I agree serrapeptase is amazing. I have stiff and painful knees from decades old meniscus tears in both knees. I started taking serrapeptase two months ago. One capsule (120,00 SPU) once a day on an empty stomach. Within a few days my knee pain disappeared. Whereas a couple of months ago I couldn't get up from a movie theatre or airplane seat without limping down the aisle from stiffness, I now had zero pain. I couldn't sit kneel and pull weeds from the garden. This summer I could. I ran out of capsules and didn't replenish my supply about two weeks ago and the knee pain and stiffness returned after about 10 days. So I will resume taking this supplement asap.