Parkinson's Disease Remedies

https://www.earthclinic.com/cures/vitamin-d-for-parkinsons.html

now the way how to use it soak a cotton swab in %3 hydrogen peroxide and smell it with breath 6 times. 4 times a day. by the same cotton swab clean your ear. for skin cancer soak the wound 10 to 12 times a day.

Now I would like to talk about one of my favorite supplements, melatonin, that a recent randomized, double-blind, placebo-controlled study showed was beneficial for PD patients after just 12 weeks of supplementing only 10 milligrams per night! Yes, finally, a quality human study confirming that melatonin is beneficial for people with PD.

This study showed multiple benefits in patients that include the following. Using standard testing, melatonin showed improvement in anxiety, depression, total antioxidant capacity, increased glutathione, and improved UPDRS Part 1 test results! Melatonin also significantly lowered the inflammatory marker, hs-CRP, or high sensitivity C-Reactive Protein and inflammatory TNF-a while lowering LDL cholesterol and improving insulin resistance! Some of these improvements are suggestive of the idea that a more extensive study and or higher dosing may produce even better results because many of these improvements imply a reduction in total oxidative stress and oxidative stress is one of the most damaging factors in PD that destroys dopaminergic neurons and other cells in the substantia nigra of the brain.

To say I am excited that this study would be an understatement! Studies showing benefits like these in humans with PD from a single supplement are almost non-existent. Hopefully, they will follow through on this study with similar studies using pharmacological dosing of melatonin and more extended length studies.

While this study is very good and confirmed that melatonin can be beneficial in people with PD, it leaves many unanswered questions such as what would have happened if the study had been 24 weeks long instead of 12 as 12 weeks is very short for a study like this? Would the benefits range increase, would the benefits stay the same or increase the level of improvement seen? What would have happened at higher dosing?

Remember that Dr. Shallenberger is using dosing that is as much as 36 times higher than what was used in this study in some of his patients, and he gives all of his patients 180 mg of melatonin per night in the form of three 60 mg capsules in the evening. He considers this a preventative dose.

Overall, I feel this study has opened a door that has been closed for too long, and hopefully, there will be follow up studies to answer these questions! Here is a link to that very recent study abstract :

https://pubmed.ncbi.nlm.nih.gov/32417629/

Art

Go look up Kombucha mushroom, which isn't a mushroom (more akin to the mother in apple cider vinegar). Dr. Josn Axe (chiropracter) has a good article on his site. First heard of this one as a tea to take for cancer - actually you are fermenting your regular tea, which produces the probiotics (good guys in your gut). If you can't find someone locally with mushrooms to give away, you can go on line and order one. Another article you might want to read is an article on Dr. Bradstreet, Dr. Ncholas Gonzales & another whose name I do not remember. These 3 doctors are no longer with us as all 3 were collaborating on a study. Finding that their autistic and their cancer patients all had a foreign substance in their blood called nagalase. First heard of nagalase in Ty Bollinger's Quest for Renedues for cancer,. A female doctor in another country was telling Ty they had found all their cancer patients had nagalase in their blood and they were treating them with probiotics called Bravo and it was working and they knew it was because the nagalase level was dropping. Apparently they found how the nagalase disabled the immune system before these 3 doctors started their research because they were treating their autism & cancer patients with GcMaf, a messenger that one part of our immune systems transmits to another area of the immunne system to trigber the production of macrophages or large white blood cells that are also called the pac men of our immune system because they gobble up the invading pathogens which make us sick. Not sure what the G is for but suspect it is Globulin & and c denoted the type of globulin, The Maf is macrophage activating factor. There was one one lab on our planet testing for nagalase and only one source of GcMaf which were both located close together, but not in the USA or South America. These 3 doctors were seeing 100% success of various kinds of cancer and 85% success with improvement in the other 15% of their autistic patients, before they got raided by the FDA, who confiscated all their information, their data on their research & all their charts. Dr. Bradstreet suddenly disappeared the day his clinic was raided. His body was found floating in a river 3 days later with a bullet wound to the chest & declared a suicide with no investigation whatever. His family, friends & peers said no way did he commit suicide & IMO no way did this man who had become outspoken against vaccines when his own 4 year old son developed autism. No way would this man have killed himself when he knew something was helping his son and there was any chance of getting more of it. No way could he have known that their equivalent of our FDA had raided the only lab testing for nagalase and the only source of GcMaf had also been raided and destroyed about the same time these 3 doctors' clinics were raided & destroyed,

