Neuropathy Remedies

R-Lipoic Acid
Posted by Delores (Kansas City, Mo) on 05/14/2013
0 out of 5 stars

Art/Vancouver/R-lipoic acid: I tried Art's protocol for neuropathy. He recommended 500 mgs 3/day...I got up to 700 mgs once a day and woke up with calf cramps on both legs front and back. From 4:00AM to 6:00AM screaming calf cramps. Maybe I'm using the wrong brand (natrol)? They do seem to differ a bit.

R-Lipoic Acid
Posted by Greg (Alameda) on 07/29/2016

R-alpha lipoic acid is the best form to use. Alpha lipoic acid has both S & R. R is produced naturally in the body and S is not.

Alpha Lipoic Acid
Posted by Paula (Salt Lake City, Ut) on 05/13/2013

Does Bill from the Phillipines or Ted from Bangkok know anything about the GS-7977 clinical study for hepatitis c? I am also interested. Thank you.

Oxygen Therapy
Posted by Rita (Wareham, Ma.) on 04/28/2013

Hi Bill from the Phillipines. I am a newcomer (3 months) to this site. This is my first post. I have terrible peripheral neuropathy. I was told that would help me. I just went trough a 3 weeks trial of arginine and the other amino acid recommended by Dr. Louis Ignaro on his site... 6000 mgs of argine a day and 1000 mgs of L-Citrulline... I was on this for 3 weeks and it set me bak 1 1/2 years. I can hardly walk and excrutiating pain. The supplements on are not cheap and I would like your opinion. Thank you very much and blessing to you.

p.s. Forgot to mention that I also have hep-c and have tried every protocol including BHT and only made my heart race 100BPM and every protocal for P.N. I have spent about $10,000.00 on supplements and am getting nowwhere and am getting broke as well. Thx again.

EC: Please note, the mentioned website appears to us to be untrustworthy in the extreme.

Oxygen Therapy
Posted by Nolongersad (Queensland, Australia) on 04/29/2013

Hi there, just reading your post and felt I wanted to comment about your periphal neuropathy. My husband also had this, started with the soles of feet and pain/ burning. He was diagnosed with POEMS disease. This is quite rare but maybe a visit to the G.P is needed. Most doctors have never heard of it so maybe read up on it first. His diagnosis took 3 years.

Oxygen Therapy
Posted by Rita (Wareham, Ma) on 04/30/2013

I may have been unclear on the previous post. What I meant to say was I have spent $10,000.00 on supplements from other sources. I was trying to see if Bill from the Philipines knows anything about that site before I get involved. Thx and sorry if I created any confusion. It's sort of a new concept and I am skeptical of anything until it's been proven not just take their word for it...

Oxygen Therapy
Posted by Tiny Dancer (Dayton, Oh) on 05/01/2013

Try B12 "PATCHES"..... it worked for me and is still working.

Oxygen Therapy
Posted by Kathy (the USA) on 05/02/2013

Hi Rita--Blackstrap Molasses is a rich source of vitamins and minerals. It is also an excellent source of B vitamins. A nutrition almanac emphasizes taking B vitamins as a whole because if you take just one, you cause a deficiency in the others so if a B-12 patch is being used a TBP of BSM would very beneficial. The B vitamins can also reduce pain.

Binders and fillers of vitamins, supplements and medications cause more trouble than is being recognized. They can cause more pain than the active ingredient is helping. I learned over twenty years ago that I cannot ingest the gelatin capsule without causing problems. Another culprit was in my table salt. That tiny amount used to cause me excruciating sciatica. The flowing/anti-caking agent in the spices are another thing to watch out for. This has been a result of piecemeal learning for over twenty years. I'm just sharing what I have learned, applied and what worked for me.

I will add that I've had multiple head, neck and back injuries from horses, cars and hurried missteps. Since I have using food and spices as my medicine, with better results, even my PCP is impressed and after looking at an MRI, the MD for the head and neck traumas wondered why I was not in so much pain. He had me go to neck specialists questioning whether I should have surgery to no avail. I just wish I had learned what I know now long ago. That's what makes me sad.

Both of my babies were breech but only one was a caesarean. Learning how to eat to avoid pain has helped the bowel difficulties, but I wish I had known this twenty-nine years ago because there is damage that cannot be repaired.

Apple Cider Vinegar
Posted by Denise (Seattle, Wa) on 04/15/2013

Question for Bill from Phillipines. I have Peripheral Neuropathy and hep-c. I want to take your alkalizing remedy but when I take even one tablespoon of ACV, I get freezing cold in my feet and everywhere in fact. Also, when I take vitamin E (even 200 IU's) I get freezing cold. Don't understand it. Thank you and Blessings.

Apple Cider Vinegar
Posted by Denise (Seattle, Wa) on 04/19/2013

Hi Bill, Thank you for the quick response. I tried the Berkson therapy for 10 months and my enzymes stayed the same and even went up a bit. I get terribly cold when I take even a small amount of chlorella. I have used chianca piedra for 6 months and my enzymes went down slightly. I currently take lugol's solution 2% on Mondays and Thursdays. I take kelp the other days which has 330 mcg of iodine in it. Last night I took a 1/8th teaspoon of baking soda with real lemon juice (2 tbls) and woke up freezing. I took my temp and it was 96.3. I had some chicken broth which warms me up enough to go to sleep.

Any other suggestions. And thank you again. And blessings.

Laser Therapy Pen
Posted by Steve (Las Vegas, Nv) on 03/30/2013
5 out of 5 stars

That's great the laser worked for you, Alice. My brother has some diabetic neuropathy and has gotten good results using a laser therapy pen. He says it helps with other aches and pains as well.

Burdock Root
Posted by Diane (Framingham, Ma) on 03/23/2013

Hello Ky Mama, Could you tell me when you took your burdock root? Before-during or after eating? Also, how big is a 00 capsule compared to a 1/4 teaspoonfull. I can't get capsules. Thx much

Burdock Root
Posted by Denise (Seattle, WA) on 08/29/2013

To Ky Mama from Clinton, Ky: I see where you have taken 3 or 4 capsules a day of Burdock root with food for 3 months to resolve your neuropathy. My question is... Does 4 capsules equal a teaspoon? If so, then you were taking 3 teaspoons a day. Could I take that in a glass of water instead of putting it in capsules? In other words 3 teaspoons a day of burdock. Thank you for reading.

Burdock Root
Posted by Ky Mama (Clinton, Ky) on 08/29/2013

Yes, it worked out to about 3 teaspoons a day. It would be fine to just take the powder in water. It has a mild taste. It is used for food in other countries. I hope it helps you as much as it helped me. God bless you! KY Mama

Burdock Root
Posted by Denise (Seattle, WA) on 08/30/2013

I will start taking Burdock (1 teasp) 3x a day with turmeric (1 teasp)3x day... One last question. I have terrible calf cramps. Will the diuretic effect of the burdock effect my cramps> I'm in hell with these cramps.. They wake me up every day sometimes with both calves at once cramped.. Screaming pain... I've had these for 27 months. Thank you KY Mama...

Burdock Root
Posted by Ky Mama (Clinton, Ky) on 08/30/2013


So sorry about the cramping you are having! Because Burdock is a natural diuretic, I would not expect it to have a bad effect. I am thinking it is making your system work better, thus the diuretic effect. I was breastfeeding when I took burdock and definitely had a high need for liquid. I didn't notice a diuretic effect. (But I do drink a ton of water and might not have noticed! ) However, at least one herbalist recommends starting slow with a blood cleansing herb like this so as not to overwhelm the system. I didn't know this when I tried it and started with 3 t. Per day. I had no problems. But you might want to start with 1/3 t. three times a day and build up to 1 t. three times a day over the course of a week or two.

Burdock Root might help your cramping. It has potassium and magnesium in it, which are good for cramping.

