★★★★★
https://www.frontiersin.org/journals/endocrinology/articles/10.3389/fendo.2026.1825853/full
Here is a relevant quote from the review :
' Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine–metabolic disorder in which reproductive dysfunction coexists with insulin resistance, chronic low-grade inflammation, and heightened oxidative stress (OS). Increasing evidence indicates that these abnormalities are not independent phenomena but components of a self-perpetuating redox-endocrine network that sustains hyperandrogenism, anovulation, and metabolic impairment. This review critically synthesizes experimental, translational, and clinical data to examine whether vitamin D, myo-inositol, and melatonin, three widely used but often studied in isolation bioactives, can act synergistically as a mechanistically coherent ‘bioactive cocktail' in PCOS. Vitamin D modulates inflammatory tone and steroidogenic signaling through vitamin D receptor-dependent transcription and immune–metabolic crosstalk; myo-inositol restores insulin signaling via inositolphosphoglycan second-messenger pathways, thereby attenuating hyperinsulinemia-driven androgen excess; and melatonin exerts pleiotropic effects on mitochondrial function, circadian regulation, and redox balance. Therefore, these agents converge on shared molecular hubs, including NF-κB, Nrf2, PI3K/Akt, and AMPK, linking OS reduction with endocrine and metabolic recalibration. The review further integrates emerging insights into gut microbiota-adipokineinteractions, highlighting how dysbiosis and altered adipokine profiles amplify oxidative and hormonal disturbances, and how these bioactives may counteract such system-level disruptions. While existing clinical trials report improvements in ovulatory function, insulin resistance indices, and OS biomarkers, outcomes remain heterogeneous due to differences in dosing, duration, and phenotype stratification. We propose a redox-guided, phenotype-aware framework for future trials, emphasizing biomarker-anchored outcomes and systems-level integration. If validated, combined vitamin D, myo-inositol, and melatonin supplementation may represent a precision nutraceutical strategy that targets the pathogenic core of PCOS rather than its isolated clinical manifestations. '
The following comprehensive review highlights the use of melatonin for PCOS :
https://pmc.ncbi.nlm.nih.gov/articles/PMC10725523/
Here is a relevant quote from the review :
' This review explores the multifaceted role of melatonin, a hormone primarily known for regulating circadian rhythms, in PCOS management. Melatonin's potential impact on hormonal balance, oxidative stress, sleep quality, and mood is comprehensively examined. It has been shown to enhance insulin sensitivity, regulate sex hormones, and influence gonadotropins, offering promise in addressing the intricate hormonal imbalances common in PCOS. As a potent antioxidant and anti-inflammatory agent, melatonin mitigates oxidative stress and its associated complications. Its role in improving sleep quality and mood can significantly enhance the psychological well-being and daily functioning of PCOS patients. We discuss the potential implications of melatonin as a complementary or adjunct therapy, alongside existing PCOS treatments, and its significance in improving the overall quality of life for individuals with this syndrome. While further research is needed, melatonin's multifaceted effects promise a brighter future for PCOS patients.'
Art
Microbiome PCOS Connection
★★★★★
This is based on study microbial overgrowth syndrome. In an interview Dr. Pimental Mt. Sinai research team discussed an underlying cause of POS is rothia mucilaginosa when overgrown it triggers higher testosterone in women that causes PCOS. I believe this is big part of cure is fully understanding the underlying factor that drives PCOS. I think before theory held was that it was inherited DNA that changed hormonal imbalance which is now perhaps not the case. Do your own research. Wishing everyone good health.
Spearmint
Spearmint
★★★★★
Inositol
★★★★★
Dietary Changes
I commend you for all you are doing to control your PCOS. It takes a lot of perseverance and the right mindset which isn't always easy.
I would suggest you add Chasteberry (Vitex Agnes Castus), a few drops of tincture in water first thing in the morning. It should reduce the heavy blood flow and help to regulate your periods.
Good luck and hope you keep getting better.
General Feedback
Dietary Changes
★★★★★
I've always had irregular periods since puberty at 11. I grew up on junk food (90s kid) and continued to eat that way throughout early adulthood (fast food and junk food). I developed psoriasis when I was 12 and it gradually got worse over the years.
In 2010ish I had an episode where I bled very heavily. Massive blood clots, could not make it to the bathroom without my vision turning white, head pounding, heart palpitations. I eventually recovered but never tried to figure out what happened. The same episodes happened again in 2015 and 2017. In 2017, I was hospitalized twice and the second time I was sent to ICU because my hemoglobin dropped to 2.4. They put me on birth control for the first time (high dose estrogen) and my bleeding stopped.