Consider the following points:

(a) Malassezia is an unusual yeast in that it is lipophilic (meaning it feeds on lipids rather than sugars/starches like candida). AND it seeks melanin & infects melanocytes. The dopaminergic neurons in the brain -- the area affected by PD -- contains high levels of neuromelanin. Neuromelanin in turn has an affinity for lipids and for iron, both of which favor the growth of this yeast. Note: because it feeds on lipids rather than sugars, it will NOT grow in the usual fungal cultures performed in hospitals (they use sugar/starches in the medium, no lipids). So it is "under the radar" in the sense that there seems to be little testing ever done for it.

(b) Malassezia is known to infect melanocytes in the skin... and I suspect it is involved in causing skin cancer. If so, this would explain the higher rate of skin cancer found in Parkinson's. Also, because it is in the skin (IN, not only "on"), it could hypothetically be pushed into the bloodstream or spinal fluid by medical procedures like injections or spinal taps.

(c) L-DOPA is a precursor to MELANIN, so it makes sense that Malassezia might take it up ... thereby reducing the amount available for normal brain functioning. Low L-DOPA is a key feature of PD.

(d) Acetaldehyde -- produced by yeast -- converts dopamine into a neurotoxin called salsalinol ... which may cause the eventual aptosis of dopaminergic neurons. It also promotes increased iron content and the release of iron, both of which would favor fungal growth.

(e) Malassezia is extremely common and extremely slow-growing. It may be that people have it for decades or a lifetime. I speculate that risk factors for developing PD might include: prolonged use of antibiotics (esp. intravenous) or steroids/immunosuppressants, depleted flora from any other source including packaged foods which contain additives or may be irradiated to remove flora, accumulative lifetime exposure to UV radiation, including sunlight, medical procedures like CT scans et al; eating a lot of oleic acid (vegetable oils including olive oil are the primary culprit here, but also animal fats), high cholesterol/triglycerides, PRN lipid therapy, taking Vit D or iron, use of certain psych meds like antipsychotics that increase lipids. Meds that cause photosensitivity (= less resistance to UV radiation) might be another area of concern.

If my hypothesis is correct, there are definite implications for prevention steps and maybe also treatment. Some possibilities that come to mind are increasing dietary sulfur (antifungal), increasing "good" flora, avoidance of risk factors including dietary veg. oil/animal fat, etc. Based on my reading, buckwheat also contains an antifungal compound. Whether such steps would have an effect, I don't know. More research is clearly needed.

My father had Parkinson's. He was 72 at that time and still was very active. He stopped driving and this was shocking for him as it was the first time that he was unable to drive.

He was told to consume magnesium daily after every meal, breakfast lunch and dinner. He chose chelate magnesium (it was about 480mg) as it is the form with the highest absorption rate (approximately 40% when taken without any dairy products). Sometimes at night he took 2 of them, as even in the best case scenarios less than 1 would be absorbed. Also, he avoided any exposure to aluminium in his food (aluminium pots, trays, foil, etc). After a month he had visible improvement and on the second month he was planning for his future. He passed away at the age of 94.

This is a personal experience, not medical advice.

I am amazed that after one and a half days of taking methylene blue with vitamin c my 85 year old dad, who has Parkinson's, initiated transfer to his wheelchair and needed much less assistance than yesterday. Yesterday he was not weight bearing much. This morning I did not pick him up to get in his chair, just guided him. I broke out into laughter of happiness!

