Pancreatitis Remedies

| Modified on Mar 26, 2024
Aloe Vera and Papaya Juices
Posted by Lisa Smith (Marshall, TX) on 02/16/2009 6 posts
★★★★★

21 year old sister. diagnosed with and treated in Hospital and home health care, use of PICC line [Peripherally Inserted Central Catheter] nutritionally for acute to severe Pancreatitis.... When conventional meds did not work and placed on a 500gm no fat diet and basically left for death....I prayed for a miracle ....the response was aloe vera juice and papaya real juice....

She was still in the hospital when my mom purchased both and began give her 1/3 cup of each 3 times daily ...she has 1/3 of her pancreas left....Immediately the first day in doctor came in the room and reported her amylase levels and all test levels were normal...He has since begain addding this to his patient regime for pancreatitis treatment...my grandmother's uncle age 70+ also used this treatment in the hospital following an acute pancreatitis attack.. he recovered within hours....

Give it a try...My sister was dying...Years of substance abuse and fatty diet was killing her pancreas...she is alive and well at 30..

Aloe Vera and Papaya Juices
Posted by Mltyner (Jacksonville, Fl Duval) on 09/25/2011
★★★★★

After an ERCP to remove a gallstone in the common bile duct, I was one of those cases that got pancreatitis on Feb. 17th. I have lost 29 pounds and having pain after eating every meal. I have had every test imagineable and gone to Mayo Clinic as well. All that was found was a cyst in my pancreas that was 2mm. But even though the testing all testing came back normal I still had pain after every meal. I have been praying for God to help me, to heal me. I was drawn to one of the articles on this site about drinking Aloe Juice and Papaya Juice. I started yesterday and within a few hours I could tell the difference in my pain. This morning I got up and had no pain. I believe this is my answer. Thank you for your post and Thank God for finding this.


Aloe Vera and Papaya Juices
Posted by Lisa (Marshall, Texas) on 03/16/2012 6 posts
★★★★★

omgosh!!!! I had forgot this posting and I am amazed and blessed by hearing this has helped others.. It changed my sister's life.. She has never had acute pancreatitis again. We also had an older family member cured as well. My mom mixed them together because aloe juice is not so fantastic (taste wise) by itself and she used organic papaya juice pure... I'm sure any color will be fine... She used 1/3 cup each 3 times a day.. You may have play around with it to see what works for you.... For our family it is a God given cure.. God bless.. I will check back more frequently to make sure I can reply for help.


Apple Cider Vinegar
Posted by Jonathan. (RYDE, Isle of Wight) on 08/15/2021
★★★★★

I have chronic pancreatitis caused by a gallstone lodging in the mouth of my pancreas and causing calcification. Two people have recommended organic and raw apple cider vinegar and having used this first thing in the morning. For the last month, I have found a remarkable change and no more pain. I was on morphine! The Braggs one has the mother in it and you must get this one. Good luck


Chanca Piedra
Posted by DS (India) on 07/30/2019
★★★★★

Chanca Piedra is a life saver!

I woke up one day not being able to tolerate sweets. My blood sugar was going haywire. Nausea. Pain on left side radiating to back. Palpitations. Indigestion. Loose stools. Feverish etc. Research told me this was pancreatitis. Possibly caused by gallstone blockage. (It happens when there quick weight loss/gain.) I tried everything-ACV, Apple juice, baking soda, enzymes, aloe/papaya juice, lime juice...nothing worked. So got bhumiamlaki (chanca piedra). One cup of tea and could feel the gall stone blockage melting away!! The symptoms are fading now, even though apparently recovery can take up to 6 weeks.

Now I'm focused in healing - gymnema and neem help, aloe/papaya also helps along with Amla juice(Vit C) and activated charcoal poultices. Hopefully my pancreas will be brand new soon. But I will never be without my chanca piedra again. Hope this post helps others.

Aloe Vera and Papaya Juices
Posted by Edvee (Los Angeles) on 12/15/2016
★★★★★

Aloe Vera and Papaya smoothie for Pancreatitis worked for me, but it must be fresh and also you must stay off meat and alcohol. Juice and eat very light. This means no heavy meals, no fatty foods and most of all no meats or alcohol. Strictly vegan and no dairy. If you consume dairy, it must be fat free. I.e. fat free yogurt. The papaya and aloe must be blended and drank 3 times a day for a week. Drink it an hour before your meal. Do not buy aloe or papaya drinks. This has to be fresh from the grocery store in order to work.

