For those who may remember, I have previously reported the benefits of high dose vitamin B-1 /Thiamine HCL for Parkinson's disease.
Now I would like to talk about one of my favorite supplements, melatonin, that a recent randomized, double-blind, placebo-controlled study showed was beneficial for PD patients after just 12 weeks of supplementing only 10 milligrams per night! Yes, finally, a quality human study confirming that melatonin is beneficial for people with PD.
This study showed multiple benefits in patients that include the following. Using standard testing, melatonin showed improvement in anxiety, depression, total antioxidant capacity, increased glutathione, and improved UPDRS Part 1 test results! Melatonin also significantly lowered the inflammatory marker, hs-CRP, or high sensitivity C-Reactive Protein and inflammatory TNF-a while lowering LDL cholesterol and improving insulin resistance! Some of these improvements are suggestive of the idea that a more extensive study and or higher dosing may produce even better results because many of these improvements imply a reduction in total oxidative stress and oxidative stress is one of the most damaging factors in PD that destroys dopaminergic neurons and other cells in the substantia nigra of the brain.
To say I am excited that this study would be an understatement! Studies showing benefits like these in humans with PD from a single supplement are almost non-existent. Hopefully, they will follow through on this study with similar studies using pharmacological dosing of melatonin and more extended length studies.
While this study is very good and confirmed that melatonin can be beneficial in people with PD, it leaves many unanswered questions such as what would have happened if the study had been 24 weeks long instead of 12 as 12 weeks is very short for a study like this? Would the benefits range increase, would the benefits stay the same or increase the level of improvement seen? What would have happened at higher dosing?
Remember that Dr. Shallenberger is using dosing that is as much as 36 times higher than what was used in this study in some of his patients, and he gives all of his patients 180 mg of melatonin per night in the form of three 60 mg capsules in the evening. He considers this a preventative dose.
Overall, I feel this study has opened a door that has been closed for too long, and hopefully, there will be follow up studies to answer these questions! Here is a link to that very recent study abstract :
Editorial Note: Art's research on vitamin D is to be found here:
fg hydrogen peroxide to 3% have done too many good to me. i been using it for the last 16 months. i have cured edema, bronchitis, skin cancer, curb niel, easy breathing. all that happened by hydrogen peroxide.
now the way how to use it soak a cotton swab in %3 hydrogen peroxide and smell it with breath 6 times. 4 times a day. by the same cotton swab clean your ear. for skin cancer soak the wound 10 to 12 times a day.
Melatonin is lowered by high dose vitamin D, but raising the melatonin level in conjunction with the vitamin D level is synergistic in terms of fighting certain virus and disease such as Covid-19 and PD. Vitamin D has shown benefit for PD in multiple studies and can act as an antioxidant also, though not nearly as potently as melatonin which can neutralize up to 10 oxygen radicals compared to other antioxidants that can reduce only one oxygen radical.
In PD, melatonin is elevated in the blood as the body's attempt to raise its total antioxidant capacity which is depleted by PD and melatonin is capable of doing that if there is enough of it, but the body is only able to raise melatonin so high and consequently the bodies own antioxidant system is not able to completely come back into the normal range as reflected in studies which show that glutathione is lower or insufficient in PD patients.
The study link in the original post shows that just 10 mg of melatonin every night is able to raise glutathione levels up as well as the total antioxidant capacity. This is a very important activity in PD as oxygen radicals and peroxynitrite are at elevated levels and both destroy dopaminergic neurons and other brain cells in the substantia nigra specifically and the brain in general.
Melatonin is a potent scavenger of peroxynitrite and oxygen radicals and an inhibitor of NADPH Oxidase which is a promoter of peroxynitrite. What this all shows is that oxidative stress, peroxynitrite and other oxidants including H202are doing a considerable amount of cellular damage and melatonin is able to ameliorate some of this damage with just 10 mg/night. At a minimum the available literature suggests that melatonin may slow disease progression as well as ameliorate some of the many symptoms of PD through its multitude of protective actions in the body including acting in a potent antiinflammatory capacity and again this is important because the excessive oxidant activity which raises inflammatory markers and levels in patients with PD.
Melatonin has also shown synergy with other antioxidants such as vitamin C, D and E and supplements such as NAC, ALA and Quercetin to name a few.
Melatonin is a unique and amazing molecule that is the most potent antioxidant in the human body!
I have taken Macuna since 2009. I find it to be very valuable. Have never taken a specific PD pharmaceutical, and won't. The side effects are far too dramatic. Macuna has no negative side effects.
