Serrapeptase: Reviews, Dosages, and Side Effects

| Modified on Mar 11, 2023
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Serrapeptase, a nutritional supplement, is an enzyme derived from silkworms.  This enzyme breaks down non-living tissue, making it useful for a wide variety of conditions.  It is commonly recommended to remove plaque from arteries, dissolve scar tissue, decrease inflammation, dissolve blood clots, help varicose veins and heal cysts. Others have used it for lung disease, asthma and sinus problems, including polyps. It is also suggested for blocked fallopian tubes and varicose veins.

Serrapeptase Dosages

Serrapeptase can be bought in health food stores and online.  It is recommended to take one or two capsules one to three times a day on an empty stomach, with a glass of water.  Amounts in one capsule vary from manufacturer to manufacturer.  Some have as little as 40,000 Serratiopeptidase units per capsule. Others have as much as 120,000! When beginning a new supplement it is always best to start with the lowest dose and increase slowly to avoid side effects or detox reactions.

Serrapeptase Warnings

Reported side effects of serrapeptase include an increase in pain or worsening of symptoms. Side effects do seem to be rare for this supplement.
There are some people who should not use serrapeptase. For example, if you have had surgery for a hernia repair, the long term repair is dependent upon the scar tissue produced and attached to the mesh. Serrapeptase dissolves scar tissue, and this would be counterproductive for a hernia repair patient. Some cosmetic surgeries and procedures may also be compromised by serrapeptase use, including fat injections and face lifts. If a surgical procedure is supported by any non-living tissue, serrapeptase should not be used.

Serrapeptase Reviews

Earth Clinic readers have reported wonderful results when using serrapeptase as a natural remedy.

Trish from England reports: "I have suffered most of my life with sinus problems have had an operation were they drilled the bone at top of my nose had some relief for a short time but I was told to try serrapeptase and the relief has been brilliant I take 2 80,000 tablets morning and night and they have been excellent."

Amy from Michigan also had excellent results also.  She says, "Take serrapeptase 1-2 x daily on an empty stomach. It literally is amazing. When you are in pain, you will search for instant relief and this was it for me."

Please scroll down to see what Earth Clinic readers have experienced when using serrapeptase.

If you use serrapeptase, be sure to share your story with us!

Blocked Arteries

1 User Review
1 star (1) 

Posted by Mike (Mudgee) on 09/04/2018
1 out of 5 stars

Used high doses of serrapeptase for almost 2 years to try and clear blocked carotid arteries, combining this with careful diet and exercise but with no apparent effect as checked with ultra sound.

Replied by Vlad
(New York)

Absolutely useless, I would not give it even one star. I thought I am protected with 120000 units, together with double dose of nattokinase, 200 mg), twice a day ( quite aggressive dosages) from clots, etc. My walking distance due to intermittent claudication would not improve, if not getting worse, which suggests that my PAD is progressing. After realizing that my headaches are caused with narrowing blood vessels I started again baby aspirin (which I previously thought I didn't need thanks to the above supplements) and my headaches miraculously stopped. I appreciate that serrap. helped rats, but it helped me like a poultice to dead body. I also tried citrus pectin, which was short of miraculous for swains' arteries (that research was also funded by NIH), but where are those swains, who saw them?

To be fair, not only these oral enzymes and pectin are useless; same results, if not worse, I got from NIH TACT study of IV EDTA, in which I participated in 2005, after which my 90% open artery successfully closed.

Eventually (for leg arteries) I had to turn for revascularization (no matter how much I wanted to avoid it), and now, three years later, my surgeon is quietly waiting for my return, because he knows damn well that despite all this hoopla about miracle supplements I will come back by the simple reason - I still cannot walk, nor I can spend all my life to develop sufficient collateral circulation.

I also hoped to get rid from sinus infection at the same time, so I stopped washing my nose with antibiotic solution. Regardless of that, and twice a day wash with saline solution after several months of getting nowhere, I realized that I again should start Wilson wash.

So it is not all gold which shines. Keep your hope, but at the same time keep looking for more established remedy.