I was not getting better and by the third day on this regimen I started feeling a change. I also used grape seed extract, turmeric plus ibuprofen to bring the inflammation down. I am planning on following the low fat diet and no alcohol for the rest of my life. Please understand you must too, in order to get well. It is an adjustment but if you value your life, you have to make some positive changes. Good luck to all!

Fresh Beet and Apple Juice
Posted by Max (Crowley, Texas) on 12/17/2009
★★★★★

Pancreatitis:

juice 1/2 medium size beet (raw) 3 to 4 apples (raw), serve over crushed ice . My daughter liked to have died with e-coli 0157. When she was pulling out of the illness her body was so contaminated that she had severe pancreatitis. This simple drink cured her pancreatitis within 2 days.The crushed ice is optional.

Aloe Vera and Papaya Juices
Posted by Clarence (Mumbai, India) on 10/25/2010
★★★★★

I was suffering from pancreatitis and was getting constant pain in the upper abdomen. The first thing was that I adopted a total vegetarian dies eating leafy vegetables, I lost a lot of weight suddenly over a span of six months. I then read of Aloe vera & papaya juice. I started taking 15ml each by mixing both the juices, twice a day for two weeks. My appetite & digestion has improved improved and I am on the road to recovery. It is a miracle potent.


Acute Pancreatitis Triggers
Posted by Ted (Bangkok, Thailand) on 06/19/2010 391 posts

Atkins diet is based on acid forming foods and the pancreas is a large reservoir of alkaline substance. The pancreas needs alkaline substances to protect itself and thus the Atkins diet is likely to be one of the causes of acute pancreatitis. The remedy, I believe, is to rebuild the lost bicarbonates by taking baking soda, at 1/2 teaspoon two or three times a day [Ed note: mixed with 8 oz of water] after meals about 30 minutes. It takes about two weeks to notice improvement as the body tries to get the bicarbonate to its normal level. It should be noted that weight loss is due more to dietary intake of proteins rather then Atkin's diet per se. However proteins breakdown into amino acids, and the meat products are high in phosphate and they are cancer causing. If the body has insufficient ability to neutralize the acid causing meats, the pancreas get damage. This brings to possible autoimmunity disorder, where one methods I used to reduce them is taking some borax (boron) supplementation, such as 1/4 teaspoon in a liter of drinking water for one week. A daily dose of 1/4 to 1/2 teaspoon of sea salt in a cup of water will help increase the salinity as a way of raising the body's immune system. Thereafter, once two weeks has passed, the baking soda should still be continued, to at least 2 times a day to keep the pancreas fully bathed.

If weight loss is desired, there is a much simpler protocol, just avoid the sugars, fats and carbohydrates. When Dr. Atkins died, he did have a high cholesterol level. So obviously fatty liver can be from high fat meats, and fatty liver can occur. Hence granulated lecithin 1 teaspoon twice a day is taken also to restore liver to it's normal state, by removing the fats using a fat emulsifiying lecithin. In any case if you want to market any latest weight loss fad, it has to be complicated enough that people will buy book, too simple is simply unmarketable. Weight gain is generally seen as too much sugar in the system is converted to glycogen and fats, and fats are simply that, the body has great difficulty converting fats to energy, while proteins has little or no energy content and hence doesn't make you fat in general. However, as in all sugar, carbohydrate and protein they make your body acid, and the first organ to go is the pancreas since that's the major organ that has the most bicarbonates and hence are sensitive to acid forming food.

