Methylene Blue
Health Benefits

Methylene Blue - Editor's Choice

on Jul 09, 2023| Modified on May 13, 2025
Add New Post Comments
Methylene Blue Benefits.

Methylene blue, an organic compound with deep medicinal roots, has been used for over a century to treat conditions like malaria, urinary tract infections, and methemoglobinemia. Today, its therapeutic applications extend to neurological conditions, depression, and even anti-aging.

Recent studies highlight its potential for cognitive health and mitochondrial function. By improving cellular energy, methylene blue can protect neurons, reduce inflammation, and combat oxidative stress—making it a promising option for conditions like Alzheimer’s and Parkinson’s.

What is Methylene Blue?

Methylene blue is a chemical compound that stands out for its particular molecular configuration, which renders it useful in the medical field. It is a dark green powder in its dry state, but when dissolved in water, it transforms into a vivid blue solution. This stark blue hue has practical applications in medical settings, where it can be used to delineate tissues and bodily fluids during procedures.

In addition to its visual utility, methylene blue shares functional similarities with hemoglobin—the vital protein in blood cells that carries oxygen throughout the body. Its ability to mimic hemoglobin's oxygen-transporting role enables methylene blue to effectively treat a range of medical issues.

Health Benefits of Methylene Blue

In the sections below, we explore methylene blue's powerful therapeutic potential, highlighting its ability to benefit individuals with various medical conditions.

Antidepressant Properties

Methylene blue shows promise as an antidepressant, helping reduce depression symptoms even in patients who haven't responded to traditional medications. (1)

It works by increasing the activity of key neurotransmitters in the brain, such as serotonin and norepinephrine, which are essential for regulating mood. (2)

Anti-Inflammatory Effects

Methylene blue has strong anti-inflammatory properties, which may help treat chronic diseases like Alzheimer's, cancer, and heart disease by reducing inflammation. In studies on mice, it reduced brain inflammation and prevented cognitive decline. (3)

Alzheimer's Disease

Methylene blue shows promise in treating Alzheimer's by reducing toxic protein buildup in the brain, including amyloid plaques and tau tangles, which are key contributors to the disease. This may slow or halt its progression. (4)

These toxic proteins, amyloid plaques, and tau tangles are believed to be the underlying cause of Alzheimer's disease. By reducing the buildup of these proteins, methylene blue may be able to slow or even halt the progression of the disease.

Sepsis Management

Methylene blue can help treat sepsis by reducing inflammation and improving blood flow, potentially preventing organ failure. Studies have shown it improves survival rates in sepsis patients. (5)

Parkinson's Disease Treatment

Methylene blue may slow or halt Parkinson's progression by protecting dopamine-producing neurons in the brain. (6)

Malaria Treatment

Methylene blue has been found effective in treating malaria by killing the parasite that causes the disease. (7)

Methemoglobinemia Therapy

Methylene blue treats methemoglobinemia by converting methemoglobin to its normal form, allowing blood to transport oxygen effectively. (8)

Cyanide Poisoning

Methylene blue can neutralize cyanide, converting it into a less toxic form. (9)

Acute Respiratory Distress Syndrome Management

It may improve lung function and reduce inflammation in ARDS patients. (10)

Neurological Disorder Treatments

Methylene blue may help treat multiple sclerosis, spinal cord injury, and stroke by protecting neurons and reducing inflammation. (11)

Radiation-Induced Tissue Injury Management

Methylene blue reduces oxidative stress and inflammation, helping protect against radiation damage.  (12)

Diabetes

In animal studies, Methylene blue has been found to improve insulin sensitivity and lower blood sugar levels. (13)

Ulcer Treatment

It may help reduce ulcer formation by inhibiting the growth of Helicobacter pylori, a bacterium linked to ulcers. (14)

Skin Conditions

Methylene blue may treat conditions like psoriasis and eczema by reducing inflammation and improving the skin barrier. (15)

Antiviral Properties

It has shown antiviral effects against viruses like dengue and Zika by inhibiting viral replication. (16)