75 posts

I was reading up on serrapeptase and first read 2 stories by users of the pill, then I read the horrible story about another that had high hopes on his Artery Plaque blockage being removed but unfortunately, it didn't help him. As a fair and objective person, I would say that one shoe size does not fit all and so he tried to no avail. There is no reason to bad mouth the product or messenger, they did the best they could, so did earth clinic, they all wanted you to succeed, I am sorry. Have you ever been helped by viewing this site? My son has had similar problems with different medicines, so I continue the search. It's been a few years, I hope you're doing well. Joseph

Lad S.

High dose Serrapeptase seemed an absolute miracle for my sinusitis, allergies and stuffy nose, and I was hoping it'd eventually help my PAD.

But I, and a friend I turned-on to it, both had synovial knuckle "blow outs" and subsequent cysts / bone-spurs while using it. This seems odd, since Serrapeptase is widely touted for join problems, but my friend recalled reading others online confirming this nasty side-effect.

I later learned from a hand specialist that it is the joint scar tissue that keeps the joints sealed and prevents cysts from returning. Seeing how Serrapeptase is also said to digest internal scarring, this is likely how it is bad for those with this joint condition. I wish Serapeptase was still available as a nasal spray formula so I could localize it's positive effects.

Pacific Coast Lady
(Crescent City, CA)
192 posts

I so hope this helps me. I just discovered the Serrapeptase on a video of Dr. Berg's. I have had awful post nasal drip for a couple of years at the least, maybe longer. I had to go with a Type 2 diabetic diet which made it better, way better, but still there and I worry about that constant drainage causing worse issues later on.

So I'm going to try it, but would you be kind enough to let me know about the enzyme and a good brand since I notice with many supplements, you have to get the "right" type, the real deal. I accidentally bought synthetic Vitamin C for example, then had to buy the whole foods type, again, the real deal ;)

Thanks much!!


Lad S. I have this sinus and joint condition you mention. I hadn't considered the joint thing was due to the serrapeptase though. Have you found any resolution? I've had surgery on a hand cyst only for it to return. My sinuses are some better. I'd like to find a natural cure for the synovial joint cyst though.

Pacific Coast Lady
(Crescent City, CA)
192 posts

I am on 120,000 spu's a day of Serrapeptase by Carlyle. I really have not noticed a difference in my sinus issue but am wondering if I am taking enough. I thought I had read somewhere (but can't find it now) that it does not absorb good, or not water soluble. So I think that means it should be taken with food. But I thought I also saw it should be taken on an empty stomach. Guess I need to do my homework much better. I'd like to hear feedback on how much others are taking, those that are getting results using it as an anti-inflammatory?

I'll keep taking mine but double the dosage and see if that sets well. I've been taking in after my breakfast as I don't do well taking "any" of my supplements on an empty stomach. Thanks in advance for any help at all on this :)

Pacific Coast Lady
(Crescent City, CA)
192 posts

I did have horrible sinus infection, over and over, and in 2010, I got one so bad I was in and out of emergency 3 times and they kept giving me antibiotics. I was so sick it finally effected my equilibrium, and I felt like I was in another world my brain was so clogged, I made it to my sisters house and used her computer and did a search for "alternative remedies for sinus infections" an ACV popped up. I knew my sis must have that in her cupboard so I went for it, drank a tbsp in very, little water, didn't care, was willing to try anything at that point. I went and laid on the couch and didn't feel well enough to read, or watch tv even. I'd been sick with this 3 solid months. All of a sudden I felt my head doing something, something inside my head. It was like the dam broke, or the cement must have just started melting, can't describe it. I began feeling normal that day, that night, and by the next day I was on the mend. I could fully tell. My cupboard is never without ACV, but I don't use it for every, little thing. And, I can say with all honesty, to this day I have NEVER had another sinus infection. I don't take it as a preventitive either so I don't know how it all worked, it just did. I will use ACV for upset stomach, or cramping from something I ate too much of maybe and it always works for that too.

