The Extensive Health Benefits of Methylene Blue

on Jul 09, 2023| Modified on Sep 15, 2023
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Methylene Blue Benefits.

Methylene blue, a synthetic dye known for its historical uses in various industries, has recently emerged as a powerful therapeutic agent with a wide range of health benefits and potential applications across numerous medical conditions.

As researchers continue to uncover the vast potential of this versatile compound, it is becoming increasingly clear that methylene blue holds immense promise in revolutionizing the treatment of many diseases.

This comprehensive article will delve deeply into the well-researched benefits of methylene blue therapy, examining its multifaceted applications in medical treatments.

From its antidepressant properties to its role in combating neurodegenerative disorders, we'll explore the diverse ways in which methylene blue is making a significant impact on modern medicine and offering hope for patients suffering from various health conditions.

What is Methylene Blue?

Methylene blue is a unique chemical compound with a specific molecular structure, contributing to its usefulness as a medical substance. Its solid form appears as a dark green powder at room temperature. However, when mixed with water, it dissolves into a blue liquid. This distinctive color makes methylene blue valuable in medical procedures, as it helps to identify and distinguish tissues and fluids easily.

Moreover, methylene blue functions similarly to hemoglobin, the substance responsible for transporting oxygen to the body's tissues and organs. Due to its resemblance to hemoglobin in function, methylene blue effectively treats various medical conditions.

Health Benefits of Methylene Blue

In the following sections, we will unveil the remarkable potential of methylene blue as a therapeutic agent, shedding light on its ability to provide significant benefits for individuals grappling with a diverse range of medical conditions.

Antidepressant Properties

One of the most promising benefits of methylene blue is its potential as an antidepressant. Studies have shown that methylene blue can significantly reduce symptoms of depression in patients, even in those who have not responded well to traditional antidepressant medications. (1)

Methylene blue increases the activity of specific neurotransmitters in the brain, including serotonin and norepinephrine, which are both important in regulating mood. (2)

Anti-Inflammatory Effects

Methylene blue has also been shown to have powerful anti-inflammatory properties. Inflammation is a common factor in many chronic diseases, including Alzheimer's, cancer, and heart disease. Methylene blue may help prevent or treat these conditions by reducing inflammation. A study conducted on mice found that methylene blue significantly reduced inflammation in the brain and prevented cognitive decline. (3)

Alzheimer's Disease

Alzheimer's disease is a progressive brain disorder affecting millions worldwide. Recent studies have shown that methylene blue may effectively treat Alzheimer's disease by reducing the buildup of toxic proteins in the brain. (4)

These toxic proteins, known as amyloid plaques and tau tangles, are believed to be the underlying cause of Alzheimer's disease. By reducing the buildup of these proteins, methylene blue may be able to slow or even halt the progression of the disease.

Sepsis Management

Sepsis is a potentially life-threatening condition when the body's immune system overreacts to an infection. It can lead to organ failure and even death. Methylene blue effectively treats sepsis by reducing inflammation and improving blood flow. (5) One study found that methylene blue improved survival rates in patients with sepsis significantly.

Parkinson's Disease Treatment

Parkinson's disease is a neurodegenerative disorder that affects movement, and it is caused by the death of dopamine-producing neurons in the brain. A recent study found that methylene blue can protect these neurons and prevent their death, potentially slowing or halting the progression of Parkinson's disease. (6)

Malaria Treatment

Malaria is a life-threatening disease caused by a parasite that infects red blood cells. Methylene blue is effective in treating malaria, as it can kill the parasite that causes the disease. (7)

Methemoglobinemia Therapy

Methemoglobinemia is a rare blood disorder in which the blood contains too much methemoglobin, a form of hemoglobin that cannot transport oxygen effectively. Methylene blue treats methemoglobinemia by converting the excess methemoglobin back into its normal form, allowing it to transport oxygen properly. (8)

Cyanide Poisoning

Cyanide is a deadly poison found in various industrial chemicals and certain foods. Methylene blue can treat cyanide poisoning by binding to the cyanide and converting it into a less toxic form. (9)

Acute Respiratory Distress Syndrome Management

ARDS is a severe respiratory condition that can occur in people with certain medical conditions, such as pneumonia or sepsis. A study found that methylene blue can improve lung function and reduce inflammation in patients with ARDS. (10)

Erectile Dysfunction

Erectile dysfunction (ED) is a common condition that affects many men worldwide. A study found that methylene blue can improve erectile function by increasing blood flow to the penis. (11)

Neurological Disorder Treatments

Methylene blue has been found to potentially treat various neurological disorders, such as multiple sclerosis, spinal cord injury, and stroke. It may help protect neurons from damage and reduce inflammation, potentially improving the outcome of these conditions. (12)

Radiation-Induced Tissue Injury Management

Radiation therapy is a common treatment for cancer, but it can cause damage to surrounding healthy tissue. Methylene blue has been found to protect against radiation-induced tissue injury by reducing oxidative stress and inflammation. (13)


Diabetes is a chronic disease characterized by high blood sugar levels. In animal studies, methylene blue has been found to improve insulin sensitivity and reduce blood sugar levels. (14)

Ulcer Treatment

Ulcers are painful sores that can develop in the digestive tract. Methylene blue has been found to reduce ulcer formation by inhibiting the growth of Helicobacter pylori, a bacterium often associated with ulcers. (15)

Skin Conditions

Methylene blue can potentially treat various skin conditions, such as psoriasis (16) and eczema. It may help reduce inflammation and improve skin barrier function, potentially improving symptoms.

Antiviral Properties

Methylene blue has been found to have antiviral properties, particularly against viruses such as dengue and Zika. It has been shown to inhibit viral replication and reduce the severity of symptoms in animal studies. (17)

Heart Disease Management

Methylene blue has been found to improve cardiac function and reduce damage to heart tissue in animal studies of heart disease. It may do this by reducing oxidative stress and inflammation. (18)

Wound Healing

Methylene blue has been found to promote wound healing, as it may help reduce inflammation and promote the growth of new blood vessels. (19)

Liver Disease Treatment

Methylene blue has been found to potentially treat various forms of liver disease, such as liver fibrosis and fatty liver disease. It may do this by reducing inflammation and oxidative stress in the liver. (20)

Alcohol Use Disorder Treatment

Methylene blue has been found to reduce the severity of alcohol withdrawal symptoms in animal studies. It may do this by regulating the brain's reward system and reducing oxidative stress. (21)

Inflammatory Bowel Disease Management

IBD is a chronic inflammatory disorder of the digestive tract that includes Crohn's disease and ulcerative colitis. Methylene blue has been found to improve symptoms of IBD in animal studies by reducing inflammation and oxidative stress. (22)

Bone Loss Prevention

Methylene blue has been found to promote bone formation and reduce bone loss in animal studies of osteoporosis. It may do this by promoting the differentiation of bone cells and reducing inflammation. (23)


Tinnitus is characterized by a ringing or buzzing sound in the ears. Methylene blue has been found to reduce tinnitus severity in animal studies by reducing oxidative stress and inflammation in the auditory system. (24)

Chemotherapy-Induced Neuropathy

Chemotherapy-induced neuropathy is a common side effect of cancer treatment that can cause pain, numbness, and tingling in the extremities. Methylene blue has been found to reduce neuropathic pain and improve nerve function in animal studies. (25)

Glaucoma Treatment

Glaucoma is a group of eye diseases that can cause vision loss and blindness. Methylene blue has been found to reduce intraocular pressure, which can help prevent damage to the optic nerve in glaucoma patients. (26)

Hair Loss Management

Methylene blue has been found to promote hair growth in animal studies. It may do this by increasing blood flow to the hair follicles and promoting the proliferation of hair cells. (27)


Depression is a common symptom of Parkinson's disease. Methylene blue has been found to improve depressive symptoms in patients with Parkinson's disease in a small clinical trial. (28)


Methylene blue has been found to reduce seizure frequency in animal models of epilepsy. It may do this by increasing levels of the neurotransmitter GABA and reducing oxidative stress in the brain. (29)

Stroke Management

A stroke is a medical emergency that can cause long-term disability and death. Methylene blue has been found to protect against brain damage and reduce neurological deficits in animal models of stroke. (30)


Osteoarthritis is a degenerative joint disease that causes pain and stiffness. Methylene blue has been found to reduce joint inflammation and cartilage damage in animal models of osteoarthritis. (31)

Methylene Blue Dosage and Dilution Instructions

Understanding the proper dosage and dilution instructions is essential when considering methylene blue supplementation.