Heart Disease Management

Methylene blue may improve heart function by reducing oxidative stress and inflammation, which protects heart tissue. (17)

Wound Healing

It has been found to promote wound healing by reducing inflammation and encouraging new blood vessel growth. (18)

Liver Disease Treatment

Methylene blue shows potential in treating liver conditions like fibrosis and fatty liver disease by reducing inflammation. (19)

Alcohol Use Disorder Treatment

Studies suggest methylene blue may reduce alcohol withdrawal symptoms by regulating the brain's reward system. (20)

Inflammatory Bowel Disease Management

Methylene blue may help improve symptoms of IBD, including Crohn's disease and ulcerative colitis, by reducing inflammation and oxidative stress. (21)

Bone Loss Prevention

It has been shown to promote bone formation and reduce bone loss in osteoporosis studies. (22)

Tinnitus

Methylene blue may reduce tinnitus symptoms by lowering oxidative stress in the auditory system. (23)

Chemotherapy-Induced Neuropathy

It may help reduce pain and improve nerve function in patients with neuropathy from chemotherapy. (24)

Glaucoma Treatment

Methylene blue has been shown to lower intraocular pressure, potentially preventing vision loss in glaucoma patients. (25)

Hair Loss Management

Methylene blue may help promote hair growth by increasing blood flow to hair follicles and stimulating cell proliferation. (26)

Depression

It has shown promise in improving depressive symptoms, particularly in patients with Parkinson's disease.  (27)

Epilepsy

Methylene blue may reduce seizure frequency by increasing GABA levels and lowering oxidative stress in the brain. (28)

Stroke Management

It has been found to protect against brain damage and reduce neurological deficits in stroke models. (29)

Osteoarthritis

Methylene blue may reduce joint inflammation and cartilage damage in osteoarthritis. (30)

Methylene Blue Dosage and Dilution Instructions

Consult a healthcare professional before starting methylene blue. Purchase pharmaceutical-grade methylene blue and dilute it properly in distilled water as instructed by your provider. Start with the lowest dose, as small amounts can cause strong effects. It can be taken orally, intravenously, or topically, but always follow your doctor’s advice. Monitor for side effects like dizziness, mania, or gastrointestinal upset, and adjust dosage as needed with guidance from your healthcare professional.

Proceed With Caution: Methylene Blue's Potent MAO Inhibition and Potential Drug Interactions

Methylene blue is a powerful MAO inhibitor that increases neurotransmitter levels, but it can also cause severe interactions, especially with medications like SSRIs, SNRIs, or tramadol. This could lead to serotonin syndrome, a potentially life-threatening condition. Symptoms include shivering, diarrhea, muscle rigidity, or seizures. It's crucial to consult your healthcare provider before using methylene blue, especially if you're taking other medications. Close monitoring and open communication with your provider can help manage risks.32

Methylene blue is a versatile medicinal agent with applications ranging from antidepressant and anti-inflammatory uses to potential treatments for Alzheimer's and Parkinson's. It has proven effective for conditions like sepsis, malaria, and heart disease, and ongoing research is uncovering even more benefits, including managing diabetes and skin conditions. As research continues, methylene blue's role in medicine will likely expand.

Keep reading below to see how Earth Clinic users have benefited from methylene blue. Have you tried it? Share your experience!

References

  1. Delport, A., Harvey, B.H., Petzer, A. et al. Methylene blue and its analogues as antidepressant compounds. Metab Brain Dis 32, 1357–1382 (2017). https://doi.org/10.1007/s11011-017-0081-6