Pacific Coast Lady
(Crescent City, CA)
192 posts

So far, since Nov. 1st, so just 21 days, I am not seeing a huge improvement in my post, nasal drip. Although, I haven't been kept awake gagging from it, and that is an improvement. I think it is loosening, not as thick. I know this sounds so gross, but I know there might be others out there suffering from this, so I want them to know if they come here and read. It feels as if I've been on the Serrapeptase much longer, but since I haven't, I will keep up the dosage I am on which is usually just one a day. I think I will try and up that to two, if I can just remember to take one at bedtime as well. I am hoping for a lower cholesterol # on my next labs as well, possible due to the addition of the serrapeptase as well. So if I take 2 a day, am taking 2 X 120,000 spu. I had to look up what that spu means, but it's a safe dosage from what I read. I'll be back after the labs are done in another month or so :)


Exactly. this is called pharmacogenomics. Pharmacogenomics is the study of the role of the genome in drug response. Its name reflects its combining of pharmacology and genomics. Pharmacogenomics analyzes how the genetic makeup of an individual affects their response to drugs. Steroids for example save lives to millions. It nearly killed me and my child. Should I badmouth Prednisone?

Replied by Jillery
(Durtham, Nc)
89 posts

There is a familial type of heart issues that are genetic and does not respond well the natural cures.... perhaps you are one of these types of people? I can see your frustration and I am so sorry. Keep up with good diet practices and supplements but take your meds, buddy. Virtual hugs.

Replied by Alan
(W Yorks)

Have you considered Nattokinase?

1 posts

I did find a naturopath answering your question that you missed.

Monday, 19 July 2021 | 8:25

We have not had any negative feedback in the last 21 years and millions of doses.


HI U P C LADY,,,,, ORH here and as usual have a story for you. In CHF and Sat week got up from my computer to do a chore and blacked out on our front steps. Neighbor is a retired EMT and checked me out. He told me to get to the heart hospital in Knoxville. Did so early Sunday morning and notified my cardiologist, who did an Angiogram. It was slick as a baby's butt, 7 years earlier. Following the procedure he told me that I was a poster child for EDTA Chelation because at 85 my heart and blood vessels were clean and amazing.

My problem is electrical. I am now on a heart monitor and another cardiologist will see if I am qualified for a Watchman device. Now think my Tractor Driver picked up Covid at the hospital. We have all the tools and that will be another story........ if so.

As usual, my advice to all is not to get old.


Pacific Coast Lady
(Crescent City, CA)
192 posts

Hi ORH, always nice to hear from you ;) My heart is still in TN for one reason, but the other, I always like what you have to share;) I have a pacemaker, and it is because of the "electrical" part of my heart is how it was explained to me in terms I could understand ;) It is officially called a 3rd degree AV Node block. Since 97 I have had no issue at all due to the packmakers (I've had 3, one was replaced in Florence AL. I think my issues could be a lot of things, and I don't want to live to long in the world the way things are now. I truly miss the South, and would live there again if I could, but this is probably it for me so I will just be grateful for that. I do look forward to seeing if my cholesterol numbers go down even though I didn't know Serrapeptase was good for that supposedly, but hoping it helps with a few things that are caused by inflammation (like what isn't right). I am keeping my diabetes #'s down, for almost a year now on a keto diet. Also down to my normal weight which will help in a lot of areas.

Glad you so like you are getting things checked out. Do come back and let me know, would love to hear from you again, PC Lady ;)

Pacific Coast Lady
(Crescent City, CA)
192 posts

Can anyone tell me what the difference is between Nattokinase and Serrapeptase? They sound the same to me when I look them up but I would love to hear from someone that has had success with either, or both?


Natto and Serrapeptase enzymes are often closely compared and sometimes combined in remedies. BUT I URGE CAUTION TO READERS OUT THERE.

See my earlier comment about how Serrapeptase may actually damage joints further.

Using Serrapeptase to dissolve internal scar tissue can normally be a good thing, (ie endometriosis) unless that kind of scarring is also what patches-up joint damage (ie, splits in synovial tissue layers). Then it can cause more problems. A friend and I both found this out the hard way, repeatedly.

Another thing I am now very surprised to read is that Serrapeptase helps produce more Tumor Necrosis Factor - Alpha (TNF-A).

TNF-A has benefits in normal, youthful balance. BUT, it often gets overproduced with age and really contributes to autoimmune disorders and joint damage.

This may have been another reason why Serrapeptase, (for all its good benefits), was so awful to me and my friend's finger joints. This was in spite of my friend, at first calling it a "natural Ibuprofen." The damage soon followed.

I personally suspect the same, potential joint problems with other, inflammatory-reducing proteolytic enzymes I tried since then. It's just they are not as strong as Serrapeptase.