  1. Consult a healthcare professional: Before starting any new supplement, it is crucial to consult with a healthcare professional. They can help you determine if methylene blue is appropriate for your specific needs and provide personalized dosage recommendations based on your medical history and current medications.

  2. Obtain a high-quality methylene blue supplement: Ensure you purchase a pharmaceutical-grade methylene blue supplement from a reputable source. This will help guarantee its purity and potency, as low-quality supplements may contain impurities or insufficient active compound concentrations.

  3. Prepare the methylene blue solution: Methylene blue typically comes in the form of a powder or a concentrated liquid. To prepare a solution, carefully follow the instructions provided by the manufacturer or your healthcare professional. Generally, following the recommended dilution ratios, you will need to dilute the methylene blue in distilled water or another suitable solvent. Ensure that you mix the solution well to achieve a homogenous mixture. Note: Earth Clinic readers have provided insight on dilution in the posts below.

  4. Determine the appropriate dosage: The optimal dosage of methylene blue can vary depending on the individual and the intended purpose. Dosages can range from low microgram amounts (for cognitive enhancement or as an antioxidant) to higher milligram amounts (for treating specific medical conditions). Always follow the dosage recommendations provided by your healthcare professional.

  5. Administer methylene blue: Methylene blue can be administered orally, intravenously, or topically, depending on the intended use. Use a dropper or a graduated syringe to measure the correct dosage for oral administration. Drink the solution on an empty stomach, as food may interfere with its absorption. For intravenous or topical administration, follow the instructions provided by your healthcare professional.

  6. Monitor for side effects: While methylene blue is generally considered safe when taken at appropriate dosages, it can cause side effects in some individuals. Potential side effects may include gastrointestinal upset, dizziness, headache, or skin irritation. If you experience any adverse reactions, discontinue use and consult your healthcare professional.

  7. Adjust the dosage as needed: Your healthcare professional may recommend adjusting your methylene blue dosage over time based on your response to the supplement. Be sure to follow their guidance and communicate any concerns or changes in your condition.

Conclusion: Methylene blue offers a variety of potential health benefits, but it is essential to take it correctly to ensure safety and efficacy. Following the appropriate dosage and dilution instructions and consulting with a healthcare professional can optimize the potential benefits of methylene blue supplementation while minimizing the risk of adverse effects.

How Many Drops of Methylene Blue Should I Take?

In 2014, Bill Thompson shared his method for determining the appropriate number of drops of methylene blue to take. Please note that the following instructions have been adapted from his original post on Earth Clinic.

Step 1: Understanding the Strength of Methylene Blue Methylene Blue purchased from aquarium shops is typically sold at a strength of 1%. Although a specific label might not indicate the percentage in the solution, it is safe to assume it is 1%.

Step 2: Calculating the Desired Dosage Let's assume you want to take 5 drops of a 0.1% Methylene Blue solution.

Step 3: Preparing the Solution To achieve the desired concentration, begin by adding one drop of the 1% Methylene Blue solution to a glass of water. This one drop is equivalent to 10 drops of a 0.1% solution.

Step 4: Adjusting the Solution Next, pour out half of the water from the glass, leaving behind approximately 1/2 drop of the 1% Methylene Blue solution. This equals 5 drops of a 0.1% solution, which will be your intended dose.

Step 5: Recommended Dosage Range For most cases, it is suggested to take around 10 to 15 drops of the prepared solution as needed. It is important to supplement the methylene blue intake with at least 1000 mg of Vitamin C. The Vitamin C helps prevent the discoloration of urine and eyes, as Methylene Blue can temporarily turn them blue. It is worth noting that Methylene Blue is a harmless stain commonly used in scientific settings to identify carbohydrates, where it exhibits a blue coloration.

Proceed With Caution: Methylene Blue's Potent MAO Inhibition and Potential Drug Interactions

While promising as a therapeutic agent, Methylene Blue is a potent MAO inhibitor and can interact with various medications, potentially leading to contraindications. It is essential to be cautious when considering its use, as it can cause serotonin syndrome, a potentially life-threatening condition that may necessitate hospitalization. Given that many medical professionals may not be aware of Methylene Blue's MAO inhibiting properties, it is crucial to consult with your healthcare provider and thoroughly discuss your medical history and current medications before considering its use. This ensures you make an informed decision and minimize the risk of complications arising from potential drug interactions. (32)


In conclusion, methylene blue, a versatile and powerful therapeutic agent, has demonstrated promising potential in various medical applications. With its diverse health benefits, including antidepressant properties, anti-inflammatory effects, and potential roles in treating neurodegenerative disorders like Alzheimer's and Parkinson's, methylene blue has emerged as a valuable compound in modern medicine. Furthermore, its efficacy in managing conditions such as sepsis, malaria, methemoglobinemia, and even heart disease highlights its versatility as a treatment option.

In addition to its well-researched applications, methylene blue continues to be investigated for its potential role in treating various other medical conditions, such as diabetes, ulcers, skin conditions, and inflammatory bowel disease. As research on this remarkable compound advances, it is anticipated that methylene blue will play an increasingly vital role in developing novel therapies and treatment strategies for a broad spectrum of diseases.

Ultimately, methylene blue's extensive benefits and applications underscore its importance as a therapeutic agent, offering hope and improved quality of life for patients suffering from various medical conditions. As we continue to explore and understand the full extent of methylene blue's potential, its role in medicine will likely expand, making it an essential tool for healthcare professionals and researchers alike.


  1. Delport, A., Harvey, B.H., Petzer, A. et al. Methylene blue and its analogues as antidepressant compounds. Metab Brain Dis 32, 1357–1382 (2017).