Are you doing anything else for the cramps? Have you tried Blackstrap Molasses? It works wonders for my family. We take 1 T. When we have a cramp. 1 T. twice a day will prevent them for a lot of people.

KY Mama

Burdock Root
Posted by Denise (Seattle) on 08/31/2013

Ky Mama to many, Thanks you for the feedback... I don't think it's a good idea for me to take BSM as it is high in iron. I have hepatitis c as well as neuropathy... I've read iron will help the viris replicate... Maybe I should try it for just one day and see... Hmmm?... I believe the hep-c caused the neuropathy... I had stage 4 chirossis in july 2011 and at the exact same time my neuropathy surfaced... I believe the two are connected... I got rid of chirrosis in 5 months but my neuropathy is still here... I tried a product recently called Padma 28 and got severe headache ans swollen glands in my neck, which I still have.. I certainly will try burdock root and start low and increase... Interestingly enough I took Essiac tea for about a year and it didn't help my cramps. It has 4 herbs and one of them is Burdock... My guess is the burdock is a low dose in the tea.. Again thank you for the feedback and bless you muchly.....

Burdock Root
Posted by Ky Mama (Clinton, Ky) on 09/02/2013

Hi Denise,

Yes, I see why you would be hesitant to try the Blackstrap. I don't know if Dandelion Tea is an option for you, but I knew someone long ago who got Hep. C and drank Dandelion Tea and it did cure him. Also, for the swollen lymph nodes, I have found castor oil (topically) to help that a lot. I don't mean to minimize your health issues--sometimes the solutions are very complex. At the same time, sometimes there are some simple things that do help a lot. I hope that is the case for you. Please keep us posted on how you are doing. KY Mama

Burdock Root
Posted by Denise (Seattle) on 09/03/2013

Hello Ky Mama, Yes, I have been applying castor oil to my swollen glands in my neck. It has taken over a week but they are now subsiding. I will give dandelion tea a try... I have taken the berkson protocol for maybe 8 months religiously and my liver enzymes went up... My neuropathy is maddening... Non stop pain and I'm taking 3 heaping teaspoons of tumeric a day with pepper. And about 20 other supplements...

Severe Neuropathy Remedies
Posted by Steve (Las Vegas, Nv Nevada) on 03/12/2013

Magnesium oil should bring some relief to the areas of pain. Also my brother has had some success using a laser therapy pen to relieve his neuropathy pain. Steve

Severe Neuropathy Remedies
Posted by Connie (Slc, Utah, Usa) on 03/13/2013

Hi Katie;

This website provides alot of information about the signs and symptoms of B12 deficiency. Neuropathy is a primary one. Treatment of B12 deficiency neuropathy is intensive and life-long. Healing can take many months, even years.

Severe Neuropathy Remedies
Posted by J (Ny) on 03/20/2014

Try r - alpha lipoic acid 300mg 3 x daily
Benfotiamine 500 2x daily
Acetyl l carnitine 2x daily
Methly b12 15000mcg sublingual 2x daily
B complex vitamin 2x daily
10000 iu vit d3 daily. Excessively lotion all affected skin twice daily since neuropathic doesnt sweat. Elevate feet at night above the level of the heart. Thick soft socks or footies
You can try the neuropathy oil they sell in cvs pharmacy, a tea tree oil neura.... Something like that sorry dont remember the name exactly. Stay away from alcohol consumption Forever! God bless you I will pray for you. J

Severe Neuropathy Remedies
Posted by Laura (Newark, Ohio) on 05/21/2014

Hi, Check out MMS and Jim Humble. I really think this can help and possibly cure your lyme's disease. Let me know if you try this.

Alpha Lipoic Acid
Posted by Al (Alvena) on 06/03/2013

I don't use any multivitamins. I buy everything individually and don't use vitamin B6 at all other than small amounts in some foods. Al

Alpha Lipoic Acid
Posted by Timh (Louisville, Ky) on 03/01/2013 2083 posts

Karen: R-alpha is the more bioavailable, hence more potent, form of Lipoic Acid. If you're not getting results from 600mg regular A.L.A. I would recommend other treatment options.

Alpha Lipoic Acid
Posted by Connie (Slc, Utah, Usa) on 03/01/2013

Hi Karen; The neuropathy is probably a painful result of vitamin B12 deficiency. Treatment involves high doses, even injections, and can take a long time to heal (up to a year). Treatment of B12 deficiency is life-long.

Neuropathy is one of the many symptoms of B12 deficiency, and skin pigmentation changes is another; hyperpigmentation, and/or hypopigmentation, for instance. (I bring this up because I remember a post about discoloration of the feet.)

Good Wishes

Alpha Lipoic Acid
Posted by Karen (Tampa, Fl) on 03/02/2013

Hello Connie, I had been taking B-12 at 1000 per day. I had my levels checked 6 months later and they were 1000 points over the normal. I have stopped taking it as I felt it is not the reason for my neuropathy..

Hello Timh, Are you saying try other forms of therapy such as benfotiamine, B-12, tumeric, l-carnitine, etc. Etc. Or are you saying try R-lipoic acid? There is not much I haven't tried. I have an option to get ALA by IV and may investigate it...

Thanks for your time and concern. God bless.

Alpha Lipoic Acid
Posted by Duh (Here) on 09/27/2017

That's a low dose for pain.. most use 1000mg/day just for energy. For liver disease 800-1600/day. For chronic pain ... I've read 2000-3000mg/day. Should be broken down 2-3 times a day ... 30 min before meals.

Alpha Lipoic Acid
Posted by Becky (Ca) on 11/21/2017 35 posts

Can anyone tell me which tests are most accurate for vitamin/minerals like b12 .I did a high mineral test that revealed everything was low. I was told to take Lithium and then b12 or else the b12 would get lower. Then I did a Spectracell test which stated most b vitamin were low except b12. Very frustarting to know what to do. I have systemic candida and am developing Neuropathy.

thank you

Water Cure
Posted by Diane (Framingham, Ma) on 01/31/2013

I have a question for anybody. I have peripheral neuropathy. After trying many, many remedies, I have recently connected with a person that says water salt and sugar cures just about anything. He says he was schooled by Dr. Batmangheli (SP?), who discovered the water cure. This person I spoke to has a site called "Goof proof " It's something that I am doubful about... But... Thanks

Water Cure
Posted by Oldriska (Prague, Czech Republic) on 02/01/2013

Hi Diane, I'd be a bit suspicious about treating neuropathy with water with salt and sugar. I have neuralgia in my face and have tried many treatments and read a lot on the subject of neuralgias/neuropathies. Sugar is not recommended for nerve pain and salt can increase blood pressure which conseqently can increase pressure on the nerves. I think if it was this easy to treat the condition there wouldn't be all the people suffering with chronic nerve pain. Still, if you give it a go and have good results with it I'd be only happy to hear your feedback and change my opinion! Take care, Oldriska

Water Cure
Posted by Diane (Framingham, Ma) on 02/01/2013

Hi Oldriske, The person I told you about tells me he has cured MS, Diabetes, cancer, neuropathy and other big issues with this therapy. Part of his logic is when you go to a hospital they give you saline solution which has water, salt and sugar. He has a point, but... Thanks much for the reply.

Water Cure
Posted by Diane (Framingham, Ma) on 02/03/2013

To Laurie B from Boise, Idaho. Would you please forward me the diet that you used for your daughter. I will indeed try it. Confused about 100% gluten free diet.

Do you know what caused your daughters neuropathy? I had stage 4 liver chirrosis, brought on by hepatitis c. I got rid of the chirrosis, but still have hep-c. Congratulations to your daughter.

She is lucky to have a mother who would not take no for an answer. God Bless.

Water Cure
Posted by Char (Texas) on 01/29/2018

Please share what she could eat. I'm currently having numbness in feet and lower legs. Thank you!

