Melatonin Cures

Latest Research on Melatonin

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Posted by Art (California) on 01/31/2024 2136 posts
★★★★★

This new (January 30, 2024) comprehensive review of melatonin confirms the many health benefits of melatonin in people :

https://www.cell.com/heliyon/fulltext/S2405-8440(24)00297-4?_returnURL=https://linkinghub.elsevier.com/retrieve/pii/S2405844024002974?showall=true

Here is a relevant quote from the review :

While melatonin was initially understood to only regulate circadian rhythms, recent studies indicate that it has a far-reaching effect on various organs and physiological systems, such as immunity, cardiovascular function, antioxidant defense, and lipid hemostasis. As a potent antioxidant, anti-cancer, anti-inflammatory, and immunoregulatory agent, multiple therapeutic applications have been proposed for melatonin.

While this sounds great, not everything is yet known about all of the health benefits that melatonin provides to humans, animals and plant life and that means that melatonin can do even more than this review highlights. I'm still at 132 mg of melatonin per day and I am bolstering this with regular use of melatonin lotion. The natural age related decline of melatonin in people can not be good for our long term health based on the thousands of studies illustrating how melatonin helps maintain our health.

Art


Life-Extending Properties of Melatonin

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Posted by Art (California) on 06/09/2023 2136 posts
★★★★★

I frequently discuss the health-promoting value of melatonin, but often wonder why melatonin declines as we age and gets to a very low level of production around age 40 or about the same time as age-related diseases start to increase.

Although melatonin does many things to try and maintain homeostasis in our bodies, the decline of melatonin as we age doesn't allow melatonin to do this job as effectively as it did when we were younger.

So in thinking about this, I have considered that perhaps melatonin is actually a molecule mechanism built into the body to help prevent population overgrowth. An age related decline of melatonin would help to ensure that people do not live too long as living too long would quickly promote overpopulation of the planet and would result in insufficient food to feed the overpopulated planet. This idea brought forth the question of how the body would know that it needs to reduce melatonin production in order to help prevent overpopulation.

One way that I thought of is through calorie intake. When the body regularly receives a healthful caloric intake, that means there is plenty of food available and prospects are good for continued survival and the body responds to this by decreasing melatonin production at the rate we currently see. On the other hand, if caloric intake declines significantly, as in people are starving, melatonin levels decline even further by 20% in just one week or less as discussed in the following study :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3402070/#:~:text=Short-term voluntary fasting by, % (26–28).

Here is a relevant quote from the study, keeping in mind that this study comes closest to the caloric restriction seen in starving, but not actually starving, as mild to moderate caloric restriction has been shown to have life extending effects :

' Short-term voluntary fasting by total rejection of food or with very limited intake of energy (<300 kcal per day) from 2 to 7 days reduces melatonin concentration in the blood by about 20% (2628). '

A reduction of melatonin by 20% would significantly lessen the pro health and pro survival effects of melatonin and a very likely outcome from such a scenario would be shortened life expectancy due to increased inflammation, oxidative stress, increased cardiovascular disease, increased cancer rates and reduced total antioxidant capacity. This in turn would likely increase mortality at an earlier age, thereby reducing planet population growth until healthful caloric intake could be restored.

In contrast, increased melatonin intake to try and offset the natural age related decline of melatonin will significantly reduce the number one cause of death in the world, cardiovascular disease (CVD) as I previously discussed here :

https://www.earthclinic.com/cures/melatonin-for-cardiovascular-disease.html

If you significantly reduce the number one cause of death in the world, CVD, it seems a reasonable expectation that people are likely to live longer. When you add the organ protective effects and bone protective effects of melatonin to that equation, increased life expectancy also seems a reasonable conclusion. Adding further to this, when you also take into consideration the multiple anticancer mechanisms of melatonin as discussed in the following link, it seems longer life expectancy due to melatonin is a reasonable idea :

https://cancerci.biomedcentral.com/articles/10.1186/s12935-021-01892-1#:~:text=Melatonin inhibits proliferation of cancer, signaling pathways in tumor cells.

