! ABC news just reported that.
Does anyone besides me find it odd that his administration never once mentioned that melatonin might be useful to fight Covid-19 and yet it is what they are giving him???
This recent report (August 26,2020) of an 87 year old who was treated with HDM and treated early, survived with no complications!
Here is a link to the brief article:
Although it is just one case, 87 years old is a definite high risk case and he survived with High Dose Melatonin, along with vitamin D, zinc and vitamin C. Melatonin has shown synergy with these vitamins in recent studies. These four supplements are noted for having very good safety profiles and are all commonly available over the counter and are inexpensive. Simple, easy and effective and can be started earlier than the drugs being prescribed for Covid-19 in most cases.
This bodes well for the elderly!
Here is the latest very promising report on Dr. Neels melatonin / Covid-19 protocol as used in a Texas convalescent facility. As many of you already know, these convalescent facilities are fairing very poorly with many patient deaths being the norm! This convalescent facility didn't waste anytime implementing Dr. Neels protocol once they had their first two cases die from Covid-19. They started using HDM right away and had no more deaths from Covid-19! One patient died afterward from another health issue. This is very important because this is a senior population with health issues and age that put them at increased risk of succumbing to Covid-19.The rest lived.
Here is a link to the latest article :
In this latest update from Dr. Neel, he mentions that although the amount of new cases in his area of Texas have slowed a bit, the current strain affecting his area is definitely more difficult to treat than the previous strain he was working against. He has shown a willingness to raise the melatonin dosing level to help deal with this current strain because with this strain it has taken 3 days to start to see improvement whereas with the previous strain he was seeing improvement in just one day.
One thing he didn't mention is the number of patients he has treated as of today(8/26/2020). The last time he mentioned the number, he said over 400 patients treated. He still not has reported any deaths as of this update. Here is a link to the update:
Here is another upcoming melatonin / Covid-19 study that is going to be done in Spain using 60 mg / day and what makes this study different is that they are injecting those 60 mgs of melatonin and this will be a randomized, placebo controlled, double blind study which is also a first when it comes to melatonin / Covid-19. I don't think they have a randomized, placebo controlled, double blind study for Hydroxychloroquine yet :
Below is a link to an article about a 4 year old boy in Texas who got sick shortly after his father tested positive for Covid-19.
Of note related to this story is that 4 to 7 year olds are at or very near the peak of natural melatonin levels seen in humans suggesting that melatonin can not prevent infection, but it can apparently reverse it in short order based on this and many other reports! This could be useful information for all of those people who have kids or grandkids! Here is a link to that article :
Dr. Neel has treated over 400 Covid-19 patients now, as of July 22, 2020!
Since his patient load has increased very considerably, so has his knowledge and understanding of the use of HDM (High Dose Melatonin) in Covid-19 patients. This seems like one of his most informative updates so far!
Dr. Neel is now seeing patients who are in multiple higher risk categories and treating some of them is no walk in the park. Dr Neel is now using even higher doses of melatonin in these harder to treat patients at dosing that is closer to what Dr. Shallenberger uses in almost all of his non cancer patients and similar to what Dr. Reiter has used in some of his studies. Dr. Shallenberger uses much higher dosing in his cancer patients though.
Dr. Neel also mentions that he is now seeing many more young patients than in the previous 3 months. He also mentions that people with asthma are having a harder time with Covid-19 than his patients who don't have asthma. He is also seeing more young patients who are developing gastrointestinal issues. He does not mention any deaths in this latest update.
He also mentions that he is seeing at least one strain of virus that seems to be more virulent. The information he includes with this latest update does not seem to bode too well for the supposedly soon to be available vaccinations, if the virus is mutating significantly. Here is the link to this latest update:
July update From One of Dr. Neel's Patients Describing Her Experience
This is an update from one of Dr. Neel's patients describing her experience using high dose melatonin (HDM) to treat her Covid-19 case. She adds confirmation to what Dr. Neel has been saying about the rapid onset of action by HDM (High Dose Melatonin).
Also of interest in this update is the fact that Dr. Neel appears willing to go slightly above his proposed dosing schedule of 1 mg of melatonin per kilogram if he deems it necessary.
This is essentially one patient's play by play of her experience with Covid-19 and HDM:
Here is the latest update (6/23/2020) from Dr. Neel. It appears that he now has about 100 patients based on what he says in his update and he gives a brief idea of how things are going for his Covid-19 patients and his results are holding up very well as his patient base continues to expand (Texas appears to be having a significant increase in Covid-19 cases) and no deaths to report among his Covid-19 patients!