Alpha Lipoic Acid
Posted by Jeffreyw65 (Lowell, Ma, Usa) on 01/24/2013
4 out of 5 stars

Hello, I am loving this site! I listen to am radio from our area where there doctors whom really push holistic medicine it works and it needs more pushing for the really bad sickness like I have been dealing with since I have had cancer. I love what I learn about the different sulliments for ailments. It is good to try them to see if they work for my ailment.

I just increased my intake of lipoic acid and my feet have been better and the meralgia paresthetica seems to be easing the sharp electrical shock shooting zaps. They are terrible and I am hoping to see if I can get off the pain meds and increase the dietary supplements that I have increased to help me get better. I have different ailments that have made me unable to get around so I will come back on here in 60 days and give a report on my status on my pain so keep looking for my feedback. Thanks Jeff from Lowell, type 2 diabetic with meralgia paesthetica and facet joint arthritus / upper thoraic arthritus philbitus and neuropathy from the pinced nerve is terrible. The color of my legs scares me there, a color that is bad like black and blue, so keep looking for me and wish me well. ok bye all

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 12/02/2012
4 out of 5 stars

3 months now since I started ALA & ALCAR and I have been working full time - just around 60 hours per week in the log book. I am quite surprised at how well I am doing. At the end of the first week I was exhausted, partially due to icy roads on days 4 & 5, and thought I would need to take a break midweek for a few weeks but kept at it and didn't need to. I still have a bit of pain, tingling and numbness but it is still receding. I expect that it will take many months to completely recover if I ever do. I am maintaining my supplement regimen but have reduced the Lyrica by 50% a week ago, resulting in an increase in the pain level, and have also reduced the amount of Diamicron MR that I am taking by 50% as well due to the blood sugar getting too low, a good indication that the curcumin and Diamicron MR are actually healing the pancreas as I am healing the neuropathy. Maybe the two are complementary. I saw another acquaintance today that I hadn't seen since June and he didn't recognize me due to my hair colour returning. Onwards and upwards.

Alpha Lipoic Acid
Posted by Kay (In The Valley, Ca) on 12/08/2012

Is that 20 drops of 5% every day? How long can you safely do this? Thanks, Kay

Alpha Lipoic Acid
Posted by Kilgore (Jackson, Ms) on 12/10/2012

Yes work up to 20 drops. In my experience, the protocol can be done indefinitely, but if you experience detox symptoms, you can take breaks from the iodine and use the salt loading protocol to clear out toxins.

Alpha Lipoic Acid
Posted by Lily (Kelowna, British Columbia) on 01/14/2013

Research ideopathic gluten sensitivity. I have had relief from kicking gluten from my diet!! I tried all the other stuff & got some relief BUT this was relief and it happened within days of being diligent about NO GLUTEN.

Alpha Lipoic Acid
Posted by Elaine (Oklahoma) on 02/05/2017

Are we talking about the iodine we buy at the drug store? Like for a cut?

Alpha Lipoic Acid
Posted by Charlotte (Texas) on 04/19/2017

I have tried staying away from gluten at times... like no wheat products...but this is difficult. How did you do it?

General Feedback
Posted by Karen (Tampa, Fl.) on 11/20/2012

I have peripheral neuropathy and have tried everything on this site and more to no avail... My assumption is it's from cirrhosis that I had in 7/2011 which I got rid of with several therapies...

My neuropathy is horrendous and for the last 2 months I constantly have twitches and muscle jerks which are quite maddening... The muscle jerks keep me awake most of the night... That and the CONSTANT hot needles, electric shocks INFLAMED feet are making life very, very painful... If anyone could offer any suggestions I would be grateful, mostly on the muscle jerks as I feel the only way to get rid of my neuropathy is to get rid my my hepatitis C... I'm quite a mess... About 14 months ago I was running and working out... No more... Have trouble getting up stairs...

I even tried lions mane which came highly recommended and only gave me a splitting headache... Thank you for reading...

General Feedback
Posted by Mmsg (Somewhere, Europe) on 11/21/2012

Karen, maybe start with Epsom Salts baths. Can't hurt and can quite possibly help.

General Feedback
Posted by Timh (Louisville, Ky, Usa) on 11/21/2012 2083 posts

Karen: if you successfully reversed Cirrhosis, please post your methods as this could help others. I am fallowing some of the studies Professor Derik Mann is doing w/ noticeable results, unfortunately it's all undocumented and undiagnosed; but seems obvious to me and further verified by your symptoms of Neuropathy as I have many of the same but with less severity.

It seems appropriate to do some heavy metal detoxing as well as possible zenobiotics. Ionic Foot Spa, Detox Foot Pads, Steam or Sauna, increase antioxidants and Glutathione. Wear Magnetic foot soles. The very first few minutes of wearing magnetic foot soles elicited the shocking or voltage-like sensation from my feet to my liver. Clay and Mineral foot or whole-body baths will also help.

General Feedback
Posted by Karen (Tampa, Fl) on 11/21/2012

Timh, What name brand of magnetic foot soles? There are many types on the web... I take saunas and many antioxidents... I can't sit too long as cramping in my calves and leg biceps is a HUGE problem... Can't think straight at times...

ultra violet blood irradation with 2 1/2 cc's of H2O2 at the end took me out of cirrohosis in 6 months... I had 10 treatments and was cleared of cirrosis after 5... It cost me $1700. 00.. Each treatment takes about an hour... They remove your blood and put it thru a untra violet light machine and then re-infuse it again inot you thru the machine... So the blood gets exposed to the ultra violet light twice... At the end they put in the H2O2... Also, while I was doing this, they had a Far Infra Red pad placed over my liver the whole time...

General Feedback
Posted by Timh (Louisville, Ky, Usa) on 11/22/2012 2083 posts

Karen: I have used two different m soles but wore them out and couldn't tell you the brand, sorry. Try to find a magnetic kit w/ various sizes, soles, and such as you would likely profit from wearing a belt over the liver, as I have. If you happen to have any extra refrigerator magnets laying around the house you could cut and fit for the soles. The side that sticks to metal is the side you want to contact the body with.

Also, I will second Mmsg's Epsom Salt bath recommendation as I have good results with. MSM is also good for detox and oxygen boosting; I get good energy boost with MSM. ALA is good for detox, Liver health, and neuropathy.

B Vitamins
Posted by Diane (Framingham, Ma) on 11/12/2012

Ted or Bill, I have gotten conflicting information from 2 doctors regarding my B vitamin levels... First of all I have terrible peripheral neuropathyand have tried everything out there... I had a test for my B vitamins and one Dr.said I was high in my B-6 which is 96... (normal range is 5-50)..

I was also told by this Dr. that my B-2 was high at 67 (normal range is 2-15).

She told me to go off any B vites and my neuropathy would ease up as this was contributing to my pain etc...

I decided to get a second opinion and the new Dr. said that, "the only neuropathy ever seen with B vitamins was when people absurdly took 4000-6000 mg of daily B-6 per day which caused mild neuropathy that was reversable when they discontinued that absurd dosing.. Some Dr. S tell you this as though it could happen at normal doses. " This is directly from the report.

I want to take high B-6 and B-3 and am understandably confused... and in pain... Thank you.

B Vitamins
Posted by Art (Vancouver Bc., Canada) on 11/14/2012

My first question is, are you using artificial sweeteners like splenda. That causes neuropathy and blood sugar spikes. It harms the liver as well and damages the imune system. I did not know this as I am trying to heal my neuropathy and just found out. The splenda is now in the garbage.

My doctor supports the use of vitamin B12 for neuropathy and even gives B12 shots for it but that is very expensive. You have to take the B12 on an empty stomach which I just discovered. Now I have started using ALA (alpha lipoic acid) taken with food and that seems to be helping.

I would suggest that your doctors read the hippocratic oath as they seem to be causing more harm than good. Some times I just can't believe what I read about these quacks. If you don't believe me go to the ailments tab and click on neuropathy.

