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Hi ariley...It's certainly true that prion diseases like Altzheimers, Parkinson's and Creutzfeldt-Jakob disease(CJD) are currently incurable by allopathic medicine and I would also wholeheartedly agree with you that the accompanying neuronal demise can be caused by NAD+ and coenzyme Q10 depletion.

To save time, here are some useful tips on how to alternatively treat prion diseases involving misfolded tau and amyloid beta proteins. Here's what I would personaly use to treat diseases relating to prion disease:

1. Methylene Blue(MB) - Through my own research I have found that MB is the only nutraceutical with the ability to actually destroy prions in the body. Also be aware that that although MB in its pro-oxidant form can indeed neutralize and eliminate prions, it cannot really fix the neuronal damage that has already been caused by prions disease. See links below:

Methylene blue and Alzheimer's disease https://www.sciencedirect.com/science/article/abs/pii/S0006295209003359

Binding of methylene blue to a surface cleft inhibits the oligomerization and fibrillization of prion protein
https://www.sciencedirect.com/science/article/pii/S0925443912002141

2. Coconut oil. There are several coconut research reports and many case histories describing describing successful remission from Altzheimers Disease. See below:

Peer Reviewed Coconut oil Research
https://coconutoil.com/peer_reviewed/

Other Coconut Oil Research(not peer reviewed)
https://coconutoil.com/coconut-oil-research-alzheimers/

3. Niacin/Niacinamide. And the easiest way to increases NAD+ stores in the body would be to supplement high dose niacin or niacinamde(3gms per day directly after meals). Abraham Hoffer, an orthomolecular psychiatric researcher) has some interesting things to say about taking high dose niacin/niacinamide here:

Therapeutic potential of niacin in Alzheimer's disease
https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002/alz.040679

4. Lithium Orotate(LO). Dr Hans Nieper is quite famous and well known for creating a whole range of unique, alkaline mineral formulas. I recommend LO because the brain, in old age, always shrinks in size and there is no reasonable scientific explanation for this brain size reduction other than "It's just old age that cause the brain to shrink, right?". Wrong! If you take LO every day, this will actually stimulate brain growth. So, according to my way of thinking, LO therefore stimulates the proper use of protein for brain growth. Also please remember that tau and amyloid beta are forms of protein in the brain!

I've been taking all the above supplements fairly regularly to keep my own brain in top health. Notably, all the above nutrients are also capable of penetrating the blood brain barrier.

I must also mention that mid-2024 I started forgetting things. Simple words, mainly places, names etc. As a 76 yo man, this was quite worrying for me. The supplements that made the most difference for me are all the supplements mentioned above. My memory is back to normal now.

Here are my preventative dosages:

Methylene Blue: Between 10 and 30 drops of MB in water taken once or twice a day depending on the coming stress levels that day. MB dosage is difficult to advise because people have different sensitivity to MB. So my advice to you is to start low and increase your MB drop dosage until your brain "wakes up" -- and that is your dosage.

Coconut Oil(CO): As a preventative take tablespoons of CO per day directly after a meal. If you have Altzheimers/Parkinsons then take 3 tablespoons CO a day directly after meals.

Niacin/Niacinamide: As a preventative -- 500 mgs per day taken after a meal. For Altzheimers/Parkinsons you can take up to 3 gms of niacin/niacinamide per day in split doses. Take 1 gm niacin or niacinamide 3 times a day after meals.

Lithium Orotate(LO): As a preventative, 10 mgs LO per day taken outside meal times. For Altzheimers/Parkinsons you can take 20mgs or more LO in split dosages, it's up to you.