I've been experimenting with Methylene Blue(MB) for many years and I thought it might be useful to clear up some of the unfortunate myths that have arisen concerning MB usage.So this post should hopefully help to clarify many apparently confusing aspects when someone supplements MB for the first time for whatever reason.
First, because there seems to be so much dosage confusion about MB percentage strength and number of drops used, I'm going to use a completely different quantitative method that determines how many milligrams or how many drops to supplement MB with water. There has been much of confusion over this.
But first some information that I have found to be extremely useful in helping to more fully understand the effective dosage amounts of MB needed for particular ailments :
1 drop of 1% Methylene Blue contains 0.5 mgs of MB.
1 drop of 0.1% Methylene Blue contains 0.05 mgs of MB
1 drop pf 2.33% Methylene Blue(Aquarium version ) contains 1 mg(approx.)
A half teaspoon of MB is 40 drops.
A full teaspoon of MB is 80 drops.
So armed with the above helpful definitions, I will now only describe MB dosages in milligram amounts only. Doing it this way eliminates all the confusion(and myths) of how you should use 0.1% or 1% or 2.33% MB. After all, it's the dose of MB powder in water that you supplement that is all-important -- not the percentage of MB in your dropper bottle. Right?
Ted from Bangkok has also maintained in his MB posts that supplementing the cheaper aquarium version of Methylene Blue is certainly good enough and pure enough for supplementing in humans. But if that last statement makes some readers balk in fear of "heavy metal impurites" then it's perhaps also useful to appreciate that fish live and breath in water and humans breath air. But water is a much more dense medium than air. And that means that fish are much more sensitive to poisons, heavy metals etc in their water than humans are. So if the aquarium version of MB is good enough for the more sensitive fish then it should certainly follow that aquarium MB is pure enough for us humans as well. And that's also why I've been using the aquarium version of MB, without any problems whatsoever, for over 10 years now.
Other things to remember about MB is that low MB dosages will be good enough to help give you energy and to help MB act as both an antioxidant and antimicrobial for the brain, thus helping to increase and maintain mental cognition as well as helping to prevent dementia(Alzheimer's Disease, Parkinson's Disease etc). However, much larger doses of MB will be required to kill viruses or bacteria, cure malaria, kill fungus, kill parasites, treat Methemoglobinemia, help remove blood clots etc.
But what do I mean when I say take a low dose of MB in water? -- And here is where all the confusion happens. I've read that for some people 2 drops of 1% MB(which is equivalent to 1 mg MB powder on water) is enough to fully energize them. I've also read where other people need to take as much as 16 mgs or even 100 mgs of MB(which is still a low dose for MB) to get energized. The point that I'm making here is that you will normally always have to find your own MB dose that works for you personally.
My own dose, which suits me for getting more energy and obtaining the cognitive benefits from using MB, is based on Dr Golwalkar's method that he has been using over the years to treat and cure both tuberculosis and COVID-19. He uses a teaspoon of 0.1% Methylene Blue for nebulizing(which is equivalent to 4 mgs MB powder in water) and he also recommends taking a half teaspoon of 0.1% MB orally as a sub-lingual dose(which is equivalent to taking 2 mgs MB powder in water).
My own everyday MB dose is slightly different to Dr Golwalkar's sub-lingual dose. I just add half a tablespoon of water to a small empty glass and then add 4 drops of 2.33% Methylene blue(which is equivalent to taking approximately 4 mgs of MB powder) and supplement that twice a day. But I have also taken the equivalent of more that 25 mg MB powder per day without a problem. I would also recommend using Dr Golwalker's recommendation of using 5 mls or 1 teaspoon of 0.1% MB(which is equivalent to 4 mgs MB powder in water) in a nebulizer two or three times a day when infected with COVID-19.
Some more MB facts for you. When you supplement Methylene Blue then between 75% and 80% of the MB taken orally is directly and quickly absorbed into the blood. Methylene Blue has a half-life in the human body of about 6 hours. That means that half the amount of MB that you supplemented will still be in your body after 6 hours. It's for reason of this persistence of MB in the body that I would at least advise that for low dose MB you should at least take one day off a week to reset your system and get rid of all the MB in your body.