Take care, art

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 11/11/2012

Tom from Eu, those are very interesting links, especially the first one. As far as the second one it seems that the site is not being maintained any more and I could not post to it. My neuropathy started with numbness and loss of motor nerves, then tingling and loss of sensory nerves followed by the onset of pain which peaked about a year or so after starting the chemo. What is strange is that my fingers healed as my feet and legs got worse. By the time I started on ALA the pain and numbness had receded to just my feet but I still had motor and sensory nerve issues in my legs. I was experiencing reduced pain with grape seed extract, I believe because of its antioxidant activity, and so am still taking that. Now that the nerves are functioning better I am to the point, with my feet, where I saw my fingers at in relation to pain a few months before they became just highly sensitive. My fingers are still quite sensitive but not to the point of being painful. I expect that within a month or two my toes and the soles of my feet will be at that stage. I believe that the nerves have actually regenerated and that the sensitivity I am experiencing is from the unconditioned state of the regenerated sensory nerves similar to that experienced after a cut or burn heals.

I went back to work driving a truck hauling containers to and from the rail. It involves a lot of climbing in and out of the truck and a lot of walking as well as about 3000 km of driving per week with 12 - 14 hour days and the only thing that really bothered me was wearing steel toed shoes at one rail yard.

I have also been switched from Lyrica to Cymbalta due to the vision blurring aspect of Lyrica. I am still seeing no improvement in the tinnitus. I have increased the dosage of ALA to 500mg twice a day in an attempt to speed the healing/chelating process. I have no idea if it is helping as I have nothing to compare it to. I do notice a substantial difference in pain now when I take the ALCAR unlike when I first started using it.

Alpha Lipoic Acid
Posted by Enda (Europe) on 02/12/2013

Hi, I was going to start taking ALA to help with neuropathy however I was wondering to I need to take any vitamin supplements etc to assist this. I have a couple of mercury fillings in place for a few years now so I am hoping that this will turn out o.k. Wondering if AL from Canada would post an update on his neuropathy as I know he was having success with his ALa/ALCAR combination when I last checked in.

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 03/02/2013

It is now six months since I started on ALA and four months since I went back to work. After about three months I hit a plateau where it seemed the improvement slowed down with all the supplements noted in my previous posts. I tryed the vitamin B12 at doses up to 40, 000 mcgs per day with some success and again hit a plateau. I stumbled across L-arginine, it is supposed to increase circulation, and added it to my regimen. I thought it would help by allowing more nutrients to get to my nerves but found that it actually improved things by making my feet feel warmer. I did some more research and found out that phosphorous is good for nerve health and went looking for phosphorous. I found it in a bone supplement with huge amounts of calcium included in it but tried it anyway. It is helping. I began to feel that something else was missing so I added in potassium and magnesium (at the same time) and am seeing beneficial results. The 'electric shock jolts' are now gone but I still have a small patch of numbness in the soles of my feet and a varying level of a burning sensation pain in my feet. I am not entirely healed yet but I am still improving and am working as much as 76 hours per week without issues. I have discontinued Lyrica as it no longer helps the tinnitus. I have also noticed that the timing of my medication/supplements is not critical any more. I take everything in the morning after breakfast and selected ones after supper which is usually about 15 hours later. I also find that if I move my toes around when they get painful that the pain is reduced fairly quickly now. My doctor informed me a couple of weeks ago that ALA is going to be available by prescription in Canada very soon for neuropathy.

My experience is telling me that we all need to try everything available and must utilize all of the vitamin and mineral supplements that can support nerves to promote healing in the quickest manner possible. I can now see that I will completely recover from my chemotherapy induced neuropathy in spite of being told by my neurologist that "where it is a year after chemo is as good as it will get". I am now 37 months from having started chemo and am still improving.

As I am now working full time and long hours, if anyone has specific questions for me, you may contact me directly at gustafsonal (at) hotmail {dot] com. Thank you. Al

Alpha Lipoic Acid
Posted by Happy (Up The Creek In, Wv, Usa) on 03/03/2013

in response to: Al from Alvena, Sk., Canada: "It is now six months since I started on ALA ......."

Your symptoms sound like a classic case vitamin B6 over-dose. Read all the labels on all your multiple vitamin bottles, and eliminate all the b6 you find. The 'electric shock jolts' are a big clue.... So is the numbness. STOP THE B6 INTAKE. Root it out.

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 03/12/2013

IMPORTANT UPDATE. I missed a dose of ALA and my feet improved a bit during the associated time so I haven't taken any for three days now. It seems that the ALA resulted in a major improvement by removing the heavy metals from my system but then stopped improving things. I saw further improvement every time I added a nerve nutrient to my regimen and then would hit another plateau. I think that the ALA was consuming the B vitamins and minerals faster than my body could absorb them and now that I haven't been taking the ALA any more I am seeing more improvement. It is noticeable in only three days. Perhaps we need to realize that there comes a point that we need to discontinue supplements when they are no longer needed/have done the job they were taken for.

To Happy from WV, USA, I no longer have the sharp shooting pain and just recently added a small dose of vitamin B6 that gave a small improvement. I am sure that the B6 is not a problem. The numbness at one point was up to my mid thigh in both legs and was also in my hands and face. My hands and face are better and I recognize the same sequence of improvement in my feet and legs. I only have a very small patch of numbness on the soles of my feet that is now affecting only my big toes and part of the mid sole area. the cold sensitivity is also improving in that cold doesn't cause as much pain increase now as it did in the past.

To Lily from Kelowna, BC. I don't think gluten is an issue. We don't use flour from modern wheat as my wife has/had celiac disease. I found out about some old varieties of wheat, Red Fife and Marquis, that have a different gluten structure than the dwarf wheat that is commonly grown now and that can be consumed by people with celiac disease. In fact my wife got rid of all symptoms of celiac disease in only six months by switching from gluten free to Red Fife wheat. We now use Red Fife and Marquis flour for all of our cooking and have it locally available at a local organic grower who has a Kelowna company mill it for him.

Thanks to everyone who has replied and given me ideas of things to try. I am still open to trying more supplements in the interest of completely curing this problem. I am sure that the time frame involved is making it more difficult for me than it could have been but I am claiming my life back after what I can only describe as a brutal and demoralizing three year disability thanks to supplements, vitamins and minerals that doctors and specialists that treated me knew nothing about. Don't ever give up. Stay positive to win the battle against poor health. Thanks also to the Earth Clinic site. Awesome. Al

Alpha Lipoic Acid
Posted by Denise (Seattle,wa) on 09/23/2013

Hi Al, What exactly are you taking these days? I have terrible neuropathy with the elec shocks, stabbing and numbness all day and night. It's maddening.. Of course the dr's tell me ther is nothing I can do. I took fentenyl and it screwed me up terribly with voices and terrible hives... Stopped it and they both went away. and I also have, calf cramping, and neuropathy in my arms. I recently took a B-12 patch (Dr. D----) with "all the essential vitamins" and it got worse.. Maybe from the B-6? The dose was only 3 mgs but possibly the patch made it more effective? Don't know... Please let me know and congratulations for your success. I admire your persistance. I also have been trying things for over 2 years but don't have a great deal of success. Thank you.

Alpha Lipoic Acid
Posted by Art (Vancouver Bc, Canada) on 09/24/2013

Dear Al.

I am so glad to hear about your success with the ALA. I have had great success with it as well with the burning sensation just above my knees and pressure aches on both wrist. I was taking 2x250mg with every meal and then I discovered I only need to take it at noon and supper. Without this my life would be hellish painful. It was your posts that got me started on the ALA. I did try the R factor ALA with little success.


Alpha Lipoic Acid
Posted by Paula (Salt Lake City, Ut) on 09/25/2013

Hi Art from Vancouver, Do you take any additional supplements for your neuropathy? How long have you been on ALA at the 250/twice a day routine? Thank you, I have PN in legs and feet and all the symptoms.

