Melatonin For Diabetic Wound Healing
17 days agoThis new (March, 2025) study suggests that melatonin can be useful for helping to heal diabetic wounds :
https://www.sciencedirect.com/science/article/abs/pii/S0040816625001648?via=ihub
Here are relevant quotes from the study :
Highlights
- HG inhibits the AMPK/SIRT1 pathway in endothelial cells.
- Mel activates the AMPK/SIRT1 pathway.
- Mel upregulates HIF-1α expression by activating the AMPK/SIRT1 pathway.
- Mel improves endothelial cell angiogenesis and mitochondrial function via AMPK/SIRT1/HIF-1α pathway to promote wound healing.
The study lays a theoretical foundation for a deeper understanding of the mechanism of Mel to improve diabetic wound healing.
Melatonin Gel may be a potential way to apply melatonin for this purpose. Directions how to make melatonin gel here :
https://www.earthclinic.com/supplements/melatonin-gel.html
Art
Re: How to Increase Melatonin Naturally
17 days agoRe: Siamese Cat With Mouth Tumor
17 days agoHydrogen Peroxide for Skin Infection
17 days agoI scraped my foot on a rock at the beach and didn't try to squeeze any blood out nor treat it with disinfectant, thinking it would just heal ok on its own. Unfortunately it got infected. I tried all the remedies listed on EC plus some creams recommended by a few pharmacists in different countries.
One thing I noticed is that the infection was always not painful after getting deep sleep, but then it would get painful during the day. So deep sleep is always key, but it wasn't sufficient to fully heal. Next, I noticed that simply keeping the wound moist was critical. Even soap water on some paper taped onto the area helped a bit. Any EC remedy which keeps the area moist without allowing more pathogens to grow will help.
But the only thing that actually strongly fought the infection during the day was 6% h2o2 taped onto the wound. It would need to be reapplied every few hours as otherwise it dries up. The reason I think this works better than other EC remedies (which exception of DMSO which wasn'tt listed but should work), is because the 6% h2o2 literally dissolves skin (slowly) and scab formation, so it is able to slowly penetrate into the area in this way despite not being able to penetrate skin directly or immediately.
I was really shocked that neither AI nor any medical professional knew how to treat a skin infection correctly. I am glad I had this learning experience because it's a very common problem for many people.
Siamese Cat With Mouth Tumor
17 days agoHi, we are treating our Siamese cat who has a growing mouth tumor that is pink, and now has white pus(?) in it as well.. we are giving NHV tinctures, celloquent, cbd/thc and panacure…
wondering if we could dab castor oil or black salve on it to shrink the tumor? Help! Our fav cat!
DMSO For Bronchitis
17 days agoI, like many of my family members, get bronchitis nearly every time I get a cold. This time, for me, was especially bad. I had been reading about DMSO and its incredible claims for cures and pain relief from anything to joint pain to brain bleeds. There is actually quite a few research papers and studies on this incredible solvent, which I will leave to you to research. I looked to see if anyone with bronchitis had used DMSO, since it is a powerful anti-inflammatory, and indeed they had. So, I took pharmaceutical grade DMSO, made a solution of half water and half DMSO and rubbed it on my chest and upper back. The coughing stopped within 20 minutes and the next day my bronchitis was nearly gone—just a bit of lingering congestion. I was more than amazed. I wish I had known about this my entire life! I've read that you can do a 70-30 solution, but I'm sensitive so I instead used 50/50. I will use the solution for three days twice a day. Be sure to test the solution on your skin first to make sure you tolerate it well. And remember that DMSO carries things extremely efficiently into your blood stream, so be free of lotions, etc. in the area you are treating. DMSO has a long list of things it helps in the human body, with great effectiveness. A Midwestern Doc on Substack has done extensive writing about this solution and its history. I am absolutely blown away by my quick turnaround from a bad case of bronchitis and wanted to share.
