I like 5-HTP very much. I take one of the smallest dosages, 50 mg., but it has been very helpful.
I've been on different antidepressants the last several years, natural and pharmaceutical and have found DHEA supplementation to be one of the most effective for myself. I'm currently taking usually 150mg /day of dhea and 200mg of Zoloft. Added in deer antler velvet this last month. The jury's still out on the DAV. I aso just tried Saint John's Wart standardized for hypericin and hyperforin and can't say it did any good. D3 didn't help. Will probably try urine drinking last if at all. Rhodiola may be next and/or a trip to a sunnier climate. I just saw some info at Perlmutter Health Center (Naples Fl) web site about hyperbaric oxygen giving some people depression relief, so that will be in the future as well.