Health Benefits of Nattokinase: Evidence-Based Findings

| Modified on Mar 02, 2024
Posted by Elaine (Flint, Texas) on 02/23/2011

I have been reading earth clinic for about a year now looking for relief of 15 plus years of debilitating migraines. About 8 months ago I started taking 400 mg. Of CoQ 10 everyday and for awhile I thought I had my migraines under control. It wasn't unusual for me to wake up every morning with one and some days they would last for 4 days with the nausea, vomiting, sensitivity to noise, smells and light. I notice they started letting up some and came less frequent and for shorter duration with the addition of the CoQ10 but I was still having them just less frequently. This is where I decided to add Nattokinase. I take one a day and it's 2000 FU. I have been on the Natto now for a little over 4 months and I have not had one single migraine. I felt I needed to shout to the world my experience. The migraines had ruled my life for so long. Kept me from living a normal life. I hope migraine sufferers will try this combo and see if it works for them. I know I have stumbled upon a miracle I have long prayed for. Hope this helps someone else.

Carotid Artery Circulation
Posted by Glen (Montauk, NY) on 12/11/2016

I started taking Nattokinase (2000 fu, once a day) a few months ago instead of a daily aspirin for heart attack and stroke prevention after reading studies on it. Interestingly, I got a slight case of tinnitus for a few minutes within 2 hours only the first two days of taking it.. just in my left ear. Felt like the inner ear was adjusting to increased blood flow. The noise went high pitched and then quiet. I also got a temporary pain in my left temple/brain. I suspect thought I don't know for sure this was a sign of carotid artery circulation improvement. Well I ran out of my nattokinase a couple of weeks ago. I ordered it online and had a week off of it while I waited for it to arrive. I started back on a few days ago and got the exactly same symptoms. Just for a day as my body adjusted to the supplement again. I am wondering if anyone else on this site had the same symptoms on Natto?

Best Way to Take Nattokinase
Posted by Destiny (Alexandria, Va) on 06/19/2018

Just reiterating what Joe Tulsa said - Nattokinase is to be taken on an empty stomach ... at least one hour before eating or 2-3 hours after eating.

It is my understanding that you get the best results when taken on an empty stomach because when you take it with food, the enzymes will work on breaking down any protein you have just eaten instead of the problem proteins you want it to work on.

I take it along with Serrapeptase and I leave them on my bathroom counter so I can take them when I wake up in the night to use the restroom. That way, by the time I wake up the hour has passed and I can eat my breakfast without worrying! It is great that it's working for you - it will probably work even better on an empty stomach :-)

Posted by Hisjewel (Usa) on 01/16/2018

Nattokinase is an excellent blood thinner. It is worth reading up on and studying. I have read that older adults that means like sixty, should take Pine Bark or Boron or another supplement that strengthens blood vessels when using nattokinase long lengths. It is said that this rule actually applies when taking any blood thinner such as aspirin etc.

Nattokinase has helped me with circulation problems. I do use Pine bark also.


Trigeminal Neuralgia
Posted by Natalia (Romania) on 07/19/2021

I had debilitating trigeminal neuralgia. Let say pain score 1-10 I have had 15. Classic therapy Gabapentin 600 mg, Stugeron 50 mg, Diclofenac or either Naproxen, Magnesium bisglicinate gave me just temporary relief.

Then I took 200 mg of Nattokinase because it was throbbing in spite of all this and started in the middle of the night while I was sleeping, so to take all this again was a bit too much. After about 1 hr pain stopped. In the morning I had just a vague sensation of throbbing maybe 1-2 out of 10.

So I took 200 mg of Nattokinase more and NO PAIN. AND I DID NOT TAKE ANYTHING FROM THE LIST ABOVE.

I am so happy! I will continue to have Nattokinase 100 mg as a support for the next few days. I am an emergency physician myself and I can say this supplement is miraculous. In the way to replace Aspirin, but now with your post, it saved my life. Thank you.

Hyperviscosity, Heart Disease, Varicose Veins
Posted by Mandy (Qld) on 01/12/2023

I use Nattokinase due to hyperviscosity, I have severe varicose veins, and hemorrhoids and cannot take blood thinners.

After multiple thromboses, 2 heart attacks, and a stroke, I found out about it on a coronary care website.

