Top Natural Remedies for Peripheral Neuropathy: Dosages & Benefits


Posted by Nina (Massachusetts) on 08/13/2013

Will MSM help with peripheral neuropathy pain. I have it in my feet, calves, thighs and arms and hands and even get electrical shots in my torso in the middle of the night and on my fingers. I even got one in my eye. It seems to be getting worse.. Thank you for reading...

Replied by Steve
(Las Vegas)

MSM should be somewhat helpful. I believe there are also some good nerve rejuvenation tonics out there like Dr Schulze's. You should be able to find some good nerve rejuvenation tonics on google as well.

Replied by Steve
(Las Vegas)

Check out the benefits of magnesium oil for neuropathy. You rub it into the areas of pain and it helps to relieve the pain.

Replied by Nina

Steve from Las Vegas. I am using magnesium oil and R-lipoic acid, and acetyl L carnitine, fish oil, sunflower lecithin and many other supplements but I am not improving. I will try the nerve regeneration suggestion... Every doctor I speak to tell me there's no cure... Then I see many people curing themselves with supplements...

Replied by Rsw
(Uniontown, Oh)

Nina, recent studies have shown Lion's Mane mushroom as being beneficial in restoring nerves and Myelin sheath. It is helpful with MS symptoms so I am wondering if it would help with repairing the nerves in neuropathy? It may be an avenue to investigate. I imagine you would want a full spectrum product, and I have recently learned that kits can be purchased to grow your own mushrooms. Full spectrum, multi-mushroom products can also be found online. Best wishes.

Replied by Nina

RSW from Uniontown, OH. Thank you much for the response. Would you elaborate with regard to what you mean by, "Full spectrum product" for Lion's Mane?

Replied by Rsw
(Uniontown, Oh)

Nina, full spectrum means all the parts of the mushroom, not just some of the mushroom. Full-Spectrum (Primordia, Mycelia, Fruiting Bodies & Extracellular Compounds). I imagine that way, you will benefit from everything that the mushroom has to offer and not miss out on any of the individual component attributes. Generally, the seller will say if the product is full spectrum. Best wishes!

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Posted by Bandi (Oakland, Ca) on 12/20/2017

I had neuropathy in my feet for at least 15 years. From what I read, I am controlling it better than most. While I have the usual symptoms (tingling, pins, sensitivity, numbness, burning, some cramps etc etc) I can walk, jog and sleep well at night. All that I list below I used for at least 6 months and are effective for me.

Cure? No :-(

But I am working on it :-)

Gabapentin 300 mg 1x/day. If I forget to take it before going to bed, while usually not excessive, the symptoms keep waking me up.

While during the day I often don't notice the symptoms, around 5 pm they start getting bothersome. At that time I rub some Chinese liniment called Zheng Gu Shui (avalable on ebay) on the ball and sole of my feet. It increases blood flow and the result its less sensitivity. It contains camphora among other ingredients, so wash your hands afterwords or your eyes may water :-)

Before going to bed, I use another Chinese liniment, called Shaolin I-Ching Ling. I used to get bruised while practicing Tae Kwon Do karate and had some remnant in a bottle. Sure enough, it calmed my nerves. Available on the Internet, just search on I-Ching Ling. I now make my own. Takes about 3 months but it is worth it. When my shoulder, knee, finger etc ache or I pulled a tendon or my muscles ache, a small application usually helps within minutes.

Somewhat less effective, but still useful for neuropathy pains is a gel called Diclac. I bought them in Hungary but seen it on Internet. That one was made in Germany.

All of the above are effective shortly after application.

Since I am using several remedies simultaneously, I can not prove the effectiveness of the following 2 remedies. But they seem to slow the progress of neuropathy.

Twice a day I take 150 mg Benfotiamine. Read Appearently it has been used in Europe for a long time.

Twice a day I take 1300 mg Borage (for LA, GLA OA) + 300 mg timed release Alha Lipoic Acid + 500 mg Vitamin C

Read and do search on GLA

I know it may be boring BUT it is worth reading:

Ok the above is what I practice right now in December of 2017

So what else is there?