To me that is awesome news compared to all other major drugs being trialed and tested, as even the best of these are showing patients still dying, but at a lesser rate. Importantly, he once again reiterates the importance of vitamin D based on the Italian vitamin D statistical analysis as it relates to Covid-19 patients. In this latest update you can see that Dr. Neel is becoming even more focused in treating his covid-19 patients quickly and has had no major complications or deaths!
Dr. Neel also mentions the study trial in Manila that will treat 350 Covid-19 patients who also have pneumonia. It seems pretty bold to focus on Covid-19 patients with pneumonia, as this group has a significantly higher death rate!
Here is a link to his latest update:
This new article explains how melatonin inhibits the cytokine storm that is proving to be a serious problem from Covid-19 : https://www.sciencedirect.com/science/article/pii/S2590098620300312?via%3Dihub Art
GREAT NEWS!!! The latest from Dr. Neel is that over 50 of his Covid-19 patients have recovered using his high dose melatonin protocol!!! https://devinenews.com/50-covid-patients-recover-under-dr-neels-care/ Art
Apparently, the Doctors Hospital in Manila, Philippines has gotten funding to do a clinical trial of high dose melatonin (HDM) in 350 patients with "Covid-19 and pneumonia or other Covid-19 related high risk features" based on their experience of successfully treating their Covid-19 patients with HDM. They still have not publicly released their Covid-19 patient data that they said they were going to publish in a scientific journal, but they did manage to get funding for this study based on their initial experience with HDM and the study is being funded by their Department of Science and Technology (DOST). They also mentioned that melatonin is being used in other countries for Covid-19. They further stated that the trial will last at least 4 months which suggest that the results will be available near halloween. https://news.abs-cbn.com/news/06/12/20/dost-allots-p98-million-for-melatonin-clinical-trials-to-treat-covid-19 Art
Why melatonin for Covid-19? Melatonin also protects endothelial cells as well as red blood cells being damaged by excess oxidative stress as seen in Covid-19 which can lead to blood clots, while also being the most potent antioxidant in the body ( more powerful than glutathione) that helps to neutralize the significantly elevated levels of ROS that is seen in patients that damages endothelial cells, a potent antiinflammatory agent, an upregulator of the gene expression of the bodies own potent antioxidants, catalase, superoxide dismutase and glutathione peroxidase. Melatonin also scavenges reactive oxygen species/hydroxyl radicals, reactive nitrogen species and peroxynitrite. Melatonin is also protective of all major organs in the body that the virus has shown itself to damage. Melatonin is an excellent protector of the lungs which is very important in Covid-19 to help protect against the cytokine storm. Melatonin acts as an anticoagulant which is very useful in Covid-19 as it has shown itself to cause blood clots. Melatonin also lowers the inflammatory cytokine IL-6, chemokine IL-8, IL-17, inflammatory mediator TNF-alpha, NF Kappa b and IL-1b which are all elevated in Covid-19. There is much more that melatonin does to fight Covid-19, such that if one was trying to create a good drug to fight the effects of the virus, melatonin could possibly be it. Art
Hi, Steve, Yes, melatonin does affect sleep, but it does way more than that! Melatonin does not stop the virus, but it reduces the the innate immune response which is what can trigger the potentially deadly cytokine storm and inhibits the potential for pneumonia and thus eliminates the need for a ventilator, three important actions associated with death in Covid-19. Melatonin also is protective of all major organs of the body which in autopsies have all been shown to have been attacked by the virus, including the brain, liver,kidneys, pancreas, spleen, eyes, skin, lungs and heart. Dr. Neel is able to turn his patients around in just 24 hours after starting them on HDM! By not attacking the virus directly, the body can then use its adaptive immune response to create antibodies that will fight the virus as the body is supposed to do. Kill the virus too fast and the body may not be able to generate enough antibodies before the virus is eradicated and this is important in case the virus comes back each year as other Coronaviruses have and scientists are indicating is very possible. By having adequate antibodies in your system, the body should be able to eradicate the virus on its own next time around. In hydroxychloroquine studies that used zinc and azithromycin, the zinc has not shown effectiveness even though hydroxy is supposed to act as an ionophore to help the zinc to have better cell access. Yes, people still died with this combination! Art
Apparently the combination of melatonin and vitamin D may have synergy against Covid-19 health issues according to the following new study. Is anybody surprised? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7227533/ I am glad that they released this study, because it is already known that high dose vitamin D lowers native melatonin levels in humans, so having more of both will nullify this issue and likely speed the healing process. I wonder what they will find if they add vitamin C? You just know that this combination is likely to be more effective than any of the drugs which they are continuing to test despite dismal results in Covid-19. EC has the answers and governments and their scientists continue to look in all the wrong places! Art