5 weeks ago, I began with 4000 FU per day increasing to 4x 4000 FU per day for 3 weeks. Will shortly drop back to 4000 FU per day. I use alongside K2 every second day. My issues have settled, my varicose veins are noticeably less, not hard and painful anymore. ( I have had this chronic complaint for approximately 35 years.)

To say that I am impressed by the results is an understatement.

My heartbeat is still often irregular however I am seeing better results and quicker recovery times.

Deep Vein Thrombosis
Posted by Prioris (Fl, Usa) on 03/05/2014

The solution for DVT is fairly simple - use nattokinase. It should resolve the pain and problem within a month. Take higher dosage for first couple weeks.

Look for my posts on nattokinase by searching earth clinic "+prioris+nattokinase".

You will also find a lot of positive anecdotal reports on internet from people.

Posted by Mary (Newport, RI) on 05/14/2018

I have had poor circulation my whole life, especially cold hands and feet, which got worse when I hit my 60s. I started on 1 capsule of nattokinase at dinnertime and rapidly felt more warmth in my hands. Then about a week later I had more warmth in my feet. This improvement to my extremities is remarkable to me because I have tried other supplements to improve circulation like horse chestnut but they absolutely did not help.

I will continue to take 1 capsule of 2,000 a day. Only side effect is that I tend to bruise more easily but that's okay.

Nattokinase Side Effects
Posted by Bethany (Boulder, Co) on 04/15/2017

I started using Nattokinase supplementation about a year ago after reading about it online in numerous articles are research docs on pubmed. I wanted to take something to prevent blood clots as heart disease and strokes runs in one side of my family. I think this is an amazing supplement, but wanted to warn that people it is extremely powerful (more so than aspirin) and people should always start off with a very low dose for at least a week. I consistently get a high pitched ringing in my one of my ears if I go off it and then start up on it. I like to take time off from all of my supplements, so I do this every week or so (take a few days off from supplements, that it). The high pitched EEEEEE happens once or twice after about 4 hours of taking nattokinase and then no more, but it always happens. I now take only 1/3 of a capsule per day. I pour open the capsules and pour 1/3 of the contents into a 1/2 cup of water and drink that down.

The other thing worth mentioning is to be very careful if you take nattokinase with Advil as it may cause blurry vision. I took an advil at night a few days ago to help with muscle stiffness and the next morning my vision was extremely blurry for the most of the day. Advil can cause blurry vision (one of the listed side effects), but I have never had that before. Worth noting. Would love to hear from other's experience. Can't find much about feedback from real people about nattokinase side effects on the web.

Calf Pain
Posted by Deborah (MI) on 02/27/2022

I wanted to add my wonderful experience using Nattokinase I ordered off Amazon. I had a horrid knot in my left calf for three straight months. I thought it was a spasm but it never went away no matter what I tried. I think it was a clot. Took the Nattokinase and after 3 days the pain was totally gone. Took two 800mg capsules per directions on the label. So happy I tried this.

Nattokinase Side Effects
Posted by joe233 (United Kingdom) on 09/03/2021

Hi everyone,

Just thought it is worth sharing my experience with Nattokinase. Took it for a week without any other supplement, everything went fine even noticed a decline in the size of a small cyst.
Yesterday I took the supplement with Chaga mushroom, this morning I woke up and passed blood in my urine, little clots nothing major. Persisted throughout the day, went the GP they confirmed I have no infection and the GP and I both believe it is the Chaga interacting with the Nattokinase in a negative way, so I have no stopped Nattokinase and will stop all supplements for a few days to allow my body to reset.

Once this is done, I will resume with just chaga. Natto is good but make sure due to its blood thinning properties you are careful with what you mix it with.

Take care all, Joe

Blood Clots
Posted by Feporam (Carlton, Pa, United States) on 04/21/2012

I have a history of blood clots, my doctor started me on Nattokinase and, as long as I take it, I have had no further incidents. I went off of it for a couple of weeks and ended up with 2 clots, but they quickly disappeared after a few days back on nattokinase. This also has helped to ease my menstrual issues.

