Top 10 Health Benefits of Nattokinase

| Modified: Jun 19, 2020
Add New Post Top 10 Benefits of Nattokinase

Nattokinase is a health supplement that is derived from a fermented soy product. Nattokinase is used as a natural remedy for a variety of circulatory conditions, fertility issues, and problems caused by inflammation.

To make "natto," soybeans are fermented with the bacteria bacillus subtilis natto.  The resulting food is an acquired taste for many people. It has a strong flavor in addition to a slimy texture. Nattokinase is the enzyme that is derived from the natto. A nattokinase supplement provides the benefits of natto to those who, for whatever reason, do not want to incorporate natto into their diet.

What Can Nattokinase Do for Me?

1. Lower Blood Pressure

Nattokinase thins the blood and dissolves accumulated solids in it. Consequently blood pressure is lowered.

2. Reduce Pain

Because of its anti-inflammatory effects, nattokinase has been used to help with pain from arthritis, including that of rheumatoid arthritis. Women with painful periods, especially if the pain is caused by fibroids or endometriosis, may find that their pain is reduced with a nattokinase supplement.

3. Dissolve Clots 

Because nattokinase is an enzyme, it can dissolve proteins like fibrin, which are a cause of clots and blockages in the blood in the first place.

4. Facilitate Brain Function

Because nattokinase thins and cleans up the blood the resulting improved circulation improves oxygenation to the brain. This can reduce brain fog and may lower the risk of Alzheimer's disease.

5. Assist Vision

Nattokinase have been used to treat cataracts and eye floaters because of its ability to dissolve proteins and fibers that are the cause of these eye issues.

6. Increase Fertility

 Fibroids and endometriosis are both chronic and painful conditions that can cause infertility.  Nattokinase can be used in these conditions to help dissolve the fibroids and endometriosis.

7. Improve Libido

Because nattokinase improves circulation as it thins bloods and breaks up congestion, it is helpful for low libido in men, especially when the low libido is caused by poor circulation.

8. Eliminate Migraines

Migraines can have many causes. For those whose migraines are caused by thick blood and poor circulation, regular use of nattokinase can solve the root cause of migraines.

9. Relieve Edema

A common theme edema is poor circulation. Because nattokinase improves circulation, a benefit of nattokinase is a reduction in edema. Clots in the legs (deep vein thrombosis) can also cause edema. Nattokinase addresses this cause of edema as well.

10. Heal Varicose Veins

The blood thinning and oxygenating properties of nattokinase make it an appropriate remedy for varicose veins. Hemorrhoid sufferers will be glad to know that nattokinse works for hemorrhoids as well since hemorrhoids are a type of varicose vein.

Is Nattokinase a Stand Alone Supplement?

While nattokinase is a powerful supplement that can help a variety of health conditions, most people will find that it works best as part of a holistic approach to health.

If you are taking nattokinase for a serious health problem, you need to address any dietary or lifestyle choices that have caused the health problem in the first place.

Nattokinase is most likely to help you if it is one part of a healthier you. A good diet, daily exercise, sunshine, adequate rest and proper hydration are also important components of good health.

Is Nattokinase for Everyone?

If you have hypotension, nattokinase may not be appropriate for you as it can lower blood pressure.

Because nattokinase thins the blood, those on blood thinners or who take aspirin should not take nattokinase without careful supervision of a doctor.

If you bruise easily or are prone to nosebleeds nattokinanase is not recommended because it can make these problems worse.

Those with bleeding disorders or blood conditions (like ITP) should not take nattokinase as it can make your bleeding issues worse.

Women may find that the blood thinning effects of nattokinase makes their periods heavier. Women with heavy periods may need to avoid the use of nattokinase, especially right before and during their periods.

Because nattokinase is a soy based supplement, if you have a soy sensitivity or allergy, nattokinase should be avoided.

Have you tried nattokinase? We would love to hear from you!

Additional Pages of Interest:



Atrial Fib

Posted by Pat (Pa) on 03/31/2017


Does anyone know how much Nattokinase to take everyday for blood thinning? I don't know whether to take 50mg daily or if I need 100mg daily? I also take VitE, Garlic and a good Fish oil but thought I should start that also! Don't want to go on Pharmaceutical blood thinners! Don't like that idea!