Acupuncture, Detox Herbal Remedies
I'm treating my Parkinson's disease with herbals, exercise, & have chosen TCM ACUPUNCTURE (Traditional Chinese Medicine) over traditional DBS;
After 4 treatments, I can now FAST WALK a block without the walker.
I also added Calcium Edonite Clay to detox from a plant-sourced Vit C which contains "ESSENTIAL TRACE ELEMENTS"--unlike my usual fastidiousness in Research, I 'paid no mind' to what the TRACE ELEMENTS are! I progressed rapidly with ~ 4 months use: TRACE MINERAL ELEMENTS, aka: UDOMS ARE DEADLY FOR P.D. PATIENTS!! ANCIENT HEAVY METALS washed up from the sea!!! Just what P.D. does NOT WANT! Within 3 days of detox (metals, pollutants, herbicides & Pesticides, fluoride from tap water treatment, etc).
Note: I called the Nat'l Parkinsons Foundation: rep said she had never heard of any detox!!
Just a plug for my favorite help regarding Parkinson's Disease. I have found in at least three cases I know of personally, that the use of AEP has slowed or stopped the progress of the disease. Please take a look at the on line article by googling, "Nutrition Review... Calcium AEP Membrane Integrity Factor" which talks of the many benefits of AEP. Lately AEP has also been shown to help PD. AEP can be found on line but I rarely can find it in health food stores. I first saw the benefits from reading Dr. Adkins' book, Vita Nutrients. He used it in IV form with his MS patients. I get mine from Wellness Resources.
I have been hearing a lot lately about cholesterol lowering drugs, and the link to alzhiemers . Don't you think, it could also be a factor in Parkinsons disease??? The brain is mostly cholesterol anyway. Not sure, but in 80-90% range. I would bet a lot of Parkinsons patients take these drugs. Just a theory. God Bless all who are looking for answers and Help. He has never failed to help me.
I believe Malassezia yeast may be the actual/most common cause of Parkinson's, in combination with environmental & virulence factors that favor its growth and aggressiveness. If so, this has definite implications for prevention & treatment.
Consider the following points:
(a) Malassezia is an unusual yeast in that it is lipophilic (meaning it feeds on lipids rather than sugars/starches like candida). AND it seeks melanin & infects melanocytes. The dopaminergic neurons in the brain -- the area affected by PD -- contains high levels of neuromelanin. Neuromelanin in turn has an affinity for lipids and for iron, both of which favor the growth of this yeast. Note: because it feeds on lipids rather than sugars, it will NOT grow in the usual fungal cultures performed in hospitals (they use sugar/starches in the medium, no lipids). So it is "under the radar" in the sense that there seems to be little testing ever done for it.
(b) Malassezia is known to infect melanocytes in the skin... and I suspect it is involved in causing skin cancer. If so, this would explain the higher rate of skin cancer found in Parkinson's. Also, because it is in the skin (IN, not only "on"), it could hypothetically be pushed into the bloodstream or spinal fluid by medical procedures like injections or spinal taps.
(c) L-DOPA is a precursor to MELANIN, so it makes sense that Malassezia might take it up ... thereby reducing the amount available for normal brain functioning. Low L-DOPA is a key feature of PD.
(d) Acetaldehyde -- produced by yeast -- converts dopamine into a neurotoxin called salsalinol ... which may cause the eventual aptosis of dopaminergic neurons. It also promotes increased iron content and the release of iron, both of which would favor fungal growth.
(e) Malassezia is extremely common and extremely slow-growing. It may be that people have it for decades or a lifetime. I speculate that risk factors for developing PD might include: prolonged use of antibiotics (esp. intravenous) or steroids/immunosuppressants, depleted flora from any other source including packaged foods which contain additives or may be irradiated to remove flora, accumulative lifetime exposure to UV radiation, including sunlight, medical procedures like CT scans et al; eating a lot of oleic acid (vegetable oils including olive oil are the primary culprit here, but also animal fats), high cholesterol/triglycerides, PRN lipid therapy, taking Vit D or iron, use of certain psych meds like antipsychotics that increase lipids. Meds that cause photosensitivity (= less resistance to UV radiation) might be another area of concern.
If my hypothesis is correct, there are definite implications for prevention steps and maybe also treatment. Some possibilities that come to mind are increasing dietary sulfur (antifungal), increasing "good" flora, avoidance of risk factors including dietary veg. oil/animal fat, etc. Based on my reading, buckwheat also contains an antifungal compound. Whether such steps would have an effect, I don't know. More research is clearly needed.
I'd urge everyone to look into CoQ10. This research study gave 1200mg of CoQ10 per day to those with early Parkinson's and showed evidence of slowing functional decline: https://www.ncbi.nlm.nih.gov/pubmed/12374491
Ted, my sister is 47 years old and was recently diagnosed with Parkinson's Disease. Please advise on a course of vitamins and supplements as well as a diet plan for her. Please state dosage and time of day to take each vitamin/supplement. Thank you for your time.
