Blood Clots - Art Solbrig
Natural Remedies

Blood Clots, Heart Disease, and How Melatonin Can Help

on Feb 19, 2022
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Blood Clots, Heart Disease and Melatonin.

When you look at all of the reasons that Dr. Malcom Kendrick recently gave Dr. Mercola as his hypothesis that blood clots might be the root cause for arteriosclerosis and the resulting cardiovascular diseases, and then look at those reasons compared to melatonin in studies, you quickly see that melatonin ameliorates many of them, including blood clots.

Here is a quote from the above study:

>>> '  A single dose of oral melatonin was associated with lower plasma levels of procoagulant factors 60 min later. There might be a dose-response relationship between the plasma concentration of melatonin and coagulation activity. ' <<<

This is the same reason that Covid-19 is able to damage the endothelium and cause blood clots to form rapidly in the wake of the damage and cause heart attacks and strokes even in younger adults. It's the damage-causing inflammation and oxidative stress that Covid-19 creates against the endothelium. Stop that, and stop the damage in its tracks.

Dr. Neel's work illustrates that melatonin shows the potential to stop some of this damage from Covid-19 to the endothelium as his patients manage to avoid much of these complications.

Melatonin repairs damage to the endothelium until it can no longer keep up with the rate of damage being done possibly due to the age-related decline of melatonin production. Melatonin levels decline vary significantly between the ages of 40 and 50. At that same time, while melatonin is declining in humans between 40 and 50, age-related diseases, of which cardiovascular diseases (CVD) are included, are increasing as shown in this link that shows that men start to get CVD around age 45. Interestingly, by age 50 our melatonin level has declined to that of a newborn, the lowest level seen until age 50, and melatonin levels continue to decline even further after 50, though at a slower rate.

Melatonin level by age :

So it should come as no surprise that by age 55 the rate of CVD has doubled in men and by age 65 heart attacks and strokes become a much more common occurrence!

If what gets the initial endothelial damage started is oxidative stress and the resulting inflammation-causing lesions, melatonin is a potent anti-inflammatory and antioxidant and scavenges Reactive Oxygen Species (ROS) and Reactive  Nitrogen Species (RNS) and Peroxynitrite very effectively and melatonin has protective effects for endothelial cells and the vascular endothelium. It may be the most effective treatment possible if it stops the process in the very first stages and studies show that it may do just that even once the process is already established!

Here are the results of this study :

>>> ' After 1 month of melatonin treatment, the mean level of ICAM, VCAM, and CRP showed a statistically significant decrease in the case group. On the other hand, the mean level of VCAM increased significantly in the control group. The mean levels of CRP and ICAM were also increased in the control group, but the difference did not reach the significant threshold. With respect to NO, there was a statistically significant increase in the case group, while there was a statistically significant decrease in serum NO in the control group.

The results of this study suggested that melatonin may have beneficial effects on endothelial oxidative stress even in patient with severe and advanced atherosclerosis. ' <<<

I wrote two articles on this very subject for EC in 2020 and 2021 here:

The point of all of this is that preventing or treating atherosclerosis should alleviate many cardiovascular events in our lives and it seems appropriate that our own bodies produce a substance, melatonin, that can do this very well!

Here is a relevant quote from the study :

>>> ' MLT alleviated endothelial injury by inhibiting inflammatory response, oxidative stress and cell apoptosis in atherosclerosis. Of note, MLT exerted strongly inhibitory effect on cellular senescence in aging-related vascular endothelial cells in atherosclerosis. In addition, MLT had a positive improvement on telomere length and telomerase activity, which might partly explain the potential mechanism by which MLT attenuated senescence in atherosclerosis. ' <<<

We may need to compensate for the age related decline of melatonin, either through supplementing or natural means for those who can't supplement melatonin, or, both supplement and natural means. I discuss two ways for you to naturally stimulate melatonin production in the following article :

Melatonin is made in every mitochondrion in the body and mitochondria are in all cells of the body except red blood cells, but even red blood cells produce melatonin! Melatonin is produced in the brain via the pineal gland and it is also produced in the gut at a rate that is said to be at least 400 times that of the pineal gland. The rate of production in the mitochondria eclipses that of the gut. Melatonin receptors are found throughout the body.

These are all huge clues as to how important melatonin is to our health. It is the same for animals who also naturally produce melatonin. It is also the same for plant life who flourish on melatonin. We do not currently know all that melatonin does to protect our health, but what we already know is that when we have higher levels of melatonin when we are younger, we are also healthier. It may be a coincidence, but studies confirm the positive health effects of melatonin. Melatonin's decline in production inversely mirrors the rise of age related diseases and declining health.

The importance of all of this is that heart disease is the number one killer in the world for both men and women!

Melatonin protects our bodies in so many ways and because of that, it might be a good idea for us to do everything that we practically can in order to help bolster our declining levels of melatonin. Cardiovascular disease is just the tip of the iceberg!


About The Author

Art Solbrig is a researcher who has been reading scientific studies and testing natural remedies for over 30 years searching for useful studies and alternatives that apply positively to human health issues and natural treatments using minerals, vitamins, amino acids, essential oils, herbs, homeopathy, colloidal silver, combination treatments, and other alternatives to improve the quality of life of others by writing about his findings and test results in places like Earth Clinic. He documents and writes about many of his experiences in helping others. Art is a native of sunny California.

Melatonin Dosage

Posted by parkypuss (Burson, CA) on 04/08/2022

I read through this rather quickly & didn't see any mention of what dosage is most effective. Any specifics?

Replied by Art
1515 posts


This first study used 10 mg of melatonin per day and showed benefits :

This next study used 250 mg of melatonin per day and showed benefits :

Both studies showed benefits, but the 250 mg study showed more benefit.



250 mg per day???

Why so much? For how long?

1515 posts


The nature of melatonin studies these days is that they are pushing dosing levels to new highs to try and determine if more is better and in this case, more was better. The toxic dose of melatonin in humans has not been found yet and in this case, they showed that 250 mg/day is not only not toxic, but very helpful for the heart! The 10 mg study was also beneficial, but not as much as the 250 mg study. This study was only for 12 weeks, but there was an ALS study that used 300 mg/day for up to 2 years.

Part of the issue with melatonin is that most people are mainly aware of it as a sleep aid at a very low dosing of 1/3 mg to 5 mg, so automatically 250 mg sounds like a huge amount of melatonin. If a study used 250 mg of vitamin C per day, most people would say that is so low of a dose that it isn't going to do anything.

There are other ways to get melatonin than supplementing with pills and I have previously written about two of those ways on EC here and I will soon be adding a third way:

The advantage of getting melatonin naturally is that it has no side effects, only health effects.