Replied by Robert Henry
Ten Mile , Tn

PAT,,,,,,,, I have no clue, but I take one capsule a day that is 2,000 FU / capsule. I take that because that is what my integrative doctor gives his wife for her A FIB. I take one Rx and several other supplements that are in EC's archives. I do bruise easily, but maybe that goes with age.


Replied by Pat

Thanks, but what is 2000 FU? The Nattokinase I find is 50 mg or 100 mg! Don't know how much to take! Never saw any labeled 2000 FU

EC: Pat, FU is the acronym for Fibrinolytic Units, which are defined as enzyme activity units specific for breaking down fibrin. If you search on Amazon for Nattokinase, you will see various brands of Nattokinase have 2,000 - 4,000 FU per capsule. More info regarding Fibrin Units in a Q&A on Amazon here.


Replied by Hwkmn05
104 posts

Pat, 100mg = 2,000 FU

Replied by Hwkmn05
104 posts

Pat, how goes the afib battle? I found a Vit D protocol that seems to work for many. Also, high dosage of Lugol's Iodine for some. Hope all is well.

Blood Clots

Posted by Feporam (Carlton, Pa, United States) on 04/21/2012
5 out of 5 stars

I have a history of blood clots, my doctor started me on Nattokinase and, as long as I take it, I have had no further incidents. I went off of it for a couple of weeks and ended up with 2 clots, but they quickly disappeared after a few days back on nattokinase. This also has helped to ease my menstrual issues.

Carotid Artery Circulation

Posted by Glen (Montauk, NY) on 12/11/2016
5 out of 5 stars

I started taking Nattokinase (2000 fu, once a day) a few months ago instead of a daily aspirin for heart attack and stroke prevention after reading studies on it. Interestingly, I got a slight case of tinnitus for a few minutes within 2 hours only the first two days of taking it.. just in my left ear. Felt like the inner ear was adjusting to increased blood flow. The noise went high pitched and then quiet. I also got a temporary pain in my left temple/brain. I suspect thought I don't know for sure this was a sign of carotid artery circulation improvement. Well I ran out of my nattokinase a couple of weeks ago. I ordered it online and had a week off of it while I waited for it to arrive. I started back on a few days ago and got the exactly same symptoms. Just for a day as my body adjusted to the supplement again. I am wondering if anyone else on this site had the same symptoms on Natto?

Replied by Whimofnature


Today is day #2 on Nattokinase. 2 hours after intake I experienced high pitched tinnitus for 5 seconds. Same yesterday.

Replied by Whimofnature

Day #3: no tinnitus


Posted by Hisjewel (Usa) on 01/16/2018
5 out of 5 stars

Nattokinase is an excellent blood thinner. It is worth reading up on and studying. I have read that older adults that means like sixty, should take Pine Bark or Boron or another supplement that strengthens blood vessels when using nattokinase long lengths. It is said that this rule actually applies when taking any blood thinner such as aspirin etc.

Nattokinase has helped me with circulation problems. I do use Pine bark also.


Replied by Marguerita

To strengthen my veins, I take standardized hawthorn, standardized ginkgo, and a plant-derived vitamin C.

Fibrocystic Breasts

Posted by Kelly (Memphis, Tn) on 11/28/2016
5 out of 5 stars

I've had painful fibrocystic breasts for years. A couple months ago I started taking Nattokinase after reading about it in one of the posts on this site (can't remember which page). I take it daily instead of an aspirin for heart health and circulation. Amazingly, I have no more pain in my breasts. 0%!!!! This is incredible to me because they get so painful the closer I get to my period. Hope this post helps another woman with the same issue.

I take 1 capsule of Nattokinase (2000 fu) with breakfast. The nattokinase I use has the Vitamin K removed (not sure if this makes a difference or not) and is NOT made from soybeans.

Replied by Joe

Nattokinase is to be taken on an empty stomach according to the instructions.