I continued to eat bad (chips, cookies, fast food, etc.) even though I am vegan. I never ate healthy. In 2019, I went to the RE (reproductive endocrinologist) because me and my husband could not get pregnant. She diagnosed me with PCOS after running tests. Since then, I still ate bad.
Starting this year 2020, I made the change to eliminate all inflammatory foods and get my life back. I was tired of going back and forth of being anemic. I cut out gluten, artificial and all sugars, refined oils.
I have lost 48lbs! PCOS is a low grade consistent inflammation disease and symptoms get worse from insulin spikes. Unfortunately, I am still dealing with irregular periods but that just tells me that I have a long ways to go.
My journey does not end here just because I lost 48lbs. I'm going to keep going until I get my symptoms under control.
My daily routine consists of: Intermittent Fasting Hot Green Tea (I can feel a huge difference when taking this daily on my testosterone levels)
11am-VERY LOW INTENSITY Indoor Cycling
11:30am- VERY LOW INTENSITY Weights >10lbs (push, pull, legs 5x a week)
12pm- Eat My Heaviest Meal (consists of whole foods; choice of beans or pulse, big bag of steamed veggies and choice of vinegar based sauce, choice of spices), extra virgin olive oil, cooked in cast iron pan. 2-3 squares of 90% dark chocolate lemon water throughout the day drink as much water as possible 5pm-Berry Smoothie with Myo-Inositol (blueberries, almond milk, chia seeds, vanilla pea protein, banana or dates) Gingerbread Smoothie with Myo-Inositol(blackstrap molasses, ginger powder, cinnamon powder, almond milk, chia seeds)
My period schedule: Prenatal with applesauce with breakfast and inositol with lemon water 23g Chelated Iron with lunch Blackstrap Molasses shake for dinner. Ibuprofen when I'm really desperate. I don't exercise during this time. My periods are extremely heavy and prolonged.
Massive clots then drop every time I go to the bathroom and flooding of bright red blood for 3 days then I spot the rest of the month.
Focusing on anti-inflammatory foods, healthy carbs, fiber, and loads of iron rich foods really helps me! P.S. I forgot to mention above that I had to have 10 blood transfusions and platelet transfusions. That's how much I bleed! Also I drink red raspberry leaf tea in the mornings in place of green tea if I feel like it, I feel it lightens up my period a bit.
★★★★★
This is a very good (long) article about how inadequate zinc and high copper levels contribute to PCOS, among other things.
http://goddessignited.com/copper-estrogen-zinc-hormone-imbalance/
Please note that cacao/chocolate is very high in copper. Hemp seeds are high in zinc and low in copper. A ratio of 7.5 parts zinc to 1 copper is recommended. 40mg per day is considered the tolerable upper intake level for zinc.
Raw Vegan Diet, Kale Juice
Blackstrap Molasses, Charcoal, Aloe
Blackstrap Molasses, Charcoal, Aloe
★★★☆☆
WORKED TEMPORARILY
2 years I not seeing periods and I take molasses, charcoal tablet and aloe an blend it an drink. It work last year but like period came for 5 days an never come back. Please advise other remedies I can try.
Maca Powder
Maca Powder
Dietary Changes
NAC
★★★★★
I ordered NAC for other reasons and was amazed to see how many other benefits it has including treatment of PCOS. I ordered her some as well and she is going to take it to her Dr and tell him she wants to try this rather than prescription drugs (ie Metformin - same results, but no side effects). According to scientific studies there was a trial of NAC and women taking 1.6g a day apparently had decreased BMI, hair loss, acne etc..
If anyone else has tried this I would like to know their experience with it and I will also report down the track on results for my daughter.
Saw Palmetto
★★★★★
Saw palmetto has worked for me also, pcos symptoms gone and period cycle has returned to normal.
Chaste Tree Berry
Apple Cider Vinegar
Apple Cider Vinegar
My question is can I take ACV/VITEX at the same time?
Hope you can help. Thanks.
Chaste Tree Berry
Apple Cider Vinegar
★★★★★
Hi guyz I use Apple Cider Vinegar and I saw the effect in just 4 days, but I have a question should I take it during periods too? By the way, Apple Cider Vinegar should be taken regularly or I can use its just a few days before my periods? My periods also come less so for that I used flaxseed oil +omega3,6,9 if u guyz want u can try it.
