Oral DMSO Side Effects
1 day ago
Water retention and changes in urination frequency due to oral ingestion of DMSO
I'm 35 years old, I take DMSO orally since a couple of months ago. The reason was to increase supplement absorption, for health purposes such as anti-inflammation.
I was taking about 4 drops of 99.9% DMSO in 350-400ml of distilled water twice a day on an empty stomach, in the morning and before bed. I've stopped now, but I sometimes mixed it with supplements.
In addition, I routinely use supplements such as methylene blue, NMN, alpha-lipoic acid, spermidine, CoQ10, resveratrol, omega-3, magnesium, GABA, glycine, and melatonin—mainly those that support mitochondrial function and provide antioxidant benefits.
However, my body has recently started showing signs of water retention. Since I don't have a scale at home, I always weigh myself at the gym in the early afternoon or evening, and my weight has increased by 3-4 kg.Caffeine and potassium-rich teas, which used to have an immediate diuretic effect on me, no longer work as quickly. I also suspected kidney failure and heart failure, but the blood tests showed no abnormalities.However, for some reason, I don't really notice much edema in my body. Since I have a job that requires standing, I feel my legs are slightly swollen after work, but there's no noticeable edema.
I don't have any problems going about my daily life, but the pace at which fluids are expelled as urine is slow, and I wake up 2-3 times during the night to use the bathroom. Each time, I urinate the maximum capacity my bladder can hold. This happens every 3-4 hours. It might also be related to the fact that I was dependent on Ketamine, marijuana, Kratom for several months and was taking high doses every night.
It's been 4 days since I stopped ingesting DMSO, and my symptoms haven't gone away. Since I'm continuing to apply it for dental treatment, I can't say I've completely discontinued use, but I have stopped oral intake. After doing some research, I heard that DMSO can sometimes cause fluid retention. Does anyone have similar experiences from DMSO intake, or have you heard about such cases?
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I remember watching a video about how one should add a specific amount of healing ingredients to a specific amount of water when doing a foot soak but I forgot the ratios and can't find the video.
In the video it was claimed that if one mixes to much or to little then there will be less or no absorption and less or no detox.
Anybody knows how much healing ingredients should go with how much water in a foot soak?
Thank you
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2 days agoHi Michele,
Two other things you can try while testing the oral borax are mag oil or melatonin lotion.
Here is a link to a typical mag oil spray :
Here is a link to how to make melatonin lotion and what it has shown benefit for :
https://www.earthclinic.com/supplements/melatonin-lotion.html
The two topicals can also be used simultaneously.
Melatonin has shown benefit for tendon issues as discussed here :
https://pmc.ncbi.nlm.nih.gov/articles/PMC7714296/
Here is a relevant quote from the article :
' Exogenous melatonin application in overuse tendinopathy reduces oxidative stress and inflammation. Melatonin might be an alternative potential molecule to corticosteroids in the treatment of chronic tendinopathy. '
The use of melatonin lotion instead of oral melatonin will allow you to reach very high local tissue levels in your fingers and hand that are not possible with oral melatonin.
Magnesium has anti inflammatory effects and may help the tendons as discussed here by Google :
- Reduces inflammation: Magnesium has anti-inflammatory properties that can help decrease inflammation in tendons, a common issue in conditions like tendonitis.
- Aids in tissue repair: It helps activate enzymes necessary for injured tissue repair and plays a role in nerve impulses for muscle contraction and relaxation.
- Promotes muscle relaxation: By helping to relax tense muscles and reduce spasms, magnesium can provide relief for the muscles surrounding an injured tendon.
- Improves circulation: It can improve blood circulation to the muscles, which aids in healing and recovery.
- Inhibits calcification: Studies indicate that magnesium can help inhibit the calcification (hardening) of the extracellular matrix in tendons, which is linked to a decrease in the magnesium-to-calcium ratio.