Replied by Destiny
Alexandria, Va

Just reiterating what Joe Tulsa said - Nattokinase is to be taken on an empty stomach ... at least one hour before eating or 2-3 hours after eating. It is my understanding that you get the best results when taken on an empty stomach because when you take it with food, the enzymes will work on breaking down any protein you have just eaten instead of the problem proteins you want it to work on. I take it along with Serrapeptase and I leave them on my bathroom counter so I can take them when I wake up in the night to use the restroom. That way, by the time I wake up the hour has passed and I can eat my breakfast without worrying! It is great that it's working for you - it will probably work even better on an empty stomach :-). I wish you continued success!


Posted by Elaine (Flint, Texas) on 02/23/2011
5 out of 5 stars

I have been reading earth clinic for about a year now looking for relief of 15 plus years of debilitating migraines. About 8 months ago I started taking 400 mg. Of CoQ 10 everyday and for awhile I thought I had my migraines under control. It wasn't unusual for me to wake up every morning with one and some days they would last for 4 days with the nausea, vomiting, sensitivity to noise, smells and light. I notice they started letting up some and came less frequent and for shorter duration with the addition of the CoQ10 but I was still having them just less frequently. This is where I decided to add Nattokinase. I take one a day and it's 2000 FU. I have been on the Natto now for a little over 4 months and I have not had one single migraine. I felt I needed to shout to the world my experience. The migraines had ruled my life for so long. Kept me from living a normal life. I hope migraine sufferers will try this combo and see if it works for them. I know I have stumbled upon a miracle I have long prayed for. Hope this helps someone else.

Replied by Pat

thx Elaine! I started using Nattokinase as blood thinner for Afib about 6 mos ago Only my bottle says 50 mg and another at store said 100 mg. Why does everyone say 2000 FU? Am I taking right dose? I take 1 a day! No side effects. Hope it is working. I think it is!

Nattokinase Side Effects

Posted by Reba (Alabama ) on 07/01/2017
0 out of 5 stars

Is it possible for Nattokanisse to raise blood pressure? I am taking myself off of the drug lisinopril and trying to cure my high blood pressure naturally. I have been taking one and sometimes two Nattokinesse capsules for one week and my blood pressure is ranging around 167/101. It didn't seem to get that half before I started taking this supplement. Has anyone else been affected in this way when taking Nattokanisse?

Replied by Vincent

Hi Reba, Thick blood can often be too many animal products.Cut down for a month and see how you feel.Most cheeses are very very high in fats.Best Wishes, Vince.

Replied by Kevin

If you've only been taking the Nattokinase for a short time then it hasn't had the time to compensate for your meds. If on meds your bp is 130/80 chances are that with no meds it would be about 180/110.

Only taking Natto for one week it's likely it's lowered your bp 13/9 from what it would have been if you weren't on any meds.

This is why one should always take the natural supplement at least a month before starting to taper slowly off the meds while keeping close watch on bp.

Posted by Bethany (Boulder, Co) on 04/15/2017
0 out of 5 stars

I started using Nattokinase supplementation about a year ago after reading about it online in numerous articles are research docs on pubmed. I wanted to take something to prevent blood clots as heart disease and strokes runs in one side of my family. I think this is an amazing supplement, but wanted to warn that people it is extremely powerful (more so than aspirin) and people should always start off with a very low dose for at least a week. I consistently get a high pitched ringing in my one of my ears if I go off it and then start up on it. I like to take time off from all of my supplements, so I do this every week or so (take a few days off from supplements, that it). The high pitched EEEEEE happens once or twice after about 4 hours of taking nattokinase and then no more, but it always happens. I now take only 1/3 of a capsule per day. I pour open the capsules and pour 1/3 of the contents into a 1/2 cup of water and drink that down.

The other thing worth mentioning is to be very careful if you take nattokinase with Advil as it may cause blurry vision. I took an advil at night a few days ago to help with muscle stiffness and the next morning my vision was extremely blurry for the most of the day. Advil can cause blurry vision (one of the listed side effects), but I have never had that before. Worth noting. Would love to hear from other's experience. Can't find much about feedback from real people about nattokinase side effects on the web.

Nattokinase Storage

Posted by Angelo (Ottawa, Canada) on 05/29/2018

Is nattokinase affected by the air temperature during shipment and storage? I been taking Doctors Best NK for 6 mts. I am not sure if it is active. How it can be tested?

What brand of NK is recommended?