Natural Remedies for Peripheral Neuropathy

| Modified on Nov 17, 2021

Macademia Nut Oil
Posted by Tom (Currently Yuma, Az) on 12/27/2020
5 out of 5 stars

In 2011, I got rid of numbness and tingling in my toes by taking two tablespoons of NOW brand unrefined macadamia oil after meals. This was twice per day. In two months and one 16 oz bottle later, my toe numbness disappeared and my fungal great toenail also lifted off and a new, healthy toenail grew in over the next year.

NOW brand discontinued the macadamia oil, but PipingRock has excellent oils, including macadamia oil. Macadamia oil has the highest percentage of the antimicrobial, palmitoleic acid, at 18%, which I now believe is antifungal as well.


That dosage for macadamia nut oil was just one measuring tablespoon after meals, up to twice per day.

That way, one 16 oz bottle would last about 32 days since there are 2 tablespoons to a fluid ounce.

However, just a half measuring tablespoon after meals might be enough, though, for the first two months. A half tbsp ended up being my maintenance dose for years, at once per day.

Assuming 13.3 grams per tablespoon of oil, 18% of that is 2.39 grams or almost 2400 mg of palmitoleic acid per measuring tablespoon.

At the time, I was using a flatware tablespoon that holds half of a measuring tablespoon, and I would take two of them after meals for the first two months. I no longer take macadamia oil, but the numbness in fingers and toes has never returned, nor has any fungal toenail.

EC: Thank you, Tom! Cross-posted from this thread: 

Posted by Gord235 (Vancouver, British Columbia) on 10/16/2017


I am now up to 960,000SU(8 capsules)per day of Serrapeptase after reading that 1,000,000 SU per day is not uncommon. I am also taking ALA 800mg (8 capsules) per day and continue to see improvement with the pain in my foot steadily decreasing in intensity and frequency. Take note that Serrapeptase needs to be taken away from food, either 1/2 hr. before eating or 2hr. after eating. Search Serrapeptase on Youtube for more information. Good luck to all.

Posted by Michelle (Austin, Tx) on 04/08/2011
5 out of 5 stars

I have had peripheral neuropathy for years. I have discovered several things along my journey. The absolute best supplement (but not a cure) for me has been transdermal magnesium oil or gel. One of the symptoms of magnesium deficiency is numbness/tingling. The reason to use the magnesium transdermally is that you can get more absorbed directly into your system without the possible side effect of diarrhea which can occur with oral dosages. I have tried many brands, but Ancient Minerals is hands-down, the best. It is made from condensed sea water. Since it can sting a little if you have sensitive skin, I just rub it on my feet twice a day and then put on socks. You should not use the magnesium if you have kidney problems or low blood pressure. If you do end up trying this, you may want to give it several weeks to a month before determining if it is helping you. Supposedly once magnesium is depleted, it is notoriously difficult to replete.

I have also discovered, that the main reason that I am so magnesium deficient is because my body is too acidic. Most people (myself included) consume a Western diet that consists of a of processed foods, meat, dairy, etc. , all of which are acidic. In the body's attempt to neutralize the acidity of the blood, it takes copius amounts of calcium, magnesium and potassium from different places in the body (bones, etc) and uses them to buffer the blood (make it more alkaline). If your problems persist, you may want to try an alkaline diet. You can also drink water with 1/2 tsp of baking soda dissolved in it (on an empty stomach, at least 30 minutes prior to eating), as this greatly helps to alkalinize your body. Hope some of these suggestions help. I know how miserable it can be to experience these symptoms!

Posted by Art (California ) on 11/08/2017 1005 posts

In reply to Gord235 (Vancouver, British Columbia), Did you actually mean, B12-10,000 mg/day? That is a huge dose that would require you to take pills all day long to achieve! Most B-12 supplements are sold in tablets containing MCG (microgram) doses, but even at that, 10,000 mcg is a lot of B-12 per day. The B-12 supplement I take is 2,500 mcg and that is considered a high dose supplement. It would take 4 of these per day just to achieve 10 mg! I get that the B vitamins will pass along quickly, but 10,000 mg per day seems impossible to take. The other B-12 supplement I have is only 1,000 mcg per tab.


Posted by Gord235 (Vancouver, British Columbia) on 01/01/2018


Since my last post I have learned that taking antibiotics can lower B12 levels and that a B12 insufficiency can be the cause of peripheral neuropathy in up to 7% of cases. I had surgery recently and was on antibiotics for two weeks. This may account for the dramatic improvement I experienced once I started taking a B12 supplement.