- Attenuates fibrosis: Magnesium ions have been shown to reduce fibrosis (scarring) in tendon grafts after surgery.
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Similarly to melatonin lotion, mag oil allows you to reach higher local tissue levels compared to oral magnesium.
Please keep us posted on your progress!
Art
Borax Treatment for Trigger Finger Not Yet Working
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3 days ago@ Hollyhock
Here is what the Amish say about Olive leaf tincture.
OLIVE LEAF - The Olive Leaf in liquid extract form is renowned for defeating harmful micro organisms. As an antibiotic, it proceeds with equal ability against virus and bacteria and many types of fungal parasite problems. The Olive Leaf possesses the ability to disrupt the virus when it tries to reproduce and stops it in its tracks. Users also report other categories of improvement, including increased energy with repair of heart and circulatory problems, and normalized blood pressure. Freedom from recurrence of colds and flu with fatigue and muscles soreness, demonstrate Olive Leaf's role in strengthening the immune system's scavenging ability.*
DOSE:40 to 80 drops (3) times per day. 40 drops per day as a maintenance. 40 drops hourly, if continued antibiotic relief is needed.
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3 days agoRe: Melatonin Gel
3 days agoHi Alan,
Melatonin does not scavenge or chelate titanium, which may be the metal used in your ankle. Melatonin does however offer anti inflammatory effects that may apply against inflammation caused by titanium as discussed here :
Here are two very relevant quotes from the link :
' In this study, we examined the potential inhibitory effects of melatonin on titanium particle-induced inflammatory osteolysis (the destruction of bone tissue through bone resorption) in a murine calvarial model and on RANKL-induced osteoclastic formation in bone marrow-derived macrophages. We found that the exogenous administration of melatonin significantly inhibited wear debris-induced bone resorption and the expression of inflammatory cytokines in vivo. Additionally, melatonin inhibited RANKL-induced osteoclast differentiation, F-actin ring formation, and osteoclastic resorption in a concentration-dependent manner in vitro. We also showed that melatonin blocked the phosphorylation of IκB-α and p65, but not IKKα, and significantly inhibited the expression of NFATc1 and c-Fos. However, melatonin had no effect on MAPK or PI3K/AKT signaling pathways. These results provide novel mechanistic insight into the anti-inflammatory and anti-bone resorptive effects of melatonin on wear debris-induced bone loss and provide an evidence-based rationale for the protective effects of melatonin as a treatment for peri-implant osteolysis. '
' Wear debris-induced chronic inflammation, osteoclastic activation and osteoblastic inhibition have been identified as critical factors of peri-implant bone loss. We previously demonstrated that melatonin, a bioactive indolamine secreted mainly by the pineal gland, activates Wnt/β-catenin signaling pathway and enhances bone regeneration at osteolytic site in vivo. In the current study, we further demonstrated that melatonin significantly suppresses wear debris-induced bone resorption and inflammatory cytokine expression in vivo. In addition, melatonin inhibits receptor activator of nuclear factor kappa-B ligand induced osteoclast formation and osteoclastic bone resorption in vitro. Meanwhile, we found that melatonin mediates its anti-inflammation and anti-bone resorption effects by abrogating nuclear factor kappa-B activation. These results further support the protective effects of melatonin on wear debris-induced peri-implant bone loss, and strongly suggest that melatonin could be considered as a potential candidate for the prevention and treatment of wear debris-induced osteolysis and subsequent aseptic loosening.
Based on this, it seems worth discussing with your doctor whether testing topical melatonin lotion or melatonin gel on your ankle area will be a good option for you to reduce the swelling, inflammation and bone destruction you are experiencing while offering potential bone repair effects as discussed in other studies. If your doctor agrees, here is how to make melatonin lotion :
https://www.earthclinic.com/supplements/melatonin-lotion.html
And how to make melatonin gel :
https://www.earthclinic.com/supplements/melatonin-gel.html
Keep us posted on your progress!
Art
