Acetyl-L-Carnitine
★★★★☆
(Manhattan, New York)
02/10/2009
Hi Mike you may try seeking the help of Qingcai Zhang, M.D. He has a long history in treating chronic viral diseases with modern Chinese herbal medicine and is based (I believe) in NYC. http://www.sinomedresearch.org/drz.htm
(Owensboro, Ky)
01/14/2012
★★★★☆
I am not saying anything conclusive yet, but I have been taking Acetyl-l-carnitine for three days. I had numbness, tingling and sometimes burning in my feet. I have been taking 800mg daily. After three day they feel remarkably better. I will post further as time goes on.
Brad, Acetyl-l-Carnitine is very similar molecule to Choline and has remarkably similar action on the body; so you might get the same results by supplementing some kind of Choline product (Soy or Sun Lecithin is a favorite). Either will work, but do not use both as they will only compete against each other.
(Vancouver, British Columbia)
10/04/2017
I too have been taking ALC (750mg/day) together with R+ALA (600mg/day) and have experienced some relief although I believe it's the R+ALA that has helped the most out of the two. My greatest progress so far has been made with B12 so I am obviously deficient in this area. I am now on to Serrapeptase. If you scroll way down you will find where I have started a thread on this relatively new treatment. Good luck to all on your journey toward an effective treatment.
(Vancouver, British Columbia)
10/10/2017
★★★★★
Update: I have been able to cut back on the B vitamins (1,6 and 50 complex) although I still take 2 X B12 5000mcg/day. I have increased the ALA (r+alpha lipoic acid) to 800mg/day as it seems to be helping the most.
I also take N-Acetyl-L-Carnite 1500mg/day and Calcium/Magnesium 2X 133/167mg/day.
This protocol has eliminated 90% of the pain and I believe it is the ALA that is helping the most. Best wishes and good luck to all in their search for relief.
(A)
10/29/2017
I was taking alpha lipoic acid for many years until recently when I read that it depletes vitamin B1 which showed up as very low in my blood test. I am taking Benfotiamine, a form of B1, and discontinued the ALA. As it was, I really never noticed any difference when I was taking it. We all have different types on neuropathy, mine is idiopathic. I am now looking into nightshades.
(Az)
10/30/2017
Hi Rosy,
It was so interesting to read your information regarding ALA and the connection to depletion of Vitamin B.
About 4 months ago, I quite literally woke up with symptoms of Peripheral Neuropathy - numbness, tingling, weakness in feet, lower legs, hands, and forearms. It was particularly alarming to me as my mother had PN so severe that she needed a walker to ambulate.
After reading the info on Earth Clinic (my first go to! ) and some other sites, I did what I always do - which is use the "shotgun approach". I started on B complex, benfotiamine, niacinamide, sunflower lecithin, passion flower, evening primrose oil, and St John's wort. I also increased my B6, B12, and ....ALA. I have experienced such a lessening of symptoms - many days are symptom free, that I am reluctant to change the regimen. However, I will surely research a bit more on the ALA. I do think the benfotiamine has been really beneficial. I initially took a B1, but after more research, was convinced that benfotiamine is a better choice. Thanks for posting!
(Vancouver, British Columbia)
11/07/2017
Hi Soazburrolady, Interesting to read your post. I've used a similar shotgun approach with much success and have achieved a 90% reduction in pain. I take B1-200mg/day, B6-200mg/day, B50-200mg/day, B12-10000mg/day, R+ALA-400mg/day, NAL-Carnite-1500mg/day and last but not least, Serrapeptase-960000SU/day. If you scroll way down you'll see where I've started a thread on Serrapeptase. Youtube has lots of info.on this.
In reply to Gord235 (Vancouver, British Columbia), Did you actually mean, B12-10,000 mg/day? That is a huge dose that would require you to take pills all day long to achieve! Most B-12 supplements are sold in tablets containing MCG (microgram) doses, but even at that, 10,000 mcg is a lot of B-12 per day. The B-12 supplement I take is 2,500 mcg and that is considered a high dose supplement. It would take 4 of these per day just to achieve 10 mg! I get that the B vitamins will pass along quickly, but 10,000 mg per day seems impossible to take. The other B-12 supplement I have is only 1,000 mcg per tab.
Art
(Kelowna)
03/24/2021
You may want to consider taking METHYLCOBLAMINE Vit.B12, sublingually. The type of B12 you take & how it is delivered to your system makes a large difference.
(Beltsville, Md)
07/10/2021
I urge caution when taking methylcobalamin. I have pernicious anemia and receive monthly shots from my doctor. I tried some oral methylcobalamin and it made me feel really awful. I felt anxious, irritable, and had horrible insomnia. Fortunately these side effects only lasted for 24 hours. I'll never take methyl anything again.
