Top Natural Remedies for Peripheral Neuropathy: Dosages & Benefits

| Modified on May 08, 2024
Macademia Nut Oil
Posted by Tom (Currently Yuma, Az) on 12/27/2020

In 2011, I got rid of numbness and tingling in my toes by taking two tablespoons of NOW brand unrefined macadamia oil after meals. This was twice per day. In two months and one 16 oz bottle later, my toe numbness disappeared and my fungal great toenail also lifted off and a new, healthy toenail grew in over the next year.

NOW brand discontinued the macadamia oil, but PipingRock has excellent oils, including macadamia oil. Macadamia oil has the highest percentage of the antimicrobial, palmitoleic acid, at 18%, which I now believe is antifungal as well.


That dosage for macadamia nut oil was just one measuring tablespoon after meals, up to twice per day.

That way, one 16 oz bottle would last about 32 days since there are 2 tablespoons to a fluid ounce.

However, just a half measuring tablespoon after meals might be enough, though, for the first two months. A half tbsp ended up being my maintenance dose for years, at once per day.

Assuming 13.3 grams per tablespoon of oil, 18% of that is 2.39 grams or almost 2400 mg of palmitoleic acid per measuring tablespoon.

At the time, I was using a flatware tablespoon that holds half of a measuring tablespoon, and I would take two of them after meals for the first two months. I no longer take macadamia oil, but the numbness in fingers and toes has never returned, nor has any fungal toenail.

Alpha-Lipoic Acid
Posted by Robert Henry (Ten Mile, Tn) on 04/25/2016


HI U GOOD FOLKS DOIN,,,,,,,, life is interesting these days and old age is at the heart of it all. Today, I got an IV using Alpha Lipoic Acid to help in my leg nerve problems. My doctor recommended one for 4 weeks and see where we are.

We had quite a diverse group in the room today. All had been down the Allopathic Medical route and that was a dead end, so they chose to pay their own way and possibly live to see another year. One 84 year old was consumed with a fungus, another was a mechanic that washed too many greasy auto parts in lead gasoline. One had gotten the mucus from his wife via their grandkids...... he was doing a Hydrogen Peroxide IV and was coming back tomorrow.

My best buddy is doing EDTA Chelation after I had begged him to do this for 5 years. Think his heart scared his mule. These folks use their insurance until they see a dead end and then they start to pay their own way to stay alive.

That is the way it is with most folks on EC. They obey their MD until they begin to see the Grim Reaper out the side of their eye and then they begin to research and find all the helpful folks on EC. Amazin how that works.


Posted by Gord235 (Vancouver, British Columbia) on 01/01/2018


Since my last post I have learned that taking antibiotics can lower B12 levels and that a B12 insufficiency can be the cause of peripheral neuropathy in up to 7% of cases. I had surgery recently and was on antibiotics for two weeks. This may account for the dramatic improvement I experienced once I started taking a B12 supplement.

As a result of this new information I have returned to my regimen of taking B1- 2X100mg/daily, B6 - 2X100mg/daily, B12 - 2X5000mcg/daily as well as ALA - 4X200mg/daily and Serrapeptase - 10X120,000SU/daily. Although not completely rid of symptoms the frequency and intensity of pain has been reduced by 90%. I anticipate that I will eventually be able to reduce the number of things I am taking but feel certain that the B12 will be the last thing to go as it has been the only thing to give me overnight relief. I wish everyone well on their search for a cure.

B-12 Injections
Posted by epeach (United States) on 05/07/2020

Use of B12 for Peripheral Neuropathy (not from Diabetes)

I fell over 2 1/2 years ago and broke my back herniated some discs, and twisted my leg in the fall. I reached out to Earth Clinic immediately for help and too many to name came to my aid with wonderful advice.

Thank you! Neuropathy pain began to develop my back, bottom, hip, leg, and foot. It was soon diagnosed as RSD commonly called Suicide Disease. I have researched for almost 3 years for a way to alleviate this unbearable pain and other symptoms associated with it. I couldn't complete any tasks and am using a cane.

Over 6 weeks ago, I found a blog about transdermal neuralgia and it sounded similar to my condition but located in the face.

A lady said that she began B12 injections 2 times a week and went into remission after 8 months. I called my doctor right away and he approved the treatment but told me not to try anything new while I am getting the injections. At first, I thought we chose the wrong treatment because I was exhausted and couldn't stay awake. After about 1 month that went away, and now my energy is out of the world and I have stamina. I have accomplished so many tasks in the last few weeks.

