My six-year old Silky-Yorkie mix was put on Ketoconazole for a fungal infection in his ears. A few days later I woke up to vomit all over the house! Took him back to vet, where he spent the day having tests, including an ultra sound for his organs.
Here is what they found: Inflamed, swollen liver, pancreatitis, extremely high blood glucose levels. And other, more minor things. Now he must have insulin injections twice a day for diabetes caused by the pancreatitis. He was overweight but in good health otherwise. He is tolerating the insulin well, but I was beside myself the day he stayed in the pet hospital, as they told me I had a very, very sick dog. His name is Harry.
I thank God he made it through, but am so sorry I ever gave him that Ketoconazole. Antifungals are rather dangerous for humans, so what was I thinking when I gave it to my dog? I have good vets and don't blame them, although I wish they had told me about the liver side effects. I think that if a drug can harm the liver, it can surely harm the pancreas. Could not be a rare coincidence, come on! And now he is a diabetic for the rest of his life. It's quite a chore making sure he gets his shots twice a day, but my Harry is worth it! You all know what I mean! -- Roxane
(Los Angeles, CA)
My dog Bailey just died today. He was on Ketoconazole, and developed pancreatitis and diabetes. We took him back to the Vet to put him on fluids and insulin. He was at the Vet overnight, when they called in the morning to say he develope a fever of 109 and to come in because he would die soon. He was only 9yrs old and was a great companion. We should put a class action suit against the drug company that makes Ketconazole.
My 4 yr old 72 lb Golden Retriever Scout died today. I believe his death may have been caused by ketoconazole. My vet prescribed ketoconazole 300 mg twice a day for a yeast infection in his ears. Scout also received his annual vaccinations for rabies and bordetella the same day the prescription began.
Scout died on the 11th day after beginning this treatment. The only symptom he exhibited over this time period was a decrease in energy and on his last day, a lack of appetite.
I will never allow my dogs to take this drug in the future. I would appreciate any information about ketoconazole and others experiences with this drug.
(Belle Center, Oh)
(Nakhon Sawan, Thailand)
For your accumulated information on adverse reactions to drugs, two of my dogs were prescribed ketoconazole for a yeast skin infection. One survived the treatment, the other died during treatment. Other than the skin infection (which was not life threatening), he had no health issues. I was not told before treatment that this medication is hepatotoxic and that it can kill, that it has been established by the manufacturer that there is a 1:10,000 risk of allergic reaction (with underreporting recognized). The vet was not aware (!) of the symptoms of allergic reaction, so when I reported them she did not stop the treatment (dark urine, extreme fatigue, skin turning black and peeling...). When I finally stopped the treatment myself, because my dog was just getting sicker and sicker (after 13 1/2 doses administered out of 30 prescribed) it was already too late. 4 days later he came down with hepititis and 34 days after starting the treatment he died (with bloody vomitting and bloody diahrrea). Although I reported all this, despite my distress) nothing was taken into consideration, everything was dismissed as being a coincidence, and I was given the classic excuse 'your dog was already sick and would have died anyway.' This is an outright lie, of course, and contradicts all the medical file of my dog. But try to get an adverse reaction taken into consideration when the 'authorities' don't want to take it into consideration! Of course there is underreporting! Normally I never give vet medicines to my animals, only homeopathy, but at the time I had no alternative therapy, as skin yeast infection is very difficult to treat. I have since gotten my second dog almost out of her condition, using probiotics and herb Robert and direct applications of hydrogen peroxide on the worst affected areas. My opinion of vets and the authorities that 'oversee' them, has descended to about 0. Would like to know if others have had bad experiences with ketoconazole.
(Desert Hills., Arizona)
If anyone is able to help I have a 55 pound golden retriever with really bad seasonal allergies she's 6 and had the same problem last fall lost all her hair on her chest cut herself up. When I brought her to the vet he gave her Medrol pills starting her off with 8 mg two times a day I'm thinking that's too much but I gave it to her 4 hrs. ago now she's getting really aggravated growling and snapping every time her brother gets near her she's even trying to bite me she's usually the sweetest, happiest, most playful dog you ever want to meet. Anyone know what could be wrong. I hope the vet didn't give her tpo strong of a dose.
My cat Limpy was given one Metacam injection after having a few bad teeth pulled. She came home and was eating and feeling good but with in a week she stopped eating. The vets found Fuild all in her chest but no signs of cancer. Sadly she passed a few days later. I had no idea there were so many reports about the side effects of Metacam. There is a web site called Metacam kills.com. I will always believe this drug killed my cat. The vets are so misguided by the drug companies and seem to be more interested in padding their wallets. I lost the best cat I have ever known because of the vets and this drug Metacam.
I took my 5.5 month old ragdoll kitten for spaying this week. After 2 of the 4 doses of metacam given to her for pain I noticed she was so hyper, jumping up walls and nonstop climbing. She also appeared to be watching the ceiling and I could not get her attention (possibly hallucinating). She responded very well after surgery, ate , drank and went to bathroom almost immediately after coming home from surgery.She did not appear to be in pain but I did not want to take a chance so that is why I gave her the pain meds. Today did not give pain meds but she is very calm and not hyper like on metacam. I believe this was not a good med for her. I will continue to monitor for any changes in behavior and changes.
