Top 10 Health Benefits of Nattokinase

| Modified on Jan 25, 2023
Add New Post Comments
Top 10 Benefits of Nattokinase

Nattokinase is a natural health supplement derived from a fermented soy product called Natto. This supplement is used as a natural remedy for various circulatory conditions, fertility issues, and problems caused by inflammation.

To make "natto," soybeans are fermented with the bacterium bacillus subtilis. The resulting food is an acquired taste for many people. It has a strong flavor in addition to a slimy texture.

Nattokinase is the enzyme that is derived from the natto.  A nattokinase supplement provides the many benefits of natto to those who want an easy way to introduce it into their diet.

10 Nattokinase Health Benefits

1. Lowers Blood Pressure

Studies have found that nattokinase thins the blood and dissolves accumulated solids in it. Consequently, blood pressure is lowered. (1)

2. Reduces Pain

Because of its anti-inflammatory effects, nattokinase has been used to help with pain from arthritis, including that of rheumatoid arthritis. Women with painful periods, especially if the pain is caused by fibroids or endometriosis, may find that their pain is reduced with a nattokinase supplement.

3. Dissolves Blood Clots 

Because nattokinase is an enzyme, it can dissolve proteins like fibrin, which are a cause of clots and blockages in the blood in the first place. One 2004 study of nattokinase in stroke patients found that showed a clear protective effect.(2)

4. Facilitates Brain Function

Because nattokinase thins and cleans up the blood, the resulting improved circulation improves oxygenation to the brain. This can reduce brain fog and may lower the risk of Alzheimer's disease. (3)

5. Helps Vision

Nattokinase has been used to treat cataracts and eye floaters because of its ability to dissolve proteins and fibers that cause these eye issues.

6. Increases Fertility

 Fibroids and endometriosis are both chronic and painful conditions that can cause infertility. Nattokinase can be used in these conditions to help dissolve the fibroids and endometriosis.

7. Improves Libido

Because nattokinase improves circulation as it thins the blood and breaks up congestion, it can help low libido in men, primarily when the low libido is caused by poor circulation.

8. Eliminates Migraines

Migraines can have many causes. For those whose migraines are caused by thick blood and poor circulation, regular use of nattokinase can solve migraines' root cause.

One Earth Clinic reader has not experienced a migraine since she started taking nattokinase.

9. Relieves Edema

Because nattokinase improves circulation, a benefit of nattokinase is a reduction in edema. Clots in the legs (deep vein thrombosis) can also cause edema. Nattokinase addresses this cause of edema as well.

10. Heals Varicose Veins

The blood thinning and oxygenating properties of nattokinase make it an appropriate remedy for varicose veins. Hemorrhoid sufferers will be glad to know that nattokinase works for hemorrhoids since hemorrhoids are a type of varicose vein.

How to Take Nattokinase for Best Results

For optimal results, one capsule of 2,000 fu (100 mg) nattokinase should be taken on an empty stomach, either 1 hour before eating, or 2-3 hours after eating.

How Long Does Nattokinase Last in the Body?

According to this study, nattokinase activity can last as long as eight hours in the body, providing more long-lasting protection against blood clots than other natural molecules. The same researchers also found that nattokinase shows an increase in activity of fibrinolysis and anticoagulant 2-8 hours after consuming it.

Possible Side Effects

  • If you have hypotension (low blood pressure), nattokinase may not be appropriate for you as it can lower blood pressure.
  • Because nattokinase thins the blood, those on blood thinners or who take aspirin should not take nattokinase without a doctor's careful supervision. 
  • If you bruise easily or are prone to nosebleeds, nattokinase is not recommended because it can worsen these problems.
  • Those with bleeding disorders or blood conditions (like ITP) should not take nattokinase as it can make your bleeding issues worse.
  • Women may find that the blood-thinning effects of nattokinase make their periods heavier. Women with heavy periods may need to avoid the use of nattokinase, especially right before and during their periods.
  • Because nattokinase is a soy-based supplement, nattokinase should be avoided if you have a soy sensitivity or allergy.
  • Interestingly, a few Earth Clinic readers have reported a few seconds of ringing in the ears (tinnitus), between 2-4 hours after consuming nattokinase for the first time. This unique side effect occurred just for the first day or two.

