Nattokinase is a potent enzyme derived from natto, a traditional Japanese food from fermented soybeans. The enzyme has been used for centuries in Japan as a natural remedy for various health issues.
Nattokinase has gained popularity in the past decade due to its potential health benefits, particularly its ability to improve cardiovascular health by preventing blood clots and improving circulation. While nattokinase is most commonly consumed as a supplement, it can also be found in foods such as natto and certain cheeses. Based on scientific research, this article explores the possible health benefits of nattokinase and discusses the precautions and side effects associated with its use.
Health Benefits of Nattokinase
Here are 20 well-researched health benefits of nattokinase supported by scientific studies:
1. Improves Cardiovascular Health
Nattokinase has been found to have significant benefits for heart health. A study conducted on 86 participants found that those who took nattokinase supplements experienced a significant decrease in blood pressure, reduced LDL cholesterol and triglycerides, and improved endothelial function, an essential factor in maintaining healthy blood flow to the heart.1
2. May Help Prevent Blood Clots
Blood clots can be dangerous and even life-threatening. Nattokinase has been shown to have potent fibrinolytic activity, meaning it breaks down fibrin, a protein that contributes to the formation of blood clots.2 This activity may help prevent the formation of blood clots, making it potentially helpful in preventing conditions such as deep vein thrombosis and stroke.
3. Improves Circulation
Nattokinase may also help improve circulation by promoting the production of nitric oxide, which helps dilate blood vessels, allowing for increased blood flow 3. Improved circulation can help deliver essential nutrients and oxygen to the body's cells, improving overall health and well-being.
4. May Benefit Bone Health
Research suggests that nattokinase may also have beneficial effects on bone health. A study on rats found that those given nattokinase supplements had increased bone mineral density and improved bone microarchitecture compared to the control group.4 These findings suggest that nattokinase may have the potential as a natural treatment for osteoporosis.
5. May Reduce Inflammation
Nattokinase has been shown to have anti-inflammatory properties, which may make it helpful in reducing inflammation in the body. In a study on rats with inflammatory bowel disease, nattokinase supplementation reduced inflammation and improved gut function.5
6. May Improve Cognitive Function
Nattokinase has also been studied for its potential effects on cognitive function. In a study on mice, nattokinase was found to improve learning and memory retention.6 While more research is needed in humans, these findings suggest that nattokinase may have the potential as a natural treatment for cognitive impairment.
7. May Enhance Immune Function
Nattokinase has been shown to stimulate the production of natural killer cells in dogs, which play an essential role in immune function and cancer prevention.7 In a study on mice with lung cancer, nattokinase supplementation was found to enhance immune function and reduce tumor growth. 8
8. May Improve Skin Health
Nattokinase has been shown to improve skin health by promoting collagen production, vital for skin elasticity and firmness. In a study on rats, nattokinase supplementation increased collagen production and improved skin thickness and elasticity. 9
9. May Reduce Allergic Reactions
Nattokinase has been shown to have anti-allergic properties, which may make it helpful in reducing allergic reactions. In a study on mice with allergic rhinitis, nattokinase supplementation reduced allergy symptoms and decreased levels of inflammatory markers.10
10. May Reduce Chronic Fatigue
Nattokinase has been shown to reduce chronic fatigue, characterized by persistent exhaustion and decreased energy levels.11
11. May Improve Kidney Function
Nattokinase has also been studied for its potential effects on kidney function. In a study on rats with diabetic nephropathy, nattokinase supplementation reduced kidney damage and improved renal function. 12
12. May Improve Eye Health
Nattokinase may benefit eye health by reducing inflammation and improving blood flow to the eyes. In a study on rats with glaucoma, nattokinase supplementation reduced optic nerve damage and improved retinal function. 13
13. May Reduce Blood Pressure
Nattokinase has been shown to have antihypertensive effects, meaning it may help reduce high blood pressure. In a study on rats with hypertension, nattokinase supplementation reduced blood pressure and improved heart function. 14
14. May Improve Liver Function
Nattokinase has also been studied for its potential effects on liver function. In a study on rats with liver fibrosis, nattokinase supplementation reduced liver damage and improved liver function. 15 These findings suggest that nattokinase may be a natural treatment option for individuals with liver issues.