In addition, there are key amino acid more directly lated to weight loss, these include, l carnitine and often taken together with alpha lipoic acid, but also glutamine and glycine, and now and then arginine and lysine. These are the common supplements I used for weight loss. Certain amino acid are inhibitory and act as appetite suppressant such as taurine and glycine. Some minerals are appetite suppressants such as boron that I see most often. I don't generally use excitotoxins such as phenylalanine as it tends to damage the nervous system and weight back come back with a vengence. That's cause these excitotoxins damages the nervous system by overexciting them. The same can be said for monosodium glutamate, in low amounts they increase appetite in high amounts they have opposite effect, but that damages the hypothalamus and causes lifelong obesity. This is why scientist inject MSG into weanling rats so they can become obese. The same effect is also true whenever vaccinations are given to babies and they sometimes do add monosodium glutamate into these vaccinations.

One particular mineral besides boron that acts as mineral appetite suppressant is the zinc. Preferably I used zinc acetate, other forms such as zinc sulfate tend to induce vomiting. I believe it's the sulfate, and can be found also in epsom salt such as magnesium sulfate. Some may not be effected, but quite many Thais here seems to initiate vomiting after taking them in two or three hours will initiate vomiting. Generally zinc acetate is taken for only 50 mg per day for only one week, then I just stop them so that there's no exccessive zinc buildup and may take it again whenever the need arise a month or two.

EC: Incidentally, Ted (aka Parhatsathid Napatalung) was just quoted in Dr. Sircus' newsletter yesterday on this very subject! Here's the link to the article entitled, "The Pancreas, Bicarbonate and Diabetes" http://blog.imva.info/?p=649#arrive. Ted is quoted in the 2nd paragraph.


Probiotics
Posted by Art (California ) on 06/28/2018 2164 posts
★★★★★

The following study discusses the use of synbiotics in pancreatitis and suggests that synbiotics (= prebiotic + probiotics). In this case, they used the common probiotics Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus and Bifidobacterium bifidum in a large dose (12 grams/day). As a prebiotic, they used Fructooligosaccharides (FOS).

Art

Here is a link to the abstract: https://www.ncbi.nlm.nih.gov/pubmed/29132740

Here is the abstract:

Clin Nutr ESPEN. 2017 Apr;18:9-15. doi: 10.1016/j.clnesp.2017.01.005. Epub 2017 Feb 21.

Effects of using symbiotics in the clinical nutritional evolution of patients with chronic pancreatitis: Study prospective, randomized, controlled, double blind.

Dos Santos PQ1, Guedes JC2, de Jesus RP3, Santos RRD3, Fiaconne RL4.

Abstract

Patients with chronic pancreatitis (CP) present malabsorption and changes in nutritional status. In this prospective, randomized, controlled, double-blinded, intervention study, developed at the Clinic of Pancreas, we aimed to assess whether the use of symbiotics changes the nutritional status, the biochemical data and the intestinal rate of these patients. The intervention consisted of administering 12 g/day of symbiotics composed of Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Bifidobacterium bifidum and fructooligosaccharides to the intervention group and 12 g/day of medium absorption complex carbohydrate to the control group. The project was approved by the Ethics Committee of College of Technology and Science - FTC under the number process 0528-2008; reg. 498 e was registered under ClinicalTrials.gov. We evaluated 60 patients and the intervention lasted for 3 months, with monthly monitoring. A statistically significant reduction was observed in the results by day in relation to the initial frequency (x = 2.3) and the use of symbiotics in the second (x = 1.47) and third (x = 1.37) months (p = 0.001). In the control group, there was no significant change in this frequency (p = 0.157). The results showed an increase in the levels of hemoglobin (p < 0.001), hematocrit (p = 0.001), red blood cells (p < 0.001), total lymphocyte count (p < 0.002), serum magnesium (p < 0.001), albumin (0.001) and total serum cholesterol reduction (p < 0.001) with the use of symbiotics. The changes were not observed in the nutritional status of both groups.

CONCLUSION:

The use of symbiotics improved the clinical and laboratory profiles of the evaluated patients with CP, favoring the best clinical outcome, and may be a therapeutic option because of the low cost and therapeutic effectiveness in this population.

Copyright © 2017 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.


Acute Pancreatitis Triggers
Posted by Art (California ) on 06/01/2017 2164 posts

Please read about the pancreatic protective effects of melatonin.