Here is a relevant study quote regarding some of the ways that melatonin works against cancer :

' Melatonin inhibits proliferation of cancer cells through triggering cell cycle arrest and causes cell death by induction of apoptosis. Melatonin suppresses metastasis angiogenesis, and proliferation of cancer cells through affecting various signaling pathways in tumor cells. Melatonin also regulates autophagy pathway in cancer cell by affecting oxidative stress condition in tumor cells. These findings suggest that melatonin may increase the sensitivity of cancer cells to anti-cancer agents and may be a potential treatment for cancers either alone or in combination with other anti-cancer drugs. '

Studies that actually test if long term use of melatonin can extend life expectancy are lacking due to the length of such a study of many years, but given the above effects of melatonin, it seems illogical to think that melatonin would not extend overall life expectancy. So far melatonin has only been used in animal and insect studies in terms of life extension. The following study discusses melatonin and how it showed life extending effects in a small mammal :

https://www.sciencedaily.com/releases/2009/06/090622064807.htm

This is a relevant quote from this 2009 study :

' Under normal conditions, this animal shows the first signs of aging after reaching 12 months, mainly through the loss of circadian rhythm in its activities. By continuously administering melatonin, starting a little before 12 months, the appearance of these first signs was delayed by at least 3 months, which is a considerable period in relation to the lifespan of this shrew*. '

The following study discusses some of the known mechanisms of melatonin by which it can potentially extend life expectancy :

https://www.sciencedirect.com/science/article/pii/S2666555721000058#:~:text=The anti-aging effect of, or indirect oxidative stress damage.

Here is a relevant study quote describing some of the mechanisms by which melatonin may offer life extension :

' MT plays an anti-aging role by upregulating the expression of silent information regulator 1/Sirtuin 1 (SIRT1). SIRT1 is a histone deacetylase, and its physiological function is to remove acetyl groups, bind DNA strands together, and silence a target gene. In 2008, a study reported that MT increases the level of SIRT1 in a mouse model of accelerated aging (SAMP8 mice), demonstrating a positive correlation between MT and SIRT1 for the first time.9 This positive correlation was supported by two other studies.10, 11 MT enhances the deacetylation of SIRT1 substrates by upregulating SIRT1 expression and thus inhibits premature senescence '

Given all of the above information, it would appear that if you get extra melatonin through supplementation or natural means it can be healthful and possibly life extending, but if you continuously have low and or declining levels of melatonin, it may shorten your time to death. Overall, melatonin should make your stay here on earth a more healthful one!

Art

Replied by Madelyn
(Idaho)
06/10/2023

Hi Art, thanks for sharing your thoughts on melatonin. How many mg of melatonin do you take daily for health benefits, longevity, etc? I'm 43 and definitely want to take this antioxidant powerhouse on a more regular basis. I bought some bulk melatonin powder and have been using it on my skin from time to time after reading some studies showing its positive effects on the skin. Just thought I'd share :)

Art
(California)
06/11/2023
2136 posts

Hi Madelyn,

Thank you for the feedback on what I wrote about melatonin and longevity!

I am currently taking 132 mg of melatonin per night. I have taken higher dose melatonin for many years, but have increased my dose over the years as studies reveal more about the multiple positive health effects of melatonin in humans, animals and plant life.

To me, given the current scientific evidence for melatonin, it makes sense to me to try to counter the proven, age related decline of melatonin in the body. This is why I have consistently written about the health effects of melatonin on EC and elsewhere to share the value of melatonin in helping to maintain our health.

Regarding topical melatonin, I use it topically also. As an example of how I might use it topically, recently a friend mentioned that her ears itch occasionally and that in one ear she also hears an annoying "whooshing noise". She was already using a topical spray of melatonin on her scalp that I had made for her to improve hair growth as I recently wrote about on EC, but can't find to link to and I suggested she try spraying the melatonin in her ears to see if it improved the itching. She called me last night and told me that the spray had alleviated the itch in her ears better than anything she had previously used for that purpose. She also said that on her first application it had also alleviated the annoying whooshing noise in her ear.

I realize I talk incessantly about the many health effects of melatonin, but this is a health forum and melatonin is one of the most healthful single supplements that I am aware of.

Art

Sue
(VA)
06/12/2023

Hi Art,

Your posts are so interesting and educational. You mentioned using melatonin topically for hair and I believe also skin. How would a lay person/non-chemist make this, or is there an existing product you like? Would such a formula be safe on the face and around the eyes? Many thanks!