Hi John...I have been using Methylene Blue(MB) plus Vit C for a while now.
I bought the 1% MB at a hardware shop in the aquatics section. Then I converted the 1% MB to 0.1% MB by adding 1 X part by volume of MB to a dropper bottle, then I added 9 parts by volume of water as well. I just use a simple bottle cap for this -- where 1 part by volume equals one cap full. This will give you 0.1% MB. I put this mixture into a suitable bottle with a dropper top.
When I need it, I take one full glass of water with 2 grms Ascorbic Acid completely crushed and dissolved in it and add just one or two drops of the 0.1% MB to it. I take this twice a day if I need the energy or if I feel a cold or flu coming one. Gives you alot of energy and significantly boosts the immune system.
The dosing for Mucuna Pruriens(MP), like Levodopa, is very individualized and will vary considerably from person to person. People wonder what is the attraction of MP over prescription Levodopa/Carbidopa since MP has as one of its main components, Levodopa and the truth is that some people just prefer what they consider a more natural approach of using a natural plant over a prescription drug. While it is true that they both contain Levodopa, but Levodopa on its own can increase oxidative stress in the brain which can then increase neuroinflammation and in the long run this is likely to be counterproductive for people with Parkinson's (PwP) as they are already suffering with elevated oxidative stress levels and elevated neuroinflammation which have been shown to increase disease progression.
What MP has that makes it possibly more effective than Levodopa is other useful components which have shown the ability to lower oxidative stress and neuroinflammation. These other components include quercetin, Betulinic Acid, Ursolic Acid, CoQ-10, NADH and more which have shown the ability to lower oxidative stress and neuroinflammation. This is very important for PwP and Levodopa alone has none of these other attributes that MP has.
You may be wondering what MP can do compared to levodopa in PwP that is different. In PwP studies, MP can significantly reduce onset of action significantly which is important because many PwP complain that it can take an hour or more to take effect while MP takes effect significantly faster probably due to the other active components in it as mentioned above. That effect alone may make it worth it for some PwP to consider MP. Another benefit of MP over levodopa alone is increased "on time" of 21.9%! Levodopa is a single component prescription drug and can not offer these other benefits of MP! Increased "on time", equates to decreased "off time and what PwP wouldn't want that?
One study went so far as to suggest that MP, "protects or prevents the progression of the disease".
On a related note, I will be posting about this in more detail soon, here on EC! I am of the opinion that a combination of levodopa and MP maybe the best of both worlds as multiple Levodopa products also contain Carbidopa or Benserazide to control levodopa breakdown before it reaches the brain and I believe it also helps prevent conversion of levodopa to dopamine outside of the brain and this is very important because dopamine can not cross the blood brain barrier.
OK this is important - if ALS is similar to Parkinson's then hopefully this treatment may work there too. This study found that in rats a copper chelator dramatically improved their health.
"As reported in the January 27 Neurobiology of Disease online, the researchers treated the mice with CuATSM, a reddish copper chelator that can carry the metal into the brain and spinal cord. There, the theory goes, the chelator releases Cu ions to the Cu/Zn superoxide dismutase 1, an enzyme that causes a rare familial form of ALS when mutated and tends to aggregate when it's missing its copper. .."
"Beckman's group was studying why those mSOD1xCCS mice fell so ill when researchers from the University of Melbourne who worked with CuATSM visited his lab. The scientists decided to try the compound in one double transgenic mouse, which was unable to stand and near the end of its short lifespan.
"The researchers dissolved CuATSM in dimethyl sulfoxide and dribbled in onto the pup's neck, where it was quickly absorbed by the skin. A few hours later, the mouse was up and moving."
Methylene Blue and Vitamin C
I am amazed that after one and a half days of taking methylene blue with vitamin c my 85 year old dad, who has Parkinson's, initiated transfer to his wheelchair and needed much less assistance than yesterday. Yesterday he was not weight bearing much. This morning I did not pick him up to get in his chair, just guided him. I broke out into laughter of happiness!
Thank you a million for the information you provide on earthclinic. I love seeing the results!
My mother was prescribed too much Carbidopa / Levodopa a.k.a. Sinemet at the outset of her Parkinson's diagnosis and she developed an allergic reaction to it that resulted in terrible rashes with debilitating itchy hives all over her body.
After many efforts to find solutions, my sister solved the allergy by having her take Benserazide / Levodopa a.k.a. Madopar [sold in Europe], which cleared up the rashes while preserving the long-term benefits of a parkinson's medication.