Thank you a million for the information you provide on earthclinic. I love seeing the results!

Jane

CBD, which I have been associated with and studied as a medical professional for decades (and owner inceptor of 2 CBD stores) is covered in National Institutes of Heal and Pub Med studies that weakly show its effectiveness against Parkinsons and all spasmodic disorders. Why do you think that people flocked to Colorado to use CBD a dedade ago when it was only used here? Why do you think Sanjay Gupta MD cried when he saw seizures disappear in minutes with his own eyes and apologized profusely for ever maligining CBD? In our stores we have a ledger that people weigh in with to describe their personal results and it is incredible what CBD does for pain, inflammation and relaxation right down to the nervous system which is why seizures and Parkinsons commonly stop forever. Supposedly, 47% of children have stopped all seizures in one day and forever. Why in the world do people think that CBD is marijuana? It cannot get you high and has almost zero thc which is another great and innocent healer. In our stores we have people with Parkinsons with resting tremors so bad they need an attendant to function and one week later they roll into the store to get some more CBD completely functional and independent. Look, I am a combat injured Marine from Viet Nam who got the high medical degree in therapeutic science OTR at 50 years old. I do not lie. Just study a bit and you will be astonished.... try CBD vs Parkinsons....CBD vs seizures... CBD vs cancer .. CBD vs pain, inflammation, depression like that. Just study. I am only asking that people get rid of old habits and look at these realities and truths. I never prescribe anything. I only ask people to study and heal as they wish.

Melatonin is lowered by high dose vitamin D, but raising the melatonin level in conjunction with the vitamin D level is synergistic in terms of fighting certain virus and disease such as Covid-19 and PD. Vitamin D has shown benefit for PD in multiple studies and can act as an antioxidant also, though not nearly as potently as melatonin which can neutralize up to 10 oxygen radicals compared to other antioxidants that can reduce only one oxygen radical.

In PD, melatonin is elevated in the blood as the body's attempt to raise its total antioxidant capacity which is depleted by PD and melatonin is capable of doing that if there is enough of it, but the body is only able to raise melatonin so high and consequently the bodies own antioxidant system is not able to completely come back into the normal range as reflected in studies which show that glutathione is lower or insufficient in PD patients.

The study link in the original post shows that just 10 mg of melatonin every night is able to raise glutathione levels up as well as the total antioxidant capacity. This is a very important activity in PD as oxygen radicals and peroxynitrite are at elevated levels and both destroy dopaminergic neurons and other brain cells in the substantia nigra specifically and the brain in general.

Melatonin is a potent scavenger of peroxynitrite and oxygen radicals and an inhibitor of NADPH Oxidase which is a promoter of peroxynitrite. What this all shows is that oxidative stress, peroxynitrite and other oxidants including H202are doing a considerable amount of cellular damage and melatonin is able to ameliorate some of this damage with just 10 mg/night. At a minimum the available literature suggests that melatonin may slow disease progression as well as ameliorate some of the many symptoms of PD through its multitude of protective actions in the body including acting in a potent antiinflammatory capacity and again this is important because the excessive oxidant activity which raises inflammatory markers and levels in patients with PD.

Melatonin has also shown synergy with other antioxidants such as vitamin C, D and E and supplements such as NAC, ALA and Quercetin to name a few.

Melatonin is a unique and amazing molecule that is the most potent antioxidant in the human body!

Art

NAC ( N-acetyl cysteine ), Taurine, Quercetin, and Selenium

This new meta-analysis (10/10/2023) of randomized controlled trials (RCT's) utilizing melatonin in people with PD suggests that melatonin is useful for PD at 10 mg/day and even more so at 50 mg/day or more, and usage length of a year or more is additive to the beneficial effects of melatonin in PD.