Melatonin has a very good safety profile and is naturally produced by the body suggesting lower potential for allergic reaction. Here in the states, it is readilly available and inexpensive. Melatonin acts as a potent antioxidant that scavenges multiple forms of radicals in the body, but also improves the bodies own highly potent antioxidant system while potentially helping to reduce an excessive inflamatory response. Melatonin is also protective of the major organs. Here are a few studies suggesting the benefit of melatonin for pancreatitis that you can print and discuss with your doctor. :

http://www.mdpi.com/1422-0067/18/5/1014

https://www.karger.com/Article/FullText/453164

http://www.wjgnet.com/1007-9327/full/v20/i45/16902.htm

https://www.ncbi.nlm.nih.gov/pubmed/25100131

http://www.hbpdint.com/fileup/HTML/2014-13-346.shtml

https://www.ncbi.nlm.nih.gov/pubmed/24251674

Lastly and importantly, melatonin also has studies to show that it can be gut protective:

https://www.ncbi.nlm.nih.gov/pubmed/28503116

https://www.ncbi.nlm.nih.gov/pubmed/27919824

Art


Aloe Vera and Papaya Juices
Posted by Kpoole40 (Atlanta, Georgia) on 05/07/2012
★★★★★

I started Aloe Vera and Papaya Juices last week and had been having problems for almost a year now. This is the first thing that has worked. Thank you all for the post! Please note that you should get "inner filet" aloe vera. I did the aloe vera juice last week, but am using the gel this week. The gel seems to be working better, but that's perhaps because I'm already a week into the regime. Although the gel makes the papaya juice thick and is a little unappealing. I just shoot it very quickly about 1/3-1/2 cup each, twice a day. The lady at the market where I get the Aloe Vera explained that the other (not "INNER FILET") makes your stomach cramp. Good luck to all. This has saved me!!!

Dietary Changes, Inositol
Posted by Jenna (South Dakota) on 02/16/2017

I have new data to counteract my hypothesis for what causes Pancreatitis, according to the article I included in my initial choice - which was Long Tailed Fatty Acids - perhaps good to remove my gold medal : )

After I sent you the email, I sent the article to my friend, a former geneticist at the CDC. I would like to share with you and the readers his response to me. After which I will give feedback on what now I believe can be the cause of Pancreatitis - in children, people who don't smoke or drink or consume large amounts of meat.

Here is the response to the article from my friend, former CDC geneticist:

"Good try if only you know a little about biochemistry.

It's not the length if the fatty acid side chain. The research shows that it's fatty acid ESTERS.

How does the body make an ester out of fatty acids? Ethanol! (alcohol)

Ethanol, while it's true that many people that drink alcohol do not get pancreatictis, this is probably because they have more robust mechanisms. Mostly in the liver, that are designed to interfere with this reaction in the body.

if your hypothesis were correct, everyone on a ketogenic, atkins, rosedale, or paleo diet would have pancreatitis"/

So, after receiving this feedback from my friend, I thought, why would children, non smokers, non-drinkers get pancreatitis? And why did my symptoms go away with eliminating long tailed fatty acids?

Let me answer the last question first: Because I had eliminated all fats, giving my pancreas a break. But here is where it get's interesting, please bear with me.

I was diagnosed with Lyme Disease in 2005. I was bit in1992, so I had was was clinically called, Latent Lyme Disease. It was serious for me - lots of symptoms in my CNS - Central Nervous Symptom, and no true cure in traditional medical field for Latent Lyme Disease - intravenous antibiotics, just make the Lyme spirochetes, and their cofactors go deeper into "hiding", and may come out later in life when the immune system isn't as strong.

After hanging on for about a year with Lyme Disease, I found a "clinic", only taking patients by word of mouth, that someone had reported to me that this Clinice had cleared her Lyme Disease. My first visit to them, they told me that I had so many hookworms in my pancreatic duct, that I was about to get Diabetes. They cleared the hookworms, and subsequently cleared the Lyme and it's cofactors. Hookworms? I have pictures of me at 3 years old on the dirt with my dog.. hookworms live in the soil.

So going back to parasite infection in the pancreatic duct and what Hulda Clark's protocol of mainly clearing Liver Flukes. According to her, Liver Flukes are on all raw veggies and harmless enough - until one is exposed to Isopropyl Alcohol. This agent causes the liver flukes to digest the lining around them, to then, reproduce in the digestive tract as real agents of concern. in other words. liver flukes are harmless, until exposed to rubbing alcohol, which cause the activation of the larva to come alive and then become harmful liver flukes.