TENS unit helps. I used to attach it to my feet while working at the computer. Check the Internet. Not too expensive. I had it handy since I originally used it for my lower back pain.Successfully I might add.

I have a toilet brush :-) With it I keep hitting the sole of my feet for a couple of minutes at night to increase blood flow. Yes it helps.

Capsaicin in any form (liquid or cream) works but the skin gets sensitized after a while so I dropped it.

Physical theraphy felt good but helped none. Acupuncture did not do much good either. But the Chinese massage I received after the treatment was worth going for :-)

I am looking into MSM, stem cells but do not hold out much hope for either right now. And please, believe in valid research not wishful thinking cloaked in scientific sounding mambo-jumbo!

Well, have a Merry Christmas and no pain!

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Posted by R. (Dallas, Texas, Usa) on 02/16/2010

Does anyone have any suggestions to ease the discomfort or to cure Peripheral Neuropathy? I have been using ACV(twice a day), Baking Soda(once a day), Vitamins B6, E, Selenium, NAC(N-Acetyl-L-Cysteine) and these are not helping yet. I am taking some prescription meds that are suppose to help, Gabapentin, and Amitriptyline and these are not helping either. Any suggestions would be greatly appreciated! Thanks in advance!

Replied by Rob
(Manhattan, New York)

This from Dr. Weil...Your first step should be a general medical checkup to determine if an underlying disease or injury is the cause of your symptoms, and if so, to determine its nature. Your doctor should do complete blood work and may refer you to a neurologist who will probably do an EMG (electromyelogram) to assess muscles and nerve conduction. If you have no underlying disease, you can try one or all of the following strategies:

Take one B-100 B-complex vitamin daily. The B vitamins are necessary for normal nerve function, and supplementing is a good preventive measure. Do not take more than 200 mg of B-6, as higher daily doses can actually cause symptoms of neuropathy.

Take 100 mg of alpha-lipoic acid daily. This antioxidant protects microcirculation to the nerves. You can gradually increase the dose to 300 mg twice a day over the next month.

Replied by R.
(Dallas, Texas, Usa)

Thanks to Rob, Selena, and Saba for your responses!

Yes I have an underlying disease that causes this, as well as the meds I take for this disease can also cause neuropathy. And yes I have had all the relevant tests. Will go by some B-100 B complex, and some Alpha-lipoic acid. I have taken the Cayenne in capsule form for other problems as well, and it worked for that. So will mix it with oil as well. The neuropathy is mostly from my knees down to my toes. This Neuropathy is very frustrating mentally more that anything else, and after 19 years with this disease, this has been my biggest challenge yet. Will let you know how these new ideas work. And thank you all again!

Replied by T
(Brooklyn, Ny)

Hi there. I was reading your post and I wondered to myself: have you ever been tested for heavy metals? I have read plus spoken w/ several holistic practitioners that say heavy metal toxicity may, or even perhaps, be linked to many neuro-degenerative diseases. I raise the issue because about two years ago, I mysteriously "came down" with a neurological disorder that not only affected the quality of my life (I was fairly healthy and happy-go-lucky) but also my ability to walk w/ both a straight or defined gait. That is, my vestibular system suddenly became out of whack and I felt (and still feel) like I am walking on foam all day long. Initially, I was told it was labyrinthitis, then just simply vertigo, then Meniere's, then it was incurable, then specialists didn't know....and so, you get the picture. :0(

After much research (of my own - traditional docs became useless) - I learned I am indeed suffering from heavy metal poisoning (I have six old amalgams one fairly recent - yr old - root canal that may have stirred up some dormant issues or introduced more metals into my system to which my immune system could no longer handle things efficiently).....and so as my body hit a "tipping point" - I was left w/ a laundry list of symptoms that had me suffering from incredible fatigue and pain. One of these symptoms - like u - was nerve pain in my hands, legs and feet. I thought I was developing peripheral neuropathy (but since I didn't want to go to the doctor anymore) I researched some remedies and found improving my diet helped a great deal, alongside doing TRANSDERMAL MAGNESIUM THERAPY.

