This brand new study suggests that drinking 480 ml of Montmorency Tart Cherry Juice or taking capsules of the tart cherry each day had little to no health benefit in the parameters tested in the study. This suggests that Montmorency Tart Cherries are a poor source of melatonin.
Here is a link to the study :
Here is a relevant quote from the abstract :
>>> ' Despite the potential benefits of antioxidants and melatonin, we did not find improvements in sleep time or quality, cellular health or BP in participants consuming MTC for 30 days, though BM decreased in capsule groups. ' <<<
This study implies that if you plan to get your melatonin and its known health benefits from cherries, that will not likely happen. Even if you are just looking for better sleep, the result is still likely to be no benefit.
Melatonin and Anti-Rejection Drugs
Because of the serious nature of your wife's condition (kidney transplant & potentially related issues), you should be talking to her transplant specialist about the use of melatonin and here are a few studies that suggest that melatonin may be beneficial, which you can show to her doctor to give a little more information on the potential utility of melatonin in kidney transplant. I am not a doctor and this is well beyond the scope of information that you should be looking for on a forum that specializes in home remedies. Here are a few relevant links that her doctor can consider as to whether melatonin will be useful for her specific case. :
Best wishes to the both of you!
Melatonin and Anti-Rejection Drugs
Attn: Art from California
My wife is on anti rejection drug for kidney transplant and blood pressure medication.
She has trouble sleeping and told me Melatonin can not taken. Please let me know is that the case.
Use vitamin d it is the sàme at over 500 u per week if sick help with more until it abates and go back to th 500 u again every week
Melatonin and Daytime Use
One of the concerns that people have with using Melatonin 4 times a day for covid or other viruses is that, because Melatonin is used to help with sleep it is presumed to make you too tired during the day. I will share some of my personal experiences with that.
When we had covid back in January we all used high dose Melatonin (thanks to Art who kept us informed about the protocol! ) I used it on everyone in the house - ages 9 to 83, based on weight, as Dr. Neel recommends. We took it 4 times a day.
My 83 year old mother in law with dementia did not know what the pills I gave her were, I just added them with her other meds and supplements. She was not symptomatic of covid, but we were using it to try and prevent covid since others in the home had it. (I think it worked, or at least helped! She never got sick, but did lose her sense of smell.) Anyway, her sleep/wake patterns were no different than when she wasn't taking round the clock melatonin. (She always takes it at night.)
It was hard to tell how it affected those of us who were actually sick. Sick people sleep more.
I take 15-20 mg of melatonin every night to help me with sleep (and it definitely improves my quality of sleep! )
Last summer, an hour after taking my melatonin dose, my daughter-in-law went into labor. I had an hour of sleep but woke up easily and drove an hour and 20 minutes to the birth center where she had the baby. I had no trouble driving and no trouble staying awake all night.
I had the opportunity to repeat the experiment last week. I had taken my 20 mg of melatonin and fallen asleep when my daughter went into labor. I woke up and stayed up the rest of the night with her and was able to see another grandchild born. (What a privilege! )
I cannot know how it affects others. But I can say that melatonin does not make it impossible for at least some people to stay awake after taking a significant dose. Certainly it would be wise to know how such a dose would affect you before driving a long way or using heavy equipment.
~Mama to Many~
Where to Buy: UK
Thank you for replying. Delivery from Piping Rock was super fast, it only took 1 week from US.
Where to Buy: UK
This one ships to the UK:
You can get melatonin by prescription in the UK and any dose is better than no dose. If your Dr. will write a script for each of you for 5 mg capsules for sleep, that amount may hold you over until your order arrives.
Where to Buy: UK
I'm in the UK & my son who is asthmatic have just been diagnosed with Covid. Did you manage to find a UK supplier please. I have ordered some from Piping Rock but it will probably take a couple of weeks to get here.
I have noticed nose bleeds with melatonin
Yes, there are people who can not tolerate melatonin as I have mentioned many times on EC, but the majority of people do tolerate melatonin as shown in many studies. Generally, as soon as you realize that there is a negative reaction to melatonin or you are not tolerating melatonin because of symptoms such as you described, it is probably a very good idea to stop using melatonin immediately rather than continuing. It is sort of like your body is trying to let you know that this is not compatible with you.