  2. Naylor, G. J., Martin, B., Hopwood, S. E., & Watson, Y. (1986). A two-year double-blind crossover trial of the prophylactic effect of methylene blue in manic-depressive psychosis. The British Journal of Psychiatry, 149(3), 353-356. https://pubmed.ncbi.nlm.nih.gov/3091097/
  3. Medina, D. X., Caccamo, A., & Oddo, S. (2011). Methylene blue reduces aβ levels and rescues early cognitive deficit by increasing proteasome activity. Brain Pathology, 21(2), 140-149. https://pubmed.ncbi.nlm.nih.gov/20731659/
  4. Atamna, H., & Kumar, R. (2010). Protective role of methylene blue in Alzheimer's disease via mitochondria and cytochrome c oxidase. Journal of Alzheimer's Disease, 20(2), 439-452. PMID: 20463399. https://pubmed.ncbi.nlm.nih.gov/20463399/
  5. Jang, D. H., Nelson, L. S., & Hoffman, R. S. (2013). Methylene blue for distributive shock: a potential new use of an old antidote. Journal of Medical Toxicology, 9(3), 242-249. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770994/
  6. Tucker, D., Lu, Y., & Zhang, Q. (2018). From mitochondrial function to neuroprotection – an emerging role for methylene blue. Molecular Neurobiology, 55(6), 5137-5153. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5826781/
  7. Schirmer, R. H., Coulibaly, B., Stich, A., Scheiwein, M., Merkle, H., Eubel, J., ... & Kouyaté, B. (2003). Methylene blue as an antimalarial agent. Redox Report, 8(5), 272-275. https://pubmed.ncbi.nlm.nih.gov/14962363/
  8. Mak, R. S. P., & Liebelt, E. L. (2021). Methylene Blue: An Antidote for Methemoglobinemia and Beyond. Pediatric Emergency Care, 37(9), 474-477. https://pubmed.ncbi.nlm.nih.gov/34463662/
  9. Haouzi, P., Gueguinou, M., Sonobe, T., Judenherc-Haouzi, A., Tubbs, N., Trebak, M., Cheung, J., & Bouillaud, F. (2018). Revisiting the physiological effects of methylene blue as a treatment of cyanide intoxication. Clinical Toxicology, 56(9), 828-840. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086742
  10. Scigliano, G., & Scigliano, G. A. (2020). Acute respiratory distress syndrome from Covid-19: A perfect storm from free radicals? Proposal for a new treatment. Medical Hypotheses, 144, 110120. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373063/
  11. Genrikhs, E. E., Stelmashook, E. V., Voronkov, D. N., Novikova, S. V., Alexandrova, O. P., Mironova, R. I., ... & Skrebitsky, V. G. (2020). The delayed neuroprotective effect of methylene blue in experimental rat brain trauma. Antioxidants, 9(5), 377. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7278725/
  12. Hrushesky, W. J., Berestka, J. S., von Roemeling, R., Olshefski, R., Langevin, T. R., Potish, R. A., Delaney, J. P., Ellefson, M., & Schwartz, S. (1988). Methylene blue protects intestinal mucosa from free radical-mediated sublethal radiation damage. Free Radical Biology and Medicine, 5(4), 207-213. https://pubmed.ncbi.nlm.nih.gov/3151072/
  13. Haluzik, M., Nedvídková, J., & Skrha, J. (1999). Treatment with the NO-synthase inhibitor, methylene blue, moderates the decrease in serum leptin concentration in streptozotocin-induced diabetes. Endocrine Research, 25(2), 163-171. https://pubmed.ncbi.nlm.nih.gov/10382678/
  14. Ogasawara, K. (2018). Helicobacter pylori Eradication Using a Light-Emitting Diode and Methylene Blue. Laser Therapy, 27(1), 21-25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958231/
  15. Salah, M., Samy, N., & Fadel, M. (2009). Methylene blue mediated photodynamic therapy for resistant plaque psoriasis. Journal of Drugs in Dermatology, 8(1), 42-49. https://pubmed.ncbi.nlm.nih.gov/19180895/
  16. Li, Z., Lang, Y., Sakamuru, S., Samrat, S., Trudeau, N., Kuo, L., ... & Xia, M. (2020). Methylene blue is a potent and broad-spectrum inhibitor against Zika virus in vitro and in vivo. Emerging Microbes & Infections, 9(1), 2404-2416. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7646565/
  17. Manghelli, J., Brown, L., Tadros, H. B., & Munfakh, N. A. (2015). A Reminder of Methylene Blue's Effectiveness in Treating Vasoplegic Syndrome after On-Pump Cardiac Surgery. Texas Heart Institute Journal, 42(5), 491-494. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591896/