Alpha Lipoic Acid
Posted by Dave (Fountain Inn, Sc) on 09/25/2013

Hello Denise,

You ask about helps for neuropathy, and I have personally had fantastic success with Calcium AEP. A good site is to google "nutritional review Calcium AEP." It was Dr Hans Nieper who advanced the use of AEP, and Dr. Robert Adkins in the book "Vitanutrients" who used the AEP in an IV drip on his MS patients. That seemed to be the most important element in his protocol for his MS patients.

Please read that site. When my mother would have flare ups with her MS I would have her take six or eight tablets and without exception the pain would subside in an hour or so.

AEP is a MIRACLE nutrient not only for MS but for fifteen other problems. Just read the site I referenced. You'll love it. Dave

Alpha Lipoic Acid
Posted by Denise (Seattle, WA) on 09/27/2013

Hello Dave from Fountain Inn, SC. I checked out the site for calcium AEP on amazon (The book by Atkins) and was impressed. However there are many kinds of Calcium AEP... And many formulas and varied prices from over $40.00 to about $10.00. Would you recommend a particular one as I am anxious to give it a try? Thank you.

Alpha Lipoic Acid
Posted by Dave (Fountain Inn, Sc) on 10/01/2013

Hello Denise form Seattle: I have used different Cal AEPs from various sources. I use one from Vitamin Research and currently use Bryon Richards "Wellness Resources". Best to you, Dave

Alpha Lipoic Acid
Posted by Julie (Fl) on 08/31/2016

Have you tried iodine??? This helps me alot!

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 11/04/2012
0 out of 5 stars

ALA will make your heart race if you have overactive thyroid problems and/or are on thyroid medication(s). You should maybe get your thyroid gland checked out and that might even fix your neuropathy. Most ALA labels caution about using it with thyroid medications.

Alpha Lipoic Acid
Posted by Diane (Oregon) on 06/12/2017

Thanks for the information about alpha lipoic acid, I thought it was just me. I have heart problems as well as NP, so that is good to know.

Micro Current Therapy
Posted by Xxx (Yyy, Zzz) on 10/23/2012
1 out of 5 stars

Here's a heads up for you the reader...

I heard about "Frequency Specific Micro Current "therapy from my chiropractor... I looked into it and called about 10 therapists around the country... 8 told me that they could cure peripheral neuropathy in ONE treatment... I had 14 treatments lasting 2 hours (28 hours).. IT CHANGED NOTHING!

I also had 14 treatments 2 hours each (28 hours) for hepatitis-c and had my enzymes checked at the end and they went UP! By just a few point however... Maybe it will work for you...however!

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 10/07/2012

I have now been using ALA for just five weeks and am off all pain medications now. I stopped taking Lyrica for numbness and pain blocking yesterday. I am anticipating a full recovery very soon.

I do have a question about the acetyl-l-carnitine. I am wondering if it would be better to take it a few hours prior to the ALA or a few hours after as my research tells me that it helps to absorb the ALA and other nutrients. There was also mention that it heals the "hairs" in your digestive tract. Perhaps it should be taken before bed with minimal liquid and allowed to stay in your digestive tract for a prolonged period for best results. Can anyone expound on this topic?

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 10/08/2012

I had to go back on Lyrica after two days without it due to the increased volume of my tinnitus and a very chilled feeling in feet and legs up to my mid thigh area. Has anyone else experienced this as the pain of neuropathy dissipates and/or found something that helps for it? The Lyrica affects my vision and I am unable to take gabapentin due to how it increases my blood sugar. Any substitute would be appreciated or even knowledge that more time on ALA & ALC would improve it.

Alpha Lipoic Acid
Posted by Connie (Slc, Utah, Usa) on 10/09/2012

Hi Al; I found that the only substance that helps my neuropathy is B12... Alot of it, every day. ( I'm now taking 10 mgs. of sublingual methylcobalamin daily.)

Also, I'm very sensitive to acidic supplements, including ALA and ALCAR, Unfortunately.

When nerves are healing, there can be increased pain for a time, so it can be difficult to determine whether healing or regression is occurring.

Since tinnitus and pain/coldness is returning, my guess is that this is a regression.

I believe that my case could be caused by some genetic defect, some problem with B12 transport throughout my body. I'm having to rely on passive diffusion to distribute it. I've found this condtion to be rather common, not so rare.

Some months ago, I posted about zinc also being helpful for neuropathy. I have also found that when I've tried higher amounts of it, it actually can interfere with B12. ( zinc can displace cobalt, and vice versa). Too much zinc can displace copper and cause neuropathy, copper deficiency type.)

I understand how painful and frustrating this can be, I hope you can find what works best for you.

Alpha Lipoic Acid
Posted by Connie (Slc, Ut) on 10/23/2012

Hi Al; This is great news! From what little I understand about inorganic chemistry, I understand that too much of one trace metal can collect and displace others. ( trouble-neuropathy )

I've read that a side effect of cisplatin is oxidative stress with glutathione depletion.

So, I can understand how the ALA can help on these levels, as it both chelates metals, and helps to increase glutathione, a most powerful antioxidant.

I'm glad you are healing!

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 10/25/2012

Connie, it is actually working so good that I am actively looking for a job. I currently have two offers, both to start in November and at the rate of improvement I am seeing that should work out about right. I might even go back driving long haul and get to see a little more of the US. I have only seen a little bit of it in about 900,000 miles of driving down there. I kind of miss it as my last load that I hauled came out of Texas and that was over three years ago.

Alpha Lipoic Acid
Posted by Mick (Europe) on 10/30/2012

Hi Al, Great to hear of your improvements. I am wondering if you are still needing to take the Lyrica. Also wondering if you found any interference/interaction with the medication when you first started supplementing. Can you state which brand of Ala/AlC you use or even where you get them. Once again great to hear of your news. Mick

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 11/02/2012

Mick, I have been using the NOW brand of ALA at 250 mg 2x per day and started off with ALCAR 500 mg x2 twice a day & benfotiamine 80 mg once a day as I had to order them and that is what they got in for me. I have since found acetyl-l-carnitine labeled as L-Carnitine in two different brands on the shelf. I buy my supplements at local health food stores/organic markets. One caution about ALA is that you should read the label and only get what says to take with food or after meals. If it says to take without food it usually has an additive to increase absorption that can cause side effects. Look to see what they are and research them. I also take zinc and B12, along with curcumin for the pancreas, milk thistle for the liver, D3(5000iu/day) for general health, grape seed extract for pain relief, grapefruit seed extract for a topical fungus infection, glucosamine and condroitin sulfate with MSM for arthritis(almost gone) and a steadily reducing amount of gliclazide MR to stimulate my pancreas to produce insulin(pancreas was damaged by chemo and gabapentin but is healing well now).

It is now two months since I started on ALA & ALCAR which was 31 months after I started chemotherapy with oxaliplatin and 30 months from when the numbness, pain and tingling started and I am going back to work full time next week which is a lot less than the five years I was anticipating with the former rate of improvement. I am not completely healed but the pain and numbness is at a tolerable level and such that I do not feel that it will be a safety issue. I now walk almost completely normally and can feel with my feet again and no longer look like a drunk when I walk. Al

Alpha Lipoic Acid
Posted by Art (Vancouver Bc, Canada) on 11/02/2012

Dear Al from Sask, I want to thank you for your posts. I have neuropathy to where my toes, fingers and the bottom of my feet are very sensitive. I also have a burning sensation at the top of my knee caps that travels up about six inches. That burning pain drove me to the doctor where he wanted to give me a script for gabapentin but I refused. I found out about B12 under the tounge and the burning in my knees calmed down. I was up to 12 x 2500mg sublingual a day for relief. I then discovered Spirulina at 18 teaspoon a day and that seemed to help me reduce the B12 to a couple a day. Then I started to get dizzy spells so I stoped the spirulina and then I was increasing the B12 again. I then discovered your posts about ALA. I got some and what a difference, My feet are no longer sensitive and it doesn't hurt to clip my toe nails any longer.

