Atherosclerosis - Art Solbrig
Natural Remedies

Grape Seed Extract: A Powerful Ally Against Atherosclerosis

on Jun 25, 2023| Modified on Feb 05, 2024
Grape Seed Extract for Atherosclerosis

The main cause of death in the world is cardiovascular disease (CVD) and Atherosclerosis is considered a main cause of CVD. I have previously written about the use of melatonin to prevent or treat CVD here:

The dominant cause of CVD is atherosclerosis as confirmed by the following article: is the dominant cause,heart failure, stroke and claudication.

Here is a relevant quote from the article:

' Atherosclerosis is the dominant cause of cardiovascular disease (CVD) including myocardial infarction (MI), heart failure, stroke and claudication. '

Atherosclerosis is the name for the buildup of fatty plaques on the inside of the arterial walls which can eventually significantly reduce blood flow or completely block it, greatly increasing the chance for heart attack or stroke. If you've ever seen the inside of old galvanized plumbing and the buildup of minerals and rust inside of the pipe that gets so thick that you can no longer see daylight when looking through the inside of the pipe from one end to the other, this gives a good idea of what atherosclerosis is like.

Grape Seed Proanthocyanidin Extract (GSPE)

Several supplements are useful for atherosclerosis besides melatonin, and it is good to have an alternative to melatonin since some people do not tolerate melatonin. The one I would like to discuss today is grape seed proanthocyanidin extract (GSPE) because it is a highly tolerable, very potent antioxidant with anti-inflammatory effects and beneficial for multiple other health issues. I like when a supplement can do more than just one thing: treating the problem at hand and improving overall health.

In the following study linked below, GSPE showed that it can not only stop atherosclerosis, but it can slowly reverse it, which is actually a very safe way to do it. If you take something that starts breaking the plaques down too quickly, pieces of the plaque can break away and flow with the blood to another restricted area in the blood vessel and cause a complete blockage. So a slow and steady approach is likely a safer way to reverse atherosclerosis.

The reason this is very important is that doctors don't actually have a treatment for atherosclerosis. Statins can reduce high cholesterol, but they don't stop atherosclerosis. If you start having problems caused by atherosclerosis, your doctor will put you on a blood thinner such as Warfarin, but this does nothing to stop or slow atherosclerosis progression. Worse yet, Warfarin has some pretty serious side effects, as listed here:

I didn't cut and paste all the side effects into this article because it looks like there are well over 50 of them, and some are very serious, such as this one:

Cardiovascular: Frequency not reported: Hemorrhage, purple toes syndrome, infarction, systemic cholesterol microembolization, vasculitis, systemic atheroemboli[Ref]

I don't understand how you treat a health issue with something that can cause much more damage than it can fix! One look at that list of side effects, and Warfarin is now a drug that I will avoid like the plague!

If your atherosclerosis is more severe, the doctor can surgically put stents in the blood vessel where the plaques have built up so much that blood can barely flow past the built up plaques or can no longer flow past the blockage of fatty deposits. A stent is basically a tube that is inserted into the blood vessel where the blockage is to allow the blood to flow through that area where the clog is. Again, this does nothing to slow, stop or reverse atherosclerosis.

Here is a link to the study with 287 participants with established atherosclerosis:

Here are some important quotes from this study illustrating how GSPE reduced plaque deposits over time, whereas the control group continued to increase plaque deposits in their arteries :

' Consecutive 287 patients diagnosed with asymptomatic carotid plaques or abnormal plaque free carotid intima-media thickness (CIMT) were randomly assigned to the GSPE group (n = 146) or control group (n = 141). The patients in the GSPE group received GSPE 200 mg per day orally, while patients in the control group were only enrolled in a lifestyle intervention program. '

' As anticipated, after treatment, GSPE resulted in significant reduction in MMCIMT progression (4.2% decrease after six months, 4.9% decrease after 12 months and 5.8% decrease after 24 months) and plaque score (10.9% decrease after six months, 24.1% decrease after 12 months and 33.1% decrease after 24 months) for the primary outcome, while MMCIMT and plaque score were stable and even increased with the time going on in control group. The number of plaques and unstable plaques also decreased after treatment of GSPE. Furthermore, the carotid plaque can disappear after treatment with GSPE. The incidence rate for transitory ischemic attack (TIA), arterial revascularization procedure, and hospital readmission for unstable angina in GSPE group were statistically significant lower (P = 0.02, 0.08, 0.002, respectively) compared with the control group. '

' GSPE inhibited the progression of MMCIMT and reduced carotid plaque size in GSPE treated patients, and with extended treatment, the superior efficacy on MMCIMT and carotid plaque occurred. Furthermore, the GSPE group showed lower rates of clinical vascular events. '

How Grape Seed Extract Reduces Plaque Over Time

The following graph clearly illustrates how GSPE reverses the plaque score from a steady rise to a steady decline over time. Here is the link to the study that contains this graph. Again a steady decline as opposed to a too-fast decline, is a safe way to deal with atherosclerosis. The first graph illustrates the gradual reduction in intima media thickness by GSPE :

So this is an important study regarding one way to deal with atherosclerosis. This study was done in 2015, and had this study used a new prescription medication instead of GSPE, every cardiologist in the world would be prescribing such a drug to all of their patients and taking it themselves! It would be a blockbuster drug and any pharmaceutical company would be proud to have and sell it for a huge amount of money. GSPE is relatively inexpensive and readily available and its biggest side effects are other health benefits!