Sometimes a slightly different take on a conventional approach can make a huge difference.
Methylene Blue and Vitamin C
Methylene blue can be purchased in two forms: pre-mixed with other elements or in a 'pure' state. ... What form is referred to by 1.0% and 9.1%? ... When adding 100 cc of methylene blue to 900 cc of water, what form of methylene blue is used - the pre-mixed or the 'pure'? ... How much Vit C is taken together with methylene blue? ... I'm asking because I would like to try methylene blue and vitamin C for my Parkinson's. ... I am 78 years old, diagnosed as having Parkinson's in 1998.
Just a quick answer to a few of your questions and comments. My Dad is 85. He began having symptoms at approximately 79 or so. He probably had symptoms earlier than that, but I did not see him all that often during that time and also the Parkinson's symptoms began insidiously.
We are not so perfect with the MB dosing. I try to give at least three doses per day. I also try to make sure he has sodium ascorbate to go along with it for at least two of the doses. I would like to be more consistent giving more frequent low doses of the MB and we are working on that.
Since my father had a stroke in November of 2008 and the early Spring of 2009, this has been a big setback. The stroke this Spring was the worst. He still has a great deal of recovery to accomplish, but he continues to improve. He is very mentally alert and aware of everything going on. He can still give advice and communicate well. He cannot walk. He needs assistance eating but he often is independent in eating. These problems are a result of the stroke. We have been eliminating and reducing offending foods and supplements as we observe problems. I am near certain that my father will not have another stroke. One of the biggest helps for him is magnesium oil applied all over his body. This has helped him very much and I learned a lesson about neglecting the magnesium oil. He will get stiff and harder to transfer when without the magnesium oil (I make ours from magnesium chloride flakes sold to saltwater fish aquarium hobbyists).
My father is not taking any prescription medicines to speak of now. We stopped the carbidopa/levodopa because he began to have mild hallucinations and we stopped it. He has only improved since stopping that medicine.
Acupuncture, Detox Herbal Remedies
If you haven't already, you might consider looking into vitamin B1/Thiamine at high dose. It doesn't work for every PwP, but it is helpful for the majority, but it can be difficult to pinpoint the correct dose. It can be a process of trial and error.
I can make another recommendation or two, but you didn't give much info in terms of her symptoms. It would be helpful to know that information. Btw, she is quite young to be diagnosed with PD as the most predictive factor for PD is age. What method did her neurologist use to diagnose her?
At just 3 pills of levodopa per day, I am going to guess that her symptoms are very mild at this point.
Hi Art, thanks for sharing such amazing, wonderful and valuable knowledge about supplementing with melatonin.
A bit off topic ... but are you aware of melatonin increasing the bodies need for other nutrients such as vitamin D, etc? Thank you!
Go look up Kombucha mushroom, which isn't a mushroom (more akin to the mother in apple cider vinegar).
Dr. Josh Axe (chiropracter) has a good article on his site. First heard of this one as a tea to take for cancer - actually you are fermenting your regular tea, which produces the probiotics (good guys in your gut). If you can't find someone locally with mushrooms to give away, you can go on line and order one. Another article you might want to read is an article on Dr. Bradstreet, Dr. Ncholas Gonzales & another whose name I do not remember.
These 3 doctors are no longer with us as all 3 were collaborating on a study. Finding that their autistic and their cancer patients all had a foreign substance in their blood called nagalase. First heard of nagalase in Ty Bollinger's Quest for Cures for cancer,.
A female doctor in another country was telling Ty they had found all their cancer patients had nagalase in their blood and they were treating them with probiotics called Bravo and it was working and they knew it was because the nagalase level was dropping. Apparently they found how the nagalase disabled the immune system before these 3 doctors started their research because they were treating their autism & cancer patients with GcMaf, a messenger that one part of our immune systems transmits to another area of the immunne system to trigber the production of macrophages or large white blood cells that are also called the pac men of our immune system because they gobble up the invading pathogens which make us sick. Not sure what the G is for but suspect it is Globulin & and c denoted the type of globulin, The Maf is macrophage activating factor.
There was one one lab on our planet testing for nagalase and only one source of GcMaf which were both located close together, but not in the USA or South America. These 3 doctors were seeing 100% cures of various kinds of cancer and 85% cure with improvement in the other 15% of their autistic patients, before they got raided by the FDA, who confiscated all their information, their data on their research & all their charts.