I've also found an easy way of converting Methylene Blue from its blue oxidant form to its colorless reduced form. I will, for instance, add my 4 drops of Methylene Blue to a little water in a glass for sublingual supplementation. Then I would add a very small amount -- a tiny amount!! -- of Ascorbic Acid to the MB and walk outside and let the sunlight quickly convert the blue oxidant form of MB to it's colorless reduced form and just take it like that without giving me a blue mouth. I've also used the reduced or colorless MB form on skin problems without any blue coloring occurring. It works well and MB is also rapidly and easily absorbed into the skin.
UPDATE; Four months of Methylene Blue.
It has no effect on chronic fatigue - doesn't give me any energy; also doesn't keep me up at night if I take it right before bed.
There are two areas where it seems to have worked magic: Cysts and Anxiety; as well as other benefits for insomnia and problem solving.
It did clear up my long term liver/kidney/diaphram/intestinal cysts, and for that, I am very grateful. I stopped taking it for about a week, and the pain radiating from what used to be the most painful cyst began to return, so I am sure this is what fixed them, although I have no idea why it came back and whether to continue taking MB indefinitely.
Anxiety: There's something about MB that fixes my generalized anxiety. It's fairly miraculous in that regard. I did not take it for anxiety, but I notice an improvement (almost total resolution) when I take it. As a result, don't need xanax. Again not sure whether it is safe to take indefinitely for anxiety.
Along with the reduced anxiety, it helps me to focus more on problem solving. Not a complete resolution but a definite improvement. I have chronic fatigue related brain fog, and it definitely gives a boost in that department so I can see why it is being used successfully in Alzheimer's patients.
I think I am sleeping better -- deeper sleep, not getting up so much in the middle of the night, because of the MB, which is huge because I've lived through 25 years of insomnia. Used to take RX sleeping pills of various kinds (4-5 days per week) but not taking them anymore.
When I first started the MB in Feb 2013, I experienced significant tingling in my head (felt like brain buzzing). I was taking several milligrams of melatonin per night, and drinking coffee during the day. Both of those were a problem while taking MB but now, after a few months, I am able to drink a regular cup of coffee now and then with no adverse reactions. I also take a much lower dose (1. 5 mg) melatonin with no side effects. For some reason, tea creates no problems.
MB had no effect on yeast/candida, herpes related virus, or fungal infections.
Other than occassional "brain buzzing", I think MB may have a negative effect on vision (blurrier, esp at higher doses). It MAY have a positive effect on acne but I've been taking a skin/nail/hair formula as well and think it is because of that that my acne has improved.
I am taking 3-5 drops of 0.1% per day.
Perhaps E.C cross post this to Anxiety/panic attacks; and intestinal cysts.
EC: Bennie's latest update has been cross posted from her thread in the Q&A section on the Methylene Blue page here: https://www.earthclinic.com/remedies/methylene-blue_questions.html#Question_4567.
(Southeast Georgia, US)
(SF Bay Area)
When diluting this, set up protective material underneath. MB stains! I rubbed vitamin C and water paste in the measuring glass and spills on the sink and counter and on my hands to get it out. If only I had a chemistry background to do a more pro job diluting it ;p
METHYLENE BLUE, I have been using MB topically on benign skin lesions, the doctor had been freezing them off, but they eventually come back and the freezing is painful. So I just applied the 2.3% (fish stuff) directly on the spots. They take up the dye, and dry up, I reapplied it to the larger spots a few times, the small spots just healed up very fast. skin is looking great, no pain.