As a result of this new information I have returned to my regimen of taking B1- 2X100mg/daily, B6 - 2X100mg/daily, B12 - 2X5000mcg/daily as well as ALA - 4X200mg/daily and Serrapeptase - 10X120,000SU/daily. Although not completely rid of symptoms the frequency and intensity of pain has been reduced by 90%. I anticipate that I will eventually be able to reduce the number of things I am taking but feel certain that the B12 will be the last thing to go as it has been the only thing to give me overnight relief. I wish everyone well on their search for a cure.

Evening Primrose Oil
Posted by Bob (Rosedale, Md) on 05/07/2016


I too suffer from nerve issues in my feet. Hurts like hell at night, the rest of the time it is numb and feels like electric flowing around my feet. Calcium and magnesium helped me. The pain and numbness is there but manageable. Reflexology every other week really helps to as well as a good deep tissue massage once a month or so.

I also have found the Lord again, and to be honest with you I believe that, phrase to the Lord, and accepting Him as my Lord and savior truly was my best pain relief. I know this is an old post but I hope if you see this it helps.

Take care,

Bob R

Multiple Remedies
Posted by Bandi (Oakland, Ca) on 12/20/2017
4 out of 5 stars

I had neuropathy in my feet for at least 15 years. From what I read, I am controlling it better than most. While I have the usual symptoms (tingling, pins, sensitivity, numbness, burning, some cramps etc etc) I can walk, jog and sleep well at night. All that I list below I used for at least 6 months and are effective for me.

Cure? No :-(

But I am working on it :-)

Gabapentin 300 mg 1x/day. If I forget to take it before going to bed, while usually not excessive, the symptoms keep waking me up.

While during the day I often don't notice the symptoms, around 5 pm they start getting bothersome. At that time I rub some Chinese liniment called Zheng Gu Shui (avalable on ebay) on the ball and sole of my feet. It increases blood flow and the result its less sensitivity. It contains camphora among other ingredients, so wash your hands afterwords or your eyes may water :-)

Before going to bed, I use another Chinese liniment, called Shaolin I-Ching Ling. I used to get bruised while practicing Tae Kwon Do karate and had some remnant in a bottle. Sure enough, it calmed my nerves. Available on the Internet, just search on I-Ching Ling. I now make my own. Takes about 3 months but it is worth it. When my shoulder, knee, finger etc ache or I pulled a tendon or my muscles ache, a small application usually helps within minutes.

Somewhat less effective, but still useful for neuropathy pains is a gel called Diclac. I bought them in Hungary but seen it on Internet. That one was made in Germany.

All of the above are effective shortly after application.

Since I am using several remedies simultaneously, I can not prove the effectiveness of the following 2 remedies. But they seem to slow the progress of neuropathy.

Twice a day I take 150 mg Benfotiamine. Read Appearently it has been used in Europe for a long time.

Twice a day I take 1300 mg Borage (for LA, GLA OA) + 300 mg timed release Alha Lipoic Acid + 500 mg Vitamin C

Read and do search on GLA

I know it may be boring BUT it is worth reading:

Ok the above is what I practice right now in December of 2017

So what else is there?

TENS unit helps. I used to attach it to my feet while working at the computer. Check the Internet. Not too expensive. I had it handy since I originally used it for my lower back pain.Successfully I might add.

I have a toilet brush :-) With it I keep hitting the sole of my feet for a couple of minutes at night to increase blood flow. Yes it helps.

Capsaicin in any form (liquid or cream) works but the skin gets sensitized after a while so I dropped it.

Physical theraphy felt good but helped none. Acupuncture did not do much good either. But the Chinese massage I received after the treatment was worth going for :-)

I am looking into MSM, stem cells but do not hold out much hope for either right now. And please, believe in valid research not wishful thinking cloaked in scientific sounding mambo-jumbo!

Well, have a Merry Christmas and no pain!

Physical Therapy Exercise
Posted by Gord235 (Vancouver, British Columbia) on 12/18/2017
5 out of 5 stars

I have been using a simple exercise I learned on Youtube to give myself temporary relief from foot pain caused by Peripheral Neuropathy. Simply pump the front of the foot up and down 30 times and repeat this exercise three times a day or as required. This forces the circulation to increase in your leg and foot and will give quick relief from pain. It also works while pumping the heel up and down although pumping the the toes and front part of the foot is more effective.

Benfotiamine, ALA and RLA
Posted by Rick (Chicago) on 06/12/2016
5 out of 5 stars

Benfotiamine helped, but did not cure my Peripheral Neuropathy, which was due to knee replacement surgery where the nerves are traumatized. PN was bad after surgery and slowly improved (I took a large vitamin stack). After ~12 months learned about benfotiamine and tried it. A little better. Then I called the company and the founder (a scientist) answered and explained how sometimes large doses were necessary at least to start with, and that toxicity was almost impossible. 1800mg a day helped - to an extent, then leveled off. I now take Drs. Best Benfotiamine 300 1x and alpha lipoic acid 300 + benfotiamine 150 8x. My neurologist approves of these supplements.

