DMSO
Health Benefits

The Health Benefits of DMSO: What You Need to Know

| Modified on Nov 08, 2025
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Side Effects
Posted by NSB (Berlin) on 11/08/2025

Water retention and changes in urination frequency due to oral ingestion of DMSO

I'm 35 years old, I take DMSO orally since a couple of months ago. The reason was to increase supplement absorption, for health purposes such as anti-inflammation.
I was taking about 4 drops of 99.9% DMSO in 350-400ml of distilled water twice a day on an empty stomach, in the morning and before bed. I've stopped now, but I sometimes mixed it with supplements.
In addition, I routinely use supplements such as methylene blue, NMN, alpha-lipoic acid, spermidine, CoQ10, resveratrol, omega-3, magnesium, GABA, glycine, and melatonin—mainly those that support mitochondrial function and provide antioxidant benefits.

However, my body has recently started showing signs of water retention. Since I don't have a scale at home, I always weigh myself at the gym in the early afternoon or evening, and my weight has increased by 3-4 kg.Caffeine and potassium-rich teas, which used to have an immediate diuretic effect on me, no longer work as quickly. I also suspected kidney failure and heart failure, but the blood tests showed no abnormalities.However, for some reason, I don't really notice much edema in my body. Since I have a job that requires standing, I feel my legs are slightly swollen after work, but there's no noticeable edema.

I don't have any problems going about my daily life, but the pace at which fluids are expelled as urine is slow, and I wake up 2-3 times during the night to use the bathroom. Each time, I urinate the maximum capacity my bladder can hold. This happens every 3-4 hours. It might also be related to the fact that I was dependent on Ketamine, marijuana, Kratom for several months and was taking high doses every night.
It's been 4 days since I stopped ingesting DMSO, and my symptoms haven't gone away. Since I'm continuing to apply it for dental treatment, I can't say I've completely discontinued use, but I have stopped oral intake. After doing some research, I heard that DMSO can sometimes cause fluid retention. Does anyone have similar experiences from DMSO intake, or have you heard about such cases?