My dad was diagnosed with mantle cell lymphoma back in Feb 2007. He has been thru chemo several times and it's to the point now that he just can't stand the strong treatments and they aren't effective now anyway. We have always believed that God put natural methods here to cure cancer etc. And one of his friends told us about Mary Martin Sloop who back in the early to mid 1900's took methylene blue for cancer after the Dr. had cut her open and then sewed her back up because they said they couldn't do anything for her. Mary Martin Sloop went on to live 40 more years after taking the methylene blue. We have no idea how to get it, use it and would it even work for my dad now since he is in pretty bad shape. He is unable to eat basically as he has trouble keeping food down and is really weak. The Dr. gave him no more than a few weeks to live. Can you please let us know quickly if there is anything that would get him well. We don't want to prolong his suffering but we would love to get him back to his active lifestyle of bowling, biking and living for the Lord. Thanks and God bless, Kevin
(Garden Grove, Ca Usa)
(North York, On, , Canada)
I was taking Methylene Blue (12-13 drops in 8 ounces of water) with a thousand milligrams of vitamin C for about a week & I noticed the severity of my candida related itchy skin was reduced, I then upped my dosage by a few more drops per day (14-15 drops) in about 9-10 ounces of water, and a few hours later my stool was loaded with dead candida overgrowth! I normally have bad constipation but this time my "relief" was smooth and easy I was amazed. Also, I use the Methylene blue stain directly on my skin where I have itchy candida rashes, yes it stains! But only for a few days & most of it will wash off with soap and water, so use it where it cannot be seen, and it will take you itchy rash away with relief within 10-15 minutes and the relief will last for like a week, until the bugs send out a new invading force! I have also use Methylene Blue in more diluted parts for itchy skin in more visible areas with relief & I found it is also good for tooth aches.
P.S when I take it in strong doses your urine turns blue for about a day, but when you stop taking it it turns back to normal & I take vit C 500-1000 mill and have had no problems with my eye coloring, which I also heard is reversible if you should happen to have that happen to you.
(Union Grove, Wisconsin)
Research indicates Vitamin C may inhibit Methylene Blue's killing of Candida
Ted's advice on many areas of health have been of great assistance to me. I became interested in trying Methylene Blue for attacking my systemic Candida, and did some additional research. I came across a study that indicates that taking Vitamin C with MB may decrease the effectiveness of its impact on Candida. The research is found at https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4780517/
The relevant quote is halfway through the abstract: "... sensitivity of Candida cells to MB could be rescued upon the supplementation of ascorbic acid, an antioxidant." In the context of the abstract, this "rescue" seemed to be contrary to the intent of killing Candida cells.
Therefore, I began to take MB 1 drop twice a day (along with BHT), but taking ascorbic acid at least two hours later. My reasoning was taking such a small dose had no risk of side effects (coloring eye, etc.), but that any potential impact on Candida would not be lessened by the ascorbic acid.
I understand that Ted is not currently up to responding, but am hopeful that this information may help others, if you or someone may take a look at it and comment on how to take MB and Vitamin C (perhaps 2 hours between the two?).
Hoping this may assist others in recovery from Candidiasis;
I am an intermittent catheter user, therefore, I have chronic bladder infections. Ever since I began using Methylene Blue I have stopped getting UTIs. I use Methylene Blue 1% solution. The normal dose is 10 drops in water morning and night. I only need 2 drops morning and night. I use a straw to drink it so my teeth won't turn blue. It has the added benefit of stopping my candida symptoms.
Having said this, I am also very careful about what I eat: no sugar or fruit of any kind. I don't use any artificial sweeteners. I avoid wheat and other grains. I eat canned beans, eggs, fish, chicken, vegetables, and brown rice. I have to avoid nuts.
(Colorado Springs, CO)
(Long Hill NJ)
I found that methylene blue works great for chronic fatigue. It was like someone hit my on switch. My energy level and thinking improved drastically and I was easily able to give up caffeine. However, the reason why methylene blue was able to work so well for me is that my chronic fatigue was due the fact that methylene blue treats mitochondria damage, and I have mitochondria damage from taking Cipro. Never take Cipro.