Immediate-release melatonin was shown to be superior to prolonged release melatonin. It is also suggested that earlier application of melatonin in the disease may be even more beneficial than application in advanced disease states.

https://www.frontiersin.org/articles/10.3389/fneur.2023.1265789/full

Some relevant quotes from the meta-analysis of RCTs :

' These findings reinforce the rationale of our study, suggesting that melatonin, when used in specific treatment regimens, may alleviate symptom severity and reduce sleep disturbances in Parkinson's disease.'

' Analysis of UPDRS total scores indicate that after at least 12 weeks of treatment, melatonin significantly impacts Parkinson's disease progression when doses of ≥10 mg/day are used. This trend of enhanced melatonin efficacy with higher doses at longer treatment durations has been consistently reported in trails comparing 50 mg/day melatonin with 0.25 mg (61,62) and 50 mg/day melatonin with 5 mg (63) for various outcomes. Furthermore, trials included in our analysis also reported significant results with 50 mg/day melatonin for 1 year (56) and non-significant results with 10 mg/day or 4 mg/day melatonin for 12 weeks (57,58). These findings, supported further by melatonin's ability to exhibit virtually no acute or chronic toxicity (64,65), strongly advocate its long-term utilization at higher doses as a safe choice. '

' Analysis of UPDRS total scores in groups receiving melatonin ≥10 mg/day revealed significant results with no heterogeneity (I2 = 0%). However, including studies with <10 mg doses increased heterogeneity substantially (I2 = 63%). Potential contributors may include dose-dependent and formulation-dependent pharmacokinetics of melatonin, as low dose studies used prolonged release formulations and high dose studies used immediate release formulations (44). Moreover, variations in treatment duration could also play a role, as longer durations with higher doses consistently demonstrated enhanced efficacy in previous studies (56–58). '

' Apart from dosage and duration, a crucial difference among these trails was the timing of melatonin intervention. In the significant study (56), melatonin was initiated in newly diagnosed patients immediately after observing a satisfactory response to anti-Parkinson's therapy. In contrast, patients in non-significant studies (57,58) had mean disease duration of 5.7 ± 1.9 and 5.0 ± 3.9 years respectively, indicating significant pre-existing damage at the time of melatonin introduction. This selection of patients with longer disease duration and introduction of melatonin at a later stage reveal an inherent flaw, as starting melatonin before neuronal loss is crucial for its free radical scavenging and antioxidant properties (18,19,31,33,42) to effectively prevent degeneration and reduce symptom severity in Parkinson's disease. In addition, a sub-analysis focusing on only immediate-release formulations, also yielded significant results, however, use of prolonged-release formulation in only one study (58) hinders appropriate comparisons. '

' Hence, melatonin can indirectly lead to an improvement in motor symptoms through sleep improvement. This effect appears to be unrelated to its antioxidant properties, indicating a multifaceted potential for melatonin in Parkinson's disease treatment. '

' As far as we know, a systematic categorization of melatonin into dose groups for motor symptoms and sleep disturbances in Parkinson's disease has not been conducted before, and is a defining feature of this meta-analysis. Furthermore, it strongly recommends the use of long-term, high-dose immediate-release melatonin in future investigations and emphasizes the significance of selecting patients with shorter disease duration and initiating melatonin early to fully explore its true therapeutic potential. '

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My favorite quote from this meta-analysis:

' These findings, supported further by melatonin's ability to exhibit virtually no acute or chronic toxicity (64,65), strongly advocate its long-term utilization at higher doses as a safe choice. '

I'm glad to see studies confirming the potential of melatonin in PwP, whereas earlier studies only hinted at such possibilities based on the known healthful methods of action of melatonin in humans.

Art

After 4 treatments, I can now FAST WALK a block without the walker.