I have been on the ALA for about 1 month now and I find I am sleeping better. Now I have to cut back on the ALA at 100mg a capsule taken with food. It did cause me gastric pain at 5 caps a day and my prostate felt like it was being sandwiched between my rectum and my bladder. I got relief right away when I cut back. Now I am taking 2 caps a day at 100mg each. I am down to one to 3 B12 at 2500mg sublingual every night and my burning sensation is gone. I know its not cured but at least I can sleep now and that alone is a miracle.

I can't thank earth clinic enough for this.

Alpha Lipoic Acid
Posted by Aim1 (West Chester, Pa) on 11/03/2012

Can you double check the amount of b12 you are taking? You have it as mg, but I think (hope) you mean mcg. Big difference.

Alpha Lipoic Acid
Posted by Art (Vancouver Bc, Canada) on 11/05/2012

I am making a correction to my post about the strength of B12 I am taking. It is 2500mcg subligual each caplet but I sure do wish I could find some in the mg dosage. I would also like to state that certain foods can cause a reaction to my neuropathy to where I am taking the B12 like candy, but for the most part ALA has really helped. art.

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 11/11/2012

Art from Vancouver, could you tell us what foods are aggravating your neuropathy? It could help us to avoid them too and maybe even get a better understanding of what is causing the problem. Thanks, Al

Alpha Lipoic Acid
Posted by Art (Vancouver Bc., Vancouver) on 11/14/2012

Yes Al, I can tell you one of the foods that I was consuming that is causing the neuropathy was the artificial sweetener splenda. I just googled that today and WOW that stuff is poison and I didn't know. Any peanuts would also cause the knee pain and it seemed like greek yougert, ice cream peanut buttercup flavor and other protien based foods were doing it as well. By bedtime my legs were well heated up. I have cut back on all of this. The splenda is in the garbage as of today and I have switched to stevia in my coffee. I also discovered that the B12 should be taken on an empty stomach which I wasn't doing. I can now take the time released B12 without getting very itchy red spots on my legs. I chew one 1000mcg late at night washing it down with water. Just took one now and had two 2500mcg sublingual early today. The night time is when this really becomes a problem while trying to sleep. I don't want to jinx it but last night was the first night in a long time I got a good sleep, touch wood.

My knees seem to be cooling as I type this at 12:24 am.

Take care. art.

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 11/15/2012

Art from Vancouver, is it just non meat protein or is it all protein that bothers you? I changed my diet many years ago after reading the book "Eat Right For Your Type" as I have B Negative blood and that fixed a lot of problems. Some foods that I didn't care for were listed as ones that I should not eat as well as the opposite. Maybe you should check it out.

Alpha Lipoic Acid
Posted by Art (Vancouver Bc, Canada) on 11/16/2012

I had some blueberry cheese cake and now that I did I can recall any cheese cake will cause an episode with my knees being agrivated. Only off the splenda for two days and sleeping better. art

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 04/09/2013

To Art from Vancouver, BC. I realized today that peanuts were causing pain in my feet, thanks to what I recalled from your posting. Also remember seeing another post about peanuts having l-arginine in them. I looked up l-arginine on Wikipedia and found out that it is related to aspartic acid (Aspartame). There is a list of other foods there that contain it. I have B neg blood and most of what is listed are foods that I should not eat according to the book EAT RIGHT FOR YOUR TYPE by Peter J. D'Adamo. I would recommend that anyone with neuropahy look l-arginine up on Wikipedia.

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 04/21/2013

After realizing that peanuts (l-arginine) were bothering me I got some l-lysine and a week ago I started taking 1000mg twice a day and have seen another significant improvement in the pain level in my feet. I am getting close to curing this problem. It seems that the platinum in the chemo destroyed the nerve sheath but left the nerves intact and "shorted out". The alpha lipoic acid apparently stops the further decay of the nerve sheath by eliminating heavy metals from the body and the rest of the nutrients I have used are actually rebuilding the nerve sheaths. It has been a long, painful experience that I dread anyone else suffering through. I encourage you to try everything that might help. Some things will make it better and some will make it worse. Not everything works the same for everyone so be aware that experimentation is necessary and can be frustrating. Don't give up. It is over three years now since my problems started and I am still improving. Al

Alpha Lipoic Acid
Posted by Al (Alvena, Saskatchewan, Canada) on 02/02/2014

Good news, I am now off of all pain killers that I was using for neuropathy. I am still taking some vitamins and minerals to support the nerves but only as part of a healthy diet and not to fix a problem. I still have a bit of tingling in my feet and lower legs but I attribute that to sensitivity of newly healed nerves. I am able to walk normally and the strength is returning in my toes now which indicates that the motor nerves are all working and have been for a while. The cold sensitivity has subsided and I am looking forward to a relatively normal life. I have found that birch and/or wintergreen oils also help to reduce tingling due to neuropathy, apparently by reducing inflammation. I use a few drops topically on my arms daily. It has taken a long time to heal due to the severity of my neuropathy and the time between chemotherapy and starting ALA but it has healed the nerves. Considering I was told by a neurologist that it wouldn't improve any more after a year from the end of chemotherapy I am quite pleased.

Alpha Lipoic Acid
Posted by Art (Vancouver Bc Canada) on 02/06/2014

Al, it is good to hear about your recovery using the ALA.

Will you keep on using it now that you consider yourself cured?

I have made great strides using the R+ALA so that I can take it with out food for those troubled times in the evening.

I have recently switched to R+NAC+SR 500mg with food at lunch and supper, reason being to help with the Liver. Have not seen that much difference and will eventually switch back to the R+ALA when depleted.

One night recently my feet felt like they were beaten with a hose at bedtime and the R+ALA gave me great relief at around 12:30am. So it really does work and I am glad for that, but when I switch back to it I can see using it to the end of days.

Thanks again Al for your input.


Grapeseed Extract
Posted by Al (Alvena, Sk., Canada) on 09/12/2012
4 out of 5 stars

The first natural product/supplement that I tried for peripheral neuropathy (caused by oxaliplatin in chemotherapy) was grapeseed oil and then grapeseed extract in a caplet form with excellent results that allowed me to reduce the amount of hydro morph contin that I was taking by about 40%.

I have told others about it and most that tried the liquid form had stomach upset from it.

I use 50-100 mg three times per day.

Grapeseed Extract
Posted by Amanda (Europe, Europer) on 09/13/2012

Hi, Can you confirm whether you take grape seed oil, grape seed extract and whether you take it in capsule or liquid form. Thanks

Alpha Lipoic Acid
Posted by Al (Alvena, Saskatchewan, Canada) on 09/03/2012
4 out of 5 stars

I developed peripheral neuropathy from an overdose of Oxalyplatin in chemotherapy for stage 3 colon cancer in February of 2010. It affected my upper palate, hands and legs up to my mid thigh. I have been on Gabapentin, 3600 mg/day, for an extended period of time and then found out it was increasing my blood sugar by 15.0 with a single 300 mg dose so was switched to Lyrica instead. I have also been on narcotic pain killers along with the others and at times nothing would touch the pain or numbness and when nerve testing was done the doctors could not believe that I could still walk as there was zero sensory and zero motor nerve conduction. I had to look where I was putting my feet as I could not feel where I was putting them. I have been very slowly and steadily healing in spite of being put into a diabetic condition by the Gabapentin.

I read about alpha Lipoic acid in an article about fat loss/muscle building with a relationship to insulin sensitivity and it listed five ingredients of which ALA was one. When I looked at ALA in the search engine and read that it would cure neuropathy and that it is used to reduce the side effects of Oxaliplatin in chemotherapy I picked some up and started using it on 1 September 2012. I immediately noticed an improvement in my feet( the only currently affected area). It was so dramatic of a change that I discontinued all other medications to see what it did by itself. I have spent a couple of sleepless nights due to pain and have started using my other medications again today. Other than Lyrica and Hydromorph contin I take grape seed extract, fenugreek, St. John's Wort, milk thistle, glucosamine and condroitin sulfate with MSM, vitamin D, B12, curcumin, Motrin, and Apo-Temazepam for a sleeping pill. After less than 4 hours since resuming my other medications with ALA my feet are about 75% better than they were three days ago.