But the best part is my mood. I am laughing all of the time. My husband is so happy. He has his wife back.

I did not realize that I was depressed, but I guess I was. Even the cashier at the local grocery store noticed the changes. I am still in excruciating pain with storms and barometric pressure changes. But the overall pain has reduced. Hopefully, with continued use that will improve as well as the other symptoms have.

Thank you for letting me share. I pray someone reads this and will receive benefit as well. God bless.

Posted by Art (California) on 09/15/2022 2158 posts

Peripheral Neuropathy And Melatonin Repair Of The Actual Nerves

The following two studies show that Melatonin can be helpful in the fight against Peripheral Neuropathy (PN). I am adding this post because Melatonin is not currently on the EC list for PN supplements, but it clearly belongs there.

In this first study / Randomized Controlled Trial (RCT) it is shown that melatonin provides benefits against PN even at the low dose of 6 mg / day :

Here is a relevant quote from the RCT :

' At the study endpoint, treatment with melatonin resulted in a considerably higher reduction in the mean NRS pain score in comparison with placebo (4.2 ± 1.83 vs. 2.9 ± 1.56; P-value < 0.001). In terms of treatment responders, a greater proportion of melatonin-treated patients satisfied the responder criterion than placebo-treated patients (63.5% vs. 43.1%). Melatonin also reduced pain-related sleep interference scores more than did placebo (3.38 ± 1.49 vs. 2.25 ± 1.26; P-value < 0.001). Further, at the endpoint, more improvement was also seen in terms of PGIC, CGIC, and Health-related QOL in patients treated with melatonin than placebo. Melatonin was also well tolerated. '

In this next study, melatonin is shown to actually repair peripheral nerves :

Here is a relevant quote from the study :

' Collectively, these findings indicate that melatonin upregulates Parkin-mediated mitophagy and promotes peripheral nerve repair. The results provide a basis for the development of effective drugs for PNI treatment. '

Admittedly, a 6 mg/day dose is rather modest considering they are trying to treat PN in the first study. Considering the results obtained in the study, future studies should use higher dosing to answer the question of whether more melatonin will have an even greater and faster effect, as shown in other studies not involving PN. In any case, working toward actual repair of peripheral nerves as opposed to trying to kill the pain, burning, tingling and numbness seems much more important IMO.


Posted by Gord235 (Vancouver, British Columbia) on 10/16/2017


I am now up to 960,000SU(8 capsules)per day of Serrapeptase after reading that 1,000,000 SU per day is not uncommon. I am also taking ALA 800mg (8 capsules) per day and continue to see improvement with the pain in my foot steadily decreasing in intensity and frequency. Take note that Serrapeptase needs to be taken away from food, either 1/2 hr. before eating or 2hr. after eating. Search Serrapeptase on Youtube for more information. Good luck to all.

Benfotiamine, ALA and RLA
Posted by Rick (Chicago) on 06/12/2016

Benfotiamine helped, but did not cure my Peripheral Neuropathy, which was due to knee replacement surgery where the nerves are traumatized. PN was bad after surgery and slowly improved (I took a large vitamin stack). After ~12 months learned about benfotiamine and tried it. A little better. Then I called the company and the founder (a scientist) answered and explained how sometimes large doses were necessary at least to start with, and that toxicity was almost impossible. 1800mg a day helped - to an extent, then leveled off. I now take Drs. Best Benfotiamine 300 1x and alpha lipoic acid 300 + benfotiamine 150 8x. My neurologist approves of these supplements.

BTW, I once used r-lipoic acid to cure my loss of taste (taste only, not smell) from taking an anti-fungal rx (never again). EENT specialist gave me prednisone which helped nothing but gave me road rage and fluid retention. Google led me to ALA and RLA studies. Cured in days. EENT doctor refused to even look at the published research articles. It was a pleasure to tell him "Your services are no longer required."

Posted by Gord235 (Vancouver, British Columbia) on 10/10/2017

Update: I have been able to cut back on the B vitamins (1,6 and 50 complex) although I still take 2 X B12 5000mcg/day. I have increased the ALA (r+alpha lipoic acid) to 800mg/day as it seems to be helping the most.

I also take N-Acetyl-L-Carnite 1500mg/day and Calcium/Magnesium 2X 133/167mg/day.