(Lyons, Colorado)
07/21/2023
For those who, like myself, have the MTHFR genetic mutation, certain substances meet to be methylated. For me, B-12 is one of them, and so is folate. It would be wise for people to see what their genetic status is. One could be wasting money on supplements that do them no good. I now use methylcobalamin and methyl folate.
(Vancouver, British Columbia)
12/14/2017
(Vancouver, British Columbia)
01/01/2018
★★★★★
Update:
Since my last post I have learned that taking antibiotics can lower B12 levels and that a B12 insufficiency can be the cause of peripheral neuropathy in up to 7% of cases. I had surgery recently and was on antibiotics for two weeks. This may account for the dramatic improvement I experienced once I started taking a B12 supplement.
As a result of this new information I have returned to my regimen of taking B1- 2X100mg/daily, B6 - 2X100mg/daily, B12 - 2X5000mcg/daily as well as ALA - 4X200mg/daily and Serrapeptase - 10X120,000SU/daily. Although not completely rid of symptoms the frequency and intensity of pain has been reduced by 90%. I anticipate that I will eventually be able to reduce the number of things I am taking but feel certain that the B12 will be the last thing to go as it has been the only thing to give me overnight relief. I wish everyone well on their search for a cure.
(Vancouver, British Columbia)
04/10/2018
Update: Since my last post, I have stopped taking Serrapeptase as it didn't seem to be making a difference. I have now switched to CBD (cannibis oil) which which is reducing the pain level in my foot as well as eliminating the Edema swelling in my leg. I plan to continue taking Vitamin B12 (1,000 mcg/day)as it was the first thing to give me relief in the beginning. I have stopped taking Alpha-Lipoic Acid as it didn't seem that effective.
Not all supplements are created equally. Make sure you buy third-party tested and USP verified. Check ingredients too. Lots are full of fillers/binders.
(Vancouver, British Columbia)
04/23/2018
Update: I made a mistake and bought ALA without the R+ and the pain in my foot returned so I have gone back to my original protocol of R+ALA plus B1, B6 and B12 vitamins. I had also cut back on the B vitamins so this might have been a contributing factor to the return of the pain. I noticed that as soon as I started back on the R+ALA and B vitamins the pain in my foot went from a 9 out of 10 to a 5 out of 10. Lesson learned - once you find something that works don't stop taking it.
Alpha-Lipoic Acid
| 5 star (4) | 80% | |
 (1) |
20% |
Kildonon,
The following may be of interest to you :
https://www.earthclinic.com/cures/five-supplements-for-peripheral-neuropathy.html
As a substitute for alpha lipoic acid, you might consider benfotiamine and or berberine. All have studies to support their use for PN.
Art
Alpha-Lipoic Acid
★★★★★
(Vancouver, British Columbia)
10/04/2017
Stephanie: Thank you for your post. The fact that ALA is being prescribed as a treatment and is covered by health insurance in Germany is very useful information to have.
I have been taking R+ALA (600mg/day) and it's working.
(Vancouver, British Columbia)
12/14/2017
Update: I have now increased the ALA to 800mg/day.
Alpha-Lipoic Acid
★★★★★
(Ten Mile, Tn)
04/25/2016
PERIPHERAL NEUROPATHY :
HI U GOOD FOLKS DOIN,,,,,,,, life is interesting these days and old age is at the heart of it all. Today, I got an IV using Alpha Lipoic Acid to help in my leg nerve problems. My doctor recommended one for 4 weeks and see where we are.
We had quite a diverse group in the room today. All had been down the Allopathic Medical route and that was a dead end, so they chose to pay their own way and possibly live to see another year. One 84 year old was consumed with a fungus, another was a mechanic that washed too many greasy auto parts in lead gasoline. One had gotten the mucus from his wife via their grandkids...... he was doing a Hydrogen Peroxide IV and was coming back tomorrow.
My best buddy is doing EDTA Chelation after I had begged him to do this for 5 years. Think his heart scared his mule. These folks use their insurance until they see a dead end and then they start to pay their own way to stay alive.
That is the way it is with most folks on EC. They obey their MD until they begin to see the Grim Reaper out the side of their eye and then they begin to research and find all the helpful folks on EC. Amazin how that works.
========ORH======
(Europe)
02/27/2013
Alpha-Lipoic Acid
★★★★★
Alpha-Lipoic Acid
★★★★★
B-12 Injections
★★★★★
I fell over 2 1/2 years ago and broke my back herniated some discs, and twisted my leg in the fall. I reached out to Earth Clinic immediately for help and too many to name came to my aid with wonderful advice.