I would also be very wary of trying Serrapeptase to treat Rheumatoid inflammatory symptoms, because these are often treated with anti TNF-A drugs instead.

But so far, I've not noticed any of these concerns from using Nattokinase alone.

Natto seems to have noticeably improved my leg circulation, which is great news, but that's about it

It still doesn't help my allergies and sinuses like Serrapeptase miraculously did - (but at least it's not further injuring my hands.)

I hate throwing cold water on all the good things about Serrapeptase because it really benefited me too. But it also can have a pretty severe Dark Side for some conditions. So, you've been warned...


1 User Review
5 star (1) 

Posted by Karen (Ma) on 09/04/2018
5 out of 5 stars

I listen to a holistic radio show hosted by naturopaths in Massachusetts and they recommend taking serrapeptase supplements if you are in the beginning stage of cataracts. They also said you can take it to prevent cataracts.


1 User Review
5 star (1) 

Posted by Cheryl (Rochester, Ny) on 09/04/2018
5 out of 5 stars

Serrapatese. I started taking about 7 months ago to help clear arteries. Interestingly I had a golf ball size cyst or lump just above my hip bone about the same time. I decided to try my own thing which involved rubbing it with castor oil every night and morning limiting my progress to a 5 week check if no progress I would go to the doctors.

To my amazement cyst was half the size. Nose polyps are gone too. In July I kept forgetting to take it and the cyst laid stagnant. I tried to remember what I was doing and realized it was the serrapatese. 1 month later almost gone. Funny thing with home remedies is that sometimes one doesn't know that they are working until you stop taking it. Lobellia and Muellein for respiratory same story. Stopped my drops woke up congested..hadnt't done my muellein and lobelia routine. Hope this helps.

Ear Fluid

1 User Review
5 star (1) 

Posted by Lyn (Heber) on 09/06/2018
5 out of 5 stars

My doctor recommended serrapeptase for drying the fluid in our ears. It worked!


1 User Review
5 star (1) 

Posted by Sue (Ks ) on 09/05/2018
5 out of 5 stars

I have only used serrapeptase for two cycles of 4 months each but have found really good results for my endometriosis. I found that it dissolved the cysts or clotting that was or had occurred. My first menstrual cycle was painful as the cysts were actually leaving my body, however every cycle after that was less and less painful until there was no pain. My cycle was also shorter. The first week I initially felt flu like symptoms which I was told to expect -dull headache, just slightly unwell feeling- I pushed through. Glad I did. I took one tablet x two times a day. I started on the 40,000. I am about to try the higher dose soon. I believe it did work well. I would recommend it to women suffering from endometriosis for sure. I will update my review after a few months on the higher dose. Make sure you take it away from any protein foods on an empty stomach.

Gastro Issues, Weight Loss

1 User Review
5 star (1) 

Posted by Tisha (Atlanta) on 07/17/2017
5 out of 5 stars


Serrapeptase (enzyme) takes care of fibroid, blocked fallopian tubes, I cant confirm IBS but it did help with my gastro issues. My tummy went down 3-4 inches just in a month of taking it.


1 User Review
5 star (1) 

Posted by Trudyg (USA) on 05/30/2013
5 out of 5 stars

For hemorrhoids - you can take serrapeptase --an enzyme that digests tissue such as scars, hemi's, etc. I take one first thing in the morning, no hemi's since then. Also, no knee pain from old injury.

Knee Pain

1 User Review
5 star (1) 

Posted by Matt (Cambridge) on 09/04/2018
5 out of 5 stars

I agree serrapeptase is amazing. I have stiff and painful knees from decades old meniscus tears in both knees. I started taking serrapeptase two months ago. One capsule (120,00 SPU) once a day on an empty stomach. Within a few days my knee pain disappeared. Whereas a couple of months ago I couldn't get up from a movie theatre or airplane seat without limping down the aisle from stiffness, I now had zero pain. I couldn't sit kneel and pull weeds from the garden. This summer I could. I ran out of capsules and didn't replenish my supply about two weeks ago and the knee pain and stiffness returned after about 10 days. So I will resume taking this supplement asap.


1 User Review
5 star (1) 

Posted by Caski (Herts, UK) on 09/05/2018
5 out of 5 stars

I have used Serrapeptase to reduce mucus. It definitely has an effect, noticeable if I stop taking it or forget to take in on holiday with me. It does clear the mucus from my lungs and I feel less chesty. Useful for COPD patients.