When I learned that magnesium (a salt) is such an important macro-mineral in the body - and is especially important for the nervous system (both for conduction and relaxation)....I tried the remedy and have never had any more nerve pain symptoms (in my extremities) to date. I still have the gait issue but that I am working on as I still have the metals in my mouth (saving for the dental procedure to remove them by a holistic dentist). [As a sidenote: heavy metals are known for depleting the body of vital minerals.] When dealing w/ prolonged heavy metal exposure (or overall toxicity) our biochemical/electrolyte make-up becomes seriously compromised. Magnesium is one of those minerals that needs to be replenished in the body almost everyday. The remedy I use is in the form of a foot bath. Magnesium oil or magnesium bath flakes are the ideal choice. Allow your feet to soak in warm water (w/ the oil or flakes) for 20-30 mins. The Mgn works almost immediately as it is quickly absorbed through the pores on your soles of your feet. Its a pretty simple treatment but IT WORKS. I did this for a duration of 5-7 days straight....took a break for a wk or two (symptoms were gone at this point)....but if I felt like I was experiencing any other heavy metal related symptom (ie. joint/muscle pain, chest pain, teeth grinding)....I did it again....and the symptoms subsided. In essence, its a staple treatment I use (in conjunction w/ cleaning up my diet) to both manage and sustain my day-to-day functioning.

God Bless You!

Replied by Lynn
(Southwest, Michigan)

I have went through 2-6 weeks of chemo and then had a bone marrow transplant. The neuropathy in my feet and legs is horrible and has spread to the rest of my body. The doctors have tried almost all meds known to them, with no relief. At first they thought it may improve, then later they tell me the chemo damages the protective shaft around the nerves and their is not anything they can do, just keep me medicated. The transplant was 7 years ago and it just keeps getting worse. After reading the input about Acetyl-L- Carnetine and Alpha Lypoic Acid, I am going to give them a try. Any suggestions on starting with just one or doing both right from the start. Any info would be greatly appreciated.

Replied by Timh
(Louisville, Ky, USA)
2064 posts

Lynn: Given the severity of your condition I would go ahead and take both the Carnitine and ALA but at separate times and as recommended on labels. If in a few weeks you don't experience any positive changes up the dose.

Also, I read an article that proved Growth Hormone can actually re-grow nerve endings. Nothing significant like to heal a spinal cord injury, but enough to relieve neuropathy. To boost Growth Hormone and prevent the "over-firing" of nerves, take 1 grm Gamma Amino Butyric Acid (GABA) before retiring.

Also, Lipid Replacement Therapy is currently showing very good results in chronic illnesses and general damaging conditions where the body isn't capable of proper regeneration.

Omega 3 Fatty Acids which are found in Fish Oil, Flax Oil, Chia Seeds/Oil, and Walnuts/Oil are critical for healing to occur anywhere in the human body. Omega 3's stimulate many different "healing pathways" in the body. Vit-E (full spectrum) is recommended to help protect the delicate Omega 3's.

Zinc, a mineral commonly deficient in the western diet, is also critical for healing to occur in the body. Burn victims, for example, have many times greater survival rates if given therapeutic doses of Zinc. Pumpkin Seeds and cooked or raw liver is the only significant dietary source of Zinc.

Replied by Art
(Vancouver Bc, Canada.)

Dear Lynn. I have had good results with R-ALA 200mg with each meal 3x times daily and Vitamin B12 sublingual 1, 000mcg once daily. At the start I was taking anywhere up to 3, 000 to 6, 000mcg daily until I found my balance. You cannot overdose with the B12 as your body will just pee out what you don't need, but it did make me dissy upon laying down. You For now I have it under control. I do know the GabaPentin will make you very drowsy but I was unable to sleep because of the pain and it didn't help, and had to use ice packs for the burning. I tried the Gabba before with the same results.


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Posted by Gord235 (Vancouver, British Columbia) on 09/07/2017

Hi Everyone. I'm new to this community and also new to posting online so I'll be brief and to the point. First; thank you to all who have contributed to this site. Peripheral Neuropathy can quite daunting.

