I have only used serrapeptase for two cycles of 4 months each but have found really good results for my endometriosis. I found that it dissolved the cysts or clotting that was or had occurred. My first menstrual cycle was painful as the cysts were actually leaving my body, however every cycle after that was less and less painful until there was no pain. My cycle was also shorter. The first week I initially felt flu like symptoms which I was told to expect -dull headache, just slightly unwell feeling- I pushed through. Glad I did. I took one tablet x two times a day. I started on the 40,000. I am about to try the higher dose soon. I believe it did work well. I would recommend it to women suffering from endometriosis for sure. I will update my review after a few months on the higher dose. Make sure you take it away from any protein foods on an empty stomach.