This protocol has eliminated 90% of the pain and I believe it is the ALA that is helping the most. Best wishes and good luck to all in their search for relief.

Posted by Soazburrolady (Az) on 10/30/2017

Hi Rosy,

It was so interesting to read your information regarding ALA and the connection to depletion of Vitamin B.

About 4 months ago, I quite literally woke up with symptoms of Peripheral Neuropathy - numbness, tingling, weakness in feet, lower legs, hands, and forearms. It was particularly alarming to me as my mother had PN so severe that she needed a walker to ambulate.

After reading the info on Earth Clinic (my first go to! ) and some other sites, I did what I always do - which is use the "shotgun approach". I started on B complex, benfotiamine, niacinamide, sunflower lecithin, passion flower, evening primrose oil, and St John's wort. I also increased my B6, B12, and ....ALA. I have experienced such a lessening of symptoms - many days are symptom free, that I am reluctant to change the regimen. However, I will surely research a bit more on the ALA. I do think the benfotiamine has been really beneficial. I initially took a B1, but after more research, was convinced that benfotiamine is a better choice. Thanks for posting!

Dietary Changes
Posted by Lynn Greene (Penticton, BC, CAN) on 12/20/2022

What happens when I eat no wheat or wheat related grains, no sugar and no milk.

Changed my diet because of pain in feet, with a constant battle against Shingles. Taking antivirals too much. No sugar, no wheat products (and of course no gluten) and no milk. Buttermilk and cream, butter, homemade ghee are fine. Results: In one month my husband and I lost our huge bellies. Still some pain in feet, but way less. Increase in energy, less body pain, Shingles seem to be gone. We still have buttermilk and 0 sugar ice cream, buckwheat and other non-wheat related foods.

The Wheatbelly cookbook is very helpful. I can't wait to see what happens next in our changes. My husband's allergies and Parkinson are improving, too.

Milk is high in lactose (just plain sugar). No itchy skin, either.

Physical Therapy Exercise
Posted by Gord235 (Vancouver, British Columbia) on 12/18/2017

I have been using a simple exercise I learned on Youtube to give myself temporary relief from foot pain caused by Peripheral Neuropathy. Simply pump the front of the foot up and down 30 times and repeat this exercise three times a day or as required. This forces the circulation to increase in your leg and foot and will give quick relief from pain. It also works while pumping the heel up and down although pumping the the toes and front part of the foot is more effective.

Alpha-Lipoic Acid
Posted by Art (California) on 06/08/2023 2158 posts


The following may be of interest to you :

As a substitute for alpha lipoic acid, you might consider benfotiamine and or berberine. All have studies to support their use for PN.


Posted by Art (California) on 10/08/2022 2158 posts


In the study, they used 6 mg of oral melatonin, they didn't apply it topically. Taken orally the melatonin goes systemic fairly quickly and is able to move into tissues throughout the body quickly. Topical application of melatonin moves at a slower pace as it traverses through the dermal layers and then into the system. Generally melatonin is taken at night before bedtime. The time can vary depending on how you react to melatonin. If it seems to cause next day sleepiness, some people have opted to take it earlier in the evening to try and reduce this effect.

Topical melatonin delivery is not required based on the study, but I imagine you can try that, but definitely not in the morning or early afternoon. I believe Zeptil comes in two different concentrations of melatonin and one is significantly at a higher concentration than the other so you will have to take that into consideration if you use it. Oral melatonin is less expensive.

On a related note, you may also be interested in this if melatonin still makes you feel to sleepy during the day or in addition to melatonin for better effect :

Sunil T. Pai MD, in Integrative Medicine (Fourth Edition), 2018

Benfotiamine: Vitamin B1

Benfotiamine, also known as S-benzoylthiamine-O-monophosphate, is a lipid-soluble derivative of vitamin B1 (thiamine) and is absorbed up to 3.6 times more than water-soluble forms. Vitamin B1 is associated with a 120-fold greater increase in the levels of metabolically active thiamine diphosphate. Its lipid solubility allows it to penetrate the nerves more readily. It has been found to provide a higher bioavailability of thiamine than its water-soluble counterparts.292-294 Benfotiamine reduces advanced glycation end-products (AGE) by 40%, which has been shown to prevent macro- and microvascular endothelial dysfunction in individuals with type 2 diabetes.295-300