Next; after considering several options I settled on the following protocol: B12 5,000 mcg/day, Acetyl-L-Carnitine 750mg/day, R+Alpha Lipoic Acid 100 mg/day, Calcium Magnesium D3 333/167 mg/day 2:1 Ratio, Enhanced Absorption. This combination worked fast and very well for me, eliminating 90% of my pain.

Fortunately, I am one with a B12 deficiency brought about by a series of diets including Paleo, Vegan, Starch-based and finally Low Carb, Moderate Protein. I am now back on track thanks to members like Al and Art who have shared their experiences here. I hope this information is helpful to those who are new to the site and trying to find their way. There are several causes for Peripheral Neuropathy and not everyone is B12 deficient but it should be worthwhile to try to determine if you are by trying this simple plan. Hopefully you are one of the lucky ones.

All the best,


Replied by Gord235
(Vancouver, British Columbia)

I would just like to add a note since my previous post. Although I have experienced much improvement following the protocol previously mentioned I am still looking for something better as I still experience some flareups. I've spent a lot of time watching Youtube in search of the 100% cure but it seems to be elusive. I tried baking soda and ACV but it didn't seem to make a difference. Then I heard that cassian cinnamon would do the trick, then it was benfotiamine that was declared to be the holly grail. In conclusion I think that the best we can do is to stick to the most popular cures mentioned on this site. I am currently holding out hope that ALA will deliver on it's promise to promote nerve healing in the long term. Best wishes to everyone.

Painkillers for Peripheral Neuropathy

Posted by Denise (Seattle, Wa) on 06/06/2013

To Art from Vancouver: Art, I also have hep-c and peripheral neuropathy. I see where you take oxycodone or oxycontin?. I am considering taking it as I have tried everything and have much much pain 24/7 and stabbing things all day and night.. It's horrendous.. How much oxycodone or whatever are you taking and how do you deal with constipation? How are your liver enzymes doing taking that? And what are they now if you don't mind sharing. Thank you much...

Replied by Art
(Vancouver Bc., Canada)

Dear Denise. I take Oxycodone for a problem related to Rhumatoid Arthritis in the knees. 10mg 3 times at night. My liver enzymes have returned to the normal range below 40 since taking Chanca Piedra 500mg once daily at different times with food. I have been taking BHT for over a year now at 350mg once in the night. My Liver Enzymes were over 300 previous to that. This Peripheral Neuropathy is new to me with a burning sensation above the knees with very sensitive toes making cutting toe nails painful. There is also a pressure sensation in the back of my hands. I use R-ALA at 200mg 3t times a day with food and B12 1, 000mcg near 9pm on an empty stomach. This seems to have it under control but not healed, if I miss a dose I will have the symptoms return, being very unpleasant.

The Oxycodone does not help with Peripheral Neuropathy, at least not my kind but it may help you. The thing is you will have to try it to find out but I would not recomend it. In the event you do, there is a generic supeudol very cheap and fast acting. The patent OxeNeo is 4 times the cost and very slow to act. As for the constipation, I have had it for over 30 years and can go for 4 days without a bowel movement, at which point I need a laxative to help. Eating bran in the morning helps but I am not regular. Good luck with your situation.


Replied by Trudyg
(Waynesboro, Va, Usa)

For arthritis pain, I take serrapeptase several times during the day away from food--it really helps with pain.

Replied by Art
(Vancouver Bc., Canada.)

Dear Trudyg. From what I know, the Serrapeptase you are taking is only recommended for 4 weeks use and has drug interactions with blood clotting.

How long have you been taking it?


Replied by Carly
(Seattle, USA)

Dear Art, your information is incorrect. I have been taking Serrapeptase daily for about a year now. Not only is it fine to take long term... It thins the blood. In fact, it is recommended that a person discontinue it a week before elective surgery for that reason.... I researched the daylights out of it before I started taking it. It is totally safe, and has been used in Europe for the past twenty five years. It is amazing stuff. I plan on taking it every day for the rest of my life.