Madelyn
(Idaho)
06/12/2023

Wow! I never would have thought it would even resolve both the itch and whooshing sounds in the ear. I am inspired now to make an all over body oil with some melatonin. Love it!

Replied by Ashley
(Santa Cruz California)
06/11/2023

Does melatonin degrade if 1 year has passed expiration date on bottle?

Art
(California)
06/11/2023
2136 posts

Sorry, Ashley,

I don't know the answer to your question because I have never had a bottle of melatonin make it to the expiration date.

Art

Replied by Timh
(KY)
06/11/2023
2063 posts

W I k I p e d I a

Function

One function of the pineal gland is to produce melatonin. Melatonin has various functions in the central nervous system, the most important of which is to help modulate sleep patterns. Melatonin production is stimulated by darkness and inhibited by light.[23][24] Light sensitive nerve cells in the retina detect light and send this signal to the suprachiasmatic nucleus (SCN), synchronizing the SCN to the day-night cycle. Nerve fibers then relay the daylight information from the SCN to the paraventricular nuclei (PVN), then to the spinal cord and via the sympathetic system to superior cervical ganglia (SCG), and from there into the pineal gland.

The compound pinoline is also claimed to be produced in the pineal gland; it is one of the beta-carbolines.[25] This claim is subject to some controversy.[citation needed]

Regulation of the pituitary gland

Studies on rodents suggest that the pineal gland influences the pituitary gland's secretion of the sex hormones, follicle-stimulating hormone (FSH), and luteinizing hormone (LH). Pinealectomy performed on rodents produced no change in pituitary weight, but caused an increase in the concentration of FSH and LH within the gland.[26] Administration of melatonin did not return the concentrations of FSH to normal levels, suggesting that the pineal gland influences pituitary gland secretion of FSH and LH through an undescribed transmitting molecule.[26]

The pineal gland contains receptors for the regulatory neuropeptide, endothelin-1, [27] which, when injected in picomolar quantities into the lateral cerebral ventricle, causes a calcium-mediated increase in pineal glucose metabolism.[28]

Regulation of bone metabolism

Studies in mice suggest that the pineal-derived melatonin regulates new bone deposition. Pineal-derived melatonin mediates its action on the bone cells through MT2 receptors. This pathway could be a potential new target for osteoporosis treatment as the study shows the curative effect of oral melatonin treatment in a postmenopausal osteoporosis mouse model.[29]

Pineal gland - Wikipedia

Art
(California)
06/11/2023
2136 posts

Timh,

Wow, it's been a minute since you've been around! Glad to see you back posting again!

I wrote about how melatonin can be very useful for osteopenia and osteoporosis here :

https://www.earthclinic.com/cures/melatonin-for-osteoporosis.html

Definitely a nice alternative to the prescribed bisphosphonates like Fosamax.

Art

Timh
(KY)
06/13/2023
2063 posts

Wow thanx Art. 😀 My health eventually got so bad that I could no longer be active here (as either a reader or contributor) and currently not yet enough functional, but I am still alive and continue making progress. I do wonder how Deirdre, Bill, Oscar, Ted among others of which I cannot properly remember, are doing??? Of your comment "it's been a minute" makes my foggy memory of how long it has actually been obvious, and recently I have been singing over & again the quote from Al Stewart "Time, time, we hardly even knew you - you never touched us with your lies"!

Art
(California)
06/12/2023
2136 posts

Sue,

Thank you for saying so!

I have not seen a ready made product of this nature.

The simplest way is to dissolve the melatonin is gin. The alcohol content in the gin will evaporate rapidly after application and the juniper berry content has anti inflammatory and antioxidant effects also. This could potentially be used under your normal face moisturizer.

Art

Art
(California)
06/16/2023
2136 posts

Timh,

Sorry to hear about your present condition and hopefully you will be able to find the best remedies to get well soon. If you need ideas, EC is a good place to find those and the remedy inventory is quite large now!

Oscar and Ted have been unavailable for years now, but Bill and Deirdre are still here!

Best wishes, Timh!