(Lady Lake, Florida)
I found out the hard way. Methylene blue is sometimes deliberately contaminated with arsenic, possibly to prevent us from benefiting from a safe effective product. The type I bought had a warning label not to be used in food producing fish. I called the store I bought it from, they said it did not have arsenic. This was a lie.
I suffered greatly from severe arsenic poisoning. I wish there was a way to be sure the source was pure, because aside from the arsenic, methylene blue was great stuff.
(San Jose, Ca)
After reading your website, I was excited to try out the methylene blue for my yeast and "brain fog". I followed instructions, taking it with powder vit c and baking soda. I took it only one time because in researching a bit more, I saw where taking Methylene blue with anti depressants can cause serious problems with the serotonin in the brain.
"Although the exact mechanism of this drug interaction is unknown, methylene blue inhibits the action of monoamine oxidase A—an enzyme responsible for breaking down serotonin in the brain. It is believed that when methylene blue is given to patients taking serotonergic psychiatric medications, high levels of serotonin can build up in the brain, causing toxicity. This is referred to as Serotonin Syndrome. " (food and drug administration webpage)
I have been on effexor for 10 years, and although I plan to go off this slowly in the summer, it looks like I will not be able to use the methylene blue as planned.
Was this on your website and I missed it? If not, you might want to add this information. I'm glad I caught it, but very disappointed I cannot benefit from taking the methylene blue. Any other suggestions?
Thank you, Pat
(Myrtle Beach, Sc)
(Digby, Nova Scotia)
The only drug known to inhibit the excessive production of reactive species and cytokines is methylene blue, a low-cost dye with antiseptic properties used effectively to treat malaria, urinary tract infections, septic shock, and methaemoglobinaemia.The relatively poor efficacy of anti-cytokine drugs is explained by the fact that they act on one or a few of the dozens of cytokines involved, and because other mediators of inflammation – reactive oxygen and nitrogen species – are not targeted. When produced in excess, reactive species cause extensive cell and tissue damage.
My name is Lisa. I am 43 years old I want to share with you an experience with Methylene blue. I have been using it for 5 years. it is effective on depression and calm anxiety. I tried 2 types of Methylene blue -- powder as well as liquid. The liquid was much expensive in comparison to the powder but both have same results. For 2 years I have been using Methylene blue powder form. I was purchasing it from cztl.
(Auckland, New Zealand)
I am having a blonde moment with math. I got a high quality 30ml (1 oz) bottle of Methylene Blue with 300mg of MB in it. 1 drop was .5mg so I did that for 2 days with 1000 C. My eyes did turn a bit blue. Most of the calculations are for 2.3% and Ted's 1 gram powder to 1000cc.
So Help Please. It would be so beneficial to know how many mg or mcg makes up 1%, and/or .1%. AND how to get 30ml of 300mg to 1% since it's not a powder.
What's crazy is seeing doses of 15mg (which would make my eyes navy blue ; ) online.
Any help is greatly appreciated.
Diluting Methylene Blue
Methylene Blue Dosages
Reading here and elsewhere all the discussion about MB, could be helpful to put it all in perspective. I ran across also an article (link posted below) that helped with some aspects of the questions. The accepted doses for various conditions cover a range of three orders of magnitude, ~ 50 mg to as little as 50 micrograms. Even if a person determined the dilution necessary for the final dose it might not be the best amount for that person. Genetics, epigenetics and the mediation of microbiomes on any medication does make fools of MDs who are inflexible. How to get a particular dose? I have several droppers from herbal extract 1 oz bottles. One is graduated in 1/4 ml increments.
So, one ml, close 2/3 of that dropper, of the fish tank solution of 2.3% methylene blue is gonna be about 23 mg methylene blue. Just now tried with water and found 8 drops ~ .25 ml. 1 ml water is 1 gram. With MB drops the equivalent could be different because of surface tension and viscosity but that I will try later. Rough estimate at the moment is 1 drop/30 mg of 2.3% MB solution contains ~0.7 mg MB. If you want a dose in that range put n drops into a glass of water.