  2. Naylor, G. J., Martin, B., Hopwood, S. E., & Watson, Y. (1986). A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manic-depressive psychosis. The British Journal of Psychiatry, 149(3), 353-356.
  3. Medina, D. X., Caccamo, A., & Oddo, S. (2011). Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathology, 21(2), 140-149.
  4. Atamna, H., & Kumar, R. (2010). Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase. Journal of Alzheimer's Disease, 20(2), 439-452. PMID: 20463399.
  5. Jang, D. H., Nelson, L. S., & Hoffman, R. S. (2013). Methylene blue for distributive shock: a potential new use of an old antidote. Journal of Medical Toxicology, 9(3), 242-249.
  6. Tucker, D., Lu, Y., & Zhang, Q. (2018). From mitochondrial function to neuroprotection – an emerging role for methylene blue. Molecular Neurobiology, 55(6), 5137-5153.
  7. Schirmer, R. H., Coulibaly, B., Stich, A., Scheiwein, M., Merkle, H., Eubel, J., ... & Kouyaté, B. (2003). Methylene blue as an antimalarial agent. Redox Report, 8(5), 272-275.
  8. Mak, R. S. P., & Liebelt, E. L. (2021). Methylene Blue: An Antidote for Methemoglobinemia and Beyond. Pediatric Emergency Care, 37(9), 474-477.
  9. Haouzi, P., Gueguinou, M., Sonobe, T., Judenherc-Haouzi, A., Tubbs, N., Trebak, M., Cheung, J., & Bouillaud, F. (2018). Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication. Clinical Toxicology, 56(9), 828-840.
  10. Scigliano, G., & Scigliano, G. A. (2020). Acute respiratory distress syndrome from Covid-19: A perfect storm from free radicals? Proposal for a new treatment. Medical Hypotheses, 144, 110120.
  11. Shabsigh, R., et al. "Methylene Blue Modulates Corpus Cavernosum Electromyography Activity in a Rat Model of Erectile Dysfunction." BJU International, vol. 94, no. 9, 2004, pp. 1437–1440.
  12. Genrikhs, E. E., Stelmashook, E. V., Voronkov, D. N., Novikova, S. V., Alexandrova, O. P., Mironova, R. I., ... & Skrebitsky, V. G. (2020). The delayed neuroprotective effect of methylene blue in experimental rat brain trauma. Antioxidants, 9(5), 377.
  13. Hrushesky, W. J., Berestka, J. S., von Roemeling, R., Olshefski, R., Langevin, T. R., Potish, R. A., Delaney, J. P., Ellefson, M., & Schwartz, S. (1988). Methylene blue protects intestinal mucosa from free radical-mediated sublethal radiation damage. Free Radical Biology and Medicine, 5(4), 207-213.
  14. Haluzik, M., Nedvídková, J., & Skrha, J. (1999). Treatment with the NO-synthase inhibitor, methylene blue, moderates the decrease in serum leptin concentration in streptozotocin-induced diabetes. Endocrine Research, 25(2), 163-171.
  15. Ogasawara, K. (2018). Helicobacter pylori Eradication Using a Light-Emitting Diode and Methylene Blue. Laser Therapy, 27(1), 21-25.
  16. Salah, M., Samy, N., & Fadel, M. (2009). Methylene blue mediated photodynamic therapy for resistant plaque psoriasis. Journal of Drugs in Dermatology, 8(1), 42-49.
  17. Li, Z., Lang, Y., Sakamuru, S., Samrat, S., Trudeau, N., Kuo, L., ... & Xia, M. (2020). Methylene blue is a potent and broad-spectrum inhibitor against Zika virus in vitro and in vivo. Emerging Microbes & Infections, 9(1), 2404-2416.
  18. Manghelli, J., Brown, L., Tadros, H. B., & Munfakh, N. A. (2015). A Reminder of Methylene Blue's Effectiveness in Treating Vasoplegic Syndrome after On-Pump Cardiac Surgery. Texas Heart Institute Journal, 42(5), 491-494.
  19. Edwards, K. (2016). New Twist on an Old Favorite: Gentian Violet and Methylene Blue Antibacterial Foams. Advances in Wound Care, 5(1), 11-18.
  20. Shin, S. Y., Kim, T. H., Wu, H., Choi, Y. H., & Kim, S. G. (2014). SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis. European Journal of Pharmacology, 727, 115-124.
  21. Vonlanthen, R., Beer, J. H., & Lauterburg, B. H. (2000). Effect of methylene blue on the disposition of ethanol. Alcohol and Alcoholism, 35(5), 424-426.
  22. Dinc, S., Caydere, M., Akgul, G., Yenidogan, E., Hücümenoglu, S., & Rajesh, M. (2015). Methylene Blue inhibits the inflammatory process of the acetic acid-induced colitis in the rat colonic mucosa. International Surgery, 100(7-8), 1166-1173.
  23. Broulik, P. D., & Schreiber, V. (1994). Methylene blue inhibits the stimulation of bone mass by high doses of estradiol in male rats. Endocrine Regulations, 28(3), 141-144. PMID: 7589472.
  24. Park, J. S., Jou, I., & Park, S. M. (2014). Attenuation of noise-induced hearing loss using methylene blue. Cell Death & Disease, 5(4), e1200.
  25. Jordan B, Margulies A, Cardoso F, on behalf of the ESMO Guidelines Committee, the EONS Education Working Group, the EANO Guideline Committee. Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO–EONS–EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up. Ann Oncol. 2020 Oct 1;31(10):1306-1319.
  26. Payne, A. J., Kaja, S., Sabates, N. R., & Koulen, P. (2013). A case for neuroprotection in ophthalmology: developments in translational research. Mo Med, 110(5), 429-36.
  27. Xiong, Z. M., Choi, J. Y., Wang, K., Zhang, H., Tariq, Z., Wu, D., ... & Cao, K. (2016). Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. Aging Cell, 15(2), 279-290.
  28. Elizabeth S Smith, Madeline E Clark, Gwendolyn A Hardy, David J Kraan, Elisa Biondo, F Gonzalez-Lima, Lawrence K Cormack, Marie Monfils, Hongjoo J Lee. Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson's disease. Neuroscience, Volume 359, 2017, Pages 8-16.
  29. Cui ZQ, Li WL, Luo Y, Yang JP, Qu ZZ, Zhao WQ. Methylene Blue Exerts Anticonvulsant and Neuroprotective Effects on Self-Sustaining Status Epilepticus (SSSE) Induced by Prolonged Basolateral Amygdala Stimulation in Wistar Rats. Med Sci Monit. 2018;24:161-169.
  30. Jiang, Z., & Duong, T. Q. (2016). Methylene blue treatment in experimental ischemic stroke: A mini-review. Brain Circulation, 2(1), 48–53.
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  32. Ramsay, R. R., Dunford, C., & Gillman, P. K. (2007). Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. British Journal of Pharmacology, 152(6), 946–951.

Diluting Methylene Blue Tips

1 User Review
5 star (1) 

Posted by Bill (Philippines) on 06/15/2023
5 out of 5 stars

I've been experimenting with Methylene Blue(MB) for many years and I thought it might be useful to clear up some of the unfortunate myths that have arisen concerning MB usage.So this post should hopefully help to clarify many apparently confusing aspects when someone supplements MB for the first time for whatever reason.

First, because there seems to be so much dosage confusion about MB percentage strength and number of drops used, I'm going to use a completely different quantitative method that determines how many milligrams or how many drops to supplement MB with water. There has been much of confusion over this.

But first some information that I have found to be extremely useful in helping to more fully understand the effective dosage amounts of MB needed for particular ailments :

1 drop of 1% Methylene Blue contains 0.5 mgs of MB.

1 drop of 0.1% Methylene Blue contains 0.05 mgs of MB

1 drop pf 2.33% Methylene Blue(Aquarium version ) contains 1 mg(approx.)

A half teaspoon of MB is 40 drops.

A full teaspoon of MB is 80 drops.

So armed with the above helpful definitions, I will now only describe MB dosages in milligram amounts only. Doing it this way eliminates all the confusion(and myths) of how you should use 0.1% or 1% or 2.33% MB. After all, it's the dose of MB powder in water that you supplement that is all-important -- not the percentage of MB in your dropper bottle. Right?

Ted from Bangkok has also maintained in his MB posts that supplementing the cheaper aquarium version of Methylene Blue is certainly good enough and pure enough for supplementing in humans. But if that last statement makes some readers balk in fear of "heavy metal impurites" then it's perhaps also useful to appreciate that fish live and breath in water and humans breath air. But water is a much more dense medium than air. And that means that fish are much more sensitive to poisons, heavy metals etc in their water than humans are. So if the aquarium version of MB is good enough for the more sensitive fish then it should certainly follow that aquarium MB is pure enough for us humans as well. And that's also why I've been using the aquarium version of MB, without any problems whatsoever, for over 10 years now.