BTW, I once used r-lipoic acid to cure my loss of taste (taste only, not smell) from taking an anti-fungal rx (never again). EENT specialist gave me prednisone which helped nothing but gave me road rage and fluid retention. Google led me to ALA and RLA studies. Cured in days. EENT doctor refused to even look at the published research articles. It was a pleasure to tell him "Your services are no longer required."

Alpha-Lipoic Acid
Posted by Mike Giller (Denver, Colorado) on 07/28/2013

Thank you for the compliment Stephanie. I get so few that I imagine everybody complimenting me so I can be happy. I was poisoned by toxic fumes, damaging my nervous system. When I was a dirty and stinky homeless person I had uncontrollable emotional outbursts during the day and nightmares at night. I have spent hundreds of hours studying and taken dozens of folk remedies trying to become calm and cognitive. I am a lot better than before but continue to have a constant nervousness. I am all right around friends but get a jolt when around strangers. Google spirulina/chlorella 2:1 ratio. A famous naturopath doctor did a complete and thorough study of them. He gives a very good explanation of all the benefits and dosages. I take 14 grams/6 grams. I weigh 180 lbs. Make sure you get Hawaiian spirulina. They get the water from a certain depth that has the most trace minerals and least pollutants. They preserve more nutrients with a special drying procedure called ocean cold. You can get either korean thin celled wall or japanese chlorella. The only company that cells the korean also sells a 5 lb. Bag of nondenatured microfiltered whey protein isolate for $60 and raw kelp from canada for $8. As for the other supplements soy lecithin does not work because it is cooked. Sunflower lecithin works because it is cold processed. Coq10 works only in the ubiquinol form. B vitamins work for 5 hours, except B12. Vitamin d works at a 1 to seven ratio with vitamin a. The dosage for d is 5000. The dosage for a is 35, 000. You can get a from fish liver oil caps for a few pennies per day. David Wolfe says raw organic cocoa powder is the only herb for increasing and balancing all the neurotransmitters. I take 30 grams in divided doses.

Alpha-Lipoic Acid
Posted by Gord235 (Vancouver, British Columbia) on 10/04/2017

Stephanie: Thank you for your post. The fact that ALA is being prescribed as a treatment and is covered by health insurance in Germany is very useful information to have.

I have been taking R+ALA (600mg/day) and it's working.

Posted by Gord235 (Vancouver, British Columbia) on 10/04/2017

I have had lots of success taking a calcium-magnesium supplement for leg cramps. It never failed to work for me.

Painkillers for Peripheral Neuropathy
Posted by Gord235 (Vancouver, British Columbia) on 11/01/2017

Art, I checked your link to Web MD and could not see anywhere where long term use of Serrapeptase is cautioned against. I am taking 960,000 SU (8 capsules) per day and it is helping quite a bit with about a 90% reduction in pain.

Posted by Gord235 (Vancouver, British Columbia) on 10/04/2017

I too have been taking ALC (750mg/day) together with R+ALA (600mg/day) and have experienced some relief although I believe it's the R+ALA that has helped the most out of the two. My greatest progress so far has been made with B12 so I am obviously deficient in this area. I am now on to Serrapeptase. If you scroll way down you will find where I have started a thread on this relatively new treatment. Good luck to all on your journey toward an effective treatment.

Posted by Soazburrolady (Az) on 10/30/2017

Hi Rosy,

It was so interesting to read your information regarding ALA and the connection to depletion of Vitamin B.

About 4 months ago, I quite literally woke up with symptoms of Peripheral Neuropathy - numbness, tingling, weakness in feet, lower legs, hands, and forearms. It was particularly alarming to me as my mother had PN so severe that she needed a walker to ambulate.

After reading the info on Earth Clinic (my first go to! ) and some other sites, I did what I always do - which is use the "shotgun approach". I started on B complex, benfotiamine, niacinamide, sunflower lecithin, passion flower, evening primrose oil, and St John's wort. I also increased my B6, B12, and ....ALA. I have experienced such a lessening of symptoms - many days are symptom free, that I am reluctant to change the regimen. However, I will surely research a bit more on the ALA. I do think the benfotiamine has been really beneficial. I initially took a B1, but after more research, was convinced that benfotiamine is a better choice. Thanks for posting!

Posted by Lily (Kelowna) on 03/24/2021

You may want to consider taking METHYLCOBLAMINE Vit.B12, sublingually. The type of B12 you take & how it is delivered to your system makes a large difference.