Dr. Bradstreet suddenly disappeared the day his clinic was raided. His body was found floating in a river 3 days later with a bullet wound to the chest & declared a suicide with no investigation whatever. His family, friends & peers said no way did he commit suicide & IMO no way did this man who had become outspoken against vaccines when his own 4 year old son developed autism. No way would this man have killed himself when he knew something was helping his son and there was any chance of getting more of it. No way could he have known that their equivalent of our FDA had raided the only lab testing for nagalase and the only source of GcMaf had also been raided and destroyed about the same time these 3 doctors' clinics were raided & destroyed,
Found this for you: AEP is Calcium AEP (Cal 2-AEP), a unique type of calcium that helps nourish nerves and cell membranes.*
Here's one product on Amazon.
Hi Ladyliza (Los Angeles, CA), I am 45 year old male. I just started having a constant twitch in my left pinky finger. I am right handed. I am panicked about the possibility of PD or ALS. I wen to chiropractor a few days ago and it "could" be nerve issues. I am not convinced of the nerve answer since, the pinky has been twitching at rest consistently throughout the entire day and night. I do notice when I do an activity, I don't notice the twitching as much, but I am not sure if that is just due to me not paying attention. I was wondering if you or people with PD or ALS have had the pinky twitch like I described. I am healthy and a realist, so I wish I could accept the nerve thing, but reading about Michael J Fox article about his left pinky twitching and then he got PD, has me very nervous. I am very active and have 2 young children, so any feedback on what I should do prior to going to the Dr would be appreciated. Thank you, Andy
Hello Max58j. I am beginning to show signs of PD more and more at age 62. I have never had high cholesterol, but my grandmother and mother both had PD. They also did not have high cholesterol. I always thought there was a genetic link, but after reading on here, it was a vitamin/supplement that we needed (perhaps).
May we suggest you read two articles https://betweentwopines.wordpress.com/2012/05/21/magnesium-chloride/ If the URL does not transmit, please look up"Father Jose Chorr magnesium chloride two pines". Also http://www.naturesapproved.com/PDFDocs/k/KXKLL0RMMTL59MR3VAJ033PEXR47DKP6.PDF If the URL does not transmit, please look up "Health from the Ocean Deep Acres USA". We recommend your mother use liquid sea minerals, such as Aussie Trace Minerals http://seamineral.com/ (order in your state, Colo.; also available from other web sites); rather than the powder that Father Chorr used. The powder in the U.S. at least, appears to be sourced from the Great Salt Lake, which apparently may contain heavy metals.
Let your mother drink 1 teaspoon liquid sea minerals in a glass of water twice a day, beginning with once a day, as Father Chorr suggested, and increasing after a few days. If the stools are too loose, decrease to 1/2 tsp. once a day and increase more gradually.
Let your mother avoid eating meat; the most success with Parkinson's is with the vegetarian (no eggs) or vegan diet. Just be sure to include at least 2 tablespoons freshly ground flax seed every day in the diet for Omega 3 essential fatty acids, and drink extra water. We wish you and mother all success.
Parkinson's Disease: Causes
Parkinson's Disease: Causes
I recently submitted a link to a new research paper suggesting that Alzheimer's disease might be associated with fungus. Existing research and other writings already support the association of Parkinson's disease with fungus, see below.
Acetaldehyde is a toxin produced by fungus. The abstract for the above-linked study from 2006 states that, "In the presence of acetaldehyde, dopamine is converted into salsolinol, a neurotoxin involved in apoptosis of dopaminergic neurons."
In other words, fungus produces a toxin which combines with dopamine to make a neurotoxin, which then causes the dopamine-making neurons to self-destruct (apoptosis is programmed cell death). The loss of most of the dopamine-making neurons in the brain's substantia nigra causes dopamine levels to drop drastically, causing parkinsonian symptoms.
Fungal volatile organic compounds: Biogenic toxins as etiological agents for Parkinson's disease
Parkinsonism secondary to bilateral striatal fungal abscesses
The book, Road to Recovery by Richard Rodgers, discusses the author's belief that Parkinson's is caused by a fungal infection. This topic is addressed on page 106. You can read that page by following the above Google Books link.
Chronic polysystemic candidiasis as a possible contributor to onset of idiopathic Parkinson's disease.
A Health-Destroying Toxin We Can't Avoid And Must Detoxify
Article is written by a Clinical Laboratory Scientist--see paragraph titled Detrimental Effects.
Acetaldehyde and parkinsonism: role of CYP450 2E1
In the paragraph titled Acetaldehyde and Parkinson's Disease, they don't mention the fact that acetaldehyde can be produced by fungus; they relate it to alcohol consumption, which is another reason for acetaldehyde to be present in the body.
Fungal infection possible pathogenic role in Parkinson disease and parkinsonism
This 2015 journal article published in Poland by researchers at Odessa National Medical University in Ukraine is written in the Russian language, but the abstract is translated into English.
