Ivermectin inhibits the SARS-CoV-2 spike protein from binding to ACE2 receptors in human tissue: Ivermectin, a common anti-parasite drug, has shown great efficacy in the fight against covid-19. For the first time, medical researchers have documented how ivermectin docks to the SARS-CoV-2 spike receptor-binding domain that is attached to the ACE2 receptor. In this way, ivermectin effectively inhibits viral attachment and replication, assisting a precise antiviral response that can target the SARS-CoV-2 spike protein at its most advantageous cleavage site. The researchers showed how ivermectin interferes with the attachment of the spike protein to the human cell membrane.
Ivermectin is a simple medicine derived from the bacterium Streptomyces avermitilis. It weakens and kills parasites by interfering with their nervous system and muscle function. Ivermectin targets the glutamate-gated chloride channels in the parasite's nerve and muscle cells, bolstering inhibitory effects in the parasite's own neurotransmission. As the chloride ions permeate, the parasite's cells are hyper-polarized and then paralyzed, resulting in their demise.
In this study, ivermectin docked in region of leucine 91 of the spike protein and at the histidine 378 of the ACE2 receptor. The binding energy and constancy of ivermectin was also measured and found to be sufficient at the ACE2 receptor, proving the anti-parasitic molecule a powerful force for blocking viral attachment of SARS-CoV-2.
Ivermectin blocks SARS CoV-2 at the ACE2 receptor in humans
The 17 randomized controlled trials that use ivermectin for early treatment and prophylaxis report positive effects, with an estimated improvement of 73 percent and 83 percent, respectively. Out of 37 early treatment and prophylaxis studies for ivermectin, 97 percent report positive effects. One of the studies documents how ivermectin inhibits the replication of SARS-CoV-2 in vitro and displays broad-spectrum anti-viral activity against the causative virus (SARS-CoV-2). This study showed a 5,000-fold reduction in viral RNA after just 48 hours.
The study also proves that effective treatments and prophylactics can mitigate the replication and spread of a virus thousands of times faster than the paranoid, isolationist approach of social distancing and lockdowns. If antivirals were encouraged early and often, then the spread of actual infectious virus would have been mitigated at rates thousands of times faster than the insane method of treating everyone as if they are infectious. By treating actual infections where symptoms are present, the spread is reduced at magnitudes thousands of times greater, while conveying immunity instead of terror.
The SARS-CoV-2 spike protein is designed to attach to angiotensin-converting enzyme 2 (ACE2) in humans. To see whether ivermectin could dock at this receptor site and block viral attachment, the researchers used a program called AutoDock Vina Extended. This docking study showed the crystal structure of the SARS-CoV-2 spike receptor binding domain. The researchers looked specifically at the human ACE2 receptor and calculated the root-mean-square deviation (RMSD) of its atomic positions. A lower RMSD value indicates a more accurate docking capacity. When the RMSD value is three or greater, no docking has occurred at the receptor site. Ivermectin did not dock at nine of the locations; however, it did dock at the leucine 91 region of the spike and histidine 378 at the intersection of proteins between SARS CoV-2 and the ACE2 receptor complex.
Previous studies proved ivermectin's efficacy, but had to use high concentrations of the drug because the study relied on African green monkey kidney epithelial cells, which do not express the human ACE2 receptor. SARS-CoV-2 is specifically equipped to infect human ACE2 receptors, so this study could prove ivermectin to be effective in much smaller dosages. Clinical trials are now underway to determine if ivermectin is an effective treatment for covid-19.
The global conspiracy to suppress effective anti-viral medicines
The World Health Organization, the FDA, and the NIH have repeatedly suggested that no antiviral treatments exist for covid-19, even though multiple antiviral herbs and drugs have been studied during previous SARS and MERS epidemics and found to be effective. This time around, many of these antivirals were used with great effectiveness by doctors who were willing to go out on a limb and save lives.
Chinese hospitals used various antiviral herbs to treat covid-19 patients. These hospitals studied the effects of the herbs for impeding virus-cell receptor binding, for stimulation of the host's immunity, for blocking virus entry into host cells through action on the host's enzymes, and for prevention of SARS-CoV-2 RNA synthesis and replication. The research found numerous phytochemicals to be effective, including: quercetin, ursolic acid, kaempferol, isorhamnetin, luteolin, glycerrhizin, and apigenin. The top three most effective plants for treating covid-19 included licorice root, (Glycyrrhiza glabra) chicory root, (Cichorium intybus) and hibiscus flowers (Hibiscus sabdariffa). A number of antiviral plants contain compounds that target all three antiviral targets, including olive leaf (Olea europaea), white horehound (Marrubium vulgare), black cumin seed (Nigella sativa), garden cress (Lepidium sativum), Judean wormwood (Artemisia Judaica), guava (Psidium guajava), chrysanthemum (Glebionis coronaria), and Maryam's flower (Anastatica).