For many years, I had trouble sleeping and took Melatonin and always felt groggy and a hangover from taking it, but since pot is not legal in TN, what choice did I have? And then all of a sudden, my whole system flipped and then suddenly I couldn't get enough sleep! Suddenly 8 hrs was not enough and I always felt exhausted! What a nightmare! Not saying the melatonin had anything to do with it, but it what I was taking and it scared the holy hell out of me!
Now I'm fighting diabetes and liver damage and thyroid malfunction which came on all of a sudden also and while I am overcoming that slowly but surely by alternate day fasting, cutting ALL wheat products out of my diet, and the old timey cottage cheese and oil (Flax, black seed & Hemp oil) medicine cancer cure remedy!
But I'm not my old self by any stretch as before I started taking melatonin every night and so am very leery about ever taking melatonin again! Besides it always makes you feel so tired and groggy and who the hell needs that when your 65 yrs old? Certainly not me! So the jury is still out on that one! The side effect of melatonin is it makes you drowsy and tired, and I need just the opposite of that!
Isn't it strange that they banned melatonin in England, Scotland and Ireland back in 1995? It's even more strange that they haven't allowed it after the thousands of studies that have been done on it since then worldwide. How archaic!
Perhaps now is a good time to start a petition in your country to legalize it for over-the-counter use.
Where to Buy: UK
I found 10 mg capsules on Ebay UK :
You may have missed my post about Xlear Nasal Spray for Covid-19, but these are the two main components I plan to use if I get Covid-19. Here is a link to that post :
Here is a link to the product on Amazon UK :
If you can, get her started on the spray if you can get it from a local drug store. The post that I linked to above shows how they used the Xlear Nasal Spray, how often and what effects it had on the small group of patients.
Good luck to you and your friend!
Where to Buy: UK
One of my friends has just been diagnosed with covid and she is higher risk so I'm worried. I am in the UK where melatonin is not available. I've been looking at buying melatonin from pharmacies in Poland but they only seem to sell 1mg or 3mg so I would need a huge number to ingest 80mg per day for covid-19. Also many refuse to post to the UK.
Can anyone advise me how to buy sufficient quantities from a reputable source?
Thank you for the feedback on melatonin!
What I have noticed is that some people can develop diarrhea from HDM [High Dose Melatonin], but in the few people I have seen or heard of this side effect, that delay, can vary from 3 days to 3 weeks. In either case, the delay makes it possible to use melatonin long enough to help achieve the desired result with Covid-19 and it may be possible to use melatonin for a very brief period even if diarrhea does occur in an attempt to have maximal effect on Covid-19. Stoppage of HDM seems to allow a fairly quick recovery from the diarrhea. I still feel that the combination of melatonin plus the addition of the Xlear Nasal Spray, suggest the potential for a quick recovery.
Here is a link to what I wrote about Xlear Nasal Spray and Covid-19 : Https://www.earthclinic.com/xlear-for-covid-recovery.html
Regarding Melatonin Side Effects,
Melatonin was a big help in starting my fight to get well even with side effects.
I decided to reorder some more Melatonin, because I was glad that I had it on hand to meet a possible emergency during my coughing fits. As I mentioned I took about 100mgs of Melatonin for each of 3 days. I took 4 to 5 pills a few times a day and once at night. They were 5mgs each. No, my brand did not make me sleep or sleepy; however, I found that when I was ready to sleep they let me sleep at least an hour or two at night. The side effect I had was loose stools.
Some years ago, I had ordered some Melatonin from eBay. I am not sure why I bought them, I do remember reading a book back then that said it was good for stopping any further memory loss in its track. Anyway, this Melatonin product was from overseas, it was a powder, and a very high mgs per tiny scoop. I do not remember the company. I remember going to sleep that night and not waking up until morning. In the garbage it went. As I used to do all night prayer often and too much sleep would interfere with my work. The interesting thing is I do not remember having any side effect, only what it said it would do give me sleep.
The Melatonin that I had on hand when I was sick this month, I bought last year because Earth Clinic, Art and others posted Melatonin benefits for COVID 19.When I decided to buy more, I noticed that I needed to find out what "Other ingredients" are in each brand and kind of Melatonin. The company that I got mine from had at least 3 different kind of Melatonin mixtures. I did not want any artificial sweeter in mine so I was reading the labels. Then it dawn on me that perhaps one of the" Other ingredients" in the brand that I already had was what caused the side effect that I encountered. So please read the label.