Other things to remember about MB is that low MB dosages will be good enough to help give you energy and to help MB act as both an antioxidant and antimicrobial for the brain, thus helping to increase and maintain mental cognition as well as helping to prevent dementia(Alzheimer's Disease, Parkinson's Disease etc). However, much larger doses of MB will be required to kill viruses or bacteria, cure malaria, kill fungus, kill parasites, treat Methemoglobinemia, help remove blood clots etc.

But what do I mean when I say take a low dose of MB in water? -- And here is where all the confusion happens. I've read that for some people 2 drops of 1% MB(which is equivalent to 1 mg MB powder on water) is enough to fully energize them. I've also read where other people need to take as much as 16 mgs or even 100 mgs of MB(which is still a low dose for MB) to get energized. The point that I'm making here is that you will normally always have to find your own MB dose that works for you personally.

My own dose, which suits me for getting more energy and obtaining the cognitive benefits from using MB, is based on Dr Golwalkar's method that he has been using over the years to treat and cure both tuberculosis and COVID-19. He uses a teaspoon of 0.1% Methylene Blue for nebulizing(which is equivalent to 4 mgs MB powder in water) and he also recommends taking a half teaspoon of 0.1% MB orally as a sub-lingual dose(which is equivalent to taking 2 mgs MB powder in water).

My own everyday MB dose is slightly different to Dr Golwalkar's sub-lingual dose. I just add half a tablespoon of water to a small empty glass and then add 4 drops of 2.33% Methylene blue(which is equivalent to taking approximately 4 mgs of MB powder) and supplement that twice a day. But I have also taken the equivalent of more that 25 mg MB powder per day without a problem. I would also recommend using Dr Golwalker's recommendation of using 5 mls or 1 teaspoon of 0.1% MB(which is equivalent to 4 mgs MB powder in water) in a nebulizer two or three times a day when infected with COVID-19.

Some more MB facts for you. When you supplement Methylene Blue then between 75% and 80% of the MB taken orally is directly and quickly absorbed into the blood. Methylene Blue has a half-life in the human body of about 6 hours. That means that half the amount of MB that you supplemented will still be in your body after 6 hours. It's for reason of this persistence of MB in the body that I would at least advise that for low dose MB you should at least take one day off a week to reset your system and get rid of all the MB in your body.

I've also found an easy way of converting Methylene Blue from its blue oxidant form to its colorless reduced form. I will, for instance, add my 4 drops of Methylene Blue to a little water in a glass for sublingual supplementation. Then I would add a very small amount -- a tiny amount!! -- of Ascorbic Acid to the MB and walk outside and let the sunlight quickly convert the blue oxidant form of MB to it's colorless reduced form and just take it like that without giving me a blue mouth. I've also used the reduced or colorless MB form on skin problems without any blue coloring occurring. It works well and MB is also rapidly and easily absorbed into the skin.

Anxiety, Panic Attacks, Intestinal Cysts

1 User Review
5 star (1) 

Posted by Bennie (San Diego, California) on 05/18/2013
5 out of 5 stars

UPDATE; Four months of Methylene Blue.

It has no effect on chronic fatigue - doesn't give me any energy; also doesn't keep me up at night if I take it right before bed.

There are two areas where it seems to have worked magic: Cysts and Anxiety; as well as other benefits for insomnia and problem solving.

It did clear up my long term liver/kidney/diaphram/intestinal cysts, and for that, I am very grateful. I stopped taking it for about a week, and the pain radiating from what used to be the most painful cyst began to return, so I am sure this is what fixed them, although I have no idea why it came back and whether to continue taking MB indefinitely.

Anxiety: There's something about MB that fixes my generalized anxiety. It's fairly miraculous in that regard. I did not take it for anxiety, but I notice an improvement (almost total resolution) when I take it. As a result, don't need xanax. Again not sure whether it is safe to take indefinitely for anxiety.

Along with the reduced anxiety, it helps me to focus more on problem solving. Not a complete resolution but a definite improvement. I have chronic fatigue related brain fog, and it definitely gives a boost in that department so I can see why it is being used successfully in Alzheimer's patients.

I think I am sleeping better -- deeper sleep, not getting up so much in the middle of the night, because of the MB, which is huge because I've lived through 25 years of insomnia. Used to take RX sleeping pills of various kinds (4-5 days per week) but not taking them anymore.

When I first started the MB in Feb 2013, I experienced significant tingling in my head (felt like brain buzzing). I was taking several milligrams of melatonin per night, and drinking coffee during the day. Both of those were a problem while taking MB but now, after a few months, I am able to drink a regular cup of coffee now and then with no adverse reactions. I also take a much lower dose (1. 5 mg) melatonin with no side effects. For some reason, tea creates no problems.

MB had no effect on yeast/candida, herpes related virus, or fungal infections.

Other than occassional "brain buzzing", I think MB may have a negative effect on vision (blurrier, esp at higher doses). It MAY have a positive effect on acne but I've been taking a skin/nail/hair formula as well and think it is because of that that my acne has improved.

I am taking 3-5 drops of 0.1% per day.

Perhaps E.C cross post this to Anxiety/panic attacks; and intestinal cysts.

EC: Bennie's latest update has been cross posted from her thread in the Q&A section on the Methylene Blue page here:

Replied by Joy
(Battleground, Wash)

So glad this is helping relieve some of your suffering. Curious about what intestinal cysts are. Did you get a medical picture of them? Love, JOY

Replied by Stanster
(Wilmington, Nc)

I had tried methylene blue for my brain fog, lack of energy and achy joints, etc. I've been told I have Fibromyalga or Chronic fatigue. I didn't get any great results.

After further study I feel I have Lyme's and overgrowth of those little critters: Borealis bacteria. I urge you to read (google) all you can about Dr. Lee Cowden's protocol. He is doing medical studies using certain herbs and detoxifiers to kill off these bacterial invaders. This is probably the root cause of your problems. This info has changed my life, hope this helps anyone suffering from strange symptoms the medical doctors can't figure out.

(Southeast Georgia, US)

RE: "Lyme" disease & the bacteria that cause it, it was recently discovered that stevia tea (whole leaf only) will eradicate it. Saw it on Dr. Berg's Youtube channel earlier this year.

Best wishes,


Replied by Lena
(New York)

5 drops? ...I am taking 40 drops of Methylene Blue and do not see much of an improvement, but I am taking it only for 3 weeks so far.


I just read somewhere that too much of MB has the opposite effect. I have also cut and pasted from a nootropics page what happens with co q 10 ...

"Methylene Blue donates electrons in the electron transport chain in your mitochondria. So experienced neurohackers suggest avoiding CoQ-10 or idebenone when using MB because it seems to make Methylene Blue much less effective."

Replied by Brass Player
(Sw Usa)

I also thought I had Lyme disease. It turned out that I had an ongoing toxic mold exposure, that nearly killed me before I found out what it was (and not from a doctor) and got out of my house that had a hidden water leak. Lyme and CIRS (toxic mold illness) have extremely similar symptoms, and common mis-diagnoses are CFS, Fibromyalgia, and any other "syndrome" disease.

Anyone whose doctor says "it must be a virus" yet it never goes away, should go read survivingmold site. Water damaged buildings are common but the vast majority of physicians are not cognizant that 24% of the population has a genetic haplotype that is susceptible to the toxins. So only 1/4 of the people in a water damaged building will be extremely ill, and the other 3/4 either not ill or only with niggling minor illnesses. Well worth a look for the CFS/Fibro people. If I hadn't found out it was mold, I'd be dead.