Method for treating diseases of fungal, yeast, and prion protein etiology
This veterinarian believes that many neurodegenerative disorders are caused by fungi. He has developed a method of treating symptoms of the disorders by administering anti-fungal fatty acids, as explained in his patent application.
My Dad is 94 years old. No one can believe it. He still lives independently, drives his own car and his memory is fantastic. He has eaten eggs all his life, so I don't worry about it. His cholesterol is 170. He also eats a lot of fast food so I don't know what his secret is.
I think you will find that "Yams" according to the latest research.. will go a long way in repairing the brain after a stroke.. Google "Yams and stroke".. I'm sure it will be what you are looking for.
Dear Jane -- Four years have passed since your query about protein for your dad with PD, but in case you're still working with your dad, I recommend you use the Oil-Protein Diet of Dr. Johanna Budwig, as given on the Healing Cancer Naturally site. Other sites have interesting comments about the Budwig diet, but the Healing Cancer Naturally site has the most accurate info as presented by Dr. Budwig. Dr. Budwig states that the oil-protein diet increases oxygen in the system. Her program has reversed MS. Lest you be concerned about the use of cottage cheese when Parkinson's patients are advised to avoid dairy products, Dr. Budwig said that the dairy-ness of the cottage cheese or quark and the fat of the flaxseed oil are both transmuted to form a highly absorbable and effective, water soluble substance when combined in the manner she prescribed.
Best wishes, Judy
Mucuna pruriens is a tropical bean and is a natural source of dopamine. Dopamine is intimately connected to arousal. It is also the critical brain chemical in Parkinson's Disease, a disorder that I have dealt with for 17 years.
A group of we PWP were experimenting with the use of Muruna last year and I can attest to its effects upon male libido. But, let's face it, a good glass of tap water can qualify for many men.
What was unusual, however, was that women reported similar effects. As one of the first to notice commented, "I knew something was up when my ex- started loooking good!"
I can't suggest a dosage since the PD has an independent effect that would make such info irrelevant, so you will have to do some trial and error. It can be ordered as a raw powder via Amazon. Since mentioning a specific brand is discouraged here, I will only say that the excellent product which I used was grown in the US, was organic, and was only about $10 to $15 per pound. One caution, the powder is an incredible black stain once it is wet. The only thing that takes it off of enameled steel is oxyclean type remover.
You are replying to a post that is 5 years old in which case the original writer is not likely to reply. I will try and give you a little information to give you and idea about what is involved with the use of MP.
Regarding MP, in a couple of studies it has shown to have similar to slightly better effects than prescription levodopa products. It also does not cause the oxidative stress that levodopa has shown in studies to cause. It also offers other health benefits. Those are some of the positives.
On the negative side, it takes huge doses of pure MP to equate to Sinemet dosing and such huge doses have the potential to cause stomach upset and are hard to take.
Manufacturers are aware of this issue and decided to make "extract versions" of MP so that a smaller, more tolerable dose can be taken. But even with extract versions, it still requires relatively large doses. One problem with the most potent extract versions is that they are essentially levodopa with little if any of the beneficial components that pure MP contains. So you don't really get any of the beneficial effects of the MP.
What some PwP do, is combine a lesser dose of Sinemet or other levodopa based drug with an extract version of MP in order to get the added benefits associated with the use of MP in conjunction with the stability and uniformity of a drug like Sinemet or Madopar. I think this is what you will find once you have done research into MP in all of its many forms.
A common form of MP extract that some PwP find benefit with is Dopa Boost :
This is an interesting product that combines MP extract with other supplements that have shown benefit for PwP. It also uses EGCG, the active component from green tea to act similarly to the Carbidopa component of the combination drug Sinemet which is comprised of Carbidopa and Levodopa. It also contains other PD useful supplements such as N Acetyl L-Tyrosine, vitamin B6 and Quercetin.
PwP use Dopa Boost with a levodopa drug like Sinemet. Sounds simple, right? Not that simple though because, in general, neurologists and movement disorder specialist are not going to be familiar with MP or a product such as Dopa Boost, and this means they will not be able to help you determine an ideal dose combination between your prescription levodopa and your non prescription MP product.
This means you will be on your own to figure out the most effective dosing of both products for you. Even if you find someone that has already done the leg work to figure out through trial and error what their best dosing schedule is for the combination of MP extract and levodopa drug is, you will only be able to use their information as a rough guideline and you will still have to fine tune your dose to meet your specific needs through trial and error.
On this general subject of alternative PD remedies, there are several that I am aware of that have shown varying degrees of benefit in improving quality of life, but like levodopa drug products, there is usually a need for trial and error testing or a learning curve to figure out the best dosing schedule for you.