These were extraordinary results in fighting atherosclerosis, but imagine if you added another antiatherosclerosis supplement with the GSPE, such as melatonin.


Something interesting about this study is the dose of GSPE that they used of just 200 mg daily. Currently, many suppliers of GSPE are selling their products in 400 mg capsules. The GSPE I take are also 400 mg capsules, and I take the recommended dose of 3 capsules per day for a total of 1200 mg of GSPE per day. One can only imagine what this study would have shown had they used 400 mg or 1200 mg per day.

Additional Benefit: Reduces Insulin Resistance

One important side effect (health benefit) of GSPE is that it helps reduce insulin resistance which is much more common than many people think, and you don't have to have diabetes to have insulin resistance. I wrote a little about GSPE and insulin resistance here:


Where to Buy


1. $20.96 Grape Seed Extract Powder -  200mg of Grapeseed Extract Powder per Serving, 1,250 servings - Click here

2. $15.95 NuSci Grape Seed (Europe) Extract Powder Standardized 95% Proanthocyanidins OPC (100 Grams (3.52 oz)) Europe Grown GMO Free Non-Irradiated - Click here


1. $9.40 Swanson Grape Seed Heart Antioxidant 380 mg 100 Capsules - Click here

2. $14.99 Bronson Grape Seed Extract 400 mg 180 Vegetarian Capsules - Click here

About The Author

Art Solbrig is a researcher who has been reading scientific studies and testing natural remedies for over 30 years, searching for useful studies and alternatives that apply positively to human health issues and natural treatments using minerals, vitamins, amino acids, essential oils, herbs, homeopathy, colloidal silver, combination treatments, and other alternatives to improve the quality of life of others by writing about his findings and test results in places like Earth Clinic. He documents and writes about many of his experiences in helping others. Art is a native of sunny California.

Related Links:

5 Supplements to Help Reduce Insulin Resistance and Improve Health
Blood Clots, Heart Disease, and How Melatonin Can Help
Cardiovascular Disease (CVD) and Melatonin
High Blood Pressure and Carditone
Top Natural Treatments for Heart Disease (Cardiovascular Disease)

Grape Seed Extract

Posted by VKRP (Charlotte, NC) on 11/30/2023

High Calcium Score of 224

Hello, My CT cardiac calcium scoring is 224 and plaque volume at 179mm3 put me in the 96th percentile according to MESA database. The results show left anterior descending (LAD) as 220 and right Coronary (RCA) as 3. My cholesterol levels are high as well.

My doctor put me on moderate intensity statins and 81mg over the counter aspirin.

After reading through EarthClinic reviews on atherosclerosis I have started 1200mg of Grape seed extract.

My questions:

1. Can I take GSE along with aspirin since I read it is not advisable to take it with aspirin or any other blood thinners.

2. Is there a time of day that is better for taking GSE.

3. Any other supplements that would help with my conditions to get off statins and bring the numbers down naturally. Will keep my PCP in loop while trying these natural remedies.

Replied by Mama To Many

Dear VKRP,

My husband is able to keep his cholesterol down by eating oatmeal diet and following a plant based diet with some lean chicken and fish. Sugar is inflammatory and should be consumed minimally. He did lose weight on this diet, which likely helped as well.

Oatmeal is also helpful to lower cholesterol.

The author of, "Left for Dead, " wrote that cayenne pepper capsules would reduce plaque in arteries.

~Mama to Many~

Replied by Jan

I would be interested in knowing this information as well.


Replied by eliya
4 posts

I am a 76 years young female who has been battling the statin war for years. I realized the doctors will only discuss statins and aspirin, etc. due to the only protocol they know. It makes more sense to me to deal with the atherosclerosis instead of just lowering cholesterol. My question is since I am on blood thinners is it wise to take GSE and /or nattokinase?

2164 posts

Hi Eliya,

Since you are already on blood thinners (More than one?), you will have to ask your doctor if you can temporarily discontinue one or more of the blood thinners in order to consider taking high dose nattokinase and grape seed proanthocyanidin extract (GSPE). It may be helpful for your cause to show your doctor the studies for nattokinase and GSPE for atherosclerosis. Since doctors don't actually have a treatment for atherosclerosis, your doctor may be willing to consider the two.

To just do it on your own may cause too much blood thinning activity which would be dangerous for you.