Thank you! Neuropathy pain began to develop my back, bottom, hip, leg, and foot. It was soon diagnosed as RSD commonly called Suicide Disease. I have researched for almost 3 years for a way to alleviate this unbearable pain and other symptoms associated with it. I couldn't complete any tasks and am using a cane.
Over 6 weeks ago, I found a blog about transdermal neuralgia and it sounded similar to my condition but located in the face.
A lady said that she began B12 injections 2 times a week and went into remission after 8 months. I called my doctor right away and he approved the treatment but told me not to try anything new while I am getting the injections. At first, I thought we chose the wrong treatment because I was exhausted and couldn't stay awake. After about 1 month that went away, and now my energy is out of the world and I have stamina. I have accomplished so many tasks in the last few weeks.
But the best part is my mood. I am laughing all of the time. My husband is so happy. He has his wife back.
I did not realize that I was depressed, but I guess I was. Even the cashier at the local grocery store noticed the changes. I am still in excruciating pain with storms and barometric pressure changes. But the overall pain has reduced. Hopefully, with continued use that will improve as well as the other symptoms have.
Thank you for letting me share. I pray someone reads this and will receive benefit as well. God bless.
B-6
I've been told by a neurologist that B-6 is good for your nerves and by another Dr. that is very bad for your nerves. Anybody have a final answer-please?
(Springfield Missouri)
12/13/2022
Have you ever or anyone reading this ever tried serrapeptase for neuropathy? It's a supplement. You can get it on Amazon. I read it's supposed to heal damaged nerves. So I'm wondering if it will heal neuropathy nerves in the feet and legs caused by diabetic peripheral neuropathy. I'm thinking about buying some for my fiance as he has severe and very painful neuropathy. He says it feels like someone is trying to put a fistful of lit cigars on his feet, and it gets to be so painful that he often cries from the pain because there is nothing he can do to stop the crazy burning and he says on a pain scale from 1 to 10 his pain is at a 9 or 10 and sometimes a 12 which is off the scale. There's also a neuropathy cream made by a company called Nuturna and you can find the company if you just Google Nuturna. My fiance gets a little relief from it, but maybe someone that doesn't have neuropathy as bad as he does could get more relief from it. Maybe these things will help someone out there who has neuropathy. Good luck and best wishes for healing health to all.
(CA)
12/28/2023
(CA)
12/30/2023
Grounding helps my leg and hip pain, I use mat and grounding bed sheets I use it for my insomnia and it's very effective, sleep well thru the night. I noticed leg pain that's been bothering me for 4 years gone!
Benfotiamine, ALA and RLA
★★★★★
BTW, I once used r-lipoic acid to cure my loss of taste (taste only, not smell) from taking an anti-fungal rx (never again). EENT specialist gave me prednisone which helped nothing but gave me road rage and fluid retention. Google led me to ALA and RLA studies. Cured in days. EENT doctor refused to even look at the published research articles. It was a pleasure to tell him "Your services are no longer required."
Borax
I have 20 mule team Borax setting in my laundry room & have been reading for hours the pros and cons of this. Does anyone have any idea if this would help my feet. I want to take back control of my health as I don't feel the Dr. Is doing anything other than giving me a drug that treats the symptoms but does not heal. Thank you.
(White Rock, Bc, Canada)
03/08/2012
★★★★★
Hello Paula, I've used the Borax remedy as a last ditch attempt to cure my aching hands, arches and metatarsalalgia.. It made a noticeable difference within 10 days and I am pain free after 2 months. Your neuropathy and foot problem sounds like a vitamin 12 deficiency I had. I had numb hands as well.. The B12 twice a day helped in literally days to relieve symproms. I had 6 of the 7 symproms listed.
(Bucyrus, Mo)
03/12/2012
Hello Rosemary, I started the Borax today... Noticed no taste while drinking mixed in 1/8th teaspoon in 1 liter of water. No aftertaste. Toughest part was getting a liter of water down over the course of the morning/early afternoon. I know I should drink more water, so if nothing else happens, at least I know it's good for me.
I have been tested for B-12 deficiency, it was negative.. I do take a B-complex. I was low in D-3 but that has been taken care of.
I just hate this neurontin I am on... It just covers up the pain somewhat, does nothing to heal. I feel it has grown worse over time and now that I have cut down to just 1 tablet (300mg) the pain is not only in feet but calves are numb & it is getting harder to walk.
Thank you for your reply. Will be following this thread. Welcome anyone's sugesstions.. it not only hurts, it makes me extremely nervous...
(Beltsville, Md)
07/10/2021
If your B12 level was tested while you were taking a B12 supplement your blood test results will be inaccurate. Your body could still be B12 deficient because it is unable to properly process the oral B12. I have this problem and I receive monthly B12 shots.