Chaste Tree Berry
I was in the same boat but I did the Apple Cider Vinegar diluted with distiller Water. One part Apple Cider Vinegar to 2 parts water. I used a turkey baster from the dollar store. Then I got a tampon and dipped it in coconut oil with oregano oil. I used the organic wild oregano oil about 15 drops per tablespoon of coconut oil. It burned for about a minute but then I felt relief. My odor was gone and all was great. A month later after having sex with my husband a few times the symptoms came again. I did the same regimen and it went away. The doctor blamed it on my husband too, but since he can't do much about it at least now I know I can.
Green Tea Extract
Thanks for the post. It makes a lot of sense because the doctor told me that high insulin equals high testosterone. I'd like to know how much green tea to take. My Chinese doctor does not want me to take green tea but said I could introduce it slowly once my body was more hot than cold (Whatever that means). Also let me know how you're doing with your symptoms.
PCOS Thinning Hair Remedies
★★★★★
Saw Palmetto
Apple Cider Vinegar
General Feedback
★☆☆☆☆
WARNING!
However, the main side effect was that it caused severe lactic acid built up in my body which resulted in severe cramps and muscle pain so that my body was in intense pain to the extent I had to be hospitalized and treated with quantitites of ibruprophen to dilute the acid.
Apple Cider Vinegar
Chaste Tree Berry
Blackstrap Molasses
★★★★★
My cycles have really started to regulate over the last five months (ranging from 35-40 day cycles but gradually becoming shorter) and I believe it is due to a number of reasons. I started seeing a naturopath doctor about a year ago and over time we have found what works. I am taking Omega supplements, 6 grams inositol daily, vitex twice a day, a whole food prenatal, and a BSM drink a few times a week when I remember before ovulation but after ovulation I make sure to take it everyday.
I was having very bad cramps when I came across BSM on this website and found that it almost eliminated my cramps in less than an hour! The first cycle I began taking it my period went 9 plus days to 5 days and this has continued since.
I believe the inositol and vitex have been essential for helping my cycle and I will continue to take these. Inositol has also been a huge help with regulating my mood especially around PMS time. I also drink a homemade green smoothie everyday.
With my cycles regulating since starting BSM, I can't help but wonder if that has been the final magic ingredient for me.
At first I could not bear the taste of BSM. Now I take BSM as a warm drink. I use a heaping tablespoon of unsulphured BSM and two teaspoons of raw cocoa powder (also has lots of health benefits). It almost tastes like hot chocolate.
Thank you Earth Clinic for multiple cures I have found on your website. I hope my story is able to help someone else.
Apple Cider Vinegar
★★★★★
Maca Powder
★★★★★
However, I used maca powder in my smoothies for 2 weeks. And voila!. my first period! I haven't been so delighted! It may taste absolutely foul and smell revolting, but it seems to be the miracle for me. I have it in my smoothies every morning.
Try it and see what the benefits are for you. Many say it does nothing for them, but you may well be the lucky one.
Good luck :)
★★★★★
This time around, I started bleeding in January 2014 and haven't stopped. It's like an ongoing spotting that never stops. From time to time I'd experience cramping/heavy bleeding/large clot for 6-7 days then resume the spotting.
I've tried the pineapple remedies, the molasses remedies, Shepherd's purse etc. to no avail. What I did was simple: 1/4 C of liquid chlorophyll 1x per day along with 1,000 mg Vitamin C. Within 3 days, the bleeding slowed up a bunch. After 16 days (ie. 2 bottles) I've not experienced any spotting, no bleeding in the last 5 days!!!! For those who are experiencing heavy bleeding, give this a try and let me know what you think.
P.S. My fatigue, palpitations, shortness of breath caused from anemia are gone as well.
Apple Cider Vinegar
Chaste Tree Berry
Raw Vegan Diet, Kale Juice
Chaste Tree Berry
Chaste Tree Berry
Chaste Tree Berry
★★★★★
Thank you :)
★★★★★
For around 6 months I did the paleo diet. Which is more or less veg and meat. Very clean way of eating.
With this I did research and read that kale juice is apparently very good, so I bought a juicer and juiced kale as often as I could.
I lost 40 pounds in about 5 months. Had 3 periods in this time which I thought was amazing as I am usually lucky to get one a year.
Now 2 years on I am fully raw vegan, it's not for everyone I know. However the effects are too great to ignore. I have completely regulated my periods, I'm a healthy weight, and I feel amazing.
I had a scan on my ovaries a few months back and my doctor was astounded he said I was more or less cured and my ovaries looked like an average pair lol.
Please please please research the raw vegan way, read the amazing stories from people who have overcome illnesses.
Oh and kale kale kale, amazing!