Art


Melatonin and Anti-Rejection Drugs

Posted by peter (chicago) on 01/24/2022

Attn: Art from California

My wife is on anti rejection drug for kidney transplant and blood pressure medication.

She has trouble sleeping and told me Melatonin can not taken. Please let me know is that the case.

Replied by Art
(California)
01/25/2022
2136 posts

Peter,

Because of the serious nature of your wife's condition (kidney transplant & potentially related issues), you should be talking to her transplant specialist about the use of melatonin and here are a few studies that suggest that melatonin may be beneficial, which you can show to her doctor to give a little more information on the potential utility of melatonin in kidney transplant. I am not a doctor and this is well beyond the scope of information that you should be looking for on a forum that specializes in home remedies. Here are a few relevant links that her doctor can consider as to whether melatonin will be useful for her specific case. :

https://joe.bioscientifica.com/view/journals/joe/229/3/R129.xml

https://www.scielo.br/j/ramb/a/JZYNnhjCVYYNtFrtMxZ6kqK/?lang=en

https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC7073605/

https://pubmed.ncbi.nlm.nih.gov/31446153/

https://pubmed.ncbi.nlm.nih.gov/30671880/

Best wishes to the both of you!

Art


Melatonin and Blood Thinners

Posted by Pam (Ponte Vedra, FL) on 01/21/2021

Does Melatonin have an effect on a person taking a blood thinner?

Replied by Art
(California)
01/23/2021
2136 posts

Hi Pam,

Yes, melatonin has blood thinning and anticlotting effects, so getting your doctor's approval if you are already on a blood thinner makes safe sense. Too much blood thinning is bad and can be dangerous. Some common supplements like vitamin E and Serrapeptase can have blood thinning effects also, so anyone who is already on a blood thinner should seek their doctor's advice if adding a supplement with blood thinning qualities.

Art


Melatonin and Daytime Use

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Posted by Mama to Many (TN) on 09/29/2021
★★★★★

One of the concerns that people have with using Melatonin 4 times a day for covid or other viruses is that, because Melatonin is used to help with sleep it is presumed to make you too tired during the day. I will share some of my personal experiences with that.

When we had covid back in January we all used high dose Melatonin (thanks to Art who kept us informed about the protocol! ) I used it on everyone in the house - ages 9 to 83, based on weight, as Dr. Neel recommends. We took it 4 times a day.

My 83 year old mother in law with dementia did not know what the pills I gave her were, I just added them with her other meds and supplements. She was not symptomatic of covid, but we were using it to try and prevent covid since others in the home had it. (I think it worked, or at least helped! She never got sick, but did lose her sense of smell.) Anyway, her sleep/wake patterns were no different than when she wasn't taking round the clock melatonin. (She always takes it at night.)

It was hard to tell how it affected those of us who were actually sick. Sick people sleep more.

I take 15-20 mg of melatonin every night to help me with sleep (and it definitely improves my quality of sleep! )

Last summer, an hour after taking my melatonin dose, my daughter-in-law went into labor. I had an hour of sleep but woke up easily and drove an hour and 20 minutes to the birth center where she had the baby. I had no trouble driving and no trouble staying awake all night.

I had the opportunity to repeat the experiment last week. I had taken my 20 mg of melatonin and fallen asleep when my daughter went into labor. I woke up and stayed up the rest of the night with her and was able to see another grandchild born. (What a privilege! )

I cannot know how it affects others. But I can say that melatonin does not make it impossible for at least some people to stay awake after taking a significant dose. Certainly it would be wise to know how such a dose would affect you before driving a long way or using heavy equipment.

~Mama to Many~


Montmorency Tart Cherries for Melatonin

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Posted by Art (California) on 07/06/2022 2136 posts
★★☆☆☆

This brand new study suggests that drinking 480 ml of Montmorency Tart Cherry Juice or taking capsules of the tart cherry each day had little to no health benefit in the parameters tested in the study. This suggests that Montmorency Tart Cherries are a poor source of melatonin.

