Yup, aspirin works for me. I read somewhere that RLS is basically the brain mis-firing low-level pain signals. Aspirin works to block just enough of those signals that RLS goes away - other painkillers work, Tylenol is the safest to take long-term (some studies show elevated liver enzymes after a few weeks, but nothing to be alarmed about and no liver damage occurs). Aspirin has side-effects like blood-thinning if taken over the long-term. I just switch 'em off, but do talk to your doctor.
I have also found that aspirin cures RLS. My dad is a doctor and he said this really works. Obviously some doctors know what is going on! I also get used to the aspirin and have to take as little as possible for it to work all the time. Try it, it works! Ibprofen does not work as well for me.
I just recently found this site and have read everything here about Restless Legs Syndrome.
Everyone in my family has this problem and I have had it since I was a small child. In my family, the "cure" for an episode of RLS is aspirin. Two 325 mg tablets stops all the twitching and crawling sensations in 12-15 minutes and keeps working for at least 3 hours. I go from total twitching overload to sound asleep in moments.
I have been to several specialists about my restless legs because it has become much worse as I get older (I am now over 60). And I develop a temporary tolerance to the aspirin if used day after day, so that I need 3 tablets or 4 to stop the symptoms if I have taken aspirin every night for a week or two. Aspirin has its own serious side effects, especially in these quantities. But, after a couple weeks of no aspirin, 2 tablets will stop the symptoms again.
The neurology specialists I have seen are surprised that common aspirin completely relieves my symptoms. They tell me they have never heard of this or read about it. Their answer is various prescription drugs that have serious side effects for me. I am very interested in several of the remedies described here, but wanted to share my family's experience as well. Has anyone else tried aspirin? It is obviously not a cure, but it stops the symptoms so I can sleep. That's BIG help when you have serious RLS.