Please do not spread misinformation. Read more, from websites that are credible... Not just blogs some people put their opinion on. Facts and reliable sources are needed when saying things such as you did. Thanks.

Replied by Art.
(Vancouver Bc., Canada)

Dear Carley, I thought I posted the link on this, from webmd which I would trust more than some one who has no data to back up what they say. Again read here.

Also one from lef. com

Says it MAY DO THIS AND THAT, and it acts like other nsaids thinning the blood and relieving the pain. Thing is it does not relieve all pain, and only works for short duration.

It may be your miracle drug, but I really hope visitors here do their research.


Replied by Tamara
(Fort Collins, Colorado)

Hi Art, while I agree with you that you should check your sources of information, no where on either of those links that you posted does it say that you shouldn't take Serrapeptase for longer than 4 weeks. All it says it that long term effects are not known. That just means that the only clinical trials done so far have been short term (<4 weeks) and long term efficacy studies have not been conducted. Absence of study does not mean that it doesn't work or shouldn't be taken. It just means that we don't have information currently to assess the risks or side effects, so caution is warranted. However, on the webmd link you posted, there are about 20 anecdotal reviews from people taking it, some for much longer, with mostly good effects. This is Earth Clinic, after all, which is based almost entirely on anecdotes!

Replied by Gord235
(Vancouver, British Columbia)

Art, I checked your link to Web MD and could not see anywhere where long term use of Serrapeptase is cautioned against. I am taking 960,000 SU (8 capsules) per day and it is helping quite a bit with about a 90% reduction in pain.

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Posted by ekvaughn (mcneal az) on 12/20/2022

Hi Art,

You listed 5 vitamins that are good for peripheral neuropathy. Are there any combo pills out there so that I would not have to take so many pills at once?

Replied by Art
2073 posts


Unfortunately, Benfotiamine, Melatonin and ALA do not come with the B vitamins in them except you can find melatonin with B6 in it, but it is the wrong form of B6. You need the form of B6 called P5P.

You can find a vitamin B multi that will have B1, B6 and B12, but these do not have the more desirable form of B1 which is called Benfotiamine, they generally contain vitamin B1 in the hydrochloride form.


Physical Therapy

Posted by Paula (Salt Lake City, Ut) on 06/09/2013

Does anyone know if physical therapy will help with my peripheral neuropathy. I have tried everything to no avail. Thank you and God bless this site.

Replied by Mmsg
(Somewhere, Europe)

Paula, search google for "Katy Bowman" and ask her. She seems to be an expert in body alignment, which might help.

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Posted by Gord235 (Vancouver, British Columbia) on 12/18/2017

I have been using a simple exercise I learned on Youtube to give myself temporary relief from foot pain caused by Peripheral Neuropathy. Simply pump the front of the foot up and down 30 times and repeat this exercise three times a day or as required. This forces the circulation to increase in your leg and foot and will give quick relief from pain. It also works while pumping the heel up and down although pumping the the toes and front part of the foot is more effective.


Posted by Gord235 (Vancouver, British Columbia) on 10/03/2017

Serrapeptase For Peripheral Neuropathy

Serrapeptase is a relatively new treatment utilising an enzyme to remove non-living cells. This has a dramatic effect on reducing pain and inflammation. It has been used successfully in Europe for thirty years but is just becoming known in North America.

I have started with 120,000 SU (2 capsules) - twice a day and plan to gradually increase the dosage after watching several clips on youtube. I would be interested in hearing about any experiences by members who have tried it.

Replied by Gord235
(Vancouver, British Columbia)


I am now up to 960,000SU(8 capsules)per day of Serrapeptase after reading that 1,000,000 SU per day is not uncommon. I am also taking ALA 800mg (8 capsules) per day and continue to see improvement with the pain in my foot steadily decreasing in intensity and frequency. Take note that Serrapeptase needs to be taken away from food, either 1/2 hr. before eating or 2hr. after eating. Search Serrapeptase on Youtube for more information. Good luck to all.