Posted by Gord235 (Vancouver, British Columbia) on 04/23/2018

Update: I made a mistake and bought ALA without the R+ and the pain in my foot returned so I have gone back to my original protocol of R+ALA plus B1, B6 and B12 vitamins. I had also cut back on the B vitamins so this might have been a contributing factor to the return of the pain. I noticed that as soon as I started back on the R+ALA and B vitamins the pain in my foot went from a 9 out of 10 to a 5 out of 10. Lesson learned - once you find something that works don't stop taking it.

Multiple Supplements
Posted by Gord235 (Vancouver, British Columbia) on 09/07/2017
5 out of 5 stars

Hi Everyone. I'm new to this community and also new to posting online so I'll be brief and to the point. First; thank you to all who have contributed to this site. Peripheral Neuropathy can quite daunting.

Next; after considering several options I settled on the following protocol: B12 5,000 mcg/day, Acetyl-L-Carnitine 750mg/day, R+Alpha Lipoic Acid 100 mg/day, Calcium Magnesium D3 333/167 mg/day 2:1 Ratio, Enhanced Absorption. This combination worked fast and very well for me, eliminating 90% of my pain.

Fortunately, I am one with a B12 deficiency brought about by a series of diets including Paleo, Vegan, Starch-based and finally Low Carb, Moderate Protein. I am now back on track thanks to members like Al and Art who have shared their experiences here. I hope this information is helpful to those who are new to the site and trying to find their way. There are several causes for Peripheral Neuropathy and not everyone is B12 deficient but it should be worthwhile to try to determine if you are by trying this simple plan. Hopefully you are one of the lucky ones.

All the best,


Posted by Bonnie (Ravenna, Ohio) on 09/03/2014
5 out of 5 stars

I had such painful cramps in my feet and legs it would wake me up at night-I remembered I had magnesium oil and the gel--put some on the bottom and top of my feet and on my legs. Also started taking Boswellia/Turmeric combo and Magnesium Malate-drank a small glass of water with 1/2 tsp. baking soda---have no more cramps--my feet are warmer, less pain when I walk too. Now gave my old dog boswellia/turmeric---she's going up and down stairs with no problem. Hope this helps. Bonnie

Posted by Cheryl (Qld) on 07/10/2018

I told my GP, as my b12 was good, that it does not always get into cells and he agreed and said MSM can help unlock the cell doors to let nutrients in and toxins out.

Alpha-Lipoic Acid
Posted by Stephanie (Ma) on 07/27/2013

In Germany the treatment for peripheral neuropathy is IV alpha lipoic Acid. It's even covered by insurance. Has anybody used this therapy with success? And if so what doesage in mg did you use. Thank you VM.

Alpha-Lipoic Acid
Posted by Mike Giller (Denver, Colorado) on 07/27/2013
5 out of 5 stars

The more fuel burned in the mitochondria, the more free radicals are produced. The 3 indigenous antioxidants that mop them up are sod, catalase, and glutathione. Sod changes the free radical into a less damaging one called hydrogen peroxide. Catalase and glutathione changes hydrogen peroxide into a harmless substance. Glutathione also makes redox signaling molecules. These are involved in cellular communication and activate all the other antioxidants, like c, e, coq10, idebonone, ubiquinol, and r-ala. A naturopath doctor discovered that all of his patients were low in sod, catalase, and glutathione. Eating raw organic foods high in trace minerals increases sod and catalase. The limiting factor in glutathione is a special amino acid only found in eggs from pastured hens eaten raw, cold processed whey, and absorbable colostrum. Taking r-ala is not a solution. The two best foods for the nerves are hawaiin spirulina and chlorella at a 2 to 1 ratio. These also contain many other benefits including trace minerals for the production of sod and catalase. For glutathione and many other benefits including growth factors take at least 20 grams nondenatured microfilotered whey protein isolate and 5 grams of absorbable colostrum. These 4 superfoods can be purchased on the internet from reputable companies at wholesale prices.