So what I am taking now, instead of Humaworm, Hulda Clarkes zapping and or wormwood conception, is potent oreganal drops, from the wild mountains of Greece, google it on Amazon, to kill parasites.

If you decide to order it, please read carefully the reviews. It is so potent that is can burn holes in you skin. I carefully put 4 or 5 drops in a gelatin capsule and down it with a huge glass of water, and sometimes with aloe vera juice, inner filet only. This oregano oil will kill any parasite in the body, but has to be used regularly. Perhaps Humaworm will be just as good, but haven't used it, so don't know.

Keep in mind that when you kill any unwanted organisms in the body too fast, you might have a Herxheimer reaction, as such go slow..... If with children, I personally would use the Humaworm, and lots of water.......Oregano Oil is for the big timers.

Hope this is helpful!


Increasing Oxygen and Cellular Nutrition
Posted by Duane (Toronto, Ontario Canada) on 10/20/2011

My 79 year old father was diagnosed with inoperable stage 4 pancreatic cancer 10 months ago. They did a stomach bypass so that food could pass the large tumour and allow him to eat, and removed his gall bladder as it was visibly affected as well. They did not touch the pancreas as it was too involved at that point. He has not undergone any chemo or radiation.

He could not eat solid food for over 6 weeks and subsequently lost weight rapidly early on. He was one of the lucky ones that makes it home after the surgery and over a month without eating surviving off of IV. I had spent 2 months from diagnosis until post surgery release researching what to do. The standard medical process said they had nothing to offer him and basically sent him home to die, so we had no other options anyways.

I believe with all my body that at the root of all cancer, cancer cures and modern diseases are four main things: quantity of cellular oxygen, quality of cellular nutrition, type and amount of toxicity and level of acidity.

These things can be easily tackled in multiple ways. His entire protocol is centred around extreme increases in oxygen and nutrition and extreme decreases in toxins and acidity.

The Cancer Centres and doctors have all said "He should have been dead months ago and does not even appear on their results grid" His weight and energy is stable, he is getting stronger, eating normally, pain free, exercises and walks daily, sleeps well, has great color and is living an entirely normal life. He is entirely symptom free now.

I believe we owe his outcome thus far to his extremely positive attitude, prayers and an extensive natural protocol to address the four areas above.

Aloe Vera and Papaya Juices
Posted by Beloved (California ) on 01/16/2022
★★★★★

I did not get a diagnosis of pancreatitis but I had a 9 out of 10 pain after eating. I went to Earth Clinic and read about drinking papaya juice(fresh, I used my Breville juicer and I bought aloe juice in a glass bottle and an aloe plant ). I also think my gallbladder was inflamed. I ate vegetables and made green smoothies in my vitamix. It's been two weeks since it all started and I feel so much better. I am still eating mostly veggies with a little bit of fruit. Less fat and sugar for now makes me feel better. Also, I bought some digestive enzymes and I think that helped. Be careful and watch everything that goes in your mouth, no alcohol, meats, cheese, and medications.

Dietary Changes, Inositol
Posted by Jenna (South Dakota) on 02/12/2017
★★★★★

I was hospitalized for pancreatitis about a month ago. The last three days, the feeling of oncoming pancreatitis started coming back, as well as accompanying anxiety thinking I was going to have to be hospitalized again., I did everything suggested on this pancreatitis forum - Ted's remedies, no alcohol, papaya and aloe vera - nothing worked! Last night, I took 4 grams of pharmaceutical inositol powder, 3 grams and woke up calm - no anxiety or depression and had slept deeply. Also, no symptoms of pancreatitis when I woke up. I started researching inositol and found that not only is it used for anxiety and depression, it is used for insulin resistance and diabetes, and the pancreas secrets insulin, so taking the inositol stopped my low blood sugar attacks on the spot! Woke up and took 3 more grams. Inositol is huge for liver detoxification as well as helping all the neurotransmitters work properly so that the serotonin, dopamine and gaba receptors are getting what they need to function properly.