(Hobart, Tasmania, Australia)
Took my healthy, normal old english sheepdog 6yrs old to vet with small scab. Removed it, gave metacam jab after op. Swelling at op site few days later, gave more metacam to reduce swelling. Then started with side effects of metacam, ie bloody stools/bloody vomit. 3 day stay in vets with gastric ulcer. They said he was fit to collect him, bring home.. But I could see he was sick, fluids on abdomen, rushed him to another vet's, referral centre. Severe advanced peritonitis, ulcer had perforated. Major op. Complication after complication, because the perforation was not detected/treated early. Feeding tubes.. 2 failed oesophagus tubes, abdomen reopened to place gastric tube, that worked. Came home, food and meds through tube for three weeks..liver/pancreas now recovered. After three months, all tests now normal. £12,000!! Couple weeks ago one of my other dog had a lesion.. Wet eczema, new vet wanted to stick him with steroids, NO WAY!
(Portsmouth, Hampshire, Uk)
My late Bichon Frise was prescribed Metacam (meloxicam) 1. 5mg oral suspension for arthritis. He did not show any symptoms of arthritic pain and was a bouncy, youthful little guy until he was given this medication. After only one dose, he became disoriented, started walking in circles and kept "crying". I immediately took him off these meds and did a search on line about this medication. There were so many side affects that I called the vet to discuss this. He refused to take my call. My little guy lived another 2 years but his quality of life was gone after just 1 dose! Please beware of this drug!
I had a 11 year old Rough collie with very bad arthritis. I had had him on Recovery for a year and a half but he was getting worse with age. I decided to try Metacam even though I had been very nervous about it. Within 10 days he became very ill - and I rushed him to the Vet. His heart rate was a way up and his gums were very pale. He ended up in the Critical Care unit and was diagnosed with ulcers and he had vomited and ingested and had pneumonia and partial bloat which they had to wait out because of his condition.
My Collie came home with many meds and he did recover. I had him on something to coat his stomach but within 2 months he had bloat again and had to be put down. I will never again put a dog on Metacam. I do not recall the measurement for Metacam but it was whatever was recommended for his weight.
Re: Metcam (allergic reaction). I had Teddy, a 2 year old pekingese who put his back out. The vet injected him with Metacam and within hours he had breathing problems and the next morning he died. The vet admitted the death was caused by an allergic reaction to the Metacam and he did what he could to counter balance the reaction but to no avail. Has anyone else had this problem?
Metronidazole -Warning- We feel our dog was hyper sensitive to this drug. Became suddenly blind-
Investigate side effects before allowing your dog to have any drugs- We wonder why the vet doesn't provide a warning sheet.? Why doesn't the FDA require this with pet meds? Our loving 7 yr old welsh terrier- we believe had a toxic reaction to this drug- our vet had prescribed this- and gave her another dose of this as she was being released from an overnight stay-when we arrived home and placed her in the house- she immediately was having a bad reaction, going in circles under the table, along the wall-we picked her up-and held her she seemed to calm down, she then rested-So we thought she was o.k.- the next morning took her out to relieve herself-she acted like she was blind!!! . Now totally confused, wobbly, -took her for a 2nd opinion they confirmed that she was now blind- due to optic neuritis inflammation- and that we should see a specialist at the emergency clinic-Went to the ER clinic- they briefly looked at her-and the tech decided she wasn't serious enough-and that the earliest appt was the next day- by the time the specialists were able to see her-it was now 2 days later. This new clinic ran lots of blood work- for $1200.00- We found out she tested positive for Lymes Disease. As we began to investigate her conditions and symptoms on line- Under METRO we saw the warnings- which she had now developed-sudden blindness, Neurologic symptoms, head tilt, confusion. 1)Our first vet administered this on a empty stomach-suppose to be given with food- we now learned 2)Not to be given when Lymes disease is present-which we later found she had 3) she now also had new liver damage due to the steroids she was given too. We feel our dog was poisoned, and mis- diagnosed, in error. Looking back (too late)We wondered why she wasn't put on emergency iv's to flush this out of her system?
To make a long story short- we had to put our sweetheart to sleep.
After looking online-We also brought these printouts of warnings in to the emergency clinic-neuro Dr's attn-at our first appt- she dismissed all of our concerns- and said "Not Likely"
As a final note- We never had to take a pet for advanced care before-(and hope we never do again)-for we have lost faith in professional vet medicine. They instead insisted we restart this drug- and they wanted a liver biopsy, MRI and spinal tap-(that next night when our dog was crying out in pain (it was suggested she was actually not in pain??? perhaps instead- out of her mind- and not coherent?)We weren't going to allow her to be a lab rat-anymore- we knew we must take her back to our new local vet and put her down- For Ayre- No more sorrow no more pain- but we feel this was really botched up.
My dog was on metronidazole last year for colitis. The vet put her on two meds. I don't remember the other off hand but another vet was surprised she was put on both at the same time. She also was given a higher dose than my other dog who is a bit bigger than her. She became incontinent. After searching the internet I found this was a side effect. It took a while but it finally passed. I believe it was the medicine and it had to completely leave her system for her to get back to normal.