Studies have shown that benfotiamine improves neuropathy scores significantly, 301, 302 increases nerve conduction velocity, 303-305 and reduces HbA1c and pain.306 On the Russian market, it is one of the most studied drugs for neuropathic pain.306 In addition, it lowers inflammation and may be useful for ameliorating the analgesic effect of mu-opioid agonists on neuropathic pain.307-309 In a randomized, placebo-controlled, double-blind pilot study and phase III clinical study, investigators demonstrated a pronounced effect on the decrease in pain310, 311 in conjunction with the previously described benefits. Benfotiamine may also be beneficial in preventing diabetic nephropathy312 and retinopathy.313 Therapeutic benefits can be seen as early as 3 weeks, with the most significant improvements occurring in patients taking the highest-dose of benfotiamine, that is, 600 mg/day at 6 weeks.310, 311, 314


The recommended dose of benfotiamine is 150–300 mg twice daily specifically for diabetic peripheral neuropathy.


Posted by Bonnie (Ravenna, Ohio) on 09/03/2014

I had such painful cramps in my feet and legs it would wake me up at night-I remembered I had magnesium oil and the gel--put some on the bottom and top of my feet and on my legs. Also started taking Boswellia/Turmeric combo and Magnesium Malate-drank a small glass of water with 1/2 tsp. baking soda---have no more cramps--my feet are warmer, less pain when I walk too. Now gave my old dog boswellia/turmeric---she's going up and down stairs with no problem. Hope this helps. Bonnie

Posted by Renee (Atlanta, Ga) on 09/10/2023

I am a bodyworker and I specialize in pain relief. I recommend Magnesium Glycinate for pain relief, insomnia and irregular heartbeat, leg cramps, etc. I am not a doctor but after 35 years, I have been thanked over and over again by people who got relief without diarrhea. 80-90% of people are chronically low on magnesium. It is called the “master mineral” because it affects so many areas of the body - your muscles, your brain, the heart and nervous system.

Evening Primrose Oil
Posted by Bob (Rosedale, Md) on 05/07/2016


I too suffer from nerve issues in my feet. Hurts like hell at night, the rest of the time it is numb and feels like electric flowing around my feet. Calcium and magnesium helped me. The pain and numbness is there but manageable. Reflexology every other week really helps to as well as a good deep tissue massage once a month or so.

Take care,

Bob R

Posted by Michelle (Austin, Tx) on 04/08/2011

I have had peripheral neuropathy for years. I have discovered several things along my journey. The absolute best supplement (but not a cure) for me has been transdermal magnesium oil or gel. One of the symptoms of magnesium deficiency is numbness/tingling. The reason to use the magnesium transdermally is that you can get more absorbed directly into your system without the possible side effect of diarrhea which can occur with oral dosages. I have tried many brands, but Ancient Minerals is hands-down, the best. It is made from condensed sea water. Since it can sting a little if you have sensitive skin, I just rub it on my feet twice a day and then put on socks. You should not use the magnesium if you have kidney problems or low blood pressure. If you do end up trying this, you may want to give it several weeks to a month before determining if it is helping you. Supposedly once magnesium is depleted, it is notoriously difficult to replete.

I have also discovered, that the main reason that I am so magnesium deficient is because my body is too acidic. Most people (myself included) consume a Western diet that consists of a of processed foods, meat, dairy, etc. , all of which are acidic. In the body's attempt to neutralize the acidity of the blood, it takes copius amounts of calcium, magnesium and potassium from different places in the body (bones, etc) and uses them to buffer the blood (make it more alkaline). If your problems persist, you may want to try an alkaline diet. You can also drink water with 1/2 tsp of baking soda dissolved in it (on an empty stomach, at least 30 minutes prior to eating), as this greatly helps to alkalinize your body. Hope some of these suggestions help. I know how miserable it can be to experience these symptoms!

Posted by Brad (Owensboro, Ky) on 01/14/2012

I am not saying anything conclusive yet, but I have been taking Acetyl-l-carnitine for three days. I had numbness, tingling and sometimes burning in my feet. I have been taking 800mg daily. After three day they feel remarkably better. I will post further as time goes on.