  18. Edwards, K. (2016). New Twist on an Old Favorite: Gentian Violet and Methylene Blue Antibacterial Foams. Advances in Wound Care, 5(1), 11-18. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4717508/
  19. Shin, S. Y., Kim, T. H., Wu, H., Choi, Y. H., & Kim, S. G. (2014). SIRT1 activation by methylene blue, a repurposed drug, leads to AMPK-mediated inhibition of steatosis and steatohepatitis. European Journal of Pharmacology, 727, 115-124. https://pubmed.ncbi.nlm.nih.gov/24486702/
  20. Vonlanthen, R., Beer, J. H., & Lauterburg, B. H. (2000). Effect of methylene blue on the disposition of ethanol. Alcohol and Alcoholism, 35(5), 424-426. https://academic.oup.com/alcalc/article/35/5/424/206576
  21. Dinc, S., Caydere, M., Akgul, G., Yenidogan, E., Hücümenoglu, S., & Rajesh, M. (2015). Methylene Blue inhibits the inflammatory process of the acetic acid-induced colitis in the rat colonic mucosa. International Surgery, 100(7-8), 1166-1173. https://pubmed.ncbi.nlm.nih.gov/26062761/
  22. Broulik, P. D., & Schreiber, V. (1994). Methylene blue inhibits the stimulation of bone mass by high doses of estradiol in male rats. Endocrine Regulations, 28(3), 141-144. PMID: 7589472. https://pubmed.ncbi.nlm.nih.gov/7858245/
  23. Park, J. S., Jou, I., & Park, S. M. (2014). Attenuation of noise-induced hearing loss using methylene blue. Cell Death & Disease, 5(4), e1200. https://www.researchgate.net/publication/261881758_Attenuation_of_noise-induced_hearing_loss_using_methylene_blue
  24. Jordan B, Margulies A, Cardoso F, on behalf of the ESMO Guidelines Committee, the EONS Education Working Group, the EANO Guideline Committee. Systemic anticancer therapy-induced peripheral and central neurotoxicity: ESMO–EONS–EANO Clinical Practice Guidelines for diagnosis, prevention, treatment and follow-up. Ann Oncol. 2020 Oct 1;31(10):1306-1319. https://www.annalsofoncology.org/article/S0923-7534(20)39938-5/fulltext
  25. Payne, A. J., Kaja, S., Sabates, N. R., & Koulen, P. (2013). A case for neuroprotection in ophthalmology: developments in translational research. Mo Med, 110(5), 429-36. https://pubmed.ncbi.nlm.nih.gov/24279196/
  26. Xiong, Z. M., Choi, J. Y., Wang, K., Zhang, H., Tariq, Z., Wu, D., ... & Cao, K. (2016). Methylene blue alleviates nuclear and mitochondrial abnormalities in progeria. Aging Cell, 15(2), 279-290. https://pubmed.ncbi.nlm.nih.gov/26663466/
  27. Elizabeth S Smith, Madeline E Clark, Gwendolyn A Hardy, David J Kraan, Elisa Biondo, F Gonzalez-Lima, Lawrence K Cormack, Marie Monfils, Hongjoo J Lee. Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson's disease. Neuroscience, Volume 359, 2017, Pages 8-16. https://pubmed.ncbi.nlm.nih.gov/28694175/
  28. Cui ZQ, Li WL, Luo Y, Yang JP, Qu ZZ, Zhao WQ. Methylene Blue Exerts Anticonvulsant and Neuroprotective Effects on Self-Sustaining Status Epilepticus (SSSE) Induced by Prolonged Basolateral Amygdala Stimulation in Wistar Rats. Med Sci Monit. 2018;24:161-169. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5771162/
  29. Jiang, Z., & Duong, T. Q. (2016). Methylene blue treatment in experimental ischemic stroke: A mini-review. Brain Circulation, 2(1), 48–53. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4817094/
  30. Li X, Tang C, Wang J, Guo P, Wang C, Wang Y, Zhang Z, Wu H. Methylene blue relieves the development of osteoarthritis by upregulating lncRNA MEG3. Exp Ther Med. 2018 Apr;15(4):3856-3864. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863598/
  31. Ramsay, R. R., Dunford, C., & Gillman, P. K. (2007). Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. British Journal of Pharmacology, 152(6), 946–951. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2078225/
  32. Ramsay RR, Dunford C, Gillman PK. Methylene blue and serotonin toxicity: inhibition of monoamine oxidase A (MAO A) confirms a theoretical prediction. Br J Pharmacol. 2007 Nov;152(6):946-51. https://pubmed.ncbi.nlm.nih.gov/17721552/