Nattokinase Side Effects
Posted by Reba (Alabama ) on 07/01/2017

Is it possible for Nattokanisse to raise blood pressure? I am taking myself off of the drug lisinopril and trying to cure my high blood pressure naturally. I have been taking one and sometimes two Nattokinesse capsules for one week and my blood pressure is ranging around 167/101. It didn't seem to get that half before I started taking this supplement. Has anyone else been affected in this way when taking Nattokanisse?

Fibrocystic Breasts
Posted by Kelly (Memphis, Tn) on 11/28/2016

I've had painful fibrocystic breasts for years. A couple months ago I started taking Nattokinase after reading about it in one of the posts on this site (can't remember which page). I take it daily instead of an aspirin for heart health and circulation. Amazingly, I have no more pain in my breasts. 0%!!!! This is incredible to me because they get so painful the closer I get to my period. Hope this post helps another woman with the same issue.

I take 1 capsule of Nattokinase (2000 fu) with breakfast. The nattokinase I use has the Vitamin K removed (not sure if this makes a difference or not) and is NOT made from soybeans.

Atrial Fib
Posted by Sharon (Wisconsin) on 12/01/2020


Have you tried magnesium supplementation for A-Fib? Lots of great information out there by Dr. Carolyn Dean.

Trigeminal Neuralgia
Posted by Kay (MI) on 07/26/2021

Look up youtube Dr. Berg for trigeminal neuralgia. It is the best treatment for trigeminal neuralgia. It is the only thing that would stop my pain and it is so simple. Dr, Berg has so many good excellent topics and the comments on his youtube videos show how much he is loved. Hope this helps.

Nattokinase Side Effects
Posted by Kevin (Wv) on 12/25/2018

If you've only been taking the Nattokinase for a short time then it hasn't had the time to compensate for your meds. If on meds your bp is 130/80 chances are that with no meds it would be about 180/110.

Only taking Natto for one week it's likely it's lowered your bp 13/9 from what it would have been if you weren't on any meds.

This is why one should always take the natural supplement at least a month before starting to taper slowly off the meds while keeping close watch on bp.

Carotid Artery Circulation
Posted by Whimofnature (Austria) on 04/25/2018

Day #3: no tinnitus

Atrial Fib
Posted by Hwkmn05 (Nh) on 01/07/2018 109 posts

Pat, 100mg = 2,000 FU

Atrial Fib
Posted by Robert Henry (Ten Mile , Tn) on 04/01/2017

PAT,,,,,,,, I have no clue, but I take one capsule a day that is 2,000 FU / capsule. I take that because that is what my integrative doctor gives his wife for her A FIB. I take one Rx and several other supplements that are in EC's archives. I do bruise easily, but maybe that goes with age.


Carotid Artery Circulation
Posted by Whimofnature (Austria) on 04/24/2018


Today is day #2 on Nattokinase. 2 hours after intake I experienced high pitched tinnitus for 5 seconds. Same yesterday.

Posted by Marguerita (Usa) on 01/18/2018

To strengthen my veins, I take standardized hawthorn, standardized ginkgo, and a plant-derived vitamin C.

Nattokinase Side Effects
Posted by Vincent (Australia) on 03/01/2018

Hi Reba, Thick blood can often be too many animal products.Cut down for a month and see how you feel.Most cheeses are very very high in fats.Best Wishes, Vince.

Atrial Fib
Posted by Hwkmn05 (Nh) on 06/19/2020 109 posts

Pat, how goes the afib battle? I found a Vit D protocol that seems to work for many. Also, high dosage of Lugol's Iodine for some. Hope all is well.

Hyperviscosity, Heart Disease, Varicose Veins
Posted by Jami (Texas) on 01/24/2023

If you please, have your cardiologist check specifically for PVCs [Premature Ventricular(sp) Compressions. They are usually benign but can feel very alarming. They are triggered by anxiety/stress. I have them and will be asking my cardiologist for Nattokinase when I see her next week. It's worth looking into.

Take Care,


Calf Pain
Posted by Art (California) on 02/28/2022 2164 posts

Hi Deborah,

Glad to hear that you were able to resolve the pain in your calf using nattokinase!

There are different strengths of nattokinase. Could you tell us what strength and brand you used? Thank you!