(Los Angeles, Ca)
our dog was was put on a long term dose of metronidazole for irritable bowel syndrome a few months ago. unfortunately the medicine caused severe neurological issues in our 12 year old lab/husky. shortly after taking his morning dose one day, he wasn't able to walk straight and lost all control of his limbs. he's mostly recovered, but i think he has had some side effects from this medicine. he was experiencing some arthritis issues prior to this but it's gone down hill rapidly since (the neurological episode occurred this past june, and now our pup can't nearly walk as far as before, despite herbal treatments and acupuncture). i think the use of a long term dose of metronidazole should really be studied further.
I am sharing a recent experience we had with our puppy - by pasting a letter I sent to our vet practice. Thanks for sharing your stories. I am angry at myself for not researching this medication before giving it to our dog. The good news is that Sammy is improving every day and we have seen no further seizures.
RE: Sammy R
Dear Office Management,
I am writing in follow-up to express concern about the care of our dog, Sammy, in your urgent care clinic. As discussed, Sammy was seen by Dr. U. on 7/24/16 for diarrhea and Dr. Y. for seizure on 7/25/16.
I have the following concerns:
Sammy was given a medication, Metronidazole, for treatment of diarrhea. Dr. U. did not discuss treatment options nor shared information about potential side effects of this medication. Of most concern, is the fact that this medication is known to have neurotoxic side effects, even at low doses. No potential side effects of this medication were listed on the “Home Care Instructions” I received at discharge.
2) When your medical team is prescribing any therapy, risks and benefits should be explained thoroughly so that pet owner can make an informed decision. Dr. U's failure to do this is simply unacceptable and substandard care.
3) Metronidazole is not recommended for use in young puppies. Sammy is 7 ½ months old. Given his age, why was this medication used as a first line approach for treatment of Sammy's diarrhea? Why weren't other treatment options offered and discussed with me?
4) I informed Dr. U. that I had given Sammy Loperamide during the night and that his diarrhea seemed improved the next day. Ironically, Dr. U. “scolded” me for giving Loperamide without calling to discuss first. Loperamide has few known side effects for Golden Retrievers. In effect, it is a much safer option than an antibiotic with known neurotoxic risks. I have consistently read in the literature “antimicrobial therapy and routine use of antibiotics in cases of acute uncomplicated diarrhea is strongly discouraged.” Antibiotics are specifically indicated only in animals with: confirmed bacterial infection, predisposition for bacterial translocation, and increased risk for sepsis. It would seem that prescribing Metronidazole as a first line approach for Sammy's uncomplicated diarrhea was completely unnecessary.
5) When Sammy had a seizure within 24 hours of initiating this therapy, I again took him to your urgent care center. Dr. Y. agreed that the medication should be discontinued, but felt that the seizure was an unlikely to be a side effect. As such, she focused on investigating possible toxins and liver disease.
6) I now know that neurotoxicity and CNS symptoms (including seizure) are well-documented side effects of Metronidazole. Dr. Y's decision to disregard the seizure as a possible medication side effect (despite the recent initiation of the medication within the preceding 24 hours) also resulted in a missed opportunity for Valium treatment. The literature states that it can take up to 2 weeks for neurological side effects from Metronidazole to resolve. This time frame is significantly reduced through the use of Valium therapy. I feel certain that Dr. Y did not even consider Valium as a treatment option for possible neurotoxicity/neuro side effects. Instead, Sammy spent the next week with lethargy, pacing, panting, confusion, and had TWO more seizures within the next 24 hours.
This experience has been extremely stressful for Sammy and our family. I have learned to never unquestioningly follow the recommendation of a vet without first doing my own research. Although it remains to be seen if Sammy's seizures and behavior changes were indeed a side effect from this medication, he is improving daily. Whatever the outcome, it does not excuse Dr. U's obligation to discuss risks of a therapy he prescribed.
Please use our experience as an opportunity to make changes to your urgent care practice.
I encourage the vets in your practice to review literature on the use of this medication and it's risks. All vets should also be aware of the recommendation for treatment of neurotoxic side effects with Valium which has been shown to facilitate a quicker resolution of symptoms.
“Most canines who develop neurologic signs secondary to metronidazole administration have received weeks to months of therapy, but toxicity after short-term therapy at relatively low dosages (<60 mg/kg/day) has been reported.”
Diazepam as a Treatment for Metronidazole Toxicosis in Dogs: A Retrospective Study of 21 Cases Jason Evans, Donald Levesque, Kim Knowles, Randy Longshore, and Scott Plummer
J Vet Intern Med 2003;17:304–310
I would also encourage the urgent care vets to use a more conservative approach to treatment of uncomplicated diarrhea.
Most importantly, the vets in your practice should always discuss possible side effects and risks associated with a recommended therapy. The neurologic adverse effects of metronidazole are well documented in humans and companion animals. I can assure you if Dr. U. informed me that neurotoxicity and seizure were know (albeit rare) side effects, I would have opted for another treatment. I cannot overstate this point.