Where to Buy Nattokinase

Nattokinase is very popular and can be found at most health food stores and online. Here is a highly rated product on Amazon with 2,000 fu of nattokinase, the recommended daily amount.

NOW Supplements, Nattokinase 100 mg (from Non-GMO Soy) with 2,000 FUs of Activity, 120 Veg Capsules



What's the difference between Nattokinase and Serrapeptase?

Serrapeptase (SP) and nattokinase (NK) are both proteolytic enzymes, which simply means that they dissolve proteins in the body that do not serve a healthy purpose. These enzymes  are used to treat different conditions.


Serrapeptase has significant anti-inflammatory, protein dissolving, and fibrin dissolving properties. It helps tissue healing and assists with a healthy respiratory system. Serrapeptase is also anti-edemic, so it is used to prevent swelling and fluid retention.


Nattokinase also has potent anti-inflammatory and fibrin-degrading activity. It prevents and dissolves blood clots, helps promote healthy circulation, and normalizes blood pressure.

Nattokinase also helps maintain healthy C-reactive protein levels called CRP. CRP is an inflammation marker and indicates a severe risk factor for heart disease.

Earth Clinic readers often take both supplements on an empty stomach each day as part of their holistic health plan.

Is Nattokinase a Stand-Alone Supplement?

No. While nattokinase is a powerful supplement that can help various health conditions, most people will find that it works best as part of a holistic approach to health.

If you are taking nattokinase for a serious health problem, you need to address any dietary or lifestyle choices that have caused the health problem in the first place.

Nattokinase is most likely to help you if it is one part of a broader holistic plan. A good diet, daily exercise, sunshine, adequate rest, and proper hydration are essential components of good health.

Continue reading below for feedback from Earth Clinic readers on their use of Nattokinase for various health ailments such as blood clots, poor circulation, and more. Have you tried nattokinase? We would love to hear from you!

Related Links:

Natto Health Benefits
Serrapeptase: Reviews, Dosages, and Side Effects

Atrial Fib

Posted by Pat (Pa) on 03/31/2017


Does anyone know how much Nattokinase to take everyday for blood thinning? I don't know whether to take 50mg daily or if I need 100mg daily? I also take VitE, Garlic and a good Fish oil but thought I should start that also! Don't want to go on Pharmaceutical blood thinners! Don't like that idea!

Replied by Robert Henry
(Ten Mile , Tn)

PAT,,,,,,,, I have no clue, but I take one capsule a day that is 2,000 FU / capsule. I take that because that is what my integrative doctor gives his wife for her A FIB. I take one Rx and several other supplements that are in EC's archives. I do bruise easily, but maybe that goes with age.


Replied by Pat

Thanks, but what is 2000 FU? The Nattokinase I find is 50 mg or 100 mg! Don't know how much to take! Never saw any labeled 2000 FU

EC: Pat, FU is the acronym for Fibrinolytic Units, which are defined as enzyme activity units specific for breaking down fibrin. If you search on Amazon for Nattokinase, you will see various brands of Nattokinase have 2,000 - 4,000 FU per capsule. More info regarding Fibrin Units in a Q&A on Amazon here.


Replied by Hwkmn05
108 posts

Pat, 100mg = 2,000 FU

Replied by Hwkmn05
108 posts

Pat, how goes the afib battle? I found a Vit D protocol that seems to work for many. Also, high dosage of Lugol's Iodine for some. Hope all is well.

Replied by Sharon


Have you tried magnesium supplementation for A-Fib? Lots of great information out there by Dr. Carolyn Dean.

Best Way to Take Nattokinase

1 User Review
5 star (1) 

Posted by Destiny (Alexandria, Va) on 06/19/2018
5 out of 5 stars

Just reiterating what Joe Tulsa said - Nattokinase is to be taken on an empty stomach ... at least one hour before eating or 2-3 hours after eating.

It is my understanding that you get the best results when taken on an empty stomach because when you take it with food, the enzymes will work on breaking down any protein you have just eaten instead of the problem proteins you want it to work on.