Alpha-Lipoic Acid
Posted by Mike Giller (Denver, Colorado) on 07/29/2013

Dear Stephani, I suffered for many years from a viral infection when I was homeless and did not understand the way food affects cellular biology. Naturopath Doctors wisened me up. I believe the solution is eating the best food the right way. This is not a diet. Eat a lot. The dosage of food is per water. The more water you drink the more food you can take. I take 1 pint an hour for 16 hours. Right before bed I take another dose. This forces me to wake up 2 hours later to go to the bathroom. Then I take another dose. So I take 4 more doses while I am sleeping. I am going to give you a list of everything I take. I weigh 180 lbs. I walk 10 miles a day. You can adjust the dosage to your weight and activity level. Take the carbs, oils, and proteins together at the same time. Remember, the more you take, the more water you have to drink and the sooner the tissues will be repaired and rejuvinated. The foods contain all the nutrients the body requires in their most bioactive form. The grams are per day. The company I buy the most from is A-----. 200 g raw honey, 200 g organic whole cane sugar, raw organic cocoa powder 2 pack s and s $25, 30 g. 21 oz absorbable colostrum $60, 10 g. Hawaiin spirulina s and s $25, 14 g. Black chia seeds 60 g, 4 pack, $26, put in 1 pint of water and stir continuously for 5 minutes. Argentina beef liver powder nondefatted, 12 oz. $10, 10 g. 90000hu cayenne, 2g, 2 pack, $16. Only 1 company has korean thin celled wall chlorella Z--------. 1 lb. $30, 6 g. Nondenatured microfiltered whey protein isolate, 40 g, 5 lb. $60. Freeze dried coconut water powder, 40 g, 5 lb. $140. Raw kelp 5 g, 1 lb. $8. Coconut oil, cold processed, 1 gallon, $69, 20g. Many reputable companies sell raw fermented skate liver oil, 1 ml. 4x. Getting 1 kg. Of non gmo aka or red miso at asian grocery store is very important, 60 g, $6. These simultaneously nourish the cells, detox the poisons, kill the bad guys, repair and rejuvinate the all the tissues. Love from all us simple country folk in Colorado.

Alpha-Lipoic Acid
Posted by Mike Giller (Denver, Colorado) on 07/31/2013

Dear Stephani. The salt is in the miso. Everybody from Newton to Einstein studied Newton's theory of gravity. They all played the role of students absorbing like a sponge. Only Einstein played the role of a detective who investigates. He stretched his intellect. He thought of clues, angles, and possibilities. He was not an extraordinary man like Thomas Edison who invented something. He just discovered something that had always been there. He investigated something that nobody had investigated before. The same thing happened to me. What you say makes sense. Too much water is washing away the nutrients. In many cases what you say is correct. So let us do an Einstein and investigate. When people eat food, nutrients are absorbed into the plasma. When the cell needs nutrients the windows and doors open and the nutrients enter the cell. When the cell has enough nutrients the windows and doors close. The remainder are excreted through the urine. When that is the case the urine turns yellow. Mine is clear. Were the nutrients not entering the cell my energy levels would drop and again that is not the case. The 500 hundred grams of sugar, 80 grams of protein, 40 grams of oil, many vitamins, minerals, and phytochemicals that I take are being utilized. So I am not wasting my money having them being washed away. When I was sick my goal was to get well. When I got well I did not feel great. I continued to feel tired. I have been tired all my life. I was reprimanded in school, fired from jobs, and kicked out of coffee houses for sleeping because I was tired. When I get tired I get lazy and stupid. That was why I was a loser who always failed. Then I read a report by Dr. Colban and his colleges. They advise elite world class athletes. He recommended eating 6 meals a day. I was taking 4 doses a day. So I took 6 doses a day and I had more energy. So I thought 6 is better than 4 so maybe 8 is better than 6 and I had more energy. So I thought maybe 16 is better than 8 and I had more energy. So I continued to be tired while sleeping and had brain fog in the morning so I took 4 more doses during the night while sleeping and that is the way I ended up with 20 doses. There is an explanation for all of this. As I increased the frequency of the doses, more nutrients were utilized, increasing metabolism, requiring more nutrients. Like the bird and the alligator. 6 hours after a meal a bird gets hungry because he has a high metabolism. 6 weeks after a meal an alligator gets hungry because he has a low metabolism. My metabolism became more like a bird's and less like an alligator's. Our goals are not the same. Your goal is to get well. In order to get well you are going to have to take more than a well person because you have to repair damaged tissues. As you increase the frequency of the doses your metabolism increases, requiring more nutrients. You want to be well yesterday. The more doses you take per day the more repair work is done and the sooner you can get well. I already got well. You are going to have to go through what I went through. Today my goal is to feel great all the time. I feel great all the time when I have plenty of energy all the time. I have plenty of energy all the time when I take 20 doses a day instead of 4.

Alpha-Lipoic Acid
Posted by Mike Giller (Denver, Colorado) on 08/02/2013

Dear Stephani, thank you for replying. The non gmo aka red miso has sun dried sea salt. They add that during the fermentation process. They sell that at the asian grocery 1 kg. For $6. If you cannot get that you can go to the natural grocery store and get sun dried sea salt 23oz. For $1.69. Take 4 grams. You can also take 2 grams dead sea salt. I take 6 grams of sun dried sea salt and 4 grams of dead sea salt every day. The hawaiin spirulina, korean chlorella, and nondefatted dessicated liver do not taste good. You may have to dilute them with water to begin with or take smaller doses. Somebody said that iron feeds the hep c virus. That may be true. I believe the special substances in the superfoods can kill the hep c virus. For many years I suffered from frequent mouth ulcers and sore throats because of a viral infection. Making smoothies from organic baby leaves and organic raw berries greatly reduced the frequency of these very painfull occurances. Taking the superfoods eliminated them. Hawaiin Spirulina has a unique substance called a sulfur polysacharide. The sulfer combines with hydrogen to form hydrogen sulfide gas. This kills all pathogens. Sulfur is the mother of all minerals. The first life on earth used sulfur for energy before there was any oxygen. Sulfur activates all the other minerals. There are four amino acids that contain sulfur. The superfooods are high in these sulfur containing amino acids. For inspiration you can watch raw vegan 80/10/10 videos on youtube. Please reply after you begin the program to tell me of the results. Thank you.