In PD, there are no cures on the horizon, only various alternatives to try and improve your quality of life. If you are interested in any of those other options, I can offer you some information regarding them if I am familiar with your choice.
Methylene Blue and Vitamin C
The methylene blue I used was from a fish aquarium store. It is usually 1% concentration. Ted encourages a dilution to 0.1%. When I first gave it to my father with the amazing results, I gave it with sodium ascorbate. It really worked to increase his energy and initiation of action. He is still taking it and it still helps. Other supplements have also helped him a great deal, like transdermal magnesium oil. This stuff has changed his life very much for the better. It has helped a great deal in reducing stiffness. What has harmed my father is bulk magnesium citrate powder from ____.com. I ordered many bulk supplements from ___ ___. I was told to give to my father "the more the better" of magnesium citrate. I did. But what I have learned, nearly too late, is that the white powder that was labeled magnesium citrate does not have the solubility characteristics and other typical characteristics of magnesium citrate at all. It has the characteristics of possibly calcium carbonate. I can pay $300.00 to have it tested at an analytical lab, but I am not able to pay for that at this time. I will do it later. The main thing is that be sure to learn from my mistake. It caused a stroke in my father. The lesson is to buy from a reputable bulk supplement suppler who actually tests the supplements that come from China. Also I think it would be prudent for us to learn to test our own purchases even if crudely by checking for the known properties of each substance, like ph and solubility. ____, the owner of ___ ____, told me that neither he nor his supplier out of Georgia test the bulk supplements they receive from China and then sell to us.
So keep up the methylene blue because it may be very helpful to you. Ted told me that it also may build up in the body's system somewhat over time. So you will need to work with the dose and be sure to take it with sodium ascorbate. It seems to be something needed together with the methylene blue. Also if you add the methylene blue to sodium ascorbate in water, the blue color disappears.
I hope this is helpful to you. I'll pass on some words given to me by a young lady who observed me working with my father. Don't give up. Never give up.
Methylene Blue and Vitamin C
Hi Jane, I am interested in making my own transdermal magnesium for head tremors. I have actually tested positive for Lyme disease and Lyme apparently consumes the Magnesium in the body. Have you considered having your dad tested for the presence of Borrelia Burgdorferi. Lyme can cause Parkinson's symptoms. I in fact believe that Michael J Fox, may be Lyme positive. He was apparently bitten by a tick and was put on a 6 week course of antibiotic therapy. He then later on developed Parkinsons. Most of us in the Lyme community know that Lyme is rarely eradicated with a 6 week course of Antibiotics. I also know that heavy metal poisoning seems to go hand in hand with a lot of these neurological symptoms. Therefore I am concerned about the claim by Ancient minerals that many of the bulk pharmaceutical grade Magnesium Chloride has lead and mercury. I have ordered some Magnesium for fish tanks off of Ebay and bought a test kit for home use and will test it for lead content. I also wrote the supplier to find out if they have a chemical analysis of the product. If it is shipped from China, I am doubting that it will. I also contacted an independent lab to find out how much testing for Mercury content would cost as I have not been able to find a home test kit for Mercury. I am hopeful that the transdermal Magnesium will be a big help. I can't afford to pay the prices that some of the companies that market the Mag Oil charges.
Vitamin D is a fat soluble vitamin, so the heavier you are, probably the more you need. Would a pale-skinned person be low in vitamin d? Perhaps.
Vitamin D3 produces Cathelicidin, which fights lots of bad stuff.
"The novel anti-infective, in either a polypeptide, peptide or nucleic acid form, may have application as a therapeutic to treat fungal or bacterial infections, including those caused by drug resistant strains, such as E. coli, Salmonella enteritides, Acinetobacter baumannii, Pseudomonas aeruginosa, Klebsiella pneumoniae, Serratia marcescens, Burkholderia cepacia, Staphylococcus aureus (MRSA i.e. methicillin resistant), Staphylococcus epidermidis, Enterococcus faecalis (VREF i.e. vancomycin resistant) and Streptococcus agalactiae, and also against fungi such as Candida albicans, Candida glabrata and Cryptococcus neoformans."
I was looking at Michael J. Fox the other day on TV... his neck/thyroid looks destroyed. Since Ted mentioned Thyroid, the Thyroid seems like something worth checking if you have this disease. In his case, perhaps his resembles Hyperthyroidism a bit; just an opinion.
I would kind of like to see a metametrix study (GI effects) on this disease.