Is there anything else that I should be taking to speed the healing/reduce the pain and numbness? Please reply directly to gustafsonal(at) Thank you. Al

Alpha Lipoic Acid
Posted by Bill (San Fernando, Philippines) on 09/03/2012

Hi Al... I think it would benefit your condition if you also took the whole spectrum of B vitamins (either as B50 or B100 complex or as De-bittered Brewer's Yeast forms) which contain Choline, B3, B6, Folate and many other nutrients which would benefit the CNS system. Higher dose B12 is also beneficial to many body processes including the nervous system. For more on the benefits of B12 read David Brownstein's book -- Vitamin B12 for Health. Adding the Gotu Kola herb and higher dose Vitamin C to your regimen would also help to accelerate nerve repair. Adding higher dose niacin(not niacinamide) would also greatly benefit you blood transport system and make it more efficient. Niacin actually changes and thins out the blood safely and the flushing effect of niacin is evdence that the capillaries and peripheral blood vessels are opening up for better delivery of the nutrients you are taking to the body peripherals -- ie to the hands and feet regions. Take 500 mgs niacin twice a day after meals dissolved in half a glass of water for best absorption into the body.

Alpha Lipoic Acid
Posted by Timh (Louisville, Ky, Usa) on 09/04/2012 2083 posts

Al, Zinc is very important for healing to occur throughout the body and also boost immunity. Another very important nutrient is the Omega 3 Fatty Acids like Fish and Krill Oil. Flax Seed Oil is converted into the EFA's that the body needs in order to reduce inflammation and promote healing. A native crop in Canada, you should find Flax Oil readily and at a good price in your grocer.

Hope this helps.

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 09/11/2012

I was trying to find the Gotu Kola herb at the same time as I found the ALA but it seems to be unavailable here (in Saskatoon, Saskatchewan). I had to order acetyl-l-Carnitine and benfotiamine as no one had them in stock but could not order the Gotu Kola. Al

Alpha Lipoic Acid
Posted by Al (Alvena, Sk.,canada) on 09/11/2012

I know about flax seed oil. It requires the protein that is in cottage cheese to be mixed with it before consuming to get the maximum benefits. I was at stage 3 with colon cancer when I had the tumour removed and shortly after went on the "Budwig Diet" which is based on flax seed oil(3 tbsp) and cottage cheese(1/2 cup) once daily. I blended them together and added liquid honey and cocoa powder to taste with some extra liquid to make a smoothy for breakfast. This diet is purported to directly attack cancer. Five weeks later all the oversize lymph nodes were back to normal size(that is when I started chemotherapy). I think this indicated that the cancer was gone and thus the overdose of oxaliplatin which damages nerves and the islands in the pancreas especially with a lack of cancer to attack. I have been cancer free for over two years now and only have to overcome the resulting neuropathy to get back to a productive life. Al

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 09/14/2012

I got my dad, 75 years old, started on ALA on Sunday, 9 September 2012 and he is already seeing enough improvement that he went to town yesterday and bought enough for four months. He has had increasing levels of pain in his feet for years (cause not known) and has been using full leg air pressure massage for four hours a day for years to remain walking. He is talking about being able to discontinue that therapy and it has only been five days to get to that point. Al

Alpha Lipoic Acid
Posted by Timh (Louisville, Ky, Usa) on 09/15/2012 2083 posts

Al, good to hear of you and your dad's success with ALA; and it's good for immune system, blood sugar, and liver health. Please specify how many mg dose? how many times daily? as it can help set a standard for other interested users.

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 09/16/2012

First, Bill, my blood pressure is normal as for an 18 year old @ 160 pounds and I am 6 feet tall, 330 lbs and 53 years old. I do not feel it would be right for me to take anything that would lower my blood pressure. What would you say to that re: niacin?

Tim, we are both taking 250 mg of ALA twice daily. I also started taking 500 mg of ALCAR twice daily yesterday and it seems to be helping.

Something quite interesting, when my dad stocked up on Wednesday the supplier told him that ALA would stop Alzhymer's disease immediately. Had we known about that sooner one of my aunts would still be with us. Have also heard that coconut oil helps Alzhymer's disease. Does anyone know if coconut oil contains ALA. If so it would probably be an excellent topical for neuropathy. Al

Alpha Lipoic Acid
Posted by Bill (San Fernando, Philippines) on 09/16/2012

Hi Al... I am 196 pounds and also 6 feet in height. My blood pressure is currently 110 (systolic) and 70 (diastolic). Since I started taking higher orthomolecular dosages of niacin, my blood pressure hasn't changed at all (I measure it myself every week). This is in line with what Abram Hoffer has said in his articles -- he maintains that particularly niacin (not niacinamide) balances high cholesterol and high blood pressure safely and I guess my experience with niacin is a confirmation of that. For blood pressure/cholesterol problems niacin is the one to supplement.

I take orthomolecular doses of niacin because it is anti-aging and helps so many other processes in the body (together with the rest of the B vits). Abram Hoffer was also sure that you would live longer if you took proper orthomolecular dosages of niacin every day. For most of his life, Hoffer also admits that he took between 0. 5 and 6 grams of niacin/niacinamide himself daily and he lived to the ripe age of 92. He has also documented that taking 0. 5 to 3 grams of niacin/niacinamide is the proper orthomolecular dose for a healthy person, depending on how good your diet is.

The current RDA recommendations for vitamin B3 is about 16 mgs a day.

Alpha Lipoic Acid
Posted by Timh (Louisville, Ky, Usa) on 09/17/2012 2083 posts

Al, thanks for your informative responses. As for ALA, I don't think it's endogenous in foods as it is a coenzyme that the body creates from nutrients like B vitamins and sulfur amino acids like Cysteine, as well as some minerals. Another coenzyme you might want to consider supplementing is CoQ10 or Ubiquinol as it works in the body differently than ALA, especially for heart health.

Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 09/18/2012

Bill, not only is my blood pressure good, but my good cholesterol is high and my bad cholesterol is low. I believe it is a result of trimming fat from food since I was young. I do not butter bread and I trim the fat from bacon as well as cooking with water, skinning poultry before cooking and eating lots of vegetables.

Timh, I have tried CoQ10 and felt no change in my health. I have no idea if it did me any good or not but I am in a very tight financial situation so even getting ALA & ALCAR & Benfotiamine means putting off paying utility bills. My monthly budget for everything comes out of an income of less than Canadian $900. That has to cover maintaining a home(paid for) and maintaining, licencing and fueling a vehicle as I live 45 miles from the nearest city. I am hoping that the improvements I have seen so far continue at the same rate and allow me to get back to work and my normal income quite soon.

I am seeing a small improvement with the benfotiamine and a significant improvement with ALCAR but the ALA is just phenomenal. Al

Alpha Lipoic Acid
Posted by Art (Vancouver Bc, Canada) on 02/08/2013
5 out of 5 stars

Update on taking ALA for Neuropathy.

I am taking one 100mg. At breakfast and one at supper, and one or two B12 2500mcg before bedtime. The burning in my knees has almost gone and things are settled to near normal. I am not cured but as long as I don't forget to take my ALA twice a day I am fine. If I do forget I am in for a night of torment with burning skin on my upper knees. I have been getting chills these last couple of months after taking Chanca Piedra for stomach issues, but will forge on since summer is near.