Alpha-Lipoic Acid
Posted by Gord235 (Vancouver, British Columbia) on 12/14/2017

Update: I have now increased the ALA to 800mg/day.

Posted by Clatterbuck (Beltsville, Md) on 07/10/2021

If your B12 level was tested while you were taking a B12 supplement your blood test results will be inaccurate. Your body could still be B12 deficient because it is unable to properly process the oral B12. I have this problem and I receive monthly B12 shots.

Alpha-Lipoic Acid
Posted by R. (Dallas, Texas, Usa) on 05/16/2010
4 out of 5 stars

Peripheral Neuropathy: Better But Not Cured: If there is a cure? Just wanted to update with the latest from previous post. 3 months ago Rob and some others suggested Alpha Lipoic Acid. I have taken this for the last 3 months, and it has gotten much better! I started out with 1 100mg tablet, three times a day, and have had to add a 100mg tablet twice in 3 months, because the discomfort returns. But as soon as I up my dose, it goes away. I am currently taking 500mg a day. I guess I keep upping my dosage until I reach the maximum, then what? lol..

Posted by Gord235 (Vancouver, British Columbia) on 10/10/2017

Update: I have been able to cut back on the B vitamins (1,6 and 50 complex) although I still take 2 X B12 5000mcg/day. I have increased the ALA (r+alpha lipoic acid) to 800mg/day as it seems to be helping the most.

I also take N-Acetyl-L-Carnite 1500mg/day and Calcium/Magnesium 2X 133/167mg/day.

This protocol has eliminated 90% of the pain and I believe it is the ALA that is helping the most. Best wishes and good luck to all in their search for relief.

Posted by Gord235 (Vancouver, British Columbia) on 10/03/2017

Serrapeptase For Peripheral Neuropathy

Serrapeptase is a relatively new treatment utilising an enzyme to remove non-living cells. This has a dramatic effect on reducing pain and inflammation. It has been used successfully in Europe for thirty years but is just becoming known in North America.

I have started with 120,000 SU (2 capsules) - twice a day and plan to gradually increase the dosage after watching several clips on youtube. I would be interested in hearing about any experiences by members who have tried it.

Multiple Supplements
Posted by Gord235 (Vancouver, British Columbia) on 09/26/2017

I would just like to add a note since my previous post. Although I have experienced much improvement following the protocol previously mentioned I am still looking for something better as I still experience some flareups. I've spent a lot of time watching Youtube in search of the 100% cure but it seems to be elusive. I tried baking soda and ACV but it didn't seem to make a difference. Then I heard that cassian cinnamon would do the trick, then it was benfotiamine that was declared to be the holly grail. In conclusion I think that the best we can do is to stick to the most popular cures mentioned on this site. I am currently holding out hope that ALA will deliver on it's promise to promote nerve healing in the long term. Best wishes to everyone.

Posted by Dave (Fountain Inn, Sc) on 09/05/2013

To Tiny Dancer:

On neuropathy, google "Calcium AEP diabetes" and "acetyl l carnitine diabetic neuropathy" and you should find what these substances do to help the condition. Especially Cal AEP works wonders for the pain you're experiencing. You may not have diabetic neuropathy but it helps on the cellular level restore electrical interaction and helps maintain cellular health. Also google an article "calcium aep nutrition review" and you'll be amazed at the many other things Cal aep can do.

Posted by Nina (Massachusetts) on 08/13/2013

Will MSM help with peripheral neuropathy pain. I have it in my feet, calves, thighs and arms and hands and even get electrical shots in my torso in the middle of the night and on my fingers. I even got one in my eye. It seems to be getting worse.. Thank you for reading...

Alpha-Lipoic Acid
Posted by Timh (Ky, Usa) on 07/30/2013 2083 posts

To insure adequate antioxidant levels from SOD, supplement Zinc/Copper and Manganese. Selenium is necessary to produce glutathione reductase. Oh, and another critical factor for proper enzyme and antioxidant levels is a NOT acidic body PH. Acidity simply depletes minerals and enzymes.

Magnesium is touted to be directly or indirectly involved in over 300 enzymatic reactions.