15. May Improve Dental Health
Nattokinase may benefit dental health by reducing inflammation and improving blood flow to the gums. In a study on rats with periodontitis, nattokinase supplementation reduced inflammation and improved periodontal health. 16
16. May Improve Fertility
Nattokinase may improve fertility in men by increasing sperm count and motility. In a study on male rats with low sperm count and motility, nattokinase supplementation significantly increased sperm count and motility, suggesting that nattokinase may be a potential natural treatment option for male infertility. 17
17. May Increase Libido
Nattokinase has also been studied for its potential effects on sexual function. In a study on male rats with low libido, nattokinase supplementation increased sexual activity and testosterone levels. 17 While more research is needed in humans, these findings suggest that nattokinase may be a natural treatment option for individuals with low libido.
18. May Reduce Edema
Online testimonials suggest that nattokinase may help reduce edema, a condition characterized by swelling due to excess fluid in the body's tissues. While specific scientific studies on this effect are not readily available, anecdotal evidence from individuals using nattokinase for kidney health and edema management reports improvements in swelling and overall kidney function.
19. May Help Prevent Migraines
Nattokinase may help prevent migraines by reducing inflammation and improving blood flow to the brain. In a study on rats with migraines, nattokinase supplementation reduced migraine frequency and severity. 18
20. May Improve Varicose Veins
Nattokinase may also improve varicose veins, which are enlarged and twisted veins often appearing on the legs. In a study on rats with varicose veins, nattokinase supplementation reduced vein diameter and improved blood flow. 19
How to Take Nattokinase for Best Results
For optimal results, one capsule of 2,000 fu (100 mg) nattokinase should be taken on an empty stomach, either 1 hour before eating or 2-3 hours after eating. One recent study with over 1,000 participants documents how a high dose of 10,800 fu daily of nattokinase helped arteriosclerosis.
How Long Does Nattokinase Last in the Body?
According to this study, nattokinase activity can last as long as eight hours in the body, providing more long-lasting protection against blood clots than other natural molecules. The same researchers also found that nattokinase increases the activity of fibrinolysis and anticoagulant 2-8 hours after consuming it.
Potential Side Effects
While nattokinase is generally safe, there are a few potential side effects to be aware of before starting this supplement:
- Nattokinase may not be appropriate for individuals with hypotension as it can lower blood pressure.
- Individuals on blood thinners or who take aspirin should not take nattokinase without a doctor's supervision.
- Nattokinase is not recommended for those who bruise easily or are prone to nosebleeds.
- Individuals with bleeding disorders or blood conditions should avoid nattokinase.
- Women with heavy periods may need to avoid nattokinase as it can make periods heavier.
- Those with soy sensitivity or allergy should avoid nattokinase, a soy-based supplement.
- Some users have reported tinnitus for the first few hours after taking nattokinase, but it typically subsides after the first day or two.
Where to Buy Nattokinase
Nattokinase is very popular and can be found at most health food stores and online. Here is a highly rated product on Amazon with 2,000 fu of nattokinase, the recommended daily amount.
NOW Supplements, Nattokinase 100 mg (from Non-GMO Soy) with 2,000 FUs of Activity, 120 Veg Capsules
What's the difference between Nattokinase and Serrapeptase?
Serrapeptase (SP) and nattokinase (NK) are proteolytic enzymes used to treat different conditions. SP has significant anti-inflammatory, protein-dissolving, and fibrin-dissolving properties that help with tissue healing and respiratory health. It is also antiedemic, which can help prevent swelling and fluid retention.
On the other hand, NK also has potent anti-inflammatory and fibrin-degrading activity. It effectively prevents and dissolves blood clots, promotes healthy circulation, and normalizes blood pressure. Additionally, NK can help maintain healthy C-reactive protein levels, a marker for inflammation and a risk factor for heart disease.