Re: Oregano, Tea Tree, and Clove Oils Helped Tinea Versicolor
17 days agoRe: How to Increase Melatonin Naturally
17 days agoHi Joan,
My experience and reports from users who tried vodka as the solvent, was that it required significantly more vodka than gin, to effectively dissolve the melatonin powder where the gin looked clear again after fully dissolving the melatonin powder. This further weakens the useful effects of the aloe vera gel itself or if making melatonin lotion it results in a much watery lotion. Gin itself also has useful botanicals in it which I consider to be another plus to the gel or lotion mixes.
I suggest to friends who want to try it for the first time to make it as my friends did for their initial batch just to see if you find it helpful. If you find that it works for what you want to use it for, then you can start experimenting with other options as you now have a basis for comparison between the original mix and your variation of that mix.
I had one friend who started adding multiple other ingredients to the mix and ended up where it no longer worked for what they were using it for. They ended of going back to the original mix because they said it works.
Art
Seeking Guidance After PD Diagnosis
17 days agoHi Redwine,
The thiamine / vitamin B1 protocol for PD has two main forms, low dose dissolve in the mouth tablets or high oral capsule doses, which was the original method discovered by an Italian neurologist named Dr. Antonio Costantini. One thing he frequently mentioned was that a dose that is too low will have no effect.
There is a Facebook group which discusses the low dose dissolve in the mouth method and has a large and active following. Here is a link to that group :
https://www.facebook.com/groups/parkinsonsb1therapy/info/?_rdr
For high dose, the effective dosing range varies greatly from 25 mg/day up to 5000 mg/day. Finding the precise and most effective dose for both the high and low dose can be the greatest challenge for either regimen. If you want to know more about how Dr. Costantini determined oral dosing levels for B1 let me know as I wrote a brief article on that.
The B1 regimens do not work for everybody, but they seem to work for the great majority of people with PD (PwP). The beneficial effects vary greatly from person to person. I have made a list of the reported benefits of B1 from actual users of high dose thiamine (HDT) for PD. Let me know if you want to see that list.
There are multiple reasons for why B1 may help PwP. One is that, at higher doses of 200 or more milligrams per day it lowers the inflammatory marker IL-17 very significantly. IL-17 is a very important inflammatory mediator in neurodegenerative diseases. PwP seem to have elevated levels of IL-17 in the brain region.
Another important reason why thiamine is useful for PwP is that it promotes short chain fatty acids (SCFAs) such as propionate, acetate and butyrate in the gut microbiome, which are beneficial and health promoting for gut microbiome health as well as the whole body and help to reduce other inflammatory markers that are elevated in PwP. PwP are known to have significantly reduced SCFA levels as well as gut dysbiosis and constipation being the norm. Increased SCFA content and activity is useful for promoting a healthy gut microbiome and reducing oxidative stress and inflammation levels.
In my opinion, these two important activities of B1 are likely very useful for PwP in potentially slowing disease progression and reducing symptoms though no studies have yet directly confirmed this yet.
Vitamin B2 / Riboflavin has also shown some benefit in at least one study as discussed here :
https://pmc.ncbi.nlm.nih.gov/articles/PMC5517396/
Here is a relevant quote from the above research paper :
' In conclusion, riboflavin is a potential neuroprotective agent affecting a wide range of neurological disorders exemplified by PD, a disorder of neurodegeneration, and migraine headache, a disorder of pain. '
Vitamin B12 has also shown homocysteine lowering effects which is more important in PwP as they often have higher than normal levels of homocysteine with lower B12 levels that can increase the potential for cognitive decline and decreased mobility levels as discussed here :
https://pubmed.ncbi.nlm.nih.gov/29508904/
Here is a relevant quote from the link :
' Elevated homocysteine at baseline was associated with worse scores on the baseline MMSE. Analysis of study outcomes showed that compared with the other tertiles, participants in the low B12 tertile (<234 pmol/L; 317 pg/mL) developed greater morbidity as assessed by greater annualized worsening of the ambulatory capacity score. Elevated homocysteine was associated with greater annualized decline in MMSE (-1.96 vs. 0.06; P = 0001). '
The vitamin B group is generally considered useful for PwP.
