Melatonin and Some Interesting Coincidences

| Modified on Jul 06, 2022
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Below, Art Solbrig describes how low melatonin is associated with many health conditions.




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Posted by Art (California) on 09/13/2021 1459 posts
5 out of 5 stars

In the above chart, you can see that by age 50, melatonin levels have declined to the level of a newborn which is quite low when compared to the peak seen in childhood. In the following link, there is a chart that you have to scroll down to page 10 to see and it shows how the incidence of Parkinson's Disease (PD) increases with age. Interestingly, the incidence of PD starts to increase noticeably from age 50.

https://www.parkinsons.org.uk/sites/default/files/2018-01/Prevalence Incidence Report Latest_Public_2.pdf

Seems like an interesting coincidence.

Look at the following chart and notice how Deaths from Covid-19 start to notably increase from age 50 and up.

https://www.statista.com/statistics/1191568/reported-deaths-from-covid-by-age-us/

Seems like an interesting coincidence.

Men age 45 or older and women age 55 or older are more likely to have a heart attack than are younger men and women.

https://www.mayoclinic.org/diseases-conditions/heart-attack/symptoms-causes/syc-20373106

Seems like an interesting coincidence.

Middle age is when diabetes diagnoses really start to spike. An estimated 14% of Americans ages 45 to 64, or 11 million people, are diagnosed with type 2. That's almost five times the rate for those 18 to 44.

https://www.webmd.com/diabetes/diabetes-link-age

Seems like an interesting coincidence.

Risk increases significantly after age 50, and half of all cancers occur at age 66 and above. According to the National Cancer Institute, one quarter of new cancer diagnoses are in people aged 65 to 74. Refer to the attached chart to see where melatonin levels are at this age range.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4544764/

Seems like an interesting coincidence.

Osteoporosis also starts to become a bigger issue around age 50 when bone stability starts to head south.

https://www.hopkinsmedicine.org/health/conditions-and-diseases/osteoporosis/osteoporosis-what-you-need-to-know-as-you-age

Seems like an interesting coincidence.

From this link, you can see that stroke starts to noticeably increase from age 50.

https://www.ncbi.nlm.nih.gov/core/lw/2.0/html/tileshop_pmc/tileshop_pmc_inline.html?title=Click on image to zoom&p=PMC3&id=3006180_nihms219089f1.jpg

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3006180/

Seems like an interesting coincidence.

Another interesting coincidence is that melatonin has been shown in studies to help all of these diseases.

Art

Replied by Kathleen M Matthews
(MS)
09/15/2021

Yes, Interesting... Could you please site the studies that show that melatonin 'helps in all of these diseases'. I would be most appreciative.

Art
(California)
09/16/2021
1459 posts

Hi Kathleen M Matthews,

The studies that you asked for, I have already posted individually on Earth Clinic under the mentioned health conditions that explain exactly how melatonin helps in those specific diseases or health conditions. That post was meant to merely point out the coincidences of the relationship between depleted melatonin production and many age-related diseases.

Here are some links that will take you to some of those posts.

https://www.earthclinic.com/melatonin-for-stroke-recovery-and-prevention.html

https://www.earthclinic.com/cures/melatonin-for-cardiovascular-disease.html

https://www.earthclinic.com/melatonin-protocol-for-coronavirus.html

https://www.earthclinic.com/cures/parkinsons.html#melatonin

https://www.earthclinic.com/cures/melatonin-for-osteoporosis.html

Some I have written about elsewhere and can post some appropriate study links if you want to see them.

Art

Replied by SLR
(NY)
09/15/2021

Art, you may find the work of Dr. Stasha Gominak interesting. She explains the connections between poor sleep and disease and what you can do about it. Google her and she will come right up. My husband and I have been following her protocol since February 2021 and are sleeping much better and more alert during the day.

GertJr
(Madison)
09/16/2021

I followed Dr. Stasha Gominak's protocol, had the bloodwork done that she recommended, and nada. Not a bit of difference in my sleep.

Replied by Lisa
(Oregon)
09/16/2021

Interesting research, Art. Here is another coincidence. Melatonin is a precursor to glutathione, the major antioxidant. This also declines with age, stress and lots of free radicals. There are lots and growing studies on glutathione out there.

Art
(California)
09/16/2021
1459 posts

Hi Lisa,

Exactly! Melatonin increases Glutathione, Glutathione Peroxidase, Catalase, the Nrf2 pathway, TAC and Superoxide Dismutase. Melatonin is itself, the most potent antioxidant in the human body through direct and indirect antioxidant mechanisms. Melatonin repairs the gut mucosal barrier function while protecting endothelial cells and tight junctions in the gut. Melatonin is anticarcinogenic in multiple forms of cancer. Melatonin is a potent scavenger of reactive oxygen species, reactive nitrogen species/peroxynitrite and melatonin metabolites are also potent antioxidants and radical scavengers allowing melatonin to neutralize oxygen radicals at least 10 times what vitamin e or vitamin c can. Melatonin protects the organs of the body and mitochondria throughout the body as well as neurons in the brain.