We have had this experience with Parkinson and Multiwave oscillation. Very diappointing because the symptoms became rapidly worse after treatments! I think the patient I work with might have responded much better if he would detox from the many years of chemical drugs in his body before treatment. The oscillation might stir up too many toxins. We are now on the way to start up a very slow delicate detox process. Magnesium therapy seems to help some. We are studying vitamin D3 as a possibility. I would love to hear from others on this subject!
Similarities between Parkinsons and ALS have been found. There is a copper binding issue, combined with oxidative stress. This should hopefully give us ideas on how to treat this eg: copper chelation, or chelated copper, and a whole spectrum of anti-oxidants and anti-oxidant minerals.
Do we need more copper, ie. chelated copper?, or less copper, ie copper chelation? Or maybe a combination of the two? It sounds like there is a deficiency but I fear that if we get it wrong it could make it worse.
“We have pinpointed a protein abnormality known as the ‘SOD1 fingerprint' in regions of neuronal loss in the Parkinson's disease brain, ” said Associate Professor Kay Double who led the research published in Acta Neuropathologica.
“We believe this loss of neurons results from a combination of oxidative stress and a regional deficiency in copper, both of which occur specifically in vulnerable regions of the Parkinson's disease brain.”
Methylene Blue and Vitamin C
The methylene blue works, however, continual use of low dose is very helpful. However if it is discontinued, at least in the beginning may weaken the energy level, but further dose will allow the person to recover. Methylene blue is considered a super antioxidant for the mitochrondria. The best that I have seen so far. The brain is the highest metabolic rate in the body and hence is helpful with methylene blue since it increases energy level to normal levels through mitochrondria support. Taurine supplements and some potassium bicarbonate with baking soda are also helpful and supportive to this remedy too.
It's often best used as dose I have mentioned. I liked it so much I have since added methylene blue to my Emergency Aid kit as posted previously, although it remains I still needed some tweaking. Low levels of brain metabolism is what I believe to be causing the Parkinson's disease, and I have found the methylene blue to be helpful.
Thank you for the feedback!
Just wanted to add: if there are other yeasts that have similar characteristics (melanin-seeking, slow growing, lipophilic), they could also be potential causes. It may not be exclusively Malassezia that can cause Parkinson's.
Some ways that Malassezia or other fungi could potentially get into the brain are:
- medical procedures/treatments, such as surgery w/ anesthesia, CT scans of the head (radiation can affect the blood brain barrier temporarily), use of IV drugs (legal or illegal) esp. IV antibiotics or IV lipids;
- spinal tap: if Malassezia is present in (not just on) the skin, a tap could theoretically push yeast into the CSF;
- presence of other infections known to have the ability to cross the blood brain barrier, such as Lyme disease
If you've never heard of Howard Shifke and his site Fighting Parkinson's Drug Free, I recommend you visit it.
To Whom It May Concern,
I have a mother who is in her early 70's and has been diagnosed with Parkinson's. She fell ill with a h-pylori infection and almost died. The ER doctor put her on some strong anti biotics and she is recovering from the pylori but when we took her in she was shuffling badly, slight arm tremors and a mask like face. I've tried to get her to eat better, avoiding foods with lots of sugar, pesticides etc but she's used to her diet and is struggling. Regardless of this she has still shown signs of improvement but is complaining of weakness, stiffness and a feeling that she can't move at times when she wants to. I have read through the threads on this site about the Methylene Blue. I cannot understand the dilution. I have no way to since I am dyslexic with numbers. I have personally been taking the MB 1% diluted by taking one tspn full of MB and diluting it with 9 tspns of water. I take 5 -7 drops in the morning in 6 ounces of water with a 1/4 tspn of vit c powder and a 1/2 tspn of baking soda, sometimes a full tspn.
My questions are:
1. am I even close to the correct dilution and please don't tell me in equations because I can't understand them. What I do understand is what I've described, one teaspoon MB and 9 teaspoons of water.
2. I need to have specific information on how to give the MB to my mother and in which combination, taurine/potassium (which I don't think that she can have because of her high blood pressure)/baking soda? etc. As soon as possible please?
She weighs approximately 140 lbs, she's 5ft 2 inches tall. She's on medications, metoprolol and aspirin. I have spoken with a pharmacist who has said that there are no contraindications with her meds and the MB.
Please, she's feeling the effects and I know she's very frightened, the docs seem to think that the PD was set off by a mild stroke that she had just after my dad died almost 3 years ago. He died of institutionalized pnuemonia/parkinsons. She is not taking any parkinson's medication at this time.
I know that you all get a lot of emails asking for advice so I am not asking to be "special" I am just asking for clear concise and reliable answers as soon as you are able to. Thank you for your time and experience. I look forward to hearing from you soon.