I started to have knee issues after gaining about 10 lbs. I had been about the same weight my whole life until I turned 34. Then, after being on anti-anxiety medication for a year, I started to put on the pounds! I figured out the extra weight was putting pressure on my meniscus when I worked out and spent the next few months losing the weight. Oh yes, I went off the medication too! I also massaged my thigh muscles (front and back) daily as I learned from my doctor that too much muscle tension causes stress on the knee as well. Long story short -- I went back to my original weight and haven't had any knee problems since then.