Posted by Prioris (ME) on 09/04/2026
★★★★★
★★★★★
I noticed Diosmin isn't listed anywhere here. It is a bioflavonoid that comes from Vitamin C. For those looking for a solution for RLS, it may be worth a try.
Diosmin is used to fix problems in the lower legs, like blood pooling, pumps related to veins and vein problems in general. It has worked wonders for these problems.
So I have been taking Diosmin for a while for various things. At some point in recent weeks, I stopped taking it. I notice my RLS acting up more.
There may be a connection here. I notice Life Extension has it listed but not here. Just take two or three capsules once a day and see ifit responds.
LIFE EXTENSION
What Natural Interventions May Be Beneficial for Restless Leg Syndrome?
- Iron. Iron deficiency or altered brain iron metabolism have been linked to RLS; supplementation is often recommended for RLS patients who have been tested and shown to be deficient. Iron supplementation has been shown to significantly improve symptoms in iron-deficient RLS patients.
- Folate. Low levels of folate may play a role in RLS, especially in pregnant women. Pregnant women with lower folate levels were more likely to develop RLS than women who took vitamins during pregnancy.
- Magnesium. Low magnesium levels can cause excitability of neurons; magnesium supplements are often used to prevent abnormal activity in the nervous system. A case study indicated magnesium may improve symptoms and sleep problems associated with RLS.
- Diosmin. Diosmin is a natural flavone derivative often used for supporting venous function. Since venous disorders have been linked with RLS, diosmin is a promising possible treatment.
- Green coffee extract. Diabetes and pre-diabetes are known risk factors for RLS. Green coffee extract may help maintain healthy glucose levels.
- Valerian root. Valerian, an herbal sedative, is often used as a sleep aid. In a clinical trial, supplementation with valerian resulted in improvements in RLS symptoms and less daytime sleepiness.
- Other natural interventions that may help relieve RLS symptoms include D-ribose and vitamins C and E.