Frequently Asked Questions about Methylene Blue

What are the health benefits of methylene blue?

Methylene blue provides benefits such as neuroprotection, antidepressant effects, anti-inflammatory properties, and treatment for conditions like sepsis, malaria, and Alzheimer's.

Is methylene blue safe to use?

At low doses, methylene blue is generally safe. However, it can cause side effects like nausea or serotonin syndrome when mixed with certain medications.

How do you take methylene blue?

Methylene blue is taken orally or intravenously, with dosage recommended by healthcare providers. Proper dilution using distilled water is essential.

Can methylene blue treat neurological disorders?

Yes, methylene blue is being studied for its ability to protect neurons and reduce inflammation, showing promise in treating Parkinson's and Alzheimer's.

What conditions can methylene blue treat?

It may treat conditions such as malaria, sepsis, methemoglobinemia, depression, and various neurological disorders.


The comments below reflect the personal experiences and opinions of readers and do not represent medical advice or the views of this website. The information shared has not been evaluated by the FDA and is not intended to diagnose, treat, or prevent any disease or health condition. Always consult a qualified healthcare professional for medical concerns.

Using Methylene Blue

Posted by Bill (Philippines) on 02/26/2024
★★★★★

Editor's Choice

Hi Gina,

Methylene Blue(MB) does alot of beneficial things for the body:

1. In it's pro-oxidant or "blue" form, MB can supply increased oxygen to your cells, thus giving you more energy. Also, supplying oxygen more efficiently to all your cells helps to prevent cancer.

2. MB is an efficient wide-spectrum pathogen killer -- it kills viruses, bacteria and fungi on your body.

3. MB is used in medicine to cure Methemoglobinemia.

4. According to Dr Deepak Golwalkar who is a renowned pulmonary specialist in India -- you can use low dose 0.1% MB to both stop the deadly cytokine storms so heavily involved in COVID-19 to actually help to cure COVID-19 problems.

5. Dr Golwalkar also regularly uses a low oral dose 0.1% Methylene Blue + daily nebulized MB to cure and save his patients with serious pneumonia and tuberculosis infections.

6. MB is used as an antidote to cyanide poisoning.

7. MB has been used for over 100 years -- by the spoonful(i.e. large doses) -- against malaria.

8. MB in it's anti-oxidant form -- which is it's colorless form also known as Leucomethylene Blue -- has many cognitive benefits. There is also much research that shows that regularly supplementing low dose MB improves learning, memory, increases energy, is neuroprotective and protects the brain. This therefore makes MB extremely useful against degenerative diseases like Alzheimer's, Parkinson's and other diseases like Huntington's.

9. It's also worth remembering that Methylene Blue is useful in the body both in it's pro-oxidant or "blue" state as well as in it's colorless or reduced state as LeucoMethylene Blue.

10. Methylene Blue has a half-life in your body of abour 6 hours. So this also means that even a small or low dose of MB -- either in it's pro-oxidant or anti-oxidant form -- will protect your body for an extended and useful amount of time.

11. To be absolutely clear, it does not really matter which form of MB that you take -- the pro-oxidant form or the anti-oxidant form(with added Ascorbic Acid) -- because the MB in your body will undergo many conversions to and from it's pro-oxidant and anti-oxidant forms until it is eventually removed by the liver.