I take it along with Serrapeptase and I leave them on my bathroom counter so I can take them when I wake up in the night to use the restroom. That way, by the time I wake up the hour has passed and I can eat my breakfast without worrying! It is great that it's working for you - it will probably work even better on an empty stomach :-)

Blood Clots

2 User Reviews
5 star (2) 

Posted by Feporam (Carlton, Pa, United States) on 04/21/2012
5 out of 5 stars

I have a history of blood clots, my doctor started me on Nattokinase and, as long as I take it, I have had no further incidents. I went off of it for a couple of weeks and ended up with 2 clots, but they quickly disappeared after a few days back on nattokinase. This also has helped to ease my menstrual issues.

Replied by Samuel
(Denver, CO)
5 out of 5 stars

I was on it... it was working great for years. I was forced to switch to Xarelto, which doesn't dissolve clots. I'd like to find a doctor that can work with me in the denver, co area with both

Calf Pain

1 User Review
5 star (1) 

Posted by Deborah (MI) on 02/27/2022
5 out of 5 stars

I wanted to add my wonderful experience using Nattokinase I ordered off Amazon. I had a horrid knot in my left calf for three straight months. I thought it was a spasm but it never went away no matter what I tried. I think it was a clot. Took the Nattokinase and after 3 days the pain was totally gone. Took two 800mg capsules per directions on the label. So happy I tried this.

Replied by Art
1508 posts

Hi Deborah,

Glad to hear that you were able to resolve the pain in your calf using nattokinase!

There are different strengths of nattokinase. Could you tell us what strength and brand you used? Thank you!


Replied by Lori
(Chester. NY)

I've been experiencing calf pain, started talking 2 caps today. I hope It goes away, it's driving me crazy.

Carotid Artery Circulation

1 User Review
5 star (1) 

Posted by Glen (Montauk, NY) on 12/11/2016
5 out of 5 stars

I started taking Nattokinase (2000 fu, once a day) a few months ago instead of a daily aspirin for heart attack and stroke prevention after reading studies on it. Interestingly, I got a slight case of tinnitus for a few minutes within 2 hours only the first two days of taking it.. just in my left ear. Felt like the inner ear was adjusting to increased blood flow. The noise went high pitched and then quiet. I also got a temporary pain in my left temple/brain. I suspect thought I don't know for sure this was a sign of carotid artery circulation improvement. Well I ran out of my nattokinase a couple of weeks ago. I ordered it online and had a week off of it while I waited for it to arrive. I started back on a few days ago and got the exactly same symptoms. Just for a day as my body adjusted to the supplement again. I am wondering if anyone else on this site had the same symptoms on Natto?

Replied by Whimofnature


Today is day #2 on Nattokinase. 2 hours after intake I experienced high pitched tinnitus for 5 seconds. Same yesterday.

Replied by Whimofnature

Day #3: no tinnitus


2 User Reviews
5 star (2) 

Posted by Mary (Newport, RI) on 05/14/2018
5 out of 5 stars

I have had poor circulation my whole life, especially cold hands and feet, which got worse when I hit my 60s. I started on 1 capsule of nattokinase at dinnertime and rapidly felt more warmth in my hands. Then about a week later I had more warmth in my feet. This improvement to my extremities is remarkable to me because I have tried other supplements to improve circulation like horse chestnut but they absolutely did not help.

I will continue to take 1 capsule of 2,000 a day. Only side effect is that I tend to bruise more easily but that's okay.

Posted by Hisjewel (Usa) on 01/16/2018
5 out of 5 stars

Nattokinase is an excellent blood thinner. It is worth reading up on and studying. I have read that older adults that means like sixty, should take Pine Bark or Boron or another supplement that strengthens blood vessels when using nattokinase long lengths. It is said that this rule actually applies when taking any blood thinner such as aspirin etc.

Nattokinase has helped me with circulation problems. I do use Pine bark also.


Replied by Marguerita

To strengthen my veins, I take standardized hawthorn, standardized ginkgo, and a plant-derived vitamin C.

Deep Vein Thrombosis

1 User Review
5 star (1) 

Posted by Prioris (Fl, Usa) on 03/05/2014
5 out of 5 stars

The solution for DVT is fairly simple - use nattokinase. It should resolve the pain and problem within a month. Take higher dosage for first couple weeks.

Look for my posts on nattokinase by searching earth clinic "+prioris+nattokinase".

You will also find a lot of positive anecdotal reports on internet from people.

