I tried 5-HTP and I can't really say it worked for migraines. I did find that it caused a bit of sexual dysfunction (and this is a noted side effect). Since it didn't really seem to work, I stopped it.
Gave it a fair trial. It did nothing
I was super excited about taking 5-htp, as I use Imitrex and from what I read 5-htp seemed pretty much like a natural Imitrex. Imitrex imitates serotonin and basically alters the body's pain reception for migraines. (or something to that effect).
5-htp is a precursor to serotonin, which means your body will take 5-htp, convert it to serotonin and it in theory will act like Imitrex. Though that's where the awesomeness ended for me.
I have a few major warnings for anyone interested in 5-htp:
1) You cannot use it if you are pregnant
2) You cannot use it with many anti-depressants
3) You cannot use it within about 24 hours before or after you use Imitrex. Both anti-depressants that increase serotonin and Imitrex that imitates serotonin used with 5-htp that creates even more serotonin can cause a serotonin overdose and can be fatal.
4) I did more research on it and it turns out that 5-htp is a chemical by-product of L-tryptophan, which is responsible for making serotonin in our bodies. They used to sell tryptophan supplements but after many people started developing eosinophilia-myalgia syndrome, an incurable muscle and blood disease, from these supplements, as they were tainted, they banned the sale of tryptophan supplements in the US. (This happened mainly due to one large manufacturer going cheap, but who's to say this won't happen again with 5-htp??)
There have already been a few cases of eosinophilia-myalgia syndrome being caused by 5-htp supplements to date and that got me thinking: "Is taking this 5-htp to hopefully have a cheaper more 'natural' form of Imitrex worth it?" I decided it wasn't worth it.
I just want to warn those who are thinking about taking 5-htp that just because it's natural doesn't make it safer, and just because they sell it doesn't mean it's guaranteed safe. Supplements are not regulated by the FDA and only get any attention once a lot of people get sick from it. Use the information we are given to make the best decision for you. I ended up finding that Mint essential oil works really well for me and with no serious side effects. (or any at all for me)
I hope this helps someone, it would have been nice to have this all written for me when I was researching it. :)