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MSM Side Effects: Ammonia Build-up, Detox Reactions & Safe Dosing

| Modified on May 11, 2026
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The comments below reflect the personal experiences and opinions of readers and do not represent medical advice or the views of this website. The information shared has not been evaluated by the FDA and is not intended to diagnose, treat, or prevent any disease or health condition. Always consult a qualified healthcare professional for medical concerns.
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Depression
Posted by George (Melbourne, Australia) on 08/28/2010

Side effects: Insomnia and severe depression after taking msm for 3 weeks.

Depression
Posted by TammyQ (Chicago, IL) on 11/18/2008

MSM caused severe mood swings in me, then severe depression, so if you have mood disorders, I don't recommend to take it.



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