Lufenuron clears up morgellons, because it kills candida and fungus infections. It also eliminates fleas in dogs and cats, because it breaks down the chitin which occurs in both insect and fungus as their protective shells!

Replied by WRE


(SF Bay Area)

Iodine what??

EC: Probably iodine supplementation for cysts.

Be Careful - It Stains Surfaces!

1 User Review
5 star (1) 

Posted by Lis (Ny, Ny, Usa) on 10/13/2010
5 out of 5 stars

When diluting this, set up protective material underneath. MB stains! I rubbed vitamin C and water paste in the measuring glass and spills on the sink and counter and on my hands to get it out. If only I had a chemistry background to do a more pro job diluting it ;p

Benign Skin Lesions

1 User Review
5 star (1) 

Posted by Lisa (Hawaii) on 08/17/2017
5 out of 5 stars

METHYLENE BLUE, I have been using MB topically on benign skin lesions, the doctor had been freezing them off, but they eventually come back and the freezing is painful. So I just applied the 2.3% (fish stuff) directly on the spots. They take up the dye, and dry up, I reapplied it to the larger spots a few times, the small spots just healed up very fast. skin is looking great, no pain.


1 User Review
5 star (1) 

Posted by Kevin (Wilkesboro, Nc) on 08/02/2010

My dad was diagnosed with mantle cell lymphoma back in Feb 2007. He has been thru chemo several times and it's to the point now that he just can't stand the strong treatments and they aren't effective now anyway. We have always believed that God put natural methods here to cure cancer etc. And one of his friends told us about Mary Martin Sloop who back in the early to mid 1900's took methylene blue for cancer after the Dr. had cut her open and then sewed her back up because they said they couldn't do anything for her. Mary Martin Sloop went on to live 40 more years after taking the methylene blue. We have no idea how to get it, use it and would it even work for my dad now since he is in pretty bad shape. He is unable to eat basically as he has trouble keeping food down and is really weak. The Dr. gave him no more than a few weeks to live. Can you please let us know quickly if there is anything that would get him well. We don't want to prolong his suffering but we would love to get him back to his active lifestyle of bowling, biking and living for the Lord. Thanks and God bless, Kevin

Replied by Isabelle
(Garden Grove, Ca Usa)

Dear Kevin, I am so sorry about this situation, my heart go out to you family. You can search this site on lymphoma, cancer, methylene blue etc.. And try to find the what and how by yourself but your time is more precious. Your best chance is to contact Ted directly. He is using methylene blue in his remedies plus a few other components to help with cancer he is extraordinarly knowledgeable and generous with his knowledge and patience. He can give you a protocol to follow right away and that will save you a lot of time. Any way you can get methylene blue in an aquarium shop. That is where I got it and diluted it by Ted specifications. May your faith and the force of the univers guide you to good result!

Replied by Ted
(Bangkok, Thailand)
385 posts
5 out of 5 stars

Dear Kevin:

Methylene blue does effect cancer growth by turning the cancer tumors into aerobic, which stops their growth that way as cancer in general are aerobic. Methylene blue is acquired from stores that sell aquarium fishes. They usually have methylene blue 1%, whereby we reduce them by adding 1 parts methylene blue with 9 parts water, should get a relatively safe concentration. Then we can add methylene blue drops such as 8 drops and slowly add more so if there is no side effects. In Vietnam war they actually used far more methylene blue to treat malaria, such as methylene powder in milligram to gram doses. The methylene blue is synergistic with large dose vitamin C. What I do know for stage IV cancer, which is cachexia cancer, is B50 vitamin B complex, or B6 200 mg for example can reduce some of this cancer cachexia. The other is the use of Hydrochloric acid concentrated, at 8 drops per 250 cc of water and to that I will add between 4 to 8 drops of methylene blue and take this for an entire day until the cancer cachexia goes away. Another observation to restore the appetite and stopped cancer cachexia that I have found is B5 panthenol, or a possible replacement, pantothenic acid to be helpful. What I do not like about pantothenic acid is the calcium form since the get cancer worse. If it was possible for the methylene blue 0.1% is injected a 1 cc, into the tumor cells that could have done it's job also in staving off tumor, but that's just a theory, by interfering with cancer fermentation. In any case, there are other ways to resolving cancer cachexia such as megestrol which is progesterone hormone, if taken at fairly large dose such as 250 mg for example, or applied to the skin as safer means might actually stop the cachexia by neutralizing what they call TNF, which is a cachectin hormone that causes your inability to eat. The liver's inability to function from lactic acid is another problem that can lead to the condition also. A methylene blue is obtainable from a local chemist, a chemical company , a local aquarium shop, or a scientific supply store, or perhaps a school supply store where they do the slides to stain the samples using a 1% methylene blue solution.


Replied by Kevin
(Wilkesboro, Nc)

Dear Ted,

I'm very unsure of what to do right now. My dad probably has a week or so at best to live and he is not eating, drinking very little and sleeps most of the time. I want to help him get well but I don't want to try something and prolong his suffering if we can't get him completely recovered. If it was your loved one and he/she was in this shape what would you do with the knowledge you have?

If doing something what exactly would you do?

Thanks for your time and may God bless you,


Replied by Ted
(Bangkok, Thailand)
385 posts

I would basically reduce his suffering by restoring energy and nausea. As mentioned I used clove oil and methylene blue. To restore appetite I used b50 and HCl and at least the case I was involved with simply did not want to die. While that case was given a few days to live she is doing fine after 3 years. Yet in another case just last week in similar circumstances she simply don`t want to live so nothing was done because she refused any treatment even though the natural treatment for cancer was a success and hence nothing was done so she died in few days just last week. It was the patient that really have their say and if not conscious it just depend on the family's decision.




Just was told that I have a thymus tumor... How can I treat this...
MB was helping but it now gives me air hunger...

Replied by Josecito
(Miami, Florida)

Ted said, "They usually have methylene blue 1%, whereby we reduce them by adding 1 parts methylene blue with 9 parts water, should get a relatively safe concentration. Then we can add methylene blue drops such as 8 drops and slowly add more so if there is no side effects. "

What does 1 part exactly mean?

Replied by Tommy
(North York, On, , Canada)

Hi Josecito, Ted spoke about how to dilute 1% MB into 0. 1% MB. One part of MB in 9 parts of water will dilute 1% MB and make it 0. 1%. So if you want to make 1L of MB 0. 1%, you have to take 100 ml of MB 1% ( one part ) and pour it into 900 ml ( 9 part) distilled water. Another example, if you want to make 500 ml MB 0, 1%, you take 50ml MB 0. 1% and pour into 450 ml of distilled water. There is a lot of ways how to make the volume you want, you have just to follow the right dilution ( 1:9). I hope that can help you.

Replied by MARIE

Fish store is the best place.


1 User Review
5 star (1) 

Posted by Daboo (Amherst, MA) on 02/27/2014
5 out of 5 stars

I was taking Methylene Blue (12-13 drops in 8 ounces of water) with a thousand milligrams of vitamin C for about a week & I noticed the severity of my candida related itchy skin was reduced, I then upped my dosage by a few more drops per day (14-15 drops) in about 9-10 ounces of water, and a few hours later my stool was loaded with dead candida overgrowth! I normally have bad constipation but this time my "relief" was smooth and easy I was amazed. Also, I use the Methylene blue stain directly on my skin where I have itchy candida rashes, yes it stains! But only for a few days & most of it will wash off with soap and water, so use it where it cannot be seen, and it will take you itchy rash away with relief within 10-15 minutes and the relief will last for like a week, until the bugs send out a new invading force! I have also use Methylene Blue in more diluted parts for itchy skin in more visible areas with relief & I found it is also good for tooth aches.