Yes, melatonin has blood thinning and anticlotting effects, so getting your doctor's approval if you are already on a blood thinner makes safe sense. Too much blood thinning is bad and can be dangerous. Some common supplements like vitamin E and Serrapeptase can have blood thinning effects also, so anyone who is already on a blood thinner should seek their doctor's advice if adding a supplement with blood thinning qualities.
Melatonin and Blood Thinners
Does Melatonin have an effect on a person taking a blood thinner?
Try this combo for better sleep :
I, too, had little success with melatonin until Deirdre (I think, or was it Art?) mentioned large doses. I now take 10 mg an hour before bed and 10 mg of timed release melatonin just before bed. I also take niacin (for cholesterol, but the flush helps me sleep), only 500 mg, every night along with the timed release melatonin. I've been sleeping much better since I started this protocol. I still don't sleep great, still wake up off and on, and sleep only for about 5 hours per night, but it's so much better than it was. What does are you taking, Jake? Be careful, tho, since melatonin can make your stool loose. With my ibsd that's a real concern, but this dose I'm taking seems to do well.
I have read a report recently that talks about the mixed findings with melatonin. It's hypothesis is that it relates to the circadian rhythm and should be taken at least 2 hours away from food. It is suggested that one might try to eat dinner earlier, and/or skip breakfast so as to avoid glycemic interference.
I definitely feel your pain. I had insomnia for years. Turned out it was gluten. (Yeah, I thought I'd tried eliminating it, but I guess I hadn't. If I get even a pinch of flour, ping, eyes wide open all night long.) Melatonin makes me loopy as well unless I take a tiny tiny dose. Also, if I do high intensity workouts sometimes that makes it worse, especially if I'm fasted.
GOOD LUCK and SWEET DREAMS.
I've been taking a, for me, high dose of melatonin for insomnia. I've been taking 10 mg at 7, another 10 mg at 8 and one more at 9, then off to bed. The first night I slept fine, next night not so great and, but the third night, was having stomach troubles. So, I backed off for a week. I then to 10 mg at 7 and, at 9, took a 10 mg timed release tablet. I kept waking up but my concern is that I was dizzy. I had to be careful getting up and then was fine. So I stopped it for several days.
Then, last night, I took a 5 mg regular tablet and, during the night, woke up dizzy. Even at the gym this morning, doing barbell bench presses, I was dizzy upon sitting up. So, is this the melatonin or something else? I stay hydrated and my blood pressure was good (I took it several times), so it's not that.
Possibly low blood sugar? I had not eaten for some time when it happened. Any thoughts? I swim, so wonder if it's not my ears? I do not have vertigo during my normal day, only upon rising from flat to sitting (of course I don't stand until it passes). I don't want to visit a dr until I've eliminated other causes. Thanks. I really need relief of the insomnia! I've taking benadryl and want to stop.
Dear Gertjr - I'm very sorry to hear that your husband passed away. You have so much stress to deal with but I'm glad to hear the melatonin is helping. As difficult as it is with so much to do, you will need time just for yourself - to grieve, to rest. You are in our thoughts. Take care ...
I am very sorry for the loss of your of your husband.
I am glad that you found benefit with melatonin and I hope it continues to help you through this difficult time. You need good sleep to allow your body to repair itself after so much damaging stress. Good health to you!
Gertjr, Sorry for the loss you are going through. Griefshare is a website that will send you free daily encouragement and information on how one processes and how it affects the body.
Many people avoid talking about grief trying not to cause more pain. Then it can be difficult, not feeling like you have someone to talk to about what you are going through. First and foremost stop all negative chatter in your head . Write positive things to say to yourself. I did well and I am well. Every day I celebrate how good life is, and I remember the good things . I have suffered depression and all that comes with it so I say this to encourage you as you transition to the next beautiful stage of your life. HIs Blessings, Charity
Bless you. I am so sorry about the deep loss of your husband! 💔😢
~Mama to Many~
I tried Art's protocol over the last few days and it worked! I was so pleased. My husband passed away on Saturday and I was exhausted and really needed sleep, had finished all my Tramadol (needed to stop taking it anyway), and took 3 mg every hour, going to bed after the 3rd dose. Slept like a baby until the cat woke me up, then went back to sleep for another hour, 7 hours in all. After several nights at the hospital, this was such a blessing. The last 2 nights haven't been quite that good, but still better than I expected with having so much on my plate right now. Thanks, Art.
