I also found an effective poultice to be made from saturating 2 folded up paper towels (folded twice) with apple cider vinegar and a thick layer of baking soda to be very effective. I treated my husband's spider?/insect? bite with this. He had developed a large affected area with a black area in the middle and had been put on antibiotics. His symptoms were fever and chills, lack of appetite and he slept a lot. After I applied this poultice (pressed down on bite area until dry, a couple or more times a day), his symptoms disappeared and he recovered quickly.