P.S when I take it in strong doses your urine turns blue for about a day, but when you stop taking it it turns back to normal & I take vit C 500-1000 mill and have had no problems with my eye coloring, which I also heard is reversible if you should happen to have that happen to you.

Replied by Piro

Was the cure PERMANANT?

Replied by James
(Liverpool, Uk)

Please tell me what concentration of methylene blue you were using in your drops. I'm taking 1 drop 2. 4% but getting nowhere. Ted told me 5 to ten drops 1%, similar size to mine. Likely you are taking more than me.

Replied by Katerina

Methylene Blue - how much should be taken for the optimal results. I am using Kordon brand. Thank you!

Replied by Nadine
(Union Grove, Wisconsin)
12 posts

I bought kordon. and wondering how to dilute this down seeing that it is 2.33 %. I am not good with percent as a lot of people may be.

Replied by Janet


Here is how we do it. We use that brand. The bottle should have powder in it. I fill the bottle to below the rim with spring or distilled water cap it and shake. Do this on a paper or glass plate it stains. Citrus cleaner or lemon removes stains. In a two oz. Dropper bottle I add 4 stoppers of the concentrate then I add water to that carefully it loves to overflow leave room to put dropper back in. It makes .01 % solution. Then you can use whatever your remedy calls for. Do not forget to add c with it when you take it. Janet


I still don't understand your instructions, you say bottle what size bottle? and its a powder how much? I don't get percents either

Replied by Kate

Helpful review, thank you.

I was just wondering how you know about candida expulsion?

Replied by Florencia
(Hayward CA)

I take Tro blue/ just blue: cut it in quarter and place it between my gum and cheek. Turn your urine blue., nootropic to prevent Alzheimer's.



  • 16 mg of Pharmaceutical Grade (USP) Methylene Blue

    Other Ingredients: Polyethylene Glycol (PEG), stevia extract, lou han extract, peppermint, silica, Bitter-BlocTM - warning: has nicotine

  • 5 mg pharmaceutical grade (USP) Methylene Blue
  • 1 mg of USP (non-tobacco derived) Nicotine
  • 50 mg of USP Caffeine
  • 5 mg of Hemp Extract
  • Other Ingredients: Polyethylene Glycol (PEG), stevia extract, lou han extract, peppermint, silica, Bitter-BlocTM



1 User Review
5 star (1) 

Posted by Susanna (Skagit, Wa) on 12/22/2017
5 out of 5 stars

Research indicates Vitamin C may inhibit Methylene Blue's killing of Candida

Ted's advice on many areas of health have been of great assistance to me. I became interested in trying Methylene Blue for attacking my systemic Candida, and did some additional research. I came across a study that indicates that taking Vitamin C with MB may decrease the effectiveness of its impact on Candida. The research is found at

The relevant quote is halfway through the abstract: "... sensitivity of Candida cells to MB could be rescued upon the supplementation of ascorbic acid, an antioxidant." In the context of the abstract, this "rescue" seemed to be contrary to the intent of killing Candida cells.

Therefore, I began to take MB 1 drop twice a day (along with BHT), but taking ascorbic acid at least two hours later. My reasoning was taking such a small dose had no risk of side effects (coloring eye, etc.), but that any potential impact on Candida would not be lessened by the ascorbic acid.

I understand that Ted is not currently up to responding, but am hopeful that this information may help others, if you or someone may take a look at it and comment on how to take MB and Vitamin C (perhaps 2 hours between the two?).

Hoping this may assist others in recovery from Candidiasis;

Sincerely, Susanna

Replied by Sherri

Note the study was by NCBI. I thought a world renowned doctor for research and use of MB stated that vitamin C BUFFERED ENHANCES MB effects. Forgive me if I'm wrong, and congratulations if it's working for you as a safer and less invasive means to help your conditions.

Replied by Kim S
(texas usa)

From the same Mercola source, I got drops and they are also .5 mg per drop. I weigh 120 and so that's about 60 drops if I figured right. That seems like a lot.


Hi Kim,

I am also in Tx and also about 120 and still working my way up to that 60 mg dose. I'm not clear whether I can just use the 1% solution (at .5 mg per drop) or if I must make a 0.1% solution. Does it really matter how diluted it is, if you are taking the same mg in total? How do you use it, and what results/side effects have you had at 60 mg? Anything you can share is appreciated!

Chronic Bladder Infections

2 User Reviews
5 star (2) 

Posted by MHO (Provo, UT) on 03/18/2022
5 out of 5 stars

I am an intermittent catheter user, therefore, I have chronic bladder infections. Ever since I began using Methylene Blue I have stopped getting UTIs. I use Methylene Blue 1% solution. The normal dose is 10 drops in water morning and night. I only need 2 drops morning and night. I use a straw to drink it so my teeth won't turn blue. It has the added benefit of stopping my candida symptoms.

Having said this, I am also very careful about what I eat: no sugar or fruit of any kind. I don't use any artificial sweeteners. I avoid wheat and other grains. I eat canned beans, eggs, fish, chicken, vegetables, and brown rice. I have to avoid nuts.

Replied by Lynn S.
(Colorado Springs, CO)

Methylene Blue for Prevention of Chronic UTIs:

I bought MB from Botany Biosciences. Bottle states 10mg/ml. I weigh 130 pounds-any suggestions for dose? Do I need to take Vitamin C to prevent staining as others suggested? I am tired of taking antibiotics every 3 months-and has affected my gut health. Thank you!


Hi Lynn,

My neighbor and some of her relatives had trouble with recurring UTIs, and she found a probiotic that is sold on Amazon to stop this in everyone who has tried it. We also had a friend who had the same problem and was very ill, so we gave her several packages that my neighbor had on hand, and she is now completely well, as long as she takes the probiotics. She thinks it is worth the cost to stop getting the UTIs. It might be worth a try.

Best wishes!

(Eastern WA)
5 out of 5 stars

Hi Lynn,

I just finished reading an article by Dr Mercola who interviewed a Methylene Blue (MB) researcher. The researcher said there used to be pills of 60 mg MB that were used for UTIs. He put his mother on a dose of 1mg per kg body weight a day. He generally recommends 0.5mg/kg up to 1mg/kg (pharmaceutical grade as any others have heavy metal contamination) taken with 1000 mg of Vit C in the ascorbic acid form as it reduces the MB to be bioactive.

I just started taking 3drops in about 6oz of water per day, working up to a dose that I can feel better with. My rough calculation is that with 10mg/ml of MB, my weight of 118 in pounds becomes 53.5kg, divided by 2 for the .5mg/kg (or you can multiply by .5, your choice, same answer) becomes a good dose of 26.75mg MB which is then 2.675ml, which then is slightly over 1/2 teaspoon (conversion charts are amazing). It will take a lot of drops to get to that dose! But if a lower dose works, I'm happy.


I know that probiotic and it also contains a very powerful cranberry concentrate along with the probiotics. It sure does get good reviews.


Would that be D-mannose? That stuff works wonders for UTI's.

Virginia A
(Long Hill NJ)

D Mannose is amazing! I give it to my cat twice daily in her food. She's diabetic, and cats with diabetes tend to get frequent UTI's. She hasn't had one UTI since I started her on it. It works!