I have a bit of migraine pain today, so hopefully that's not the melatonin but the stress. I'm probably a bit dehydrated, too, so need to take better care of myself.
EC: We are so sorry for your loss, GertJr. Sending you much love.
Old post but the melatonin may have been ineffective if it was not actually melatonin - a fraudulent product. Trying a different brand might have been the solution. My brand always works for me, my Mom's does not always work for her.
thank for suggesting that the electronics be turned off earlier at night for a natural melatonin. I was reading all the comments and many of them had the electronics piece in common.
Can you express a little more on the relationship between melatonin and the pineal. Thank you.
I have been taking Melatonin for 7 months now and originally started to have vivid dreams and now my dreams are much more gentle but amazing nontheless, and great sleep indeed ... I started with a cream of 50mg per night for the first two months then upped the dose to 100mg per night for 4 months then tried the 250mg SR capsules but I was a little woosy in the morning, so I stayed on the 100mg for another month and now I am almost done the bottle when finished then I will try 250mg SR again ...(SR) stands for slow release ;) eventually working up to 400 or 500 mg at this point the pineal opens up and you begin to experience the truth of who we are ;) those who have done the research already know this.
Thank you for responding back and I appreciate your input very much! Since my last post what I have done for the next 2 nights was stay at 2mg of melatonin and even though for both those nights I got awake in the middle of the night, I fell back to sleep for each of those nights for about another 2. 5 hours approx so I guess that is a good sign. Maybe my body had to get used to it if that is possible, I don't know. Last night I upped it to 3mg and slept striaght thru for a total of about 6. 5 hours. I'm atleast happy with this because I know for years that I have only been averaging about 5-6 hours of sleep per night. So "maybe" I am on the right path with the melatonin. Time will tell.
As far as you mentioning the B-12 and methylfolate, I have tried both of those in the past and both never seemed to do me any good. I think I have tried most every supplement under the sun LOL (and then some.. Haha) I had my B-12 levels checked awhile back and they were fine.. Actually very good but at that time I was taking B-12 even though it really didn't help me. As a matter of fact I have read that some people that are hypoadrenal can't handle the extra B-12. Whether or not that is true I don't know, but maybe it was true for me. I seem to even feel more lethargic which doesn't help my depression even when I do Brewers Yeast. Maybe it is a particular B that isn't agreeing with me. I "might" have been taking too much Pantethine. I tried it because many others and other websites mention it is good for hypoadrenal but quite frankly ever since I stopped taking it, I seem to be not as fatigued and not as achey in my joints.
The site that I have frequented often which I think has a lot of good information is......says that too much intake of B-5, people can get severe fatigue and joint pain. Maybe this applies to me because ever since I stopped it I an not as fatigued nor as achey in my joints. The site actually mentions B-1 thiamine good for people that are hypoadrenal. It says that extra thiamine can help raise sodium, which I know us later stage AF'ers deal with. He also mentions choline can help with that also. Funny how when I did the Braverman test online awhile back I was also Acetylcholine deficent as well as being Dopamine deficient. So I am also starting to take CDP-Choline as well as some lecithin granules which I know Ted is very high on taking. I noticed you said you are still low cortisol. Have you tried extra thiamine? I just started yesterday taking Allithiamine. Apparently it is similar to Befotiamine that it is fat soluble, but I have read that Allithiamine may work better on the CNS where as Benfo works more periphally. Who knows but I am giving it a whirl and maybe it can atleast help to some degree with my atypical depression. The site also mentions tin being good for hypodrenal and I know Ted has mentioned it too and good for depression that can go along with it. So I am going to try that too. I just ordered some stannous chloride from a chemical supply company so I'll see how that works for me too when it arrives.
