Please read the book by Dr. Louis Ignarro. He won the Nobel prize for science in 1997. He states clearly that Arginine and Citrulline will help neuropathy. He says to take 4000 mg arginine and 1000 mg citrulline before bed and it will bring back to life your endothelial cells and your neuropathy will be helped and your heart and everything else in your body will benefit... The combination of these 2 amino acids generates Nitric oxide...
A friend of mine had peripheral neuropathy due to chemo treatment. I recommended B-vitamins, but knowing the seriousness of this, I was not willing to take chances. I advised her to buy a very good food-based B-Complex and an additional B-12. She had a very quick recovery (symptoms diminished in one day and resolved within a week or so, with no recurrence throughout chemo). Her neuropathies had just started a week or two before, so I'm sure that helped her heal quickly. The B-complex & B-12 supplements she took were Vitamin Code/Garden of Life. This is a raw, whole food formula with live probiotics and enzymes. Find it at any healthfood store in the US. She took it according to the package directions. The amounts are much less than typical supplements & it's a little pricey, but there is absolutely no doubt that this one was well-absorbed and effective for my friend. Her recovery was nothing short of amazing.
Having had plenty of back problems myself, I learned to be mindful of how mental stress causes me to tense up in my back and hips. Just being aware of this has helped me mentally combat the stress and relax my back. Easier said than done, I know, but I wish you all the best.
Ted or Bill, I have gotten conflicting information from 2 doctors regarding my B vitamin levels... First of all I have terrible peripheral neuropathyand have tried everything out there... I had a test for my B vitamins and one Dr.said I was high in my B-6 which is 96... (normal range is 5-50)..
I was also told by this Dr. that my B-2 was high at 67 (normal range is 2-15).
She told me to go off any B vites and my neuropathy would ease up as this was contributing to my pain etc...
I decided to get a second opinion and the new Dr. said that, "the only neuropathy ever seen with B vitamins was when people absurdly took 4000-6000 mg of daily B-6 per day which caused mild neuropathy that was reversable when they discontinued that absurd dosing.. Some Dr. S tell you this as though it could happen at normal doses. " This is directly from the report.
I want to take high B-6 and B-3 and am understandably confused... and in pain... Thank you.
(Vancouver Bc., Canada)
Vitamins b1 to b6 and b12, plus ala and butcher's broom, reduced my diabetes neuropathy by about 70% and another 10% by not using a recliner chair to watch tv. Maybe it presses on the nerves in the legs.
I've been using MSM for years to prevent gallstones and my neuropathy just continued on. My initial neuropathy was from B12 deficiency, which was from chronic diarrhea, which was from vaccine injury.
I tried B-12 patches for my terrible neuropathy and my cramping and shooting/stabbing pains got worse..I thought all B vitamins were water soluable so this wouldn't happen. Anybody have any suggestions as why this might happen? Thank you.
Hi John P. ; I do hope you're having some improvement by now with the B12. Have your symptoms changed at all? Oftentimes as nerves heal, numbness, tingling, and pain can alternately diminish and return temporarily. Temperature sensitivity can also shift. Although I've tried numerous subtances for neuropathy, the B12 has worked best far and away. But this only means that it worked for my case. (though there are many case studies to support B12's efficacy with neuropathy). Still, the folks here are offering good suggestions as these supplements also have an excellent track record for treating nerve injury. I also welcome suggestions because someone may just pop us the right answer!
I see you are trying transdermal applications. It still surprises me how powerful they are. In fact, I cringe when I recall that I've coated my hands with paints that were loaded with heavy metals. Then I would use nasty solvents to remove them. Now I use gloves. But I do use the solvent, DMSO with some transdermal applications. I've added 4 (20mg) B12 lozenges, crushed with a mortar and pestle, to a 1 oz. Dark glass dropper bottle, mostly filled with DMSO. I shake it vigorously for a few minutes until dissolved. This is an approximate recipe developed by Dr. Gregg. I've used this off and on for several years with good effects. I buy the DMSO and supplies from a chemical shop. The mixture is a bit sticky, and the flavorings make for an unusual scent, but it did help me. I would often use it on my left hand which had become frighteningly stiff and numb. I'm now trying it on the small numb spot on my heel to see if it speeds recovery. Castor oil is also a great medium to use either alone or with added essential oils, some good warming ones could be : Oil of Oregano, Cinnamon Oil, Black Pepper Oil, and Ginger Oil. Cayenne is very warm, but I have only seen it as a powder or extract. There are some ready-made salves, but some are with cooling mints. I do have one that is warm, it is called Badger sore muscle rub. It is mild. Good Wishes.