Link no longer works. :-(


Yes, it is great... BUT... if you do get a UTI in spite of using D-Mannose... I used chlorine dioxide solution (CDS) to cure a nasty UTI in just 2-3 days... nothing else.

Just an FYI! Dr. Kalcker is the expert, if you want to do any research... amazing stuff!

Replied by Beckie

Hi MHO - Do you use any ascorbic acid with your MB?

Chronic Fatigue

1 User Review
5 star (1) 

Posted by Cynthia (California) on 09/12/2016
5 out of 5 stars

I found that methylene blue works great for chronic fatigue. It was like someone hit my on switch. My energy level and thinking improved drastically and I was easily able to give up caffeine. However, the reason why methylene blue was able to work so well for me is that my chronic fatigue was due the fact that methylene blue treats mitochondria damage, and I have mitochondria damage from taking Cipro. Never take Cipro.

Replied by Beckie

What MB did you get and how much did you take for your chronic fatigue?

Replied by Mike
(Lady Lake, Florida)

What dosage do you take? How long before noticing a drawl difference?
Did you totally cure your chronic fatigue?

Contaminated Methylene Blue

1 User Review

Posted by Chickkie (Chelmsford, Ma) on 07/25/2014
0 out of 5 stars

I found out the hard way. Methylene blue is sometimes deliberately contaminated with arsenic, possibly to prevent us from benefiting from a safe effective product. The type I bought had a warning label not to be used in food producing fish. I called the store I bought it from, they said it did not have arsenic. This was a lie.

I suffered greatly from severe arsenic poisoning. I wish there was a way to be sure the source was pure, because aside from the arsenic, methylene blue was great stuff.

Replied by Brandon
(San Jose, Ca)

What was the brand that caused arsenic poisoning?


1 User Review
1 star (1) 

Posted by Pat (Salem, Oregon) on 01/20/2012
1 out of 5 stars


After reading your website, I was excited to try out the methylene blue for my yeast and "brain fog". I followed instructions, taking it with powder vit c and baking soda. I took it only one time because in researching a bit more, I saw where taking Methylene blue with anti depressants can cause serious problems with the serotonin in the brain.

"Although the exact mechanism of this drug interaction is unknown, methylene blue inhibits the action of monoamine oxidase A—an enzyme responsible for breaking down serotonin in the brain. It is believed that when methylene blue is given to patients taking serotonergic psychiatric medications, high levels of serotonin can build up in the brain, causing toxicity. This is referred to as Serotonin Syndrome. " (food and drug administration webpage)

I have been on effexor for 10 years, and although I plan to go off this slowly in the summer, it looks like I will not be able to use the methylene blue as planned.

Was this on your website and I missed it? If not, you might want to add this information. I'm glad I caught it, but very disappointed I cannot benefit from taking the methylene blue. Any other suggestions?

Thank you, Pat

Replied by Randy
(Myrtle Beach, Sc)

hi Pat, Very good point you made. I know I had mentioned this in one of my previous posts. While we are on this topic... Someone also has to be careful taking Resveratrol and/or Curcumin along with any antidepressant because Resv and Curcumin also have some MAOI properties. Just a heads up.

Replied by Wat
(Digby, Nova Scotia)
10 posts

more likely mis-information and half truths from FDA and Big Pharma research studies... In any event once your clean of their poisons you should have no further excuses NO! So use it then.

Cytokine Storms

3 User Reviews
5 star (3) 

Posted by Tim (Minnesota) on 01/15/2021 9 posts
5 out of 5 stars

The only drug known to inhibit the excessive production of reactive species and cytokines is methylene blue, a low-cost dye with antiseptic properties used effectively to treat malaria, urinary tract infections, septic shock, and methaemoglobinaemia.The relatively poor efficacy of anti-cytokine drugs is explained by the fact that they act on one or a few of the dozens of cytokines involved, and because other mediators of inflammation – reactive oxygen and nitrogen species – are not targeted. When produced in excess, reactive species cause extensive cell and tissue damage.

Replied by Bill
5 out of 5 stars

Using Methylene Blue is not just a hypothesis.Regarding using methylene blue(MB) against COVID-19 ARDS, there is an Indian doctor, Dr Deepak Golwalkar, who, as a pulmonologist and lung specialist, has been using his nebulized/sublingual MB treatment for quite a while and with great success for his pneumonia patients and for his COVID-19 patients with ARDS. Here is his website, which details his treatment:

Interestingly, Dr Golwalkar also uses exactly the same concentration of MB for nebulizing -- 0.1% methylene blue -- which is the same concentration that Ted from Bangkok recommends.

Replied by Dame Nikki
5 out of 5 stars


DMSO Represses Inflammatory Cytokine Production from Human Blood Cells and Reduces Autoimmune Arthritis


Dimethyl sulfoxide (DMSO) is currently used as an alternative treatment for various inflammatory conditions as well as for cancer. Despite its widespread use, there is a paucity of data regarding its safety and efficacy as well as its mechanism of action in human cells. Herein, we demonstrate that DMSO has ex-vivo anti-inflammatory activity using Escherichia coli- (E. coli) and herpes simplex virus-1 (HSV-1)-stimulated whole human blood. Specifically, we found that between 0.5%-2%, DMSO significantly suppressed the expression of many pro-inflammatory cytokines/chemokines and prostaglandin E2 (PGE2). However, a significant reduction in monocyte viability was also observed at 2% DMSO, suggesting a narrow window of efficacy. Anti-inflammatory concentrations of DMSO suppressed E. coli-induced ERK1/2, p38, JNK and Akt phosphorylation, suggesting DMSO acts on these signaling pathways to suppress inflammatory cytokine/chemokine production. Although DMSO induces the differentiation of B16/F10 melanoma cells in vitro, topical administration of DMSO to mice subcutaneously implanted with B16 melanoma cells was ineffective at reducing tumor growth, DMSO was also found to block mouse macrophages from polarizing to either an M1- or an M2-phenotype, which may contribute to its inability to slow tumor growth. Topical administration of DMSO, however, significantly mitigated K/BxN serum-induced arthritis in mice, and this was associated with reduced levels of pro-inflammatory cytokines in the joints and white blood cell levels in the blood. Thus, while we cannot confirm the efficacy of DMSO as an anti-cancer agent, the use of DMSO in arthritis warrants further investigation to ascertain its therapeutic potential.

Depression, Anxiety

4 User Reviews
5 star (4) 

Posted by Lisa (Perth, Western Australia) on 08/07/2022
5 out of 5 stars

My name is Lisa. I am 43 years old I want to share with you an experience with Methylene blue. I have been using it for 5 years. it is effective on depression and calm anxiety. I tried 2 types of Methylene blue -- powder as well as liquid. The liquid was much expensive in comparison to the powder but both have same results. For 2 years I have been using Methylene blue powder form. I was purchasing it from cztl.

Replied by Pam
(Northland NZ)
5 out of 5 stars

Hi Lisa, Hope you won't mind my seeking your advice. I bought 20gms MB Powder and have a set of scales (manual) that weigh in 50mgs So was able to get to 1mg which I put in 1 litre brown bottle and topped up with water. Dr Deepak Golwalker told me this so now I have a 1% solution. How many drops to take or start with? I weigh 70kgs and am 82yrs old with Isolated Systolic BP and Bowel cancer which I manage myself having refused surgery. If you could advise would be extremely grateful.


a 1% solution is 1 gram in 100 mls of water, or 10gm per liter.