One other thing I wanted to mention, and maybe there is some merit to this. I can't remember which book I read this from.. It might have been Wilson's book on Adrenal Fatigue, in that having dental work done can stress the adrenals. I can look back and remember that it was around the time I had some dental work done that I started feeling a lot worse. Maybe it was that, that just sent my low adrenals over the edge.. Then on top of that I burned them out more by working out at the gym too strenuously. Live and learn. Recently I have read that weight lifting (not to the point of exaustion) can actually raise cortisol but anything aerobic lowers cortisol. So I'm going to just do the weights but ditch the running on the treadmill.
I'm also gonna start on some Systemic Proteolytic Enzymes. Certainly can't hurt cause I have read some theories out there that depression can stem from too much inflammation in the body. I've started back up taking some curcumin and have added some boswellia which is also good for inflammation. I'll see how this goes too LOL
Sorry for the long post, but thanks again for your input Connie. I'll keep trudging on :)
Maybe the moderator reading this can also post this in the adrenal fatigue and depression sections, since this post also applies to those conditions. Me being new here I don't know if I should be copying and pasting this in both of those sections.
I'm from a city down the coast from you, Charleston. I really miss the ocean. It was easier to get enough sea salt there.
It appears that in your situation, there are paradoxes to negotiate. I've read that some people do have increased insomnia, anxiety, and other side effects from melatonin supplementation. It's been suggested that they may try a dosage as low as. 1-.3 mgs. I also have low cortisol, and insomnia from early childhood. Although I have tried so many substances for this; herbs, amino acids, exercise, and even medications; my best results have been from combining a low dose b-complex with a sublingual b12. There can be paradoxical reactions to them also, as some can relax and or stimulate the system. I suggest trying the b-complex made from foods. (unfortunately it's expensive) It may be only needed in smaller amounts. Try 1/2 tablet in the morning. ( I have it with an empty stomach, but it may be easier with food).
Also, try methylcobalamin sublinguals, (active-b12); because it enables the other b's to operate. A 1000 mcg. Tablet can be divided with a pill cutter into 4 wedges. It may be that only 250 mcgs. Is needed daily for sensitve individuals. I have also found that folate has been very helpful with depression, But it must be measured carefully according individual needs. I recommend methylfolate. It comes in 800 mcg. Tablets that can also be subdivided.
While there is the RDA of folate in supplements, some people with atypical depression have responded very well to extra folate. It can have mild stimulant properties for some people, so I suggest trying small amounts in the morning. (It is also good for sensitive gums and canker sores when dissolved in the mouth). I have found these supplements to also lower many types of inflammation that can deplete cortisol.
I suffer from adrenal fatigue (low cortisol) and atypical depression so I decided to try melatonin the last couple of nights to try to give my adrenals some well needed rest. Typically I only average between 5 to 6 hours of sleep per night but the last couple of nights I only got about 3.5 hours of sleep. First night I only did 1mg and last night I did 2mg and with upping the dosage I still only got 3.5 hours of sleep. Why am I getting less sleep taking melatonin? I have read where it can have the opposite effect with some people and I am wondering why this happens? Anyone else have the same experience?
I use to take melatonin, but stopped because of two side effects. One side effect was that it acted as a diuretic, so I really didn't get much sleep b/c of running to the bathroom. The other was very real dreams. It got to the point that I could not figure out if I had really had conversations with people in my dreams versus reality. Melatonin is actually a hallucinagen your body naturally produces. I guess when you add more of the chemical to your body, it coases you to dream more realistically.
Remedies to Induce Dreaming: I usually don't dream, but I have found out that whenever I take Melatonin to sleep, I have the most vividly realistic dreams I could ever imagine.
My son has been taking Melatonin for almost 4 years now. He is now taking up to 6 mgs at age 10 and he sleeps great and has had no side effects. He is ADHD and never slept well thru the night before melatonin. It really makes a difference in his behavior as well. I would strongly recommend it.
Melatonin has also been beneficial to me for sleep. I also use at varying times: -lavender essential oil rubbed into my skin (with a carrier oil) spray lavender water in the bedroom -take a "tea" of honey and apple cider vinegar (adjusting to taste) with water. (1/4 cup does the trick). -another idea, is to turn off the electrical things (like tv, computer etc) an hour before bed to allow the body to slow down and let it's natural melatonin do it's job. Turn off the lights and light a candle and have quiet time an hour before bed. Sweet dreams!