Now here's some simple maths for the sake of MB dosage clarity. I don't like using MB expressed as a % and drops as the dose of MB because it seems to always confuse people. That's why I much prefer expressing the MB dosage in milligrams per drop. See below for a useful reference:

1 drop of 0.1% MB solution contains 0.05 mgs MB powder.

1 drop of 1% MB solution contains 0.5 mgs MB powder.

1 drop of 2% MB solution contains 1 mg MB powder.

From now on, I will express all MB amounts in milligrams and you should now be able to easily work out the exact number of drops you must take -- at whateverv % concentration -- from the above conversions.

Dr Golwalkars Own Daily MB Protocol

In his many articles Dr Golwalkar has said that the only protocol or precaution he took for himself during the COVID-19 pandemic in his hospital was just to follow one MB protocol. He said that he took half a teaspoon of 0.1% MB, which is equivalent to approximately 50 drops of 0.1% MB. So from the above -- that converts to:

50 drops x 0.05 = 2.5mgs MB powder.

Dr Golwalkar would then hold the MB in his mouth for 30 seconds for fast sublingual absorption into his bloodstream and then swallow it with a little extra water. Dr Golwalkar has also said that he has had very few COVID-19 deaths at his hospital despite treating many thousands of people. He has also said that he never used a mask in his hospital when doing the rounds and visiting his patients. And he never succumbed to COVID-19 during the whole period of the pandemic. As a consequence, Dr Golwalkar is regarded as a hero in India for saving so many of his people but he still remains unknown in the West because of the FDA's efficient control over the CDC, the WHO and the ever-obedient Western media.

I currently use Dr Golwalkar's low sublingual MB protocol every day -- which helps to protect me against any COVID-19 infections and, since I'm an old guy, also helps to maintain my cognitive and neurological health as well.


Diluting Methylene Blue Tips

Posted by Bill (Philippines) on 06/15/2023
★★★★★

Editor's Choice

I've been experimenting with Methylene Blue(MB) for many years and I thought it might be useful to clear up some of the unfortunate myths that have arisen concerning MB usage.So this post should hopefully help to clarify many apparently confusing aspects when someone supplements MB for the first time for whatever reason.

First, because there seems to be so much dosage confusion about MB percentage strength and number of drops used, I'm going to use a completely different quantitative method that determines how many milligrams or how many drops to supplement MB with water. There has been much of confusion over this.

But first some information that I have found to be extremely useful in helping to more fully understand the effective dosage amounts of MB needed for particular ailments :

1 drop of 1% Methylene Blue contains 0.5 mgs of MB.

1 drop of 0.1% Methylene Blue contains 0.05 mgs of MB

1 drop pf 2.33% Methylene Blue(Aquarium version ) contains 1 mg(approx.)

A half teaspoon of MB is 40 drops.

A full teaspoon of MB is 80 drops.

So armed with the above helpful definitions, I will now only describe MB dosages in milligram amounts only. Doing it this way eliminates all the confusion(and myths) of how you should use 0.1% or 1% or 2.33% MB. After all, it's the dose of MB powder in water that you supplement that is all-important -- not the percentage of MB in your dropper bottle. Right?

Ted from Bangkok has also maintained in his MB posts that supplementing the cheaper aquarium version of Methylene Blue is certainly good enough and pure enough for supplementing in humans. But if that last statement makes some readers balk in fear of "heavy metal impurites" then it's perhaps also useful to appreciate that fish live and breath in water and humans breath air. But water is a much more dense medium than air. And that means that fish are much more sensitive to poisons, heavy metals etc in their water than humans are. So if the aquarium version of MB is good enough for the more sensitive fish then it should certainly follow that aquarium MB is pure enough for us humans as well. And that's also why I've been using the aquarium version of MB, without any problems whatsoever, for over 10 years now.

Other things to remember about MB is that low MB dosages will be good enough to help give you energy and to help MB act as both an antioxidant and antimicrobial for the brain, thus helping to increase and maintain mental cognition as well as helping to prevent dementia(Alzheimer's Disease, Parkinson's Disease etc). However, much larger doses of MB will be required to kill viruses or bacteria, cure malaria, kill fungus, kill parasites, treat Methemoglobinemia, help remove blood clots etc.