Here is a link to the study :

https://pubmed.ncbi.nlm.nih.gov/35790450/

Here is a relevant quote from the abstract :

>>> ' Despite the potential benefits of antioxidants and melatonin, we did not find improvements in sleep time or quality, cellular health or BP in participants consuming MTC for 30 days, though BM decreased in capsule groups. ' <<<

This study implies that if you plan to get your melatonin and its known health benefits from cherries, that will not likely happen. Even if you are just looking for better sleep, the result is still likely to be no benefit.

Art


Side Effects

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Posted by Deb (Treasure Island, FL) on 07/24/2021

I have noticed nose bleeds with melatonin


Side Effects
Posted by Kenny H (TN) on 03/17/2021

For many years, I had trouble sleeping and took Melatonin and always felt groggy and a hangover from taking it, but since pot is not legal in TN, what choice did I have? And then all of a sudden, my whole system flipped and then suddenly I couldn't get enough sleep! Suddenly 8 hrs was not enough and I always felt exhausted! What a nightmare! Not saying the melatonin had anything to do with it, but it what I was taking and it scared the holy hell out of me!

Now I'm fighting diabetes and liver damage and thyroid malfunction which came on all of a sudden also and while I am overcoming that slowly but surely by alternate day fasting, cutting ALL wheat products out of my diet, and the old timey cottage cheese and oil (Flax, black seed & Hemp oil) medicine cancer cure remedy!

But I'm not my old self by any stretch as before I started taking melatonin every night and so am very leery about ever taking melatonin again! Besides it always makes you feel so tired and groggy and who the hell needs that when your 65 yrs old? Certainly not me! So the jury is still out on that one! The side effect of melatonin is it makes you drowsy and tired, and I need just the opposite of that!

Replied by Art
(California)
03/17/2021
2136 posts

Hi Kenny,

Yes, there are people who can not tolerate melatonin as I have mentioned many times on EC, but the majority of people do tolerate melatonin as shown in many studies. Generally, as soon as you realize that there is a negative reaction to melatonin or you are not tolerating melatonin because of symptoms such as you described, it is probably a very good idea to stop using melatonin immediately rather than continuing. It is sort of like your body is trying to let you know that this is not compatible with you.

Art

Denise E
(Crescent City, CA)
03/29/2023

I doubt I'd wake up at all if I took as much as some folks do, I am shocked don't mind saying. I took a 10mg tablet and felt groggy for most of the a.m. so please be careful with trying it out.

I need something to help me sleep as I am weaning off clonazapam and melatonin was again suggested. I was having a hard time at night, not upping to my usual dose of 1 mg of clonazapam, so I'd just fall back into the 1 mg per day. I'm hoping just a smaller dose of Melatonin will help me and not leave me hungover, or groggy.

I found some bottles of 5 mg Melatonin, but then I kept looking, and found 3 mg bottles so I bought the later. Very inexpensive and I am hoping. It these don't work for me, then I guess I'll have to find another hopefully safe sleeping supplement.

Art
(California)
03/29/2023
2136 posts

Denise,

Amazon has melatonin down to .3 mg. for some people that is all they need for sleep. I take 132 mg/night, but I had to work my way up otherwise I felt very tired the next morning. Even now, when I move my dose up above 132 mg, I will feel it the next morning.

https://www.amazon.com/Landau-Melty-Melatonin-300-Tablets/dp/B07LDVJXSQ/ref=sr_1_3?crid=2MNKLHN4LMNO3&keywords=melatonin+.3+mg&qid=1680133910&sprefix=melatonin+.3+mg,aps,128&sr=8-3

In one study it showed that just 2 mg of melatonin before bed could reduce nocturia, which is very helpful in getting more restful sleep.

I think if you have not already been taking melatonin for awhile and then just take 10 mg, it will likely make most people feel tired in the morning. Also, not everybody can tolerate melatonin, even at low doses. For those people it is better to use the natural ways to increase your melatonin levels because melatonin made in the body does not cause side effects. I wrote about how to do that here :

https://www.earthclinic.com/supplements/how-to-increase-melatonin-naturally.html

Art

Sam
(Miami)
04/01/2023

Denise, Google Mexidol. Also chinese herbal formulas: bupleurum&dragon bone is one of what it is called “shen tonics” that is very good. Better yet see an acupuncturist/herbalist. Never buy any supplements on Amazon. Mexidol is an exception-you can only buy it on Amazon. It might take up to 3 years to get off clonazepam.