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Posted by Betsy (San Diego) on 01/21/2014

HI Bill, I have peripheral neuropathy and have tried everyting to no avail and I do mean everything...I also have hepatitis-c which is under control...It has been suggested to me to take B-1 100 mgs 5 times a day...along with Serrapeptase 1000 mgs 5 times a day... along with MSM 20,000-40,000 unit five times a day and eat saturated fats, which kind of caught me off guard as I have always read that it's not good for you...My cholesterol is 135 which is low and maybe they have a point...It has also been suggested that I eat no high glycemic fruit which I'm already am doing... First time post although I have been on this site before...Respect your opinion and don't want to make any mistakes..Thank you and bless you 1,000 times...

Replied by Bill
(San Fernando, Philippines)

Hi Betsy...I would perhaps add Alpha Lipoic Acid(300 mgs twice a day at meals) Selenium(200mcg twice a day at meals) and acetyl Carnitine (500 mgs twice a day at meals) to your protocol. Adding a teaspoon of granulated lecithin(not the oil) twice a day before meals and taking B50 vitamins every day might also help you here.

I would also continue with your serrapeptase and MSM remedies as these will also be beneficial. I now cook all my own food in coconut oil(saturated fat) because I've been very impressed with its anti-pathogenic effects and it has also helped me to lose weight.

Unfortunately, since the neuropathy you have is most likely to be caused by the Hep C, then it might also benefit you to follow Oscar's simple BHT remedy against Hep C. Your low BP problems may also be as a result of your liver problems.

Replied by Damaris
(Miami, Fl)

Good afternoon, everyone and first of all Thank God for all those who have shared their experiences. My name is Damaris I was diagnosed with peripheral neuropathy 2 years ago the cause is unknown. For about three months I've been taking a vitamin that contains B1 & B12 AND R-Alpha lipoid acid. But I still feel in both feet numbness, tingling almost daily.

Also I reach that that capsaicin cream is really good to treat pain and discomfort anybody has tried?? Fernando please let me know if you continue taking add Alpha Lipoic Acid(300 mgs twice a day at meals) Selenium(200mcg twice a day at meals) and acetyl Carnitine (500 mgs twice a day at meals) to your protocol. Adding a teaspoon of granulated lecithin(not the oil) twice a day before meals and taking B50 vitamins every day might also help you here. How do you feel now because your comment was in 2014. Again thank everybody for all comments and Blessing.

Replied by Damaris
(Miami, Fl)

Bill, please let me know if you continue taking add Alpha Lipoic Acid(300 mgs twice a day at meals) Selenium(200mcg twice a day at meals) and acetyl Carnitine (500 mgs twice a day at meals) to your protocol. Adding a teaspoon of granulated lecithin(not the oil) twice a day before meals and taking B50 vitamins every day might also help you here. How do you feel now because your comment was in 2014.

Supplements, Transdermal Magnesium, Turmeric

Posted by Lily (Kelowna,bc) on 10/31/2013

I have been taking alpha lipoic acid, acetyl-L-carnitine, sublingual liquid Vit. B12 and omega 3's for about 10 months. I found the combination helped lots but I still had symptoms. My neurologist told me to add MAGNESIUM . After lots of research I bought a transdermal gel magnesium that I apply to my feet and lower legs morning and night.That helped more. Magnesium is best absorbed through the skin. I also take a dose or two of the effervscent magnesium each day. NOW I have added turmeric capsules 3 times daily and wow lots of relief .I have been adding turmeric powder to as many foods as are suitable too. Research says that if you eat something with black pepper when you take the turmeric it boosts the power of the turmeric.

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Posted by Preston (MA) on 10/07/2022

Has anyone has positive results wit "The Rebuilder." The people at the company tell me it does cure peripheral Neuropathy but I've been doing the treatment along with low level laser with very little or no results....I've been doing the treatment daily since last Feb..Thx in advance..the rebuilder cost $1,300.00

Replied by Andrea
(Springfield Missouri)

What is the Rebuilder? Is it a machine, an exerciser, or a treatment of some sort of medications or what? Thank you in advance if someone can answer my questions.

(Summers, Arkansas)

I haven't tried this Rebuilder yet but here's a website for it:

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