But what do I mean when I say take a low dose of MB in water? -- And here is where all the confusion happens. I've read that for some people 2 drops of 1% MB(which is equivalent to 1 mg MB powder on water) is enough to fully energize them. I've also read where other people need to take as much as 16 mgs or even 100 mgs of MB(which is still a low dose for MB) to get energized. The point that I'm making here is that you will normally always have to find your own MB dose that works for you personally.

My own dose, which suits me for getting more energy and obtaining the cognitive benefits from using MB, is based on Dr Golwalkar's method that he has been using over the years to treat and cure both tuberculosis and COVID-19. He uses a teaspoon of 0.1% Methylene Blue for nebulizing(which is equivalent to 4 mgs MB powder in water) and he also recommends taking a half teaspoon of 0.1% MB orally as a sub-lingual dose(which is equivalent to taking 2 mgs MB powder in water).

My own everyday MB dose is slightly different to Dr Golwalkar's sub-lingual dose. I just add half a tablespoon of water to a small empty glass and then add 4 drops of 2.33% Methylene blue(which is equivalent to taking approximately 4 mgs of MB powder) and supplement that twice a day. But I have also taken the equivalent of more that 25 mg MB powder per day without a problem. I would also recommend using Dr Golwalker's recommendation of using 5 mls or 1 teaspoon of 0.1% MB(which is equivalent to 4 mgs MB powder in water) in a nebulizer two or three times a day when infected with COVID-19.

Some more MB facts for you. When you supplement Methylene Blue then between 75% and 80% of the MB taken orally is directly and quickly absorbed into the blood. Methylene Blue has a half-life in the human body of about 6 hours. That means that half the amount of MB that you supplemented will still be in your body after 6 hours. It's for reason of this persistence of MB in the body that I would at least advise that for low dose MB you should at least take one day off a week to reset your system and get rid of all the MB in your body.

I've also found an easy way of converting Methylene Blue from its blue oxidant form to its colorless reduced form. I will, for instance, add my 4 drops of Methylene Blue to a little water in a glass for sublingual supplementation. Then I would add a very small amount -- a tiny amount!! -- of Ascorbic Acid to the MB and walk outside and let the sunlight quickly convert the blue oxidant form of MB to it's colorless reduced form and just take it like that without giving me a blue mouth. I've also used the reduced or colorless MB form on skin problems without any blue coloring occurring. It works well and MB is also rapidly and easily absorbed into the skin.


Broad Benefits

Posted by Terry Jacks (Texas) on 12/16/2022
★★★★★

Editor's Choice

It's not working very well for you? Based on your statement about 3-5 drops of 1%, I can see why. You should consider taking AT LEAST 15mg per day, which is 30 drops of 1% strength. The typical recommended dose is 40 to 360mg. I think 360 is a bit high, but 40 is fine. I take 30 to 40mg per day with great results for energy, attitude, skin condition, muscle strength gains, diabetic neuropathy, calmness, sleep quality, blood glucose control, eyesight, circulation and lasting energy during hard work.


Chronic Bladder Infections

Posted by MHO (Provo, UT) on 03/18/2022
★★★★★

Editor's Choice

I am an intermittent catheter user, therefore, I have chronic bladder infections. Ever since I began using Methylene Blue I have stopped getting UTIs. I use Methylene Blue 1% solution. The normal dose is 10 drops in water morning and night. I only need 2 drops morning and night. I use a straw to drink it so my teeth won't turn blue. It has the added benefit of stopping my candida symptoms.

Having said this, I am also very careful about what I eat: no sugar or fruit of any kind. I don't use any artificial sweeteners. I avoid wheat and other grains. I eat canned beans, eggs, fish, chicken, vegetables, and brown rice. I have to avoid nuts.