If there is such a thing as a "smart molecule", melatonin would be it!

Art

Replied by KathyM
(VA)
09/22/2021

I'm wondering what the best form of Melatonin is to use? I currently use a liposomal form for sleeping, but it only gives 1mg/dosage... not very much.

Also, what would a recommended dosage be for the issues listed here by Art?

Thanks!

Art
(Califoria)
09/23/2021
1459 posts

Kathy M.,

The sublingual form that you let dissolve under your tongue, may have slightly better bioavailability than swallowing capsules. Melatonin has such poor bioavailability that anything to boost the bioavailability of it may be useful. Melatonin has bioavailability in the the 3% to 15% range.

Art

Replied by Mimi
(USA)
01/12/2022

Hi Art,

I took one brand of melatonin in pill form at 1 mg and slept like a baby. Then bought gummies at 10mg and had horrible dreams waking up distressed and disturbed. They were 2 different brands and forms. I wonder if there is a difference in the quality of the melatonin or just the amount. It actually scared me and I almost decided to give up on it, but I'll try the low dose one for a while and see how it works. So, do you think melatonin could be a vital part of preventing covid? If so, then I'm wondering what the optimum dose should be to prevent it. I'm a 48-year-old pre-menopausal female.

Betty
(CA)
01/12/2022

Art is the expert but I will give you my two cents worth from the time I did chemo.

Onc said NO NO NO, melatonin causes nightmares and no benefit otherwise. Well, the chemo nurses take it for anti-cancer benefit. I talked to one nurse who I trusted about melatonin and nightmares. She said feeling is with that nurse group anything under 20mg did seem to cause bad dreams/nightmares for some of them. They all upped the dose to 20mg at night and no problem she knew of.

I didn't begin taking it until recently. I take 20mg T.I.D as part of surveillance protocol now that I know its huge benefit and ND said sounded good to him also. No bad dreams/nightmares.

Art
(California)
01/12/2022
1459 posts

Hi Mimi,

Studies using melatonin for sleep have found benefits between 3 mg and 1/2 mg. If you slept like a baby at 1 mg, then that seems like a useful dose for you for sleep. Vivid dreams are a common side effect of oral melatonin so you probably want to avoid those higher doses.

If you want to increase your melatonin levels without the dream issue, I have already written about two ways to do that here on EC. Here is a link to that article:

https://www.earthclinic.com/supplements/how-to-increase-melatonin-naturally.html

Melatonin produced in the body avoids the side effects that people experience from oral melatonin.

Art

Paola
(Italy)
01/16/2022
5 out of 5 stars

Hi Art and thank you again for everything you do!

Following your advice on melatonin, my husband and I started the melatonin protocol more than a year ago. We take 80 mg melatonin powder EVERY NIGHT and have not yet had any adverse reactions to this high dosage. We are living in Italy now, where there is presently a COVID jab mandate for seniors. I was wondering if you know of any protocol with melatonin to protect yourself from the vaccine side effects?

molte grazie, arrivederci!

Paola

Art
(California)
01/16/2022
1459 posts

Hi Paola,

You are probably taking the best preventative of vaccine side effects in high dose melatonin (HDM) because of its many health and protective effects throughout the body. Truth be told, melatonin seems to be about as effective or more so than the vaccine. With the newer Omicron variant, many people who are fully vaccinated including booster shot are still getting the virus, albeit with less virulent results, if the reports are correct.

There is data suggesting that melatonin may also improve the efficacy of the vaccine.

https://www.10news.com/news/coronavirus/in-depth-could-melatonin-help-with-covid-19-infections-and-vaccinations

My questions would be is melatonin really making the vaccine better or is melatonin just better than the vaccine? Not enough available data to make that determination at this time.

I think that it would be wise to maintain your vitamin D levels (25 OH d levels) well into the reference range of 30~100 ng/ml. It can take vitamin D supplements up to 2 weeks to be fully converted into the active form of vitamin d, so taking it once you get sick or just before you get sick is not likely to be useful.

In this Cleveland Clinic study, it was shown that melatonin could actually reduce your chances of getting Covid-19 by about 30%.

https://consultqd.clevelandclinic.org/melatonin-a-promising-candidate-for-prevention-and-treatment-of-covid-19/

I think that vitamin C is likely to have synergy with melatonin as shown in the following study.

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC8512846/

They are referring to use in disease states having excess oxidative stress as a main component of the disease process, but the ill effects associated with vaccines also have excess oxidative stress as a component.

I hope this answers your question.

Now, I have a question. Where will you get melatonin in Italy?

Art