Atrial Fib
Posted by Pat (Pa) on 03/31/2017


Does anyone know how much Nattokinase to take everyday for blood thinning? I don't know whether to take 50mg daily or if I need 100mg daily? I also take VitE, Garlic and a good Fish oil but thought I should start that also! Don't want to go on Pharmaceutical blood thinners! Don't like that idea!

Atrial Fib
Posted by Pat (Pa) on 12/27/2017

Thanks, but what is 2000 FU? The Nattokinase I find is 50 mg or 100 mg! Don't know how much to take! Never saw any labeled 2000 FU

EC: Pat, FU is the acronym for Fibrinolytic Units, which are defined as enzyme activity units specific for breaking down fibrin. If you search on Amazon for Nattokinase, you will see various brands of Nattokinase have 2,000 - 4,000 FU per capsule. More info regarding Fibrin Units in a Q&A on Amazon here.


Blood Clots
Posted by Samuel (Denver, CO) on 12/02/2022

I was on it... it was working great for years. I was forced to switch to Xarelto, which doesn't dissolve clots. I'd like to find a doctor that can work with me in the denver, co area with both

Hyperviscosity, Heart Disease, Varicose Veins
Posted by Jim (CB, IA) on 03/19/2023

My girlfriend was diagnosed with PVCs, said she felt like she was having a heart attacked 24/7, doc did stress test, had her wear a heart monitor, then wanted to start her on 3 different meds (beta blocker, cholesterol med & something else heart related). We tried several OTC supps, a calcium/magnesium supplement gradually cured her in two weeks. She told her doc on a follow up visit what we did, he said his wife has the same condition and he would have to tell her about our solution. My girlfriend was taking a birth control prescription long term and I think that caused a magnesium deficiency as many prescription drugs do, I don't think she really needed the calcium in the supplement.

Fibrocystic Breasts
Posted by Martha (Keene, NH) on 01/12/2022

Glad the Nattokinase is working for you. My understanding is that it's best taken on an empty stomach; an hour before or 2-3 hours after a meal.

Calf Pain
Posted by Lori (Chester. NY) on 01/21/2023

I've been experiencing calf pain, started talking 2 caps today. I hope It goes away, it's driving me crazy.

Fibrocystic Breasts
Posted by Joe (Tulsa) on 01/09/2018

Nattokinase is to be taken on an empty stomach according to the instructions.

Posted by Pat (Pa) on 12/26/2017

thx Elaine! I started using Nattokinase as blood thinner for Afib about 6 mos ago Only my bottle says 50 mg and another at store said 100 mg. Why does everyone say 2000 FU? Am I taking right dose? I take 1 a day! No side effects. Hope it is working. I think it is!

Posted by Ampy (FL) on 12/01/2020


I just read that you were taking CoQ10 and now added the Nattokinaise and it has helped your migraines. I have migraines now for 40+ years I have been taking CoQ10 for years, my question is, do you take both of these at the same time before a meal on an empty stomach? I was told to take my supplements (which we take a lot of them) after our night time meal. So that's why I'm asking. Would love to know how you are taking this. I will try anything for migraines. Thanks in advance. Ampy

Posted by RedCardinal (Minneapolis, MN) on 12/02/2023

Be aware that there are different manufactured FU strengths per mg. You cannot go by mg, you want to go by FU's per serving. The best capsules have the lowest mg with the highest FUs

Nattokinase Daily Usage
Posted by Art (California) on 03/02/2024 2164 posts

Hi Hollyhock,

In the referenced study it was used continuously for a full 12 month period with no breaks. I am trying to follow the study regimen, so no breaks on my part so far.


Blood Clots
Posted by kcm (western NE) on 04/27/2023

Samuel, I will recommend you contact Kyle Hampton, DO in Ft. Collins, and see if he might be able to help you.

Hope this might help.


Posted by Linda (Virginia) on 08/11/2023

2,000 FU is 400 mg. Likewise, 4,000 FU is 800 mg. So if a person is taking 50 to 100 mg of Nattokinase they are taking a much lower dose than 2 or 4,000 FU. Amazon sells the higher dose of Nattokinase.

Posted by Barbara (Washington) on 10/28/2023

My husband's bottle of nattokinase states that 1 softgel = 100 mg = 2000 FU. He takes 1 a day.

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