Posted by Art (California ) on 11/08/2017 2158 posts

In reply to Gord235 (Vancouver, British Columbia), Did you actually mean, B12-10,000 mg/day? That is a huge dose that would require you to take pills all day long to achieve! Most B-12 supplements are sold in tablets containing MCG (microgram) doses, but even at that, 10,000 mcg is a lot of B-12 per day. The B-12 supplement I take is 2,500 mcg and that is considered a high dose supplement. It would take 4 of these per day just to achieve 10 mg! I get that the B vitamins will pass along quickly, but 10,000 mg per day seems impossible to take. The other B-12 supplement I have is only 1,000 mcg per tab.


Posted by Lily (Kelowna) on 03/24/2021

You may want to consider taking METHYLCOBLAMINE Vit.B12, sublingually. The type of B12 you take & how it is delivered to your system makes a large difference.

Posted by Gord235 (Vancouver, British Columbia) on 04/23/2018

Update: I made a mistake and bought ALA without the R+ and the pain in my foot returned so I have gone back to my original protocol of R+ALA plus B1, B6 and B12 vitamins. I had also cut back on the B vitamins so this might have been a contributing factor to the return of the pain. I noticed that as soon as I started back on the R+ALA and B vitamins the pain in my foot went from a 9 out of 10 to a 5 out of 10. Lesson learned - once you find something that works don't stop taking it.

Macadamia Nut Oil
Posted by Tom (Livingston, Tx) on 12/21/2022 64 posts

macadamia oil internally for suspected peripheral neuropathy or toenail fungus

Probably 10 years ago, what got rid of numbness and tingling (I assume peripheral neuropathy, PN) in my toes was taking unrefined or virgin macadamia oil.

It took about 2 months and one 16 oz bottle at 1 or 2 measuring tablespoons per day after a meal. Interestingly, my fungal great toenail dropped off or lifted off of the nail bed at the same time the numbness and tingling stopped in my toes. Then the toenail grew in healthy over the next year.

It was the NOW brand 16 oz unrefined macadamia oil, but NOW discontinued the product at the time.

So I now take PipingRock's 16 oz virgin macadamia oil or the Carlyle 16 oz virgin 3 bottle pack through Amazon.

However, the fungal toenail came back recently, so I have restarted taking the macadamia oil internally with good results. I take a flatware tablespoon of the oil, which is about a half measuring tablespoon, every 6 hours or 4 times per day. So that is about 2 measuring tablespoons per day, which is 1 oz per day. So I take it (plus or minus 2 hours) at 6 AM, 12 PM, 6 PM and 12 AM.

Macadamia oil is the highest food source for palmitoleic acid, at about 18%. Palmitoleic acid is antimicrobial, so that is what I think extinguished my fungal toenail and PN.

The macadamia oil internally also works wonders for some jaw-related pain that I have.

Next I may order a gallon of virgin macadamia oil from in Chicago. That would be 16 pints which, if ordering a gallon, would save about 2/3 of the cost if ordering 16 separate pints.

Or The Sulu on Etsy:

Posted by Old Fart (Winamac, IN) on 09/21/2022

Regarding DMSO, I have used it both internally and externally for years with what I feel are very good results. I take 1 tsp of the 99.9% pure liquid every morning along with cider vinegar and H2O2 in a glass of water. Since I've been doing this, I can get out of bed in the morning, stand up straight and walk like a normal person. I also use DMSO / aloe vera gel for aches and pains from arthritis. I am 75 and have peripheral neuropathy due to agent orange in Vietnam, and DMSO gel is also a big pain reliever for my achy feet and hands.

You can buy both products on Amazon, but I found the pure liquid is cheaper at " Pet Meds". The gel is 70% DMSO and 30% aloe. From all I've read, and that's quite a lot, it is more effective at the 70 / 30 ratio when applied toppically.

If you want to learn more about DMSO, there is a good but short book available online from "HOOPLA". I don't remember the authors name, but the book is, "What Doctors Need to Know about DMSO."

At present time, I am also using it topically to treat my 'shingles', and it is working unbelievably well. I simply apply the gel several times a day. It has stopped the spread and kept the rash to limited space, as well as reducing pain.

Multiple Remedies
Posted by Bandi (Oakland, Ca) on 12/20/2017

I had neuropathy in my feet for at least 15 years. From what I read, I am controlling it better than most. While I have the usual symptoms (tingling, pins, sensitivity, numbness, burning, some cramps etc etc) I can walk, jog and sleep well at night. All that I list below I used for at least 6 months and are effective for me.

Cure? No :-(

But I am working on it :-)

Gabapentin 300 mg 1x/day. If I forget to take it before going to bed, while usually not excessive, the symptoms keep waking me up.