Hi John P. ; A few days ago, I asked myself ; What has B12 not done for you? My hair is still 40% gray, and I haven't yet written that " hit song". Each day is a bit better, but it's so slow for me. When the neuropathy was at its worst, I began with a litany of supplements to cure it , but I was using so many at the same time , I couldn't discern what was working. I became confused. My studio became an apothecary. When I look back, I realize that there were so many obvious clues for me, but I was distracted with pain and fear, and I had spent my life on denial of my instincts. I've got a way to go with that. What I'm learning from you is that you are going about your healing process logically and methodically. I appreciate this. Although B12 is not the only one thing , Its pretty dang'd powerful. There have been and there are currently tests being done for people with MS and early ALS to at least improve their status. The amounts being used are 50 mgs. Daily by injection. This means that there could be a wide variance in an individual's needs. I've tried a wide variety of amounts, and I'm still somewhere between 2500 - 5000 mcgs. Daily now.
I've " haunted" some forums, and it appears that other people are trying a wide variety of amounts, but, most seem to be settling in the 1000 - 5000 mcg. Range. Some are lower, and some are extrordinarily higher. I have been influenced by this information, so I need to be mindful of it when making suggestions. Another thing I am noticing about B12 is that it is raising my body temperature and I am feeling warmer. ( I've read this and now I'm seeing it. I'm at 98. 2 degrees now). I believe it will help with cold legs eventually. I also believe that massaging legs and feet with oils can be wonderful. (my skin is dry, so I use castor oil). I've used various salves for pain with good effects. Since you have coldness, I would recommend that warming spices be added to your salve, such as Ginger, and Cayenne. Ginger has been recommended to raise body temperature and improve circulation. ( internally and transdermally) Best to You.
(Toogoolawah , Qld Australia)
(Phoenix, Arizona (az))
Hi John P. ; I truly hoped that you had knocked that neuropathy out of the park right away, but it usually does take time to heal nerve inflammation. It took about 8 mnths. For me , 3 1/2 yrs. Ago. Then, when I stopped taking it daily, and regressed, it took several months to again heal the nerves. Even after restarting B12, I still regressed during the first month. Now in my 6th month, I have a small, shallow numb area on the heal of my left foot, and it is recovering feeling. The area around it is sensitive and tingly. This means that time is necessary. Also, it means that we're going to have to get more technical with your process.
Firstly, I've read that oftentimes with liver trouble, potassium could go low. That can cause some cramping and pain. If you are not taking any potassium sparing meds. , such as some certain diuretics or anti-hypertensives, then consider increasing potassium foods. ( careful with the sweet ones, they can cause pain). Consider getting a copy of blood test and observe electrolytes. ( I find I feel best when K is about 4.5 mEq/L). Fresh vegetable juices are great, carrot, celery, and added greens. Smoothies are also a great option, as are homemade broths with the retained liquid from the veg.
As I see that you have expressed a sensitivity to acids, I agree that reducing them is a good way to alleviate pain. The nerves are exposed, and even beneficial acids can cause pain now. Although citric acid is natural and good, it is added to so many foods as a preservative, that it is easy to get too much. Even ascorbic acid can cause pain. I don't recommend total avoidance, but some reduction. I recommend a food type B-complex. (new chapter). It's expensive, but less is needed. I've found that it doesn't cause pain when taken with meals at 1/2 to 1 tablet. B1 and B6 are good for nerves at lower dosages, ( personal opinion ). Also, the fat soluble vitamins, A and D, can be difficult to metabolize when there is liver trouble, so I recommend getting them from food rather than supplements. Good Wishes.
Looking for Connie from Utah...
You gave me a remedy for my Periphal Neuropathy... I am now up to 10,000 mcgs of B-12 and still have pins and needles and severe cramps in the middle of the night in my calves... My legs are cold from the knees down and we're in a heat wave in August.... It seemed to subside initially, but the full neuropathy is still there... I have been doing it for about 3 weeks.. Is this something that may take months to resolve? Any feedback will be greatly appreciated... If you recall I believe that hep-c has caused this neuropathy...
(Avon, Ct, Usa)
(Alvena, Sk., Canada)
I also took the same Bs as Shrikant (the fat soluble B 12 & Metacobalin) and my neuropathy in both feet that I had for a few years got better THE NEXT 24 hours I could tell - a difference for the better. I am now still on the fat soluble Bs and it has been 1 1/2 years now. The tingling, the extreme sensitivity, the sudden jerking jolts of what felt like electric shocks within my feet are all gone.
Only thing is lately, I have noticed a tightness appearing and I cannot bend back my toes towards me comfortably. Don't know why...
Hi Mark; This doesn't look easy, but I'll put forth some guesses. Zinc may be needed. It is often times low in people who have become ill with cancer and a large variety of infections. Zinc is active throughout the body, including the nerves. The symptoms of zinc deficiency usually include problems with taste and smell, gastrological disturbance, gonadal disturbance, and growth problems, but there can be many more symptoms. Some types that are easier to find are; zinc gluconate and opti-zinc; I have found these to be effective. Also, a food derived zinc may be gentler on the stomach if sub-divided. There's a zinc-l-carnosine type that may also be easier on the stomach. If taken for long term, a small amount of copper may be needed. ( There are cases of neuropathy that were caused by zinc toxicity that then caused a copper deficiency. These cases were the result of extreme amounts of zinc used, however... in the form of denture adhesives.)