Melatonin has also shown in multiple human studies to offer some benefit. Three main driving forces of disease progression are oxidative in the form of reactive oxygen species (ROS), inflammation and neuron degeneration related to these two forces in the brain. Melatonin crosses the blood brain barrier and helps fight all three of these issues in PD. Melatonin is also a potent mitochondrial protector, but melatonin levels decline rapidly as we age and even more so in PwP, which is an age related disease. The highest risk factor for getting PD is increasing age. The following human study shows how melatonin has restorative effects on the mitochondria of PwP when taken at a total of 50 mg/day:
https://onlinelibrary.wiley.com/doi/10.1155/2021/5577541
Here is a relevant quote from the randomized, double blind placebo controlled study (RCT) :
' Taken together, our data showed that melatonin supplementation recovers mitochondrial function and diminishes oxidative stress. Thus, this indolamine could play a role as an adjuvant in the treatment of PD.'
Another consideration about melatonin is that PwP are at increased risk for cardiovascular disease (CVD) and melatonin helps fight CVD through multiple methods of action.
There are many other supplements that have shown varying degrees of benefit for PD, but this should be enough info to help you get started in finding useful supplements for PD.
Art
Seeking Guidance After PD Diagnosis
18 days agoI am 57y/o and was diagnosed with essential tremors when I was 45. At 55 I saw a new neurologist who diagnosed my with Parkinsons, I currently take 2 pills 3x a day of Carbidopa-Levo ER 25-100 per day. I take Gabapentin at night to help me settle down and sleep.
I am interested in acupuncture and vitamin supplements, but I am unsure of doses and if anyone can give me insight into the treatment of Acupuncture, if they have had much success?
How do you use Hydrogen peroxide as a supplement? drink it straight? I recently started take B-1 thiamine but it's to soon to notice a difference. 500mg should I be taking more?
Re: How to Increase Melatonin Naturally
18 days agoRe: How to Increase Melatonin Naturally
18 days agoHi PayItForward,
If oral melatonin causes you to experience nausea, here are three options that you can try as an alternative.
The first option is to try reducing the dose as you mentioned using a low dose dissolve in the mouth form of melatonin.
The second option is to get melatonin through the natural means that I mentioned at the beginning of this thread such as earlier morning sun exposure or foods rich in melatonin as two examples. This option is the one that should not cause any side effects in almost everyone.
The third option is to use Melatonin Lotion or Melatonin Gel applied to the skin. Topically applied melatonin is first absorbed into the layers of the stratum corneum and slowly released into the blood stream over 24 hours, mostly avoiding the stomach and digestive tract which may prevent the nausea you are experiencing. Topically applied melatonin is also beneficial for the skin and can relieve multiple body aches where applied. Here is a link describing how to make melatonin lotion or gel and over 40 uses for it :
Melatonin Lotion
https://www.earthclinic.com/supplements/melatonin-lotion.html
Melatonin Gel
https://www.earthclinic.com/supplements/melatonin-gel.html
Art
Where to Buy Ivermectin?
18 days agoRe: Safe Pregnancy Liver Supplements?
18 days agoDon't do it. No need. Anything can harm a developing fetus. Staying away from electronics and Wi-Fi is the most important thing. Picture scans are not harmless either. Regular ultrasounds should be limited to an absolute minimum. Lots of literature about it. Even FDA warns about it.
Re: How to Increase Melatonin Naturally
18 days agoDear Art, Appreciate you and sharing how to get melatonin naturally. If you have time, can you please make suggestions for a strong nausea response to oral melatonin? I know there are great benefits from melatonin but don't know how to quell this response. I've ordered sublingual (1mg) in hopes this form may be better than capsules.
