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Hi Patricia,

The lotion is fine for your knees. I made the melatonin gel for more sensitive areas such as the face and the fact that melatonin and aloe vera gel are both very good for the skin as a protectant and enhancer.

A friend told me she used melatonin lotion successfully for hemorrhoids, but I suggested that she might consider melatonin gel for such a sensitive area because the lotion has a ton of other ingredients, that you may not want in such a sensitive area.

I make the gel more often now because it works similarly to the lotion, but I can also use it in more sensitive areas. The cost to make either one is also similar.

The effects for either form for osteoarthritis are also going to be similar. Are you finding it beneficial for the osteoarthritis in your knees?

I have another question for you, have you tried the borax remedy for arthritis? I ask because the people who have benefited from borax for arthritis, such as myself have found it very effective. I think because of their different methods of action, melatonin lotion or melatonin gel with borax may have synergy with each other for arthritis. Here is a link to Earth clinics page on borax which explains how it is used and is also EC's #1 remedy for arthritis :

https://www.earthclinic.com/remedies/borax.html

Here is a link discussing melatonin for osteoarthritis :

https://pubmed.ncbi.nlm.nih.gov/39228264/

Here is a relevant quote from the link :

' Recent evidence indicates that the damaged regions in osteoarthritis are accompanied by the accumulation of iron ions. Ferroptosis, as an iron-dependent form of cell death, holds significant implications in osteoarthritis. Melatonin, a natural product with strong scavenging abilities against reactive oxygen species and lipid peroxidation, plays a crucial role in the treatment of osteoarthritis. This study aims to demonstrate the existence of ferroptosis in osteoarthritis and explore the specific mechanism of melatonin in suppressing ferroptosis and alleviating osteoarthritis. Our findings reveal that melatonin reverses inflammation-induced oxidative stress and lipid peroxidation while promoting the expression of extracellular matrix components in chondrocytes, safeguarding the cells. Our research has revealed that NADPH oxidase 4 (NOX4) serves as a crucial molecule in the ferroptosis process of osteoarthritis. Specifically, NOX4 is located on mitochondria in chondrocytes, which can induce disorders in mitochondrial energy metabolism and dysfunction, thereby intensifying oxidative stress and lipid peroxidation. LC-MS analysis further uncovered that GRP78 is a downstream binding protein of NOX4. NOX4 induces ferroptosis by weakening GRP78's protective effect on GPX4 and reducing its expression. Melatonin can inhibit the upregulation of NOX4 on mitochondria and mitigate mitochondrial dysfunction, effectively suppressing ferroptosis and alleviating osteoarthritis. This suggests that melatonin therapy represents a promising new approach for the treatment of osteoarthritis. '

Art