Also, some supplements can worsen neuropathy if taken in too high doses for an individual. B1, B6, ALA, Acetyl-L-Carnitine, etc, may cause irritation.
I found B12 to be most effective for my neuropathy, but it took many months to heal... About a year. But I've also found Zinc to be enormously beneficial for nerve healing. It may take a month or so to see results.
Benfotiamine for Neuropathy
Hi my.bame is Jacqui. I am now 82 years of age.
I had the worst neuroo as thick pain around 3026. Every time I P Bank, burning like fire, crushing. Electric shocks, etc. Had ne constantly scream. Cause not known. I am not diabetic but I have chronic Lyme disease with multiple co infections including Bartonella. I was on Gabapentin that worked initially but when it stopped was switched to lyrica and then horizonta. Nothing worked.
At the time I tried Aloa Lipoic Acid but it had no effect on relieving the pain, but the dosages I took were co miserably lower than 600 mg that I notice is now recommended.
Out of desperation I started to experiment with high dosages of Benfotiamine. It is a synthetic form of vitamin B1 so that it iis made fat soluable and it can enter the cell wall ( and therefore nerve cells) making it highly more effective than ordinary B1 ( thiamine(. It is known to be effective & often used for diabetic neuropathy.
I learned about it in 2005 because I had used it successfully then when I had neurologic pain in my left small toe. The usual dosage is about 300-600 mg.
At tt time I took a little more & it was successful in stopping the sensitivity and pain ( even a sheet touching the toe area would caue pain(). Eventually I stopped using it. (At the time I was not aware that I had chronic Lyme disease. I believe that is the main cause of my beuropsthy(
So, 11 years later when I had severe neuropathic pain in my legs ( surprisingly not in my feet until later on) I experimented with Benfotiamine. I was desperate and decided to take increasing amounts until hopefully the pain diminished. I found the correct dosage. 1,200 mg ( 4 300 mg capsules) every 4 hrs. I put it on a timer and took it at the middle of night. I remained on that dosage for four years. Sometimes I could decrease it. When I had Covid the neuropathy got worse and going back to 7,200 mg a day was not enough. I doubled, possibly tripled that dosage and the pain went away. Eventually I was able to decrease the dosage dramatically..
I have also found that grape seed extract, high in resveratrol also have dramatic improvement and with very high dosage ( about 1 tsp of the piwder - in a drink & extremely bitter) I could reduce the Benfotiamine. ( BTW, for years I took high dosages of tumetic, by the tablespoon very effective for my for arthritic pain but it had no effect on the beuropaty, (. Now I take tumetic 95% curcumin, excellent for inflammation & other things but I haven't noticed it helps neuropathy). Benfotiamine in very high dosages has multiple benefits. One is that it promotes angiogenesis ( regrowth of arteries). While I was on the gett high dosage for many years I was not aware I had a 99% blockage in the popital artery, the main artery from the knee down the keg. It was discovered accidentally because I had no pain at all which is miraculous. The blockage was removed in 2019 and afterwards I have read about a study done on mice in 2006 that it promotes angiogenesis and the reason I had no.pain is because the high dosage I was on for years created colkatety arteries in my legs and that is why I had no pain. I have also read Benfotiamine is good for most autoimmune diseases. including fibromyalgia and Croans disease.
I have been for many years on high dosage Benfotiamine plus many other supplements that I experiment with. I also had an EMG test a little over a year ago that showed severe sensory neuropathy in my legs, mild motor.neuropaty, & very Mild neuropathy in my arms and also carpel tunnel. About two months ago I repeated tan EMG. My last EMG tests show although it had not been severe I no longer have motor neuropathy in the legs . The severe sensory neuropathy in my legs is now mild. I no longer have mild neuropathy in my arms and there is no carpal tunbel. The neuroligist who performed this last EMG is doubtful that zi ever had neuropathy because he said it is impossible for nerves to regenerate. I am also sering another neurologist next week to go over as ll these findings and see what he has to say.
I apologised for typos. It is late at night, early morning & I am writing this on a cell phone. But I wanted to share this important information with you.
Also Sulbutiamine is another fat soluable analog of Viramin B1. It is capable of entering the blood brain barrier whereas Benfotiamine can not. I have found and studies support this too can help neuropathy but more studies have been performed with Benfotiamine.
(Mumbai Maharashtra India)
Finally! My feet are returning back to normal. Getting off the B vitamins helped within a months time. Started taking Benfotiamine, a lipid-soluble form of thiamine (vitamin B-1). I have been taking if for about 3 weeks, 600 Mils, a day. I now have feeling in my feet again!
I had PN BAD in both feet. After several tests doc told me to stop the B vitamins. B6 in excess can cause PN. I quit the B vitamins and started taking Benfotiamine and after a month my feel are returning to normal! I can finally feel my feet and the tingling is almost gone. Thank goodness!!!!
Some people cannot metabolize B6 efficiently. I'd quit taking them asap.