Side Effects
Posted by HisJewel (New York) on 01/31/2021
★★★★★

Regarding Melatonin Side Effects,

Melatonin was a big help in starting my fight to get well even with side effects.

I decided to reorder some more Melatonin, because I was glad that I had it on hand to meet a possible emergency during my coughing fits. As I mentioned I took about 100mgs of Melatonin for each of 3 days. I took 4 to 5 pills a few times a day and once at night. They were 5mgs each. No, my brand did not make me sleep or sleepy; however, I found that when I was ready to sleep they let me sleep at least an hour or two at night. The side effect I had was loose stools.

Some years ago, I had ordered some Melatonin from eBay. I am not sure why I bought them, I do remember reading a book back then that said it was good for stopping any further memory loss in its track. Anyway, this Melatonin product was from overseas, it was a powder, and a very high mgs per tiny scoop. I do not remember the company. I remember going to sleep that night and not waking up until morning. In the garbage it went. As I used to do all night prayer often and too much sleep would interfere with my work. The interesting thing is I do not remember having any side effect, only what it said it would do give me sleep.

The Melatonin that I had on hand when I was sick this month, I bought last year because Earth Clinic, Art and others posted Melatonin benefits for COVID 19.When I decided to buy more, I noticed that I needed to find out what "Other ingredients" are in each brand and kind of Melatonin. The company that I got mine from had at least 3 different kind of Melatonin mixtures. I did not want any artificial sweeter in mine so I was reading the labels. Then it dawn on me that perhaps one of the" Other ingredients" in the brand that I already had was what caused the side effect that I encountered. So please read the label.

HisJewel

Replied by Art
(California)
01/31/2021
2136 posts

Hi HisJewel,

Thank you for the feedback on melatonin!

What I have noticed is that some people can develop diarrhea from HDM [High Dose Melatonin], but in the few people I have seen or heard of this side effect, that delay, can vary from 3 days to 3 weeks. In either case, the delay makes it possible to use melatonin long enough to help achieve the desired result with Covid-19 and it may be possible to use melatonin for a very brief period even if diarrhea does occur in an attempt to have maximal effect on Covid-19. Stoppage of HDM seems to allow a fairly quick recovery from the diarrhea. I still feel that the combination of melatonin plus the addition of the Xlear Nasal Spray, suggest the potential for a quick recovery.

Here is a link to what I wrote about Xlear Nasal Spray and Covid-19 : Https://www.earthclinic.com/xlear-for-covid-recovery.html

Art


Side Effects
Posted by Gertjr (Madison) on 09/16/2020

I've been taking a, for me, high dose of melatonin for insomnia. I've been taking 10 mg at 7, another 10 mg at 8 and one more at 9, then off to bed. The first night I slept fine, next night not so great and, but the third night, was having stomach troubles. So, I backed off for a week. I then to 10 mg at 7 and, at 9, took a 10 mg timed release tablet. I kept waking up but my concern is that I was dizzy. I had to be careful getting up and then was fine. So I stopped it for several days.

Then, last night, I took a 5 mg regular tablet and, during the night, woke up dizzy. Even at the gym this morning, doing barbell bench presses, I was dizzy upon sitting up. So, is this the melatonin or something else? I stay hydrated and my blood pressure was good (I took it several times), so it's not that.

Possibly low blood sugar? I had not eaten for some time when it happened. Any thoughts? I swim, so wonder if it's not my ears? I do not have vertigo during my normal day, only upon rising from flat to sitting (of course I don't stand until it passes). I don't want to visit a dr until I've eliminated other causes. Thanks. I really need relief of the insomnia! I've taking benadryl and want to stop.

Replied by Bbhe
(Nyc)
09/21/2020

I definitely feel your pain. I had insomnia for years. Turned out it was gluten. (Yeah, I thought I'd tried eliminating it, but I guess I hadn't. If I get even a pinch of flour, ping, eyes wide open all night long.) Melatonin makes me loopy as well unless I take a tiny tiny dose. Also, if I do high intensity workouts sometimes that makes it worse, especially if I'm fasted.

GOOD LUCK and SWEET DREAMS.