While during the day I often don't notice the symptoms, around 5 pm they start getting bothersome. At that time I rub some Chinese liniment called Zheng Gu Shui (avalable on ebay) on the ball and sole of my feet. It increases blood flow and the result its less sensitivity. It contains camphora among other ingredients, so wash your hands afterwords or your eyes may water :-)

Before going to bed, I use another Chinese liniment, called Shaolin I-Ching Ling. I used to get bruised while practicing Tae Kwon Do karate and had some remnant in a bottle. Sure enough, it calmed my nerves. Available on the Internet, just search on I-Ching Ling. I now make my own. Takes about 3 months but it is worth it. When my shoulder, knee, finger etc ache or I pulled a tendon or my muscles ache, a small application usually helps within minutes.

Somewhat less effective, but still useful for neuropathy pains is a gel called Diclac. I bought them in Hungary but seen it on Internet. That one was made in Germany.

All of the above are effective shortly after application.

Since I am using several remedies simultaneously, I can not prove the effectiveness of the following 2 remedies. But they seem to slow the progress of neuropathy.

Twice a day I take 150 mg Benfotiamine. Read Appearently it has been used in Europe for a long time.

Twice a day I take 1300 mg Borage (for LA, GLA OA) + 300 mg timed release Alha Lipoic Acid + 500 mg Vitamin C

Read and do search on GLA

I know it may be boring BUT it is worth reading:

Ok the above is what I practice right now in December of 2017

So what else is there?

TENS unit helps. I used to attach it to my feet while working at the computer. Check the Internet. Not too expensive. I had it handy since I originally used it for my lower back pain.Successfully I might add.

I have a toilet brush :-) With it I keep hitting the sole of my feet for a couple of minutes at night to increase blood flow. Yes it helps.

Capsaicin in any form (liquid or cream) works but the skin gets sensitized after a while so I dropped it.

Physical theraphy felt good but helped none. Acupuncture did not do much good either. But the Chinese massage I received after the treatment was worth going for :-)

I am looking into MSM, stem cells but do not hold out much hope for either right now. And please, believe in valid research not wishful thinking cloaked in scientific sounding mambo-jumbo!

Well, have a Merry Christmas and no pain!

Alpha-Lipoic Acid
Posted by Gord235 (Vancouver, British Columbia) on 10/04/2017

Stephanie: Thank you for your post. The fact that ALA is being prescribed as a treatment and is covered by health insurance in Germany is very useful information to have.

I have been taking R+ALA (600mg/day) and it's working.

Posted by Gord235 (Vancouver, British Columbia) on 10/04/2017

I too have been taking ALC (750mg/day) together with R+ALA (600mg/day) and have experienced some relief although I believe it's the R+ALA that has helped the most out of the two. My greatest progress so far has been made with B12 so I am obviously deficient in this area. I am now on to Serrapeptase. If you scroll way down you will find where I have started a thread on this relatively new treatment. Good luck to all on your journey toward an effective treatment.

Peripheral Neuropathy Supplements
Posted by Art (California) on 12/21/2022 2158 posts


Unfortunately, Benfotiamine, Melatonin and ALA do not come with the B vitamins in them except you can find melatonin with B6 in it, but it is the wrong form of B6. You need the form of B6 called P5P.

You can find a vitamin B multi that will have B1, B6 and B12, but these do not have the more desirable form of B1 which is called Benfotiamine, they generally contain vitamin B1 in the hydrochloride form.


Multiple Supplements
Posted by Gord235 (Vancouver, British Columbia) on 09/07/2017

Hi Everyone. I'm new to this community and also new to posting online so I'll be brief and to the point. First; thank you to all who have contributed to this site. Peripheral Neuropathy can quite daunting.

Next; after considering several options I settled on the following protocol: B12 5,000 mcg/day, Acetyl-L-Carnitine 750mg/day, R+Alpha Lipoic Acid 100 mg/day, Calcium Magnesium D3 333/167 mg/day 2:1 Ratio, Enhanced Absorption. This combination worked fast and very well for me, eliminating 90% of my pain.

Fortunately, I am one with a B12 deficiency brought about by a series of diets including Paleo, Vegan, Starch-based and finally Low Carb, Moderate Protein. I am now back on track thanks to members like Al and Art who have shared their experiences here. I hope this information is helpful to those who are new to the site and trying to find their way. There are several causes for Peripheral Neuropathy and not everyone is B12 deficient but it should be worthwhile to try to determine if you are by trying this simple plan. Hopefully you are one of the lucky ones.