I also added Calcium Edonite Clay to detox from a plant-sourced Vit C which contains "ESSENTIAL TRACE ELEMENTS"--unlike my usual fastidiousness in Research, I 'paid no mind' to what the TRACE ELEMENTS are! I progressed rapidly with ~ 4 months use: TRACE MINERAL ELEMENTS, aka: UDOMS ARE DEADLY FOR P.D. PATIENTS!! ANCIENT HEAVY METALS washed up from the sea!!! Just what P.D. does NOT WANT! Within 3 days of detox (metals, pollutants, herbicides & Pesticides, fluoride from tap water treatment, etc).

Note: I called the Nat'l Parkinsons Foundation: rep said she had never heard of any detox!!

https://www.earthclinic.com/cures/parkinsons-disease-thiamine-vitamin-b-one.html

There is also a Facebook group now that deals specifically with vitamin B1 for PD, but I don't use Facebook and don't have a link for that group, but it should be easy enough to find.

Art

I bought the 1% MB at a hardware shop in the aquatics section. Then I converted the 1% MB to 0.1% MB by adding 1 X part by volume of MB to a dropper bottle, then I added 9 parts by volume of water as well. I just use a simple bottle cap for this -- where 1 part by volume equals one cap full. This will give you 0.1% MB. I put this mixture into a suitable bottle with a dropper top.

When I need it, I take one full glass of water with 2 grms Ascorbic Acid completely crushed and dissolved in it and add just one or two drops of the 0.1% MB to it. I take this twice a day if I need the energy or if I feel a cold or flu coming one. Gives you alot of energy and significantly boosts the immune system.

I recently submitted a link to a new research paper suggesting that Alzheimer's disease might be associated with fungus. Existing research and other writings already support the association of Parkinson's disease with fungus, see below.

http://www.ncbi.nlm.nih.gov/pubmed/17051898

Acetaldehyde is a toxin produced by fungus. The abstract for the above-linked study from 2006 states that, "In the presence of acetaldehyde, dopamine is converted into salsolinol, a neurotoxin involved in apoptosis of dopaminergic neurons."

In other words, fungus produces a toxin which combines with dopamine to make a neurotoxin, which then causes the dopamine-making neurons to self-destruct (apoptosis is programmed cell death). The loss of most of the dopamine-making neurons in the brain's substantia nigra causes dopamine levels to drop drastically, causing parkinsonian symptoms.

http://www.jns-journal.com/article/S0022-510X(13)00865-4/abstract

Fungal volatile organic compounds: Biogenic toxins as etiological agents for Parkinson's disease

http://onlinelibrary.wiley.com/doi/10.1002/mds.870040407/abstract;jsessionid=A3B2BCF1576B95E7AD833F0EE18DF39F.f01t01

Parkinsonism secondary to bilateral striatal fungal abscesses

https://books.google.com.cy/books?id=Kr9I8vJIUJ4C&pg=PA106&dq=Acetaldehyde+is+one+of+fifty+different+toxins+that+is+produced+by+the+Candida&hl=en&sa=X&ved=0CBoQ6AEwAGoVChMI04W-8sXlyAIVoiVyCh1TiwOd

The book, Road to Recovery by Richard Rodgers, discusses the author's belief that Parkinson's is caused by a fungal infection. This topic is addressed on page 106. You can read that page by following the above Google Books link.

http://www.ncbi.nlm.nih.gov/pubmed/17051898

Chronic polysystemic candidiasis as a possible contributor to onset of idiopathic Parkinson's disease.

http://www.vrp.com/digestive-health/a-health-destroying-toxin-we-cant-avoid-and-must-detoxify

A Health-Destroying Toxin We Can't Avoid And Must Detoxify

Article is written by a Clinical Laboratory Scientist--see paragraph titled Detrimental Effects.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3689266/

Acetaldehyde and parkinsonism: role of CYP450 2E1

In the paragraph titled Acetaldehyde and Parkinson's Disease, they don't mention the fact that acetaldehyde can be produced by fungus; they relate it to alcohol consumption, which is another reason for acetaldehyde to be present in the body.