(Bucyrus, Mo)
03/19/2012
Day 7 of the Borax and water: Drinking the 1 liter a day faithfully but DR. changed my meds from neurontin to Lyrica 2x daily, so can't really say if this drug is actually helping the neuropathy in my feet or it's the Borax or combo of both. Open to any comments, other remedies as feet are numb, burning etc. But at least I have not had the shooting pains through feet and toes in the last few days. Question: How long should I continue the Borax? Taking 1/8th tsp. In 1 liter water per day. Woman, weigh 125. Thank you.
(Fredericksburg, Virginia)
01/18/2013
Paula, the burning sounds like b12 deficiency.... and your numbers could be low and your dr just not being proactive.
(Good Ole Usa)
07/05/2013
Paula,Dr. David Brownstein writes a book Vitamin B12 for Health. He put all of his patients on B12 supplements even if their blood tests revealed within normal ranges. He found in all his years in the practice that the levels that they state may not be the levels our bodies really need. All in all, all of his patients showed remarkable improvements.
Dr. David Brownstein has not taken on new patients in well over 4 years or more. I called to get in there and asked if his partners would accept me. They too are overwhelmed with patients. The receptionist gave me the name of a website that will direct you to doctors that will test your levels and get you back onto the right path. They test for hormones, digestive issues, and vitamin and mineral absorption levels. The bottom line to any health issue is... are you absorbing your nutrients and do you have inflammation going on in your body.
View this webpage --- acam.org for finding a doctor like Dr. David Brownstein recommends. I am forever grateful I found this book and this webpage. I have already went for my first appointment and am awaiting my test results to get my health back onto the right track. Currently my feet are showing signs of neuropathy... And it is so painful!!!!! Blessings to all of you who try to find the cure... and who wish to use natural stuff.
(Kelowna, Bc)
06/07/2017
Vitamin B 12 is best absorbed into the body by injection or sublingually, regular B12 pills are not easy for the body to assimilate. My advice is B12 AND MAGNESIUM . Magnesium in powder form dissolved in water is good . Magnesium is best absorbed through our skin, so add a gel magnesium rubbed on your feet . This has been most helpful to me. The neurologist told me about magnesium. I hope this helps you.
(Usa)
06/08/2017
(Mexico)
07/10/2021
Use better methylcobalamine sublingual😀
Cayenne
★★★★★
Check Vitamin B6 Toxicity
★★★★★
Vitamin B6 toxicity can occur from long-term, high-dose supplementation, not usually from food sources alone.Symptoms include peripheral neuropathy (numbness, tingling, pain in hands and feet), ataxia (loss of balance), and muscle weakness.
MTHFR polymorphisms ( which I have) can potentially affect how the body uses vitamin B6, possibly leading to both deficiency and, in some cases, an increased risk of toxicity. Specifically, individuals with MTHFR polymorphisms may experience disruptions in the conversion of pyridoxine (B6) to its active form, PLP. This can lead to apparent high levels of B6 in the blood, even with a true cellular deficiency, or make it harder for the body to properly utilize the vitamin.
So before trying to treat your peripheral neuropathy check your vitamin B6.
Hi Elena,
Vitamin B6 can be a double edged sword as too much or too little can cause peripheral neuropathy.
P5P, the active form of pyridoxine, avoids some of the toxicity of vitamin B6.
Art
(Osaka)
05/06/2025
Because B6 toxicity is a very serious issue, One has to test B6 levels first. Take no B supplements 2-3 days before the test. If it is high while other B vitamins are normal, then one must know if they have MTHFR polymorphism. Then one has to repeat the test after switching to P-5-P to make sure it is metabolizing properly.
It might take up to 6mo for a body to reduce B6 levels in blood.
(WA)
05/07/2025
European Food Safety Administration's newly established Tolerable Upper Intake Level of 12 mg/day. For men over 50 it is 1.7mg/day
B6 toxicity is classically presented with peripheral neuropathy. The less commonly reported symptoms include ataxia, muscle weakness, disequilibrium, and dermatosis.
Products such as energy drinks, breakfast cereals and weight loss shakes can have up to 40 mg of vitamin B6,2300% RDA.
Coconut Oil
★★★★☆
Coconut Oil and Chinese Herbs
★★★★★
Dietary Changes
Hi Maggie,
It may, if your peripheral neuropathy (PN) is caused by nerve damage related to high glucose levels. This is typically seen in diabetics who have chronically high blood glucose levels that can damage the nerves among other things.
If your PN is caused by something else such as chemotherapy as a basic example, then stopping sugar may not resolve the problem.
Art