Alpha-Lipoic Acid
Posted by Lily (Kelowna, BC) on 03/24/2021

Too much water or fluids washes the vit. & minerals from your body and can cause sodium deficiency which can affect kidneys.

Posted by Prioris (Fl) on 10/14/2013

Magnesium glycinate will not cause diarrhea. Also it is easier for the body to absorb.

Posted by Rick (Usa) on 06/24/2015

I have always used generic Vicks Vapo Rub for muscle cramps. It has never failed to work for me and it is an inexpensive remedy which works immediately.

Electromyography for Peripheral Neuropathy
Posted by Cheryl (Ft. Lauderdale, Fl.) on 07/13/2013

I had it done and refused to complete the test. It is extremely painful.

Gingko Biloba
Posted by Bill (San Fernando, Philippines) on 06/25/2013

Hi Mary.... I can't really see a problem with taking ALA with mercury fillings. Personally, I think the arguments for not taking ALA verge on the ridiculous. Here are my arguments pro-ALA supplementation:

If you don't take ALA then the mercury in your fillings will still vaporize and still go down your throat and be stored as a heavy metal in your body anyway.

Is that beneficial to the body?

If you take ALA then, yes, its certainly possible that the mercury could be redistrubuted throughout your body but some of it will also be removed and excreted.

What about the other benefits of ALA?

  • ALA is a super-antioxidant that is both water soluble and fat souble -- this means it can act in both fat and aqueous mediums as an anti-oxidant throughout the body. ALA, as an antioxidant, leaves vitamins like Vitamin C and Vitamn E at the post -- these two only act as anti-oxidants in aqueous and fat mediums respectively.
  • ALA regenerates used up Vitamin A, C, D, E in the liver and also regenerates used up glutathione and CoQ10.
  • The reduced ALA form -- dihydrolipoic acid or DHLA -- also has benefcial action in the body -- mainly used to regenerate used up vitamins.
  • Both ALA and DHLA also act to extinguish a large range of dangerous free radicals in the body -- hydroxyl radicals, superoxide radicals, hypochlorous acid, peroxyl radical and singlet oxygen. Hence ALA's anti-aging effect.
  • ALA is found in high amounts in young people. These levels reduce considerably at old age. The body needs ALA for anti-aging.
  • ALA is a magnificent poison detoxer of the body, particularly useful against deadly fungal afloitoxins and mycotoxins and particularly useful against poisonous mushrooms.
  • ALA heals neuropathy problems and helps to heal the liver and pancreas due to its anti-oxidant action.
  • ALA chelates heavy metals from fat deposits and from aqueous mediums such as blood and tissue.
  • Supplementing ALA discourages cancer forming in the body.
  • ALA removes and reduces sugar in the blood. Very helpful for diabetes and other chronic problems.
  • Dr Berkson has been using ALA, Selenium and Milk Thistle for many years to help cure Hepatitis C, liver cancers and pancreatic cancers.

Source: The ALA Breakthrough by Dr B Berkson.

I think, perhaps, supplementing ALA has clinched it here since supplementing mercury -- by way of fillings -- will do nothing but extreme harm for the body over time.

And if you want to ensure protection against re-absorbtion of mercury then just supplement Chlorella and eat raw cilantro two or three times a week as a salad. This protocol rapidly removes mercury and other heavy metals from the body (without danger of re-distribution or re-absorption) and also protects against re-absorption of heavy metals from the colon.

Evening Primrose Oil
Posted by Diane (Framingham, Ma) on 02/26/2013

I also would like whatever info on evening primrose oil as I have tried everything on this site and every other site for peripheral neuropathy... I have spent close to $10,000.00 on accupuncture, micro current therapy, IV alpha lipoic acid, vitamin C , etc. etc. and am worse! I have trouble walking up stairs and have terrible pain, hot needles, electric shocks, everywhere all day and night long...

Evening Primrose Oil
Posted by Kate (PA) on 11/17/2021

I am grateful for this info as I too am trying to find relief from PN and have tried all that you mentioned with little relief. A chiro tried to sell an 8,000 pkg to me including a Tens unit and Low Level Light therapy therapeutics.

Posted by Rosemary (White Rock, Bc, Canada) on 03/08/2012
5 out of 5 stars

Hello Paula, I've used the Borax remedy as a last ditch attempt to cure my aching hands, arches and metatarsalalgia.. It made a noticeable difference within 10 days and I am pain free after 2 months. Your neuropathy and foot problem sounds like a vitamin 12 deficiency I had. I had numb hands as well.. The B12 twice a day helped in literally days to relieve symproms. I had 6 of the 7 symproms listed.

