I have been working with a naturopathic doctor for a number of ailments. Although I do not have RLS, this Dr. has a radio show (620am) in Pittsburgh and has commented on RSL causes. It is usually a mineral deficiency. Adding Calcium, Magnesium or Potassium is typically the remedy. However one must be aware that there is also an underlying cause depleting minerals in the body. Soda pop (pH=2.5), coffee (pH=5.0), alcohol can pull minerals from muscles (cramps) and bones (thinning) to ring the body back to alkaline (the blood is tightly regulated at a pH of ~7.4). Try cutting out such items and supplement with good quality minerals and you should see a marked improvement. Good luck!