Medical systems around the world are not properly equipped to strengthen the human immune response or understand what individuals need to overcome an infection. When it comes to fighting infections, the US FDA and European drug regulators parrot the same narrative of ignorance and apathy, withholding viable antivirals from the public. By the way, this is the only legal way to bring experimental vaccines to the global marketplace, by proving that no effective treatments exist. This suppression of science on antiviral treatments has paved the way for emergency use authorization of experimental vaccines and forced countless patients to suffer (and die) on ventilators, without treatment.
I have been sick since April 27 with a much stronger strain of covid (or whatever it is) and this has been the most miserable, horrible sickness in my 54 years of life.
To the point of praying for death for 3 days. That is how bad this new strain is. It took out 5 additional family members and hospitalized three of them.
My family is relatively healthy and it took them down like a tree falling in the forest.
Ivermectin is starting to dwindle in the paste form in the US.
Prices are going high very quickly as demand and supply are competing against each other.
We have about 50+ physicians in the US who will write a prescription for it.
HCQ will do nothing for someone that is already sick into a week or more.
The FLCCC website is the best source.
India is wiping out the new and much stronger strain with .4-.6 mg per kilo of body weight per day.
I have taken the paste 5 days straight without an issue and it beat it back very well but it did not completely heal me.
I went on a tele med call and was able to get a stronger prescription but only for three days.
Ivermectin is going to be worth more than gold in the coming months.
Get it while you can for you and your family.
They will be watching for people selling it openly for high prices and they will come for those people.
I live in South America in Ecuador. Two days ago I woke up with terrible chest pain, cough, high fever and a very bad sore throat. I bought Ivermectin tablets in advance for a case like this. The package has 4 tablets and costs $2 here. I took two tablets on the first day and by the following day evening I was back to normal, no cough, no fever, no chest pain and no sore throat. On the 3rd day I finished the regimen by taking the remaining 2 pills from the box. Ivermectin works like magic.
My daughter and I both got COVID at the same time. Her symptoms were quite severe, and we had just read about ivermectin. We found some animal grade Ivermectin at our local tractor and feed store in the horse section. It's for deworming horses, but don't be alarmed. Within 24 hours we were both much better and within three days we were almost completely well. Farm and Fleet also carries it. I've seen very credible doctors on YouTube who said that it would not hurt to take the veterinary ivermectin. I can tell you it didn't hurt and it cured us both for only $3.95.
My functional medicine doctor MD prescribed Ivermectin and is recommending all patients not to take any vaccines. She took it herself when her son passed on COVID to her and said her symptoms were mild for 1 day.
She still takes it as she flies at least once a month.
I got my supply from a compounding pharmacy in Orange County, CA. Maybe it's me. I would not take it from a pet feed supply store. no way of being sure what you are getting besides Ivermectin.
Ivermectin has been very effective for treating covid in our family. Usually within around 24hr reversing the symptoms. Also Zn is very important to take with hydroxychloroquine. If you go to frontlinedoctors.com they can prescribe either hydroxychloroquine or ivermectin after a consultation. I believe the fee is $90. A friend received their prescription after suffering for 15 days from Covid and it cleared up within a very short time and cannot say for sure which they prescribed for her but she was very sick.
Ivermectin destroys 98%of Covid 19 in 48 hrs.
It does work, in fact covid19 would stop in it's tracks . Effective protocols is Ivermectin Dr. Pierre Kory works with doctors that are the most published in their field in the world. He testified at the senate about Ivermectin miraculous in helping patients with covid19. His testimony went viral for a reason, it is worth watching for more data.
Covid comment, no opinion:
I was at the dr yesterday for a covid test (to calm daughter for Christmas gathering) and overheard the pharma rep talking to the doc. He said they did a study of Ivermectin in covid patients. 200 hospitalized patients in each category, mild/moderate/severe Covid. 100 in each group got ivermectin, the others placebo.
Of those receiving ivermectin, 1 in the severe group got worse, 2 in the severe group showed no change, ALL the rest showed dramatic improvement. Just another nugget of info for you to consider. Also, I asked the doc about people who come back to work after quarantining with covid. He said, yes, they will shed dead virus that can infect you and, yes, you can get it through your eyes (any moist membrane). So, bear that in mind, too.
An April article on ivermectin use in cell cultures.