All the best,


Posted by Cheryl (Qld) on 07/10/2018

I told my GP, as my b12 was good, that it does not always get into cells and he agreed and said MSM can help unlock the cell doors to let nutrients in and toxins out.

Alpha-Lipoic Acid
Posted by Stephanie (Ma) on 07/27/2013

In Germany the treatment for peripheral neuropathy is IV alpha lipoic Acid. It's even covered by insurance. Has anybody used this therapy with success? And if so what doesage in mg did you use. Thank you VM.

Posted by Clatterbuck (Beltsville, Md) on 07/10/2021

If your B12 level was tested while you were taking a B12 supplement your blood test results will be inaccurate. Your body could still be B12 deficient because it is unable to properly process the oral B12. I have this problem and I receive monthly B12 shots.

Alpha-Lipoic Acid
Posted by R. (Dallas, Texas, Usa) on 05/16/2010

Peripheral Neuropathy: Better But Not Cured: If there is a cure? Just wanted to update with the latest from previous post. 3 months ago Rob and some others suggested Alpha Lipoic Acid. I have taken this for the last 3 months, and it has gotten much better! I started out with 1 100mg tablet, three times a day, and have had to add a 100mg tablet twice in 3 months, because the discomfort returns. But as soon as I up my dose, it goes away. I am currently taking 500mg a day. I guess I keep upping my dosage until I reach the maximum, then what? lol..

Posted by Timh (Louisville, Usa) on 01/16/2012 2063 posts

Brad, Acetyl-l-Carnitine is very similar molecule to Choline and has remarkably similar action on the body; so you might get the same results by supplementing some kind of Choline product (Soy or Sun Lecithin is a favorite). Either will work, but do not use both as they will only compete against each other.

Posted by Rosy Giana (A) on 10/29/2017

I was taking alpha lipoic acid for many years until recently when I read that it depletes vitamin B1 which showed up as very low in my blood test. I am taking Benfotiamine, a form of B1, and discontinued the ALA. As it was, I really never noticed any difference when I was taking it. We all have different types on neuropathy, mine is idiopathic. I am now looking into nightshades.

Posted by Clatterbuck (Beltsville, Md) on 07/10/2021

I urge caution when taking methylcobalamin. I have pernicious anemia and receive monthly shots from my doctor. I tried some oral methylcobalamin and it made me feel really awful. I felt anxious, irritable, and had horrible insomnia. Fortunately these side effects only lasted for 24 hours. I'll never take methyl anything again.

Posted by Gord235 (Vancouver, British Columbia) on 04/10/2018

Update: Since my last post, I have stopped taking Serrapeptase as it didn't seem to be making a difference. I have now switched to CBD (cannibis oil) which which is reducing the pain level in my foot as well as eliminating the Edema swelling in my leg. I plan to continue taking Vitamin B12 (1,000 mcg/day)as it was the first thing to give me relief in the beginning. I have stopped taking Alpha-Lipoic Acid as it didn't seem that effective.

Peripheral Neuropathy Supplements
Posted by ekvaughn (mcneal az) on 12/20/2022

Hi Art,

You listed 5 vitamins that are good for peripheral neuropathy. Are there any combo pills out there so that I would not have to take so many pills at once?

Posted by Rick (Usa) on 06/24/2015

I have always used generic Vicks Vapo Rub for muscle cramps. It has never failed to work for me and it is an inexpensive remedy which works immediately.

Posted by Rose (Jamaica ) on 11/19/2022

Omg thanks sooo much Rick..I was having nerves pain on my foot for 3 days straight. Could not sleep..then remember ur post about the Vicks. I had some and I rubbed the area on my foot n got immediate relief. N it has not returned. It definitely works.

Posted by Gord235 (Vancouver, British Columbia) on 10/04/2017

I have had lots of success taking a calcium-magnesium supplement for leg cramps. It never failed to work for me.

Painkillers for Peripheral Neuropathy
Posted by Gord235 (Vancouver, British Columbia) on 11/01/2017

Art, I checked your link to Web MD and could not see anywhere where long term use of Serrapeptase is cautioned against. I am taking 960,000 SU (8 capsules) per day and it is helping quite a bit with about a 90% reduction in pain.

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