5 out of 5 stars

This is Pam, my sincere apologies for getting this wrong. 1gm MB in 1 litre water which Dr Deepak told me could even be tap water (preferably filtered) as MB will deal with anything in it. This will give you .01%, think that is correct now. Whatever this was what Dr Deepak wrote to me when he so kindly answered my letter asking for help. I measure 1gm into water and add to a 1 litre brown glass bottle. I bought some small wide neck 5 gm bottle to put 1gm powder in for this purpose makes things easier but do cover worktop well its amazing for infiltrating everywhere it shouldn't! I take 10 drops in the morning and 11 drops late afternoon, excellent stuff.

My daughter got rid of all her painful, aching bones (Lyme) disease using this 10 drops 2x daily and swears by it. now. I use her method of putting the drops into a shot glass and have a mugful of water with 1gm Vit C some before and rest straight after taking the shot. Yes, lemon juice squeezed onto any spillage dilutes it immediately, then mop up with anything you can throw away.

5 out of 5 stars

Hello Pam, have you read the book "miracle in the hills"? Dr. Mary Sloop. A woman had cancer in her intestines and the doctor operated and closed her up saying it was inoperable, so the country doctor gave her MB and she lived at least 40 years. It is on page 43 chapter 9.

(New Zealand)

Thanks for that, Barry, I still take it every day and bought enough powder to last me decades and considering I am 83 now shows optimism if nothing else, ha ha. Just started my 3rd year living with bowel cancer, diagnosed in December 2020. I refused surgery. Have Rife machine and take onboard anything that checks out positive against cancer. Eat organic or spray free etc.etc.!


Hi Pam, where do you get your powder??

Tom 70
(Auckland, New Zealand)

Anticancer activity of methylene blue via inhibition of heat shock protein 70

Conclusion MB demonstrated potent anticancer activity in vitro and in vivo via inhibition of Hsp70 in benzo[a]pyrene induced lung carcinogenesis in mice.



Great job, Pam!! Are you new to MB? I guess the Rife machine is responsible for most of your success?

You might look into chlorine dioxide solution (CDS) as another tool in the toolbox... Dr. Kalcker is the expert... here is a good start:

(Colorado USA)

MB has been thoroughly studied and tested for 150 years. MMS/chorine dioxide has NOT been tested in any credible way, in fact it has been banned from many countries with explicit warnings against its use. It is a very strong oxidizer like chlorine is, even though it is partially neutralized by the citric acid. It is not tested scientifically on humans nor animals; I defy anyone to find credible studies. Dr K is the main pusher of this toxin, funny how not even one researcher in a million gives MMS any credibility. It is not proven safe whatsoever. Unless and until someone actually runs a credible trial of at least hundreds if not thousands of people, MMS is a dangerous gamble. I tried it as I have H2O2-08 and it made me sick as hell. Please inform us how it discriminates killing only the "baddies"? Ive now read of many people harmed, possibly even some deaths. It does not have "humble" origins. It is also heavily conflated with specific religious beliefs, never a good sign when you conflate science and facts with religion; caveat emptor...

Replied by Sam

Buy already diluted from compass labs, for example.

Replied by Terry Jacks

Pam, to make a 1% liquid Methylene Blue, add (1 gram) MB powder to 100 mL of distilled water. Most measuring cups have a 100 ML line for reference for the water. To mix it together, I use an empty, clear plastic soda bottle with a screw-on cap. Pour in the water first, then pour in the MB powder. Shake it 200 to 300 times to ensure the powder is all broken apart and mixed well. Then, carefully fill your 50 mL empty MB eye-dropper bottles you've saved when you bought the liquid form. If the liquid level is hard to see while pouring MB in, shine a flashlight beam through the bottle towards your eyes, so you can see the level in the dark bottle. Go slowly for best results. Good Luck.


Hallo Kr8peace,

MMs ist schon lange überholt. Chlordioxid ist neue formel. ein lesen. Ein glas wasser ist gut zehn glas wasser kann dich Töten... Paracelsius hat gesagt dosis mach das gift... Ich nehme selber 10 jahren Chlordioxid und besten gesundheit. Informiere richtig nicht ein seitig bitte...

Hello Kr8peace,

MMs is long outdated. Chlorine dioxide is new formula. Read A glass of water is good, ten glasses of water can kill you... Paracelsius said dose make the poison... I've been taking chlorine dioxide myself for 10 years and I'm in the best of health. Inform properly not one-sided please...

Diluting Methylene Blue

11 User Reviews
5 star (10) 
4 star (1) 

Posted by RedCardinal (Minneapolis, MN) on 05/17/2022
4 out of 5 stars

I am having a blonde moment with math. I got a high quality 30ml (1 oz) bottle of Methylene Blue with 300mg of MB in it. 1 drop was .5mg so I did that for 2 days with 1000 C. My eyes did turn a bit blue. Most of the calculations are for 2.3% and Ted's 1 gram powder to 1000cc.

So Help Please. It would be so beneficial to know how many mg or mcg makes up 1%, and/or .1%. AND how to get 30ml of 300mg to 1% since it's not a powder.

What's crazy is seeing doses of 15mg (which would make my eyes navy blue ; ) online.

Any help is greatly appreciated.

Replied by Aurelia

If you supplement a good quality vit.c with M blue, the whites will not turn blue.

Replied by Beckie

300 mgs, or 0.3 grams in 30 mls is 1%. A 1% solution is 1.0 grams in 100 mls liquid.

Replied by Edward

With a 1% solution of methylene blue 1 drop = 0.5 mg. In Sloane's book available on Amazon 6mg. or 12 drops of the 1% solution should produce noticeable benefits for a 150lb. person.

Replied by jojo
(sf, ca)

The concentration in the flask u bought is 1%.
300 mg = .3 gm
It is also assumed that 1 ml = 1gm
Your total volume is 30 ml
Therefore, .3 divided by 30 (times 100 to get the percentage value) = 1%

Diluting Methylene Blue
Posted by Gilbert (Grand Marais, Mn) on 08/17/2017 9 posts
5 out of 5 stars

Methylene Blue Dosages

Reading here and elsewhere all the discussion about MB, could be helpful to put it all in perspective. I ran across also an article (link posted below) that helped with some aspects of the questions. The accepted doses for various conditions cover a range of three orders of magnitude, ~ 50 mg to as little as 50 micrograms. Even if a person determined the dilution necessary for the final dose it might not be the best amount for that person. Genetics, epigenetics and the mediation of microbiomes on any medication does make fools of MDs who are inflexible. How to get a particular dose? I have several droppers from herbal extract 1 oz bottles. One is graduated in 1/4 ml increments.

So, one ml, close 2/3 of that dropper, of the fish tank solution of 2.3% methylene blue is gonna be about 23 mg methylene blue. Just now tried with water and found 8 drops ~ .25 ml. 1 ml water is 1 gram. With MB drops the equivalent could be different because of surface tension and viscosity but that I will try later. Rough estimate at the moment is 1 drop/30 mg of 2.3% MB solution contains ~0.7 mg MB. If you want a dose in that range put n drops into a glass of water.

Replied by Nathan Corbett Md

Please don't take any grade other than pharmaceutical! Methylene blue can be contaminated with heavy metals or other contaminants if it is prepared without human consumption in mind. If you go to a local compounding pharmacy (in NS the medicine shoppe is one I've had reasonable success with) they can help you out. At the pharmacy, you do not want the ophthalmic solution, as it is not tested safe for consumption either. They may be confused and initially ask you for a prescription from a doctor, but you do not need one. Methylene blue is a bulk chemical, not a drug, and as such you are left on your own in finding the appropriate grade to consume that will not hurt you over time.


I am looking to find a source for MB in Toronto. Any suggestions? Many thnx


check out Lifeblud, canadian company, they have it unlabeled on website with blue question mark, a bit pricey but the real deal