http://www.ojs.ukw.edu.pl/index.php/johs/article/view/2015;5(3):68-78

Fungal infection possible pathogenic role in Parkinson disease and parkinsonism

This 2015 journal article published in Poland by researchers at Odessa National Medical University in Ukraine is written in the Russian language, but the abstract is translated into English.

https://www.google.com/patents/US6652866

Method for treating diseases of fungal, yeast, and prion protein etiology

This veterinarian believes that many neurodegenerative disorders are caused by fungi. He has developed a method of treating symptoms of the disorders by administering anti-fungal fatty acids, as explained in his patent application.

People with Parkinson's disease (PD) are noted for having a "musty smell" and some people refer to this smell as the smell of PD. Few people are capable of detecting this smell. Many fungal infections are said to have a musty smell also.

Dr. Laurie Mischley has trained her dogs to detect this particular smell as shown in the following video :

https://youtu.be/1XjWOD4ENAc?si=-caVE4mW7mxiL-71

She says her dogs are fairly accurate in recognizing this smell, even early in the disease process.

Vitamin B2 / Riboflavin has antimicrobial properties which include acting as an antifungal. Interestingly, people with PD often are deficient in vitamin B2 as discussed here :

https://www.google.com/search?q=are+people+with+parkinson's+disease+low+on+vitamin+B2&rlz=1C1CHBF_enUS1038US1038&oq=are+people+with+parkinson's+disease+low+on+vitamin+B2&gs_lcrp=EgZjaHJvbWUyBggAEEUYOTIHCAEQIRiPAjIHCAIQIRiPAtIBCTIzNjcwajBqN6gCALACAA&sourceid=chrome&ie=UTF-8

Here is a relevant quote from the link :

' Yes, individuals with Parkinson's Disease (PD) may have lower levels of vitamin B2 (riboflavin) and other B vitamins, particularly in their gut microbiota. Studies have shown a decrease in bacterial genes responsible for riboflavin and biotin biosynthesis in people with PD. This deficiency can affect the production of essential gut metabolites and potentially contribute to neuroinflammation, a key feature of PD. '

Perhaps vitamin B2 / Riboflavin may be worth discussing with your husband's doctor.

If you are not already informed on vitamin B1 / Thiamine and PD, it might also be worth having that discussion with his doctor.

Keep us posted!

Art

Dysfunction in the dopaminergic system relates to motor control issues due to low dopamine levels creating Parkinson's Disease.

amino acid phenylalanine converts to amino acid tyrosine: precursor for dopamine

Found in high-protein foods such as chicken, turkey, fish, dairy products, protein powders and certain nuts and seeds.

Tyrosine: essential for: Building proteins, producing important enzymes, communication between nerve cells, producing thyroid hormones.

B vitamins act as coenzymes or help activate enzymes in the body. This is why using a B-Complex is essential. When taking a food based/bio available vitamin and mineral you can add an additional B-complex. This way your spreading the nutrients throughout the day.

Digestion: is not as efficient as we age or just have general digestive problems. People that drink water with their meal may get acid reflux. Reason water dilutes the acid in the stomach hindering digestion, so sip a little water during a meal. Drink `16 oz. ½ hour before meal and 1 hour after so no interference with digestion. Gluten in grains easier to digest younger, but gluten is like little tiny razor blades that cut your intestinal track. As we get older or over indulge or body does not heal as fast. Why some countries use old wheat that not as high in gluten. Love those GMO seeds.

A smoothie is a great way to get proper nutrients: a cup of almond milk, a scoop of proteint powder. Garden of Life has a great protein and greens with enzymes and probiotics. You can add a little fruit and vege. Or other things. Make about 3 cups.