Cutting out dairy also helps too.

PS I take Natures Best 250mg​

Nerve Pain and Scarring

1 User Review
5 star (1) 

Posted by Linda (Washington) on 02/01/2023
5 out of 5 stars

Serrapeptase is a miracle I stumbled upon when faced with a very painful double nerve surgery at elbow and wrist attempting to find a holistic pain relief and no drugs after surgery plus eliminate scar tissue, when it was difficult to find in US. In Europe and Great Britain - prescription only. has a lot of info on this natural enzyme.

Dr Hans Nieper, a famous German heart Dr and researcher, made this discovery - he gave large doses to these blocked heart patients that normally he would have done bypass surgeries. These large doses were to eat the plaque and he did not perform the surgeries. Dr Nieper and parents were all Drs - now deceased, made a lot of other discoveries I suspect it could be possible people with side effects might have ordered an off brand (maybe Chinese-or possibly the ingredients are from China) that caused their issues. I have several of Dr Niepers books. He was a blessed genius.

An example of eating scar tissue: My appendix was removed in 1951…..ugly raised fat scar until 2010 when I discovered this miracle for my hand/elbow surgery. All my scars are now thin white lines. One day I scratched my stomach and huh??? If scar crosses nerves or lays along side - common sense is scar tissue grows and presses on nerves causing pain. The elbow took a year for the pain to diminish and for the pain to go, but they moved the nerve.

I never have had an issue with serrapeptase, but maybe it is me that handles it well or the brand. Wish you well!


1 User Review
5 star (1) 

Posted by Amy (Metro Detroit , Michigan) on 02/25/2013
5 out of 5 stars

Take serrapeptase 1-2 x daily on an empty stomach. It literally was amazing. When you are in pain, you will search for instant relief and this was it for me. Also take B complex and turmeric daily, message with magnesium oil or take Epsom salt baths or foot soaks. Plus add a cushion to your shoes. This really works!


Posted by Maria (Gippsland, Australia) on 12/01/2011

I have seen great results with serrapeptase on abdominal surgery scars (30 yr old).

Serrapeptase and Surgical Implants

1 User Review

Posted by Elaine (New Jersey) on 03/17/2021
0 out of 5 stars

I read the information provided by earth clinic on natural remedies for abdominal adhesions. I was hoping that you could help me understand and perhaps make a few suggestions for two of my relatives.

In the article, it said that serrapeptase should NOT be used for people who have implants. Can you explain this in more detail to me? After surgery, my relative had a titanium surgical steel implant put in her neck. Lymph nodes began to swell on both sides of her neck and they cannot figure out why this is happening. She does take serrapeptase. My theory is the serrapeptase is affecting the surgical steel and her lymph nodes are trying to filter something that has become dissolved from the steel. I am wondering if this is possible. The surgery caused scar tissue for another of my relatives. He also has implants.

What can he use to try to prevent the growth of new scar tissue which results from the surgery to remove the old scar tissue. If you can suggest something that could be used, would it still be effective even after a period of time that the body has had to heal after his recent surgery? At this time, no natural remedies have been given, therefore scar tissue has probably begun to form.

If you have some suggestions, I would be very grateful. Thank you

Replied by Earth Clinic

Hi Elaine,

That is a great question, thank you. We reached out to the author of EC's article on Abdominal Adhesions as we couldn't find the source for that warning. Here is her reply:

I wrote that as an "err on the side of caution/first do no harm" warning.

It is perhaps too broad a caution and was not based on a particular source that I recall. I think I put the caution in bc I couldn't confirm that serrapeptase would be safe with implants. It was based on inference. i.e - if serrapeptase dissolves non-living tissue and most implants are made of non-living tissue, then it seems prudent to avoid substances that dissolve non-living tissue. Of course, serrapeptase doesn't dissolve all non-living tissue, but most people don't know what their implants are made of...and do we know everything that serrapeptase dissolves?

For example, I would be concerned about using it in conjunction with certain types of hernia mesh -

"Animal-derived mesh are made of animal tissue, such as intestine or skin, that has been processed and disinfected to be suitable for use as an implanted device. These animal-derived mesh are absorbable. The majority of tissue used to produce these mesh implants are from a pig (porcine) or cow (bovine) source."