Posted by Mike (New York City, New York) on 02/09/2009
4 out of 5 stars

I have been taking Acetyl-L-Carnetine for a couple years to combat my peripheral neuropathy. It has been recommended by a neurologist in New York. My feet are progressively doing worse but I don't know how much worse they would be without it. I also take Alpha Lypoic Acid. I take about 3000mg of Acetyl-L-Carnetine a day. I am looking for whatever works. I have the neuropathy through anti-hiv meds and possible from the virus itself.

Posted by Brad (Owensboro, Ky) on 01/14/2012
4 out of 5 stars

I am not saying anything conclusive yet, but I have been taking Acetyl-l-carnitine for three days. I had numbness, tingling and sometimes burning in my feet. I have been taking 800mg daily. After three day they feel remarkably better. I will post further as time goes on.

Posted by Timh (Louisville, Usa) on 01/16/2012 2083 posts

Brad, Acetyl-l-Carnitine is very similar molecule to Choline and has remarkably similar action on the body; so you might get the same results by supplementing some kind of Choline product (Soy or Sun Lecithin is a favorite). Either will work, but do not use both as they will only compete against each other.

Posted by Rosy Giana (A) on 10/29/2017

I was taking alpha lipoic acid for many years until recently when I read that it depletes vitamin B1 which showed up as very low in my blood test. I am taking Benfotiamine, a form of B1, and discontinued the ALA. As it was, I really never noticed any difference when I was taking it. We all have different types on neuropathy, mine is idiopathic. I am not looking into nightshades.

Posted by Gord235 (Vancouver, British Columbia) on 11/07/2017

Hi Soazburrolady, Interesting to read your post. I've used a similar shotgun approach with much success and have achieved a 90% reduction in pain. I take B1-200mg/day, B6-200mg/day, B50-200mg/day, B12-10000mg/day, R+ALA-400mg/day, NAL-Carnite-1500mg/day and last but not least, Serrapeptase-960000SU/day. If you scroll way down you'll see where I've started a thread on Serrapeptase. Youtube has lots of info.on this.

Posted by Clatterbuck (Beltsville, Md) on 07/10/2021

I urge caution when taking methylcobalamin. I have pernicious anemia and receive monthly shots from my doctor. I tried some oral methylcobalamin and it made me feel really awful. I felt anxious, irritable, and had horrible insomnia. Fortunately these side effects only lasted for 24 hours. I'll never take methyl anything again.

Posted by Gord235 (Vancouver, British Columbia) on 12/14/2017

Hi Art,

Sorry, I meant to say B12 - 10,000mcg not mg.

Posted by Gord235 (Vancouver, British Columbia) on 04/10/2018

Update: Since my last post, I have stopped taking Serrapeptase as it didn't seem to be making a difference. I have now switched to CBD (cannibis oil) which which is reducing the pain level in my foot as well as eliminating the Edema swelling in my leg. I plan to continue taking Vitamin B12 (1,000 mcg/day)as it was the first thing to give me relief in the beginning. I have stopped taking Alpha-Lipoic Acid as it didn't seem that effective.

Posted by Preston (MA) on 07/29/2021

Peripheral Neuropathy

I've been told by a neurologist that B-6 is good for your nerves and by another Dr. that is very bad for your nerves. Anybody have a final answer-please?

Macademia Nut Oil
Posted by Peter (CA) on 01/04/2021


How long did you you have the numbness and tingling before you began using the macadamia oil?

B-12 Injections
Posted by epeach (United States) on 05/07/2020
5 out of 5 stars

Use of B12 for Peripheral Neuropathy (not from Diabetes)

I fell over 2 1/2 years ago and broke my back herniated some discs, and twisted my leg in the fall. I reached out to Earth Clinic immediately for help and too many to name came to my aid with wonderful advice.

Thank you! Neuropathy pain began to develop my back, bottom, hip, leg, and foot. It was soon diagnosed as RSD commonly called Suicide Disease. I have researched for almost 3 years for a way to alleviate this unbearable pain and other symptoms associated with it. I couldn't complete any tasks and am using a cane.

Over 6 weeks ago, I found a blog about transdermal neuralgia and it sounded similar to my condition but located in the face.

A lady said that she began B12 injections 2 times a week and went into remission after 8 months. I called my doctor right away and he approved the treatment but told me not to try anything new while I am getting the injections. At first, I thought we chose the wrong treatment because I was exhausted and couldn't stay awake. After about 1 month that went away, and now my energy is out of the world and I have stamina. I have accomplished so many tasks in the last few weeks.

But the best part is my mood. I am laughing all of the time. My husband is so happy. He has his wife back.

I did not realize that I was depressed, but I guess I was. Even the cashier at the local grocery store noticed the changes. I am still in excruciating pain with storms and barometric pressure changes. But the overall pain has reduced. Hopefully, with continued use that will improve as well as the other symptoms have.

Thank you for letting me share. I pray someone reads this and will receive benefit as well. God bless.

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