Dosage

Posted by Kenny (Ga.) on 06/11/2021
★★★★★

Editor's Choice

Have been using methylene blue for 2 months now with great results. I am using a teaspoon of baking soda about an hour after meals in an effort to get off of Prilosec. In doing this I have noticed that my urine is no longer blue. Anybody else noticed this after using baking soda with methylene blue?


Chronic Fatigue

Posted by Cynthia (California) on 09/12/2016
★★★★★

Editor's Choice

I found that methylene blue works great for chronic fatigue. It was like someone hit my on switch. My energy level and thinking improved drastically and I was easily able to give up caffeine. However, the reason why methylene blue was able to work so well for me is that my chronic fatigue was due the fact that methylene blue treats mitochondria damage, and I have mitochondria damage from taking Cipro. Never take Cipro.


Dosage

Posted by Bill (San Fernando, Philippines) on 10/03/2014
★★★★★

Editor's Choice

The correct dosage of 0.1% Methylene Blue is in the range of 6 to 15 drops(in a solution of vitamin C) once or twice a day dependent on your size. You can take this dose twice a day, but you should never take it after about 3 pm because of its energizing effects.

You should always take MB with at least 1000 mgs of vitamin C in water in order to avoid its side effects -- Taken just on its own, MB turns your urine green and the whites of your eyes blue because it stains carbohydrates blue. Other than that there are no side effects. I've taken MB with Vit C for 8 years and what you will also find is that it will give you an energy boost and wake you up due to its positive methylation effects on the body.

You should never take MB in the evening otherwise you might have difficulty getting to sleep because it is so energizing. Other than that, I've found MB easy to use and very useful against pathogens.

The dosage that is advised here is relatively small and very safe. In the 1960s they used to give the US troops in Vietnam MB by the spoonful to help recover them from malaria.


Fungal Infections

Posted by Ted (Bangkok, Thailand) on 01/20/2009 392 posts
★★★★★

Editor's Choice

I used methylene blue to kill fungus infections anyway. A fungus damages sensitive organs, in particular, the brain, thymus, adrenal, pancreas, spleen, thyroid, are some of the things I noticed. A fungus is killed by sodium bicarbonate because of its alkalinity, but more effectively so with potassium, magnesium, for example because it kills alkalinity intracellularly as opposed to extracellularly. This is known for ages and the doctor you have mentioned to me was Dr. Simoncini. However, I have went further to look at fungicides besides methylene blue which are more effective, such as azoxystrobin, afloxystrobin and related strobilurins. Those are much more effective at much lower dose. The depth in which baking soda is limited to extracellular fluids, but are limited in bone cancer and bone marrow where baking soda is neutralized before reaching these areas, hence the necessity to use antifungals methylene blue being one of that. The issue is not well explained at other websites WHY fungus causes cancer, but the cause is not fungus in itself, it's the toxins generated by the fungus, such as mycotoxin and aflaxtoxins are the well known cancer causing substance from fungus and perhaps mycobacterium. Hence, the toxicity of mycotoxins and aflatoxins may be reduced with the BHT, but to eliminate them effectively, a potassium should be added along with baking soda. The only issue is baking soda is not so effective because of its limited alkaline buffering capacity if we compared against the carbicarb plus potassium which goes much more deeper. The Carbicarb is a sodium carbonate plus potassium citrate (e.g. technical name is tripotassium citrate). In fact two major sodium that are more effective is the sodium citrate (e.g. trisodium citrate) and potassium citrate (e.g. tripotassium citrate) and sodium carbonate with equal mix of sodium bicarbonate (commonly called carbicarb). However the current carbicarb remedy in practice isn't that perfect and may cause some kidney pain because of sodium potassium imbalance, and hence, a potassium must be added to the carbicarb remedy to resolve this problem and larger dose can be taken.

It must be noted still that I have noted two kinds of cancer, the fast cancer and the slow cancer. The faster cancer are the metastatic cancer, which are viral in character while the slower cancer are the fungal type cancer which tends to cause bone pain and leads to osteoporosis. Still I haven't even cover how you can eliminate the tumors and this is dealt most effectively with a bloodroot tincture.

I hope this explains just a small portion of my approach to dealing with cancer.

Ted