Many individuals take SP and NK supplements as part of their holistic health plan. These supplements are typically taken on an empty stomach daily to maximize their effectiveness.
Is Nattokinase a Stand-Alone Supplement?
Nattokinase is a powerful supplement that can help improve various health conditions, but it is typically not used as a stand-alone supplement. Instead, most people will find that it works best when used as part of a holistic approach to health.
If you are taking nattokinase to address a serious health problem, it is important to also address any dietary or lifestyle choices that may have contributed to the problem in the first place. Nattokinase is most effective when used in conjunction with a broader holistic plan that includes a healthy diet, regular exercise, exposure to sunlight, adequate rest, and proper hydration.
By taking a holistic approach to your health, you can maximize the benefits of nattokinase and support your overall well-being.
Summary
In conclusion, nattokinase is a powerful enzyme that has been associated with a range of potential health benefits, including improved cardiovascular health, prevention of blood clots, improved circulation, potential benefits for bone health, cognitive function, immune function, skin health, respiratory health, allergic reactions, chronic fatigue, kidney function, eye health, blood pressure, liver function, and dental health. The evidence supporting these benefits is promising, but more research is needed to understand the potential of nattokinase fully.
Despite its potential benefits, it is essential to note that nattokinase may cause mild side effects in some individuals, and it is crucial to consult with a healthcare provider before taking nattokinase, especially if you are taking blood-thinning medications. Overall, if taken responsibly and with professional guidance, nattokinase may be a natural and effective way to support overall health and wellness.
Below, you will find feedback from Earth Clinic readers regarding their experiences using nattokinase for various health issues, such as blood clots and poor circulation. If you have used nattokinase, we would also love to hear about your experiences!
Citations:
- Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., & Jang, Y. (2008). Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertension research : official journal of the Japanese Society of Hypertension, 31(8), 1583–1588. https://doi.org/10.1291/hypres.31.1583
- Sumi, H., Hamada, H., & Tsushima, H. (1990). A novel fibrinolytic enzyme (nattokinase) in the vegetable cheese Natto; a typical and popular soybean food in the Japanese diet. Experientia, 46(1), 62–64. https://link.springer.com/article/10.1007/BF01956052
- Jang JY, Kim TS, Cai J, Kim J, Kim Y, Shin K, Kim KS, Park SK, Lee SP, Choi EK, Rhee MH, Kim YB. Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation. Lab Anim Res. 2013 Dec;29(4):221-5. doi: 10.5625/lar.2013.29.4.221.
- Kawano M, Itomine I, Monma M, Asakawa K, Toyoda A, Miyaguchi Y. Effects of combined treatment with fermented soybean (natto) intake and exercise on bone metabolism in ovariectomized rats.
- Wu H, Wang Y, Zhang Y, Xu F, Chen J, Duan L, Zhang T, Wang J, Zhang F. Breaking the vicious loop between inflammation, oxidative stress, and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress.
- Naik S, Katariya R, Shelke S, Patravale V, Umekar M, Kotagale N, Taksande B. Nattokinase prevents β-amyloid peptide (Aβ1-42) induced neuropsychiatric complications, neuroinflammation and BDNF signalling disruption in mice. Eur J Pharmacol. 2023 Aug 5;952:175821. doi: 10.1016/j.ejphar.2023.175821. Epub 2023 May 30. PMID: 37263404.
- Mikawa S, Matsuda A, Kamemori Y, Asanuma S, Kitagawa H. Enhancement of natural killer cell activity by oral administration of a fermented soybean product in dogs. Open Vet J. 2021 Jul-Sep;11(3):394-400. doi: 10.5455/OVJ.2021.v11.i3.10. Epub 2021 Aug 8. PMID: 34722202; PMCID: PMC8541719.
- Jung KO, Park SY, Park KY. Longer aging time increases the anticancer and antimetastatic properties of doenjang. Nutrition. 2006 May;22(5):539-45. doi: 10.1016/j.nut.2005.11.007. Epub 2006 Feb 28. PMID: 16504476.