Fibrocystic Breasts

1 User Review
5 star (1) 

Posted by Kelly (Memphis, Tn) on 11/28/2016
5 out of 5 stars

I've had painful fibrocystic breasts for years. A couple months ago I started taking Nattokinase after reading about it in one of the posts on this site (can't remember which page). I take it daily instead of an aspirin for heart health and circulation. Amazingly, I have no more pain in my breasts. 0%!!!! This is incredible to me because they get so painful the closer I get to my period. Hope this post helps another woman with the same issue.

I take 1 capsule of Nattokinase (2000 fu) with breakfast. The nattokinase I use has the Vitamin K removed (not sure if this makes a difference or not) and is NOT made from soybeans.

Replied by Joe

Nattokinase is to be taken on an empty stomach according to the instructions.

Replied by Susan


Can I ask what that product name is as I have a fiber and am not supposed to take K?

Replied by Martha
(Keene, NH)

Glad the Nattokinase is working for you. My understanding is that it's best taken on an empty stomach; an hour before or 2-3 hours after a meal.

Hyperviscosity, Heart Disease, Varicose Veins

1 User Review
5 star (1) 

Posted by Mandy (Qld) on 01/12/2023
5 out of 5 stars

I use Nattokinase due to hyperviscosity, I have severe varicose veins, and hemorrhoids and cannot take blood thinners.

After multiple thromboses, 2 heart attacks, and a stroke, I found out about it on a coronary care website.

5 weeks ago, I began with 4000 FU per day increasing to 4x 4000 FU per day for 3 weeks. Will shortly drop back to 4000 FU per day. I use alongside K2 every second day. My issues have settled, my varicose veins are noticeably less, not hard and painful anymore. ( I have had this chronic complaint for approximately 35 years.)

To say that I am impressed by the results is an understatement.

My heartbeat is still often irregular however I am seeing better results and quicker recovery times.

Replied by Jami

If you please, have your cardiologist check specifically for PVCs [Premature Ventricular(sp) Compressions. They are usually benign but can feel very alarming. They are triggered by anxiety/stress. I have them and will be asking my cardiologist for Nattokinase when I see her next week. It's worth looking into.

Take Care,



2 User Reviews
5 star (2) 

Posted by Elaine (Flint, Texas) on 02/23/2011
5 out of 5 stars

I have been reading earth clinic for about a year now looking for relief of 15 plus years of debilitating migraines. About 8 months ago I started taking 400 mg. Of CoQ 10 everyday and for awhile I thought I had my migraines under control. It wasn't unusual for me to wake up every morning with one and some days they would last for 4 days with the nausea, vomiting, sensitivity to noise, smells and light. I notice they started letting up some and came less frequent and for shorter duration with the addition of the CoQ10 but I was still having them just less frequently. This is where I decided to add Nattokinase. I take one a day and it's 2000 FU. I have been on the Natto now for a little over 4 months and I have not had one single migraine. I felt I needed to shout to the world my experience. The migraines had ruled my life for so long. Kept me from living a normal life. I hope migraine sufferers will try this combo and see if it works for them. I know I have stumbled upon a miracle I have long prayed for. Hope this helps someone else.

Replied by Pat

thx Elaine! I started using Nattokinase as blood thinner for Afib about 6 mos ago Only my bottle says 50 mg and another at store said 100 mg. Why does everyone say 2000 FU? Am I taking right dose? I take 1 a day! No side effects. Hope it is working. I think it is!

Replied by Ampy


I just read that you were taking CoQ10 and now added the Nattokinaise and it has helped your migraines. I have migraines now for 40+ years I have been taking CoQ10 for years, my question is, do you take both of these at the same time before a meal on an empty stomach? I was told to take my supplements (which we take a lot of them) after our night time meal. So that's why I'm asking. Would love to know how you are taking this. I will try anything for migraines. Thanks in advance. Ampy

Replied by Natalia
5 out of 5 stars

I had debilitating trigeminal neuralgia. Let say pain score 1-10 I have had 15. Classic therapy Gabapentin 600 mg, Stugeron 50 mg, Diclofenac or either Naproxen, Magnesium bisglicinate gave me just temporary relief.