Hernia Surgical Mesh Implants | FDA

Replied by Mama to Many

Dear Elaine,

From what I have read, I don't think that serrapeptase would break down metal, but I haven't done an exhaustive study on it. There are plenty of other possible causes of the pain.

Castor oil can be used to reduce scar tissue. As can comfrey. You may be able to find a salve that contains both or make your own. Many people take comfrey internally to reduce pain and promote healthy cell growth. I grow comfrey and put the leaves in smoothies all summer long.

Other anti-inflammatory/pain remedies would include turmeric, cayenne, and ginger.

I have recently found that baking soda in water once or twice a day is good for pain. Pain seems to thrive in an acidic environment.

Low water intake and sugar intake can also provoke pain.

Castor oil is also helpful for swollen lymph nodes, as is peppermint essential oil. (Be careful not to get this in the eyes! )

I hope you find some things to help your relatives!

~Mama to Many~

Replied by Katzie

For scarring, it is important to keep the area moist as this increases cellular turnover. I have used Castor Oil to remove many a scar, both old and new - though if you use manuka honey while the skin is knitting, there won't be much scarring. Any moisturizing oil is good, but Castor is the best. It takes at least 6 months to see a difference in colour. Remember also, that there is alot of action going on behind the scenes at a wound site, for up to a year! So if you start applying the Castor Oil 2x a day right away, that should mitigate scarring, as well.

Replied by Barb

I had surgery in 2018 and later was having pain from adhesions. A friend who was well-versed in the use of essential oils suggested massaging castor oil (organic) into the spots that were hurting. Worked very quickly. You also can use frankincense oil

Serrapeptase from China

3 User Reviews
5 star (1) 

Posted by peggy (northern california) on 05/20/2021
0 out of 5 stars

Re: Serrapeptase for Ascites

just fyi - I have been taking serrapeptase for about 15 years - sometimes over a million units in a day with absolutely no side effects. The brand I used sold out to a chinese corporation. I was not aware of that and purchased it after not having used it for a year. about 45 minutes after taking 2 capsules I experienced severe stomach cramps and nausea which lasted for about six hours. duckduckgoed it and found the China connection. threw it away and got my money back.

Recently tried another brand that stated 'made in USA which I know can mean 'assembled in USA from ingredients sourced from China. took two capsules and again experienced severe stomach cramps and nausea which lasted for three days. just contacted the company and asked if any of the ingredients were sourced from China. response:

'Could you please give me a call? Your question can be interpreted in a number of ways, and I'm not sure how to answer it in a concise manner.'

That answered my question in no uncertain terms. Threw it away.

Serrapeptase is a wonder supplement on so many levels. But there is a very good reason for people wanting their supplements to be 'china free'. I will now have to try another brand because it is well worth the trouble. I would very much like to name the two brands that made me sick but do not know if that is allowed. Just in case - they were Drs. Best and restoreActive

cheer and good health to us all -


Replied by Krysia
(Glenview, IL)

Can you tell which brands you did use that were good? Thanks

Replied by RH

Krysia, I have not had issues with Dr.'s Best and I have also purchases SerraGold and have no issues with that brand either.

Serrapeptase from China
Posted by Charity (Faithville, Us) on 11/05/2018
0 out of 5 stars

I spent much time reading amazon reviews today and there is a pattern of people using products in the past year that get horrific diarrhea and vomitting and having to go to ER after two perfect ~happy satisfied customer~ weeks of use of the product . Heads up . There is talk of a lawsuit. I am a little scared now, I was doing great and used 45 pills so far. Is it russian roulette. Now I feel a need to warn people incase their is a bad supplier, mine is Doctors Best and one commentor said the company was sold but I don't know?

Replied by Robert Henry
(Ten Mile, Tn)

HI U OLE PATOOTS DOIN,,,,,,,,,,, have no clue what this means, but Dr's Best is now a Chinese company. Don't have good vibes abut that.


Replied by Deirdre

I noticed about two months ago, when I went to buy more serrapeptase on Amazon, that there's an increase in negative reviews about Doctors Best Serrapeptase brand increasing from April, 2018 on. I am not convinced they are genuine reviews; a few too many about being violently ill and at least one suggesting you contact them to start a class action suit.