If your allergic to a food it enables your body to consume its nutrients. An ND Donald Lepore states in his book. Calcium and Potassium among other nutrient deficiencies (b-complex) is observed the most in Parkinson's. Calcium requires your parathyroid to utilize this mineral. You may need iodine and thyroid gland for proper functioning. If your allergic to dairy, you won't absorb the nutrients, a source of calcium, your low in potassium. An additional bio available form of Calcium, magnesium and D3 are essential. You may need to take a nutrient test to see where all the vitamins, minerals, amino acids levels are.

pH of 7 is neutral, a slightly alkaline pH of 7.35–7.45 is considered optimal for human health.

https://draxe.com/nutrition/acidic-foods/

Antioxidants are compounds that inhibit oxidation, a chemical reaction that can produce free radicals. Need more antioxidant foods.

Free radicals are unstable molecules that can cause damage to cells and DNA in the body, leading to oxidative stress and various health issues.

If you have tremors you may need a sedating nervine. Lions Mane is great for healing nerves, but some people are allergic to it. Another post creates positive results for AEP calcium. Omega 3 fish oil great for brain health. Your kidneys, immune system, digestive tract, cerebral blood flow may need attention. The list goes on.

Nerve regrowth brain: Lions Mane, Gotu Kola

B1, B6, B12

Nutrients involved in making and regulating neurotransmitters: Magnesium, zinc, iron

Dopaminergic system

Midbrain Tedmentum: includes Red Nucleus, Substantia Nigra, Periaqueductal Gray Matter

Substantia Nigra: critical for integrating voluntary movements, motor control and is linked to the regulation of dopamine

Red Nucleus: Involved in motor coordination, particularly for limb movements.

Auricular Therapy

Protocol

Parkinsonian Tremors

Midbrain Tedmentum, Stratium, Adrenal gland.C, ACTH, Point Zero, Shen Men.

Terry Oleson

Auricular Therapy Manual

Acupuncture and Auricular Therapy is about nerves. You can speed the nerve up (tonify) or slow the nerve down (sedate). They are not just about the protocol: for example in Auricular Therapy you can use an electronic probe that detects areas that need attention. So if you spinal cord, brain stem, red nucleus needs treated this smooths out the nerves to a proper functioning state.

Please see a Naturopathic Doctor, Acupuncturist that utilizes Auricular Therapy and maybe even a nutritionist. Their are to may things going on with one person to guide you properly without looking at the big picture. Its about a holistic view, not just the Parkinson's. Remember if a healthy diet is not created the supplements and healing aspects will only do so much.

One can not do everything. It is about the quality of life and what one is willing to do and can afford.

We just created a new page (updated the URL above in your reply above), so the title now comes up in searches at the top. The sub-page in the Parkinson's section was deleted. You can find the new page in the Ailments index.

Here is the new URL to your page:

https://www.earthclinic.com/parkinsons/high-dose-thiamine.html

Here is a link to the actual study done about 11 months ago :

https://www.frontiersin.org/articles/10.3389/fcimb.2023.1181315/full

They are looking at three specific strains of the Desulfovibrio bacteria (DSV) :

1. D. desulfuricans

2. D. fairfieldensis

3. D. piger

The study was done in worms, which may or may not translate to humans. In any case, there are specific antibiotics that can target these bacteria as well as supplements that also target these bacteria, but to date, no human studies have been done to test this theory.

As an example of a supplement that works against these strains, inulin made from agave has a negative impact, but it has not been shown which strains of Desulfovibrio it works against as discussed in this article :

https://www.sciencedirect.com/science/article/pii/S0022316622088551?via=ihub

Here is a relevant article quote :

' Desulfovibrio were depleted 40% with agave inulin compared with control. Agave inulin tended (P < 0.07) to reduce fecal 4-methyphenol and pH. Bivariate correlations revealed a positive association between intakes of agave inulin (g/kcal) and Bifidobacterium (r = 0.41, P < 0.001). Total dietary fiber intake (total fiber plus 0, 5.0, or 7.5 g agave inulin/d) per kilocalorie was positively associated with fecal butyrate (r = 0.30, P = 0.005), tended to be positively associated with Bifidobacterium (r = 0.19, P = 0.08), and was negatively correlated with Desulfovibrio abundance (r = −0.31, P = 0.004). '

Again, no human studies to support the use of agave inulin for PD.