Side Effects
Posted by Manti (Tulsa, OK) on 07/31/2009

I was wondering about the use of melatonin..some use it as a sleep aid and i've heard it works really well..is there any other uses..are there any side effects of the oral form, is there any longterm side effects noted from using it?

Replied by Stacey
(Greensboro, Nc)
08/04/2009

Hi Manti,

I use to take melatonin, but stopped because of two side effects. One side effect was that it acted as a diuretic, so I really didn't get much sleep b/c of running to the bathroom. The other was very real dreams. It got to the point that I could not figure out if I had really had conversations with people in my dreams versus reality. Melatonin is actually a hallucinagen your body naturally produces. I guess when you add more of the chemical to your body, it coases you to dream more realistically.


Sjogren's Syndrome

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Posted by Art (California) on 03/11/2024 2136 posts
★★★★★

In primary Sjogren's Syndrome (pSS), two of the most common symptoms are dry eyes and dry mouth. pSS damages the salivary glands (SGs), leading to dry mouth and melatonin helps protect the salivary glands from this damage, as discussed in this new March 2024 study :

https://pubmed.ncbi.nlm.nih.gov/38460474/

Here is a relevant quote from the study :

Melatonin had the potential to mitigate inflammation, oxidative stress, and apoptosis in SGs of pSS by inhibiting the IL-6/STAT3 pathway through receptor-dependent mechanisms. This intervention effectively prevented glandular damage and preserved functional integrity.

Art


Where to Buy: UK

Posted by Katie (London) on 02/08/2021

One of my friends has just been diagnosed with covid and she is higher risk so I'm worried. I am in the UK where melatonin is not available. I've been looking at buying melatonin from pharmacies in Poland but they only seem to sell 1mg or 3mg so I would need a huge number to ingest 80mg per day for covid-19. Also many refuse to post to the UK.

Can anyone advise me how to buy sufficient quantities from a reputable source?

Replied by Art
(California)
02/08/2021
2136 posts

Hi Katie,

I found 10 mg capsules on Ebay UK :

https://www.ebay.co.uk/itm/Melatonin-by-Puritans-Pride-Nighttime-Sleep-Aid-Melatonin-10mg-120-Ct-2/174484401347?epid=21027050997&hash=item28a014acc3:g:xyEAAOSw0S1fjAZe

You may have missed my post about Xlear Nasal Spray for Covid-19, but these are the two main components I plan to use if I get Covid-19. Here is a link to that post :

https://www.earthclinic.com/xlear-for-covid-recovery.html

Here is a link to the product on Amazon UK :

https://www.amazon.co.uk/Xlear-Sinus-Saline-Nasal-Xylitol/dp/B000M4W2E6/ref=sr_1_3?dchild=1&keywords=xlear+nasal+spray&qid=1612832817&sr=8-3

If you can, get her started on the spray if you can get it from a local drug store. The post that I linked to above shows how they used the Xlear Nasal Spray, how often and what effects it had on the small group of patients.

Good luck to you and your friend!

Art

Replied by MK
(NY)
02/08/2021

Isn't it strange that they banned melatonin in England, Scotland and Ireland back in 1995? It's even more strange that they haven't allowed it after the thousands of studies that have been done on it since then worldwide. How archaic!

Perhaps now is a good time to start a petition in your country to legalize it for over-the-counter use.

Replied by Glennise
(Hampshire)
09/04/2021
3 posts

Hi,

I'm in the UK & my son who is asthmatic have just been diagnosed with Covid. Did you manage to find a UK supplier please. I have ordered some from Piping Rock but it will probably take a couple of weeks to get here.

Thank you.

Art
(California)
09/06/2021
2136 posts

Hi Glennise,

This one ships to the UK:

https://www.pureformulas.com/

You can get melatonin by prescription in the UK and any dose is better than no dose. If your Dr. will write a script for each of you for 5 mg capsules for sleep, that amount may hold you over until your order arrives.

Art

Glennise
(UK)
09/09/2021
3 posts

Thank you for replying. Delivery from Piping Rock was super fast, it only took 1 week from US.

Moira
(Co. Laois)
01/09/2022

Use vitamin d it is the sàme at over 500 u per week if sick help with more until it abates and go back to th 500 u again every week



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