All sorts of issues on Amazon coming to the surface. Not just fake reviews, which is an old problem, but more fake supplement brands being sold by third parties. Here's a link to the 1 star reviews for Dr's Best Serrapeptase in case anyone is interested.

Check out how many negative reviews since April!

Replied by Frances
(Cabarlah, Qld.)

I've been using Doctor's Best Serrapeptase for quite and some time and have had no complaints.

Replied by Art
1658 posts


I agree on the fake third party brands that are being sold. I bought a two pack of eye drops that I wanted to use for a recent experiment. Both bottles were supposed to be from the same lot and should have had the same batch numbers on them, but they were different. I opened one and it had the smell of mildew which I had never noticed in any other eye drop solution before then, so I opened the other bottle to see if it also smelled like that. It didn't, so I wrote the supplier and explained the problem to them. They responded by asking if I wanted a refund for the bottle that smelled like mildew. I told them no, that I would send the bottles back and they should send me a pre-inspected replacement pair. They told me to keep the bottles and that they would refund my credit card. That response told me that they were aware of the problem before I ordered their product!

I feel like I should have contacted, Systane, the original manufacturer of the product and let them know what was going on, but I got busy and forgot about it.

Clearly, there seems to be issues with fake goods! The product I received looked just like other bottles of Systane that I have used in the past. It worries me because what if I had had a cold and could not have smelled that mildew smell? What could it have done to my eyes had I used the whole bottle?


Replied by Charlottechick
(Charlotte, Nc)

WHAT?! Doctor's Best has recently been my "go to" manufacturer! I just found this:

Doctor's Best CEO Gale Bensussen

Doctor's Best is now owned by the Kingdomway Group, a publicly traded company in China. The primary reason Kingdomway purchased Doctor's Best was to provide an authentic, manufactured in the USA brand to the rapidly expanding market in Asia. U.S. brands are considered to be of the highest quality and are sought after in those markets.

Therefore, it is fundamental to Kingdomway's investment that the brand not only maintain its authenticity and integrity, but continue to be manufactured in the USA. There have been no changes in the staff, sourcing, or our quality standards. Doctor's Best is headquartered in California and our manufacturing is done in the USA and will remain in the USA.

We appreciate the trust our consumers have in our brand and we will maintain our brands' quality and integrity as our pledge to our consumers.

Gale Bensussen CEO

Replied by KT

I purchased Serrapeptase from Does anyone else purchase anything from this site?


(Knoxville, Tn)

I used to buy from them years ago, now I buy serrapeptase 40K 'best naturals' from amazon for last 5 months. Had been using 120K 'source naturals' for last couple years. Switched due starting to get too many 'cherry angiomas'.

Replied by KT

Years ago they came in tablets and I stopped taking them due to the "inactive ingredients", one of which was a calcium ingredient and enteric coating. I don't know when they changed to capsules but the fillers have changed from being six to just two and appear to be safer. I don't ingest the capsules.


Replied by Pearl

Interesting that half the reviews on this EC page are from 9/4/18 and 9/5/18. I think we're all accustomed to watching Amazon for that kind of behavior because it suggests fake reviews, but I didn't think it would affect my favorite site, Earth Clinic.

I just ordered my 2nd bottle of Dr's Best 40,000 from Amazon, but I wanted to check the EC comments because both my husband and I got bronchitis really bad while taking it a couple of years ago. We'd never taken it for longer than a week before that. It quite certainly may have been a coincidence since it was January and that was going around, but we both ended up really sick and I got scared of taking it for awhile.

I'm starting to think if it sounds too good to be true it just might not be.

Replied by Jillery
(Durtham, Nc)
89 posts

Oy veh Robert Henry!! I think this is a good thing to keep our eyes on. The is a good response from another writer that makes me feel better about Dr's Best but but but. Do you recall the scare when powered plastic was being put in baby formula.... I think in the 60s or 70s. Always be aware of ALL companies no matter where they are located. Peace baby Peace

Replied by Prioris
5 out of 5 stars

So far, I have seen no quality drop from doctors best. In China, US and foreign brands are prized because of quality. China has an quality control problem INTERNALLY for it's domestic market due to cost cutting. There is a LACK OF TRUST by China's population regarding iNTERNALLY produced products. I can understand why it would buy the supplement company.

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