As far as a treatment for PD, given that the actual cause or causes of PD are still not known, there is no likely cure for the disease, only treatments to help reduce symptoms. The downside to the mainstream treatments for PD is that they can have significant side effects. The treatment that has been the mainstay for PD for about 50 years is the combination drug, Carbidopa /Levodopa also referred to as Sinemet.

One of the supplements that has shown significant anecdotal evidence against PD is vitamin B1 at higher dosing levels. Again, no human studies to support its use.

My personal opinion is that one of the best natural treatments for PD is fecal microbiome transplantation (FMT). Unfortunately, FMT is only approved for two diseases in the United States, neither of which is PD. In order to get FMT for PD, you might have to travel to China, which is much more progressive than most countries when it comes to FMT. This would be cost prohibitive for most people. FMT is already proven safe in human studies, but is still only approved for Clostridioides difficile, commonly referred to as C.diff, a bacterial infection of the gut which can be life threatening in severe cases. It is also approved for IBS in the US. In both diseases, it is normally only used when the standard treatments have failed to be effective.

Art

Some ways that Malassezia or other fungi could potentially get into the brain are:

- medical procedures/treatments, such as surgery w/ anesthesia, CT scans of the head (radiation can affect the blood brain barrier temporarily), use of IV drugs (legal or illegal) esp. IV antibiotics or IV lipids;

- spinal tap: if Malassezia is present in (not just on) the skin, a tap could theoretically push yeast into the CSF;

- presence of other infections known to have the ability to cross the blood brain barrier, such as Lyme disease

Red pine oil as a biofilm buster.

The dosing for Mucuna Pruriens(MP), like Levodopa, is very individualized and will vary considerably from person to person. People wonder what is the attraction of MP over prescription Levodopa/Carbidopa since MP has as one of its main components, Levodopa and the truth is that some people just prefer what they consider a more natural approach of using a natural plant over a prescription drug. While it is true that they both contain Levodopa, but Levodopa on its own can increase oxidative stress in the brain which can then increase neuroinflammation and in the long run this is likely to be counterproductive for people with Parkinson's (PwP) as they are already suffering with elevated oxidative stress levels and elevated neuroinflammation which have been shown to increase disease progression.

What MP has that makes it possibly more effective than Levodopa is other useful components which have shown the ability to lower oxidative stress and neuroinflammation. These other components include quercetin, Betulinic Acid, Ursolic Acid, CoQ-10, NADH and more which have shown the ability to lower oxidative stress and neuroinflammation. This is very important for PwP and Levodopa alone has none of these other attributes that MP has.

You may be wondering what MP can do compared to levodopa in PwP that is different. In PwP studies, MP can significantly reduce onset of action significantly which is important because many PwP complain that it can take an hour or more to take effect while MP takes effect significantly faster probably due to the other active components in it as mentioned above. That effect alone may make it worth it for some PwP to consider MP. Another benefit of MP over levodopa alone is increased "on time" of 21.9%! Levodopa is a single component prescription drug and can not offer these other benefits of MP! Increased "on time", equates to decreased "off time and what PwP wouldn't want that?

One study went so far as to suggest that MP, "protects or prevents the progression of the disease".

On a related note, I will be posting about this in more detail soon, here on EC! I am of the opinion that a combination of levodopa and MP maybe the best of both worlds as multiple Levodopa products also contain Carbidopa or Benserazide to control levodopa breakdown before it reaches the brain and I believe it also helps prevent conversion of levodopa to dopamine outside of the brain and this is very important because dopamine can not cross the blood brain barrier.

Art