Then I took 200 mg of Nattokinase because it was throbbing in spite of all this and started in the middle of the night while I was sleeping, so to take all this again was a bit too much. After about 1 hr pain stopped. In the morning I had just a vague sensation of throbbing maybe 1-2 out of 10.

So I took 200 mg of Nattokinase more and NO PAIN. AND I DID NOT TAKE ANYTHING FROM THE LIST ABOVE.

I am so happy! I will continue to have Nattokinase 100 mg as a support for the next few days. I am an emergency physician myself and I can say this supplement is miraculous. In the way to replace Aspirin, but now with your post, it saved my life. Thank you.


Look up youtube Dr. Berg for trigeminal neuralgia. It is the best treatment for trigeminal neuralgia. It is the only thing that would stop my pain and it is so simple. Dr, Berg has so many good excellent topics and the comments on his youtube videos show how much he is loved. Hope this helps.

Nattokinase Side Effects

3 User Reviews
5 star (1) 

Posted by joe233 (United Kingdom) on 09/03/2021
0 out of 5 stars

Hi everyone,

Just thought it is worth sharing my experience with Nattokinase.

Took it for a week without any other supplement, everything went fine even noticed a decline in the size of a small cyst.

Yesterday I took the supplement with Chaga mushroom, this morning I woke up and passed blood in my urine, little clots nothing major. Persisted throughout the day, went the GP they confirmed I have no infection and the GP and I both believe it is the Chaga interacting with the Nattokinase in a negative way, so I have no stopped Nattokinase and will stop all supplements for a few days to allow my body to reset.

Once this is done, I will resume with just chaga.

Natto is good but make sure due to its blood thinning properties you are careful with what you mix it with.

Take care all,


Nattokinase Side Effects
Posted by Reba (Alabama ) on 07/01/2017
0 out of 5 stars

Is it possible for Nattokanisse to raise blood pressure? I am taking myself off of the drug lisinopril and trying to cure my high blood pressure naturally. I have been taking one and sometimes two Nattokinesse capsules for one week and my blood pressure is ranging around 167/101. It didn't seem to get that half before I started taking this supplement. Has anyone else been affected in this way when taking Nattokanisse?

Replied by Vincent

Hi Reba, Thick blood can often be too many animal products.Cut down for a month and see how you feel.Most cheeses are very very high in fats.Best Wishes, Vince.

Replied by Kevin

If you've only been taking the Nattokinase for a short time then it hasn't had the time to compensate for your meds. If on meds your bp is 130/80 chances are that with no meds it would be about 180/110.

Only taking Natto for one week it's likely it's lowered your bp 13/9 from what it would have been if you weren't on any meds.

This is why one should always take the natural supplement at least a month before starting to taper slowly off the meds while keeping close watch on bp.

Nattokinase Side Effects
Posted by Bethany (Boulder, Co) on 04/15/2017
5 out of 5 stars

I started using Nattokinase supplementation about a year ago after reading about it online in numerous articles are research docs on pubmed. I wanted to take something to prevent blood clots as heart disease and strokes runs in one side of my family. I think this is an amazing supplement, but wanted to warn that people it is extremely powerful (more so than aspirin) and people should always start off with a very low dose for at least a week. I consistently get a high pitched ringing in my one of my ears if I go off it and then start up on it. I like to take time off from all of my supplements, so I do this every week or so (take a few days off from supplements, that it). The high pitched EEEEEE happens once or twice after about 4 hours of taking nattokinase and then no more, but it always happens. I now take only 1/3 of a capsule per day. I pour open the capsules and pour 1/3 of the contents into a 1/2 cup of water and drink that down.

The other thing worth mentioning is to be very careful if you take nattokinase with Advil as it may cause blurry vision. I took an advil at night a few days ago to help with muscle stiffness and the next morning my vision was extremely blurry for the most of the day. Advil can cause blurry vision (one of the listed side effects), but I have never had that before. Worth noting. Would love to hear from other's experience. Can't find much about feedback from real people about nattokinase side effects on the web.

Nattokinase Storage

Posted by Angelo (Ottawa, Canada) on 05/29/2018

Is nattokinase affected by the air temperature during shipment and storage? I been taking Doctors Best NK for 6 mts. I am not sure if it is active. How it can be tested?

What brand of NK is recommended?