Thanks much ~ Keep well.
Glutamine for Hypotension - Response to Art
18 days agoArt,
Thank you for looking at this article with me. I appreciate your wisdom.
Yes, I noticed that they stated that, Glutamine, "promotes cardiovascular health by serving as an L-Arginine precursor to optimize nitric oxide ".
Many have said that Arginine lowered their High blood pressure. I was wondering that if the Glutamine somehow "fixes blood pressure" to stay in a safe zone.
As far as how low my blood pressure dips, I have noticed that it really depends on what, and how healthy I ate that day and night before I went to bed. If my blood pressure is normal before I go to bed, I have to skip my circulation supplements, or they will drop my pressure to the forbidden zone.
When I do take supplements for blood circulation, (Pine Bark, Co Q10 and Ala), I have to give them a few minutes and check my pressure before I stand up. Glutamine is giving me a satisfactory rate for now, I will watch and see if it really is what is keeping me in the safe zone, if not, I will go back to what I was using before.
Thanks again, "I will let you know how it goes."
HisJewel
Re: Mung Bean Soaked Fermented Water for Diabetes Type II
18 days agoGlutamine for Hypotension - Question for Art
18 days agoHi HisJewel,
All studies I have read regarding glutamine suggest that it can lower high blood pressure with no mention of being able to elevate hypotension. The link you posted is similar to the other studies in this sense, mentioning the potential to decrease hypertension, but not mentioning the potential to increase hypotension blood pressure levels.
If you are correct in your idea that glutamine can raise low blood pressure levels, you may have a new use for glutamine!
As far as how it works, it may be through another mechanism of action than the mechanisms described in your link such as increased NO production which would certainly cause further decreased blood pressure.
ChatGPT says that hypotension is associated with gut dysbiosis. Glutamine at appropriate dosing is noted for improving the gut microbiome, offering another potential way that glutamine may be improving your hypotension.
The link you supplied also mentioned that glutamine can have other positive cardiovascular effects, but also mentioned that in some people it can have negative cardiovascular effects. Here are two relevant quotes from your link :
https://pmc.ncbi.nlm.nih.gov/articles/PMC6769761/
' Moreover, emerging data indicates that Gln elicits both beneficial and detrimental effects on cardiovascular health. '
' Importantly, Gln alleviates many known risk factors for cardiovascular disease, such as dyslipidemia, glucose intolerance, insulin resistance, hypertension, and obesity. However, the rewiring of Gln metabolism can also promote the development of cardiovascular disease by fueling the Krebs cycle and stimulating the unrestrained growth and migration of vascular cells and the deposition of extracellular matrix. '
So the above quotes should play a role in deciding whether glutamine is the right way to try and control hypotension for everyone. I imagine the effective dose being used would also play into that equation.
Since you also use the Licorice Extract, can you give any feedback on how effective it is for your hypotension and what dose you are using and how often?
Please keep us posted on how the glutamine works out for you!
Art
Safe Pregnancy Liver Supplements?
19 days agoWormwood, Black Walnut, Cloves for Parasites
19 days agoI have been using the Oregon's Wild Harvest Wormwood & Cloves & Herb Pharm's Black Walnut tincture to follow the Dr. Hulda Clark cleanse. I began on March 20th, 2025.
I have not followed the Dr. Hulda Clark instructions chart to the letter as it was hard for me to eat much due to the following ailments. Extreme stomach issues lack of appetite, chronic constipation, forgetfulness, waking up every single day feeling like I was beaten or hit by a big mac truck, low blood pressure after every single meal and often upon waking, total and complete insomnia (cannot sleep w/o xanax, this is the only prescription I take, besides Premarin) (Premarin got rid of my deep depression, crying & suicidal thoughts), constant vaginal infection, interstitial cystitis, left sided eye herpes (gift from Covid), kidney stones and I'm sure there are other things I deal with that I just cannot think of right now. I did have severe left sided kidney pain for 3 years and Borax did take that pain away. (Added a pinch to every cup of coffee each morning. I usually drink 4 cups.)