Alpha Lipoic Acid
Posted by Al (Alvena, Sk., Canada) on 01/22/2015

I just received an email from a lady in the UK asking for an update and telling me that the last one was in 2013. I have been busy working long hours, sometimes over 340 hours in a month. The neuropathy is still improving, but extremely slowly. All I use for pain relief now is geranium oil, topically on my hands and forearms. It a natural anti inflammatory and has no known side effects. I still feel I am missing a nutrient or two to finish curing my neuropathy. I try everything that might help and am in the process of checking out one more nutrient with my doctor and hope to try it within a few days. If it helps I will give a further update and let you know what it is and how to use it. The posting I found it in quoted a medical journal entry from the 1840's. New is not always new and maybe old is better. Al

Alpha Lipoic Acid
Posted by Al (Alvena, Saskatchewan, Canada) on 03/04/2015
1 out of 5 stars


Another update. I recently had surgery to remove the right lobe of my liver. This was due to matastatic colon cancer and as a result my blood pressure has gone up resulting in other problems including reduced energy and increased neuropathic pain. I noticed that when I had something sweet to eat like jam, cake, candy, etcetera that the neuropathic pain was reduced substantially so I started experimenting. When doing anything slightly strenuous my blood pressure and sugar would drop and my pulse would go way up so the first thing I tried was leaving out the diamacron and metformin. This allowed the sugar to increase and gave me back my energy without my blood pressure and pulse being significantly affected, but the sugar went too high so I added the metformin back in.

Big surprise!!!! The neuropathic pain went way down, more than eating something sweet made it go down. As a result I typed "diamacron" into google and clicked on "diamacron side effects" and found out that it causes neuropathic pain, conflicts with metformin, is not supposed to be used if you have liver problems, are having or recently had surgery. None of this was covered in the pharmacy information sheet I was provided. The warning is not about alpha lipoic acid, but rather it is about the diamacron prescription medication and what it does. Eliminating it has made a huge difference. I have not as yet tried the nicotine but will be soon. Al

Alpha Lipoic Acid
Posted by Timh (KY) on 03/05/2015 2083 posts

AL: Glad to see you are using your brain to help work out these pressing issues. I am in a constant state of tweaking any treatment or therapy to maximize benefit and minimize harm.

Several months ago I also reported not reading some very critical info on Statin drugs that was not included in the fact sheet from pharmacy. Two items in particular is Statins can and do produce nerve damage resulting in neuropathy, and can and do (in a certain percentage of people) produce pulmonary fibrosis. Well, here I am already w/ both these conditions so I could only surmise a worsening; which was evident particularly in the neuropathy as I had the choice of continuing the medication (and even at 50 or more % lower prescribed dose) and going down from a cane to a walker to a wheelchair or discontinue.

There is lots of Cancer info here on E.C. for the cancer so I hope you can get exact on that and get well again. There are some good Youtube vids on self-applied Ozone for rectal administration.

As for the Neuropathy, there is some promising research lately on a natural nutrient, a nucleotide Inosine for rebuilding nerves which is helping in cases like Parkinson's.

Alpha Lipoic Acid
Posted by Al (Alvena, Saskatchewan, Canada) on 03/04/2015
1 out of 5 stars


Another update. I recently had surgery to remove the right lobe of my liver. This was due to matastatic colon cancer and as a result my blood pressure has gone up resulting in other problems including reduced energy and increased neuropathic pain. I noticed that when I had something sweet to eat like jam, cake, candy, etcetera that the neuropathic pain was reduced substantially so I started experimenting. When doing anything slightly strenuous my blood pressure and sugar would drop and my pulse would go way up so the first thing I tried was leaving out the diamacron and metformin. This allowed the sugar to increase and gave me back my energy without my blood pressure and pulse being significantly affected, but the sugar went too high so I added the metformin back in. Big surprise!!!! The neuropathic pain went way down, more than eating something sweet made it go down. As a result I typed "diamacron" into google and clicked on "diamacron side effects" and found out that it causes neuropathic pain, conflicts with metformin, is not supposed to be used if you have liver problems, are having or recently had surgery. None of this was covered in the pharmacy information sheet I was provided. The warning is not about alpha lipoic acid, but rather it is about the diamacron prescription medication and what it does. Eliminating it has made a huge difference. I have not as yet tried the nicotine but will be soon. Al

Acetyl-L Carnitine, Alpha-Lipoic Acid
Posted by Joseph (Stockton, CA) on 08/11/2021 72 posts

Hi Laura, just read your posting of several years ago. 1st. Gabapentine did they sell it back then? To me I would never take due to how dangerous the side effects are. Did you suffer Side Effects at all? How long did you take? Did it really help your pain? Is there an R-Lipoic Acid? Thank you, I too love this site, however, I have lots of priorities so I can't view for hours, but would love to because I pass on info to others that need it.

If I can be of assistance with anything pls contact me. Joseph

Acetyl-L Carnitine, Alpha-Lipoic Acid
Posted by Alana (Aurora, Co) on 11/19/2012

Hi Laura - thanks for the great info. I'm so glad your neuropathy has resolved and congrats on finding the cause! I had a sudden onset of neuropathy in my legs in 2005, which has since spread to my hands. Doctors believe the cause is either autoimmune or a spinal cord cyst. I'm interested to try your approach, but also fearful of giving up beloved gluten, dairy, etcetera and having it not work. So, my question is, how long were you doing the gf thing before you noticed a difference? Even though I've tested negative for gluten sensitivity, I've gone off of it for periods up to 2 weeks without any difference. Thanks in advance for any info!

Acetyl-L Carnitine, Alpha-Lipoic Acid
Posted by Tlkleen (Halifax, Nova Scotia) on 02/10/2013

My husband has a rare disease called Tangiers. It causes neuropathy mainly in his limbs, but has lost feeling all over. He suffers from alot of pain. He is getting ALA treatment from his naturopath. They are starting a new treatment that involves a new natural med that will be administered before the ALA to help the body absorbe it. They say he will notice a difference with in 30 days. Fingers crossed!

Acetyl-L Carnitine, Alpha-Lipoic Acid
Posted by Cheryl G (Groves, Texas, United States) on 03/09/2013

Tikeen from Halfax: My husband has neuropathy pretty severe, I'm interested to hear how the treatment goes with ur husband. Wishing ya'll best of luck!! Pls let me know how it goes! XOXOXO

Acetyl-L Carnitine, Alpha-Lipoic Acid
Posted by Steve (Las Vegas, Nv Nevada) on 03/09/2013

My brother has had some success relieving neuropathy in his fingers and toes using a low level laser therapy pen. There is lots of research on low level laser therapy for neuropathy you can read as well:


Acetyl-L Carnitine, Alpha-Lipoic Acid
Posted by Rosea (Michigan ) on 01/25/2017


How long did it take for the alpha lipoic acid to work? Also how much did you take a day?

Acetyl-L Carnitine, Alpha-Lipoic Acid
Posted by Rich (San Jose) on 08/02/2017

Each person has a different reaction when taking meds or supplements.

at best trial and error.

Acetyl-L Carnitine, Alpha-Lipoic Acid
Posted by Stella (New York) on 06/15/2020

Were you ever on the D pill before you started the B-12? and fish oil??

Alpha Lipoic Acid
Posted by Normared (Knoxville, East Tennessee, Us) on 05/03/2012
5 out of 5 stars

After a bad two-week long spell of sharp, needle-like pain in my feet I looked at this site for advice. At my next doctors appointment a few days later, I checked with him for his opinion, and based on that added ALA to my treatment (which was metanx pills he gave me last year). Within 24 hours of taking one 600 mg tablet of ALA the pains were down by at least 50% intensity, and now a week later they are almost completely gone. A few days ago, I also added a B complex, and plan on adding a B12 lozenge too.

My doctor - a foot doctor who specializes in neuropathy - had no problem with these 'additions', in fact he is the one who suggested B12 in a lozenge form, not a tablet. I'm now a strong believer in taking ALA B vitamins for those pains in my feet!

BTW: Bought my 600mg ALA tabs at GNC - they've got an amazing vanilla flavor and are a pleasure to take! I take 3 per day and a Bcomplex once a day.

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