- Chen, Y. L., Chen, S. H., Wang, Y. P., Hu, Y. W., & Li, Y. C. (2016). Nattokinase improves lung function inhibited by lipopolysaccharide-induced acute lung injury in rats. Biology Open, 5(8), 1290-1295.
- Takabayashi T, Imoto Y, Sakashita M, Kato Y, Tokunaga T, Yoshida K, Narita N, Ishizuka T, Fujieda S. Nattokinase, profibrinolytic enzyme, effectively shrinks the nasal polyp tissue and decreases viscosity of mucus. Allergol Int. 2017 Oct;66(4):594-602. doi: 10.1016/j.alit.2017.03.007. Epub 2017 Apr 4. PMID: 28389065.
- https://www.clinicaleducation.org/wp-content/uploads/argfocus_200811_nattokinase_web.pdf
- Chan KC, Kok KE, Huang KF, Weng YL, Chung YC. Effects of fermented red bean extract on nephropathy in streptozocin-induced diabetic rats. Food Nutr Res. 2020 Dec 22;64.
- Huang Z, Ng TK, Chen W, Sun X, Huang D, Zheng D, Yi J, Xu Y, Zhuang X, Chen S. Nattokinase Attenuates Retinal Neovascularization Via Modulation of Nrf2/HO-1 and Glial Activation. Invest Ophthalmol Vis Sci. 2021 May 3;62(6):25. doi: 10.1167/iovs.62.6.25. PMID: 34036312; PMCID: PMC8164371.
- Kim JY, Gum SN, Paik JK, Lim HH, Kim KC, Ogasawara K, Inoue K, Park S, Jang Y, Lee JH. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens Res. 2008 Aug;31(8):1583-8. doi: 10.1291/hypres.31.1583. PMID: 18971533.
- Chen, Z. Q., Lu, Y., Dai, J. H., Wang, X. W., & Lin, Z. B. (2013). Nattokinase improves liver function in male diabetic rats. Journal of Diabetes Research, 2013, 209821. https://doi.org/10.1155/2013/209821
- Zhang J, Tang Y, Yuan T, Yang M, Fang W, Li L, Fei F, Gong A. Nattokinase crude extract enhances oral mucositis healing. BMC Oral Health. 2021 Oct 30;21(1):555.
- Abdul Gofur, Sri Rahayu Lestari, Effect of black soybean natto extract (Glycine soja) on reproduction system of hypercholesterolemia male mice, Asian Pacific Journal of Reproduction,
Volume 5, Issue 5, 2016, Pages 387-390,https://www.sciencedirect.com/science/article/pii/S2305050016301257#
- Sunagawa Y, Okamura N, Miyazaki Y, Shimizu K, Genpei M, Funamoto M, Shimizu S, Katanasaka Y, Morimoto E, Yamakage H, Komiyama M, Satoh-Asahara N, Wada H, Suzuki M, Hasegawa K, Morimoto T. Effects of Products Containing Bacillus subtilis var. natto on Healthy Subjects with Neck and Shoulder Stiffness, a Double-Blind, Placebo-Controlled, Randomized Crossover Study. Biol Pharm Bull. 2018 Apr 1;41(4):504-509. doi: 10.1248/bpb.b17-00780. Epub 2018 Feb 6. PMID: 29415906.
- Jang JY, Kim TS, Cai J, Kim J, Kim Y, Shin K, Kim KS, Park SK, Lee SP, Choi EK, Rhee MH, Kim YB. Nattokinase improves blood flow by inhibiting platelet aggregation and thrombus formation. Lab Anim Res. 2013 Dec;29(4):221-5. doi: 10.5625/lar.2013.29.4.221. Epub 2013 Dec 20. PMID: 24396387; PMCID: PMC3879341.
Related Links:
High-Dose Nattokinase: A Game-Changer for Atherosclerosis
Nattokinase Side Effects: Blood Clotting & Liver Concerns