I picked up parasites when on a trip to Belize in May 2017. Although, I didn't have any immediate reactions after eating at a roadside dive with 10,000 flies and dog walking around that was literally skin and bones, but I saw the people feeding the dog, so I know it wasn't because it wasn't being fed.
Within 5 weeks of returning, my nightmare began with constant crying, depression, hopelessness and wanting to commit suicide. I had nothing wrong with me other than this at the time. My crying, depression, hopelessness & suicidal thoughts grew worse by the day. I also started passing parasites over the next year. I went to many doctors, showed them pictures of the parasites I passed and even took one in alcohol to them. All recommended stool testing and none of the 2 different stool tests ever showed I had parasites. This is how doctors invalidate you and make you think you're crazy when YOU'RE NOT!
On a side note: I had also suffered from terrible halitosis prior to going to Belize and my MIL suggested taking Chlorophyllin to get rid of it. I took the Chlorophyllin off and on and then one day in March 2018 I ended up with Copper poisoning after taking 3 doses of Chlorophyllin in a day (Chlorophyllin contain 100% of DV of copper per dose and is not naturally occurring in actual Chlorophyll plants) Magnesium is at the center of chlorophyll plants. Copper Sulfate is added to Chlorophyllin and makes Chlorophyllin an inorganic source. My eyes turned yellow, it went straight to my head and I immediately had neuropathy in my hands and feet. Since becoming Copper Toxic, verified by an MD, DO Doctor, via Copper Serum and Zinc Serum measured test (Don't fall for the ridiculous hair test way of measuring) I have not been able to fall asleep on my own a single day. No naps, just simply can't fall asleep and if I do happen to fall asleep (very, very rare w/o xanax) I constantly startle awake every 5 to 15 min.
Through this doctor, I was able to get rid of the peripheral neuropathy with 1 round of DMPS Chelation. It costs $500 a pop though, but the other 4 sessions did not change anything else for me. In fact, this is what I believe caused severe food allergies for me and an ulcer as well as SIBO, because I had an underlying Fungal infection. Forgot to mention those things above.
I intend to do 4 cleanses back to back as the 2nd reviewer Ramona stated of the two testimonials for Wormwood, BW, Cloves: Ilovelife (Tucson, Az) on 11/15/2013 and Ramona (Euless, Tx) on 06/08/2010.
I noticed that both of them took a complete tincture form and not the pill combo tincture form that is now offered on Dr. Clark Store website. (both reviewers referenced the Dr. Hulda Clark Cleanse). I follow the Dr. Clark (18 day chart you can find on their website), but do not use their products as they became extremely high priced for awhile and because their "green black walnut tincture" has either chlorophyllin added to it or food coloring as I have never seen any real green black walnut tincture be HIGHLIGHTER GREEN. It is unnaturally HIGHLIGHTER GREEN. Well, I guess Dr. Christopher's is too.
I assume after Dr. Hulda Clark was ran out of the country and went to practice in Mexico I believe, that the company was forced to change their products from tincture only to pill/tincture combo.
Today is 4/14/2025 and although I have not resolved even 1/2 of my issues the most amazing thing that it has cured me of, is feeling like I've been beaten or run over by a big mac truck every night while sleeping and upon waking. Praise God!
Also, I am feeling like taking my xanax at 9 PM to 10 PM every night and going to bed, which hasn't happening in years. Usually, I would stay up past midnight til anywhere between 2 am & 4 am before taking xanax to sleep.
Also, nighttime hunger and constantly wanting to eat junk at night has drastically reduced to nearly zero.
I have been severely underweight for many years as well and has helped me to gain 6 lbs. I assume that whether you are under weight or overweight, that it will help regulate your weight over time and you will begin to absorb the nutrition and calories properly from your food.
I will update my post over the next few weeks months to let you all know my progress.