But the lack of inositol wasn't the problem for the pancreatic symptoms rising. It was my primary diet of Long Chained Fatty Acids. I was eating lots of grass fed beef, eggs, tons of GLA (found in primrose, borage and current oil) . Long Chained are found in meat, egg yolks, avocados, olive oil, GLA and fish and fish oil - you can research this further. Coconut Oil and Palm oil are medium chained fatty acids and are the oils of choice.This article (link below) explains why Long Chained Fatty Acids, as well as alcohol, and the ensuing calcium release causes pancreatitis. It's more on the scientific life but if you can bear through that, you will see what actually causes pancreatitis - Long Chained Fatty Acids, Calcium.....

http://www.the-scientist.com/?articles.view/articleNo/31621/title/The-War-Within/

And on Inositol:

https://clinicaltrials.gov/ct2/show/NCT01514942

The above link on inositol targets mostly how it is used for insulin resistance, but you can goole it for anxiety or depression and liver detoxification. For me using inositol eliminated complete my low blood sugar bouts, which causes huge stress hormones to be released.

Avoid Alcohol
Posted by Billy ( Cook County, Il) on 05/13/2015
★★★★★

Alcohol, alcohol, alcohol.....stay away from alcohol at all costs...it is THE leading cause of acute pancreatitis. (I'm goin through an episode of it as I am typing this. Cause: Alcohol) lots of AVOIDABLE and UNNECESSARY pain. DO NOT DRINK ALCOHOL!


String Bean Juice
Posted by Glenda (Matteson, Cook County, Illinois) on 06/09/2013
★★★★★

Pancreas: As stated in the Heinerman's Encylopedia of Healing juices, "There is nothing better, I mean nothing better, than stringbean juice for the liver, spleen, and pancreas." I have used it according to instructions and it's so true! One woman in the hospital was told that they could not bring her blood sugar down and nothing was working, my daughter-in-law took her some juiced stringbeans and bam! The doctors said, "I don't know what happen but you can go home in the morning". No, she didn't tell them about the juice *_*

Aloe Vera and Papaya Juices
Posted by Lillie (Brooklyn, New York, Usa) on 12/21/2012

To Rebeccah from New York, New York and all the people: you should buy both papaya and aloe vera leaf fresh from grocery store, only when raw and unprocessed can they cure your pancreas, b/c only then they contain enzymes that your pancreas is lacking. Green unripe papaya contains more enzymes; on the other hand, ripe orange papaya has a lot of vitamin A which is also very healing, so use both, or choose medium ripe. Aloe vera leaf cut at base and place standing in a jar for an hour or so, to let all the juice leak out. You can use the juice to make a cosmetic mask for your face or your hair. Skin the leaf and use the inner gel. Place some papaya, some aloe vera gel and some water in a blender and make a smoothie. It doesn't matter the exact amount, make at least a cup 3 times a day, and take it separately from other food, at least 1 hour away. It's also very beneficial to relax and meditate, or just daydream after you have this drink. Health and happiness to all. Love and peace.


Supplements
Posted by Art (California) on 11/27/2022 2164 posts

Cru,

I know you were asking about MCT and boron and you mentioned that boron is anti inflammatory, but melatonin is a more potent anti inflammatory and also lowers elevated levels of oxidatative stress, which are in play in acute pancreatitis, while being protective of the pancreas.

Imo, melatonin is a very good option to protect the pancreas and more specifically, ameliorate the inflammation involved in pancreatitis. Her are some links to studies that suggest the same :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3347751/#:~:text=Specific receptors for melatonin have, damage caused by acute inflammation.

Here is a relevant quote from the study :

' Specific receptors for melatonin have been detected in many gastrointestinal tissues including the pancreas. Melatonin as well as its precursor, L-tryptophan, attenuates the severity of acute pancreatitis and protects the pancreatic tissue from the damage caused by acute inflammation. The beneficial effect of melatonin on acute pancreatitis, which has been reported in many experimental studies and supported by clinical observations, is related to: (1) enhancement of antioxidant defense of the pancreatic tissue, through direct scavenging of toxic radical oxygen (ROS) and nitrogen (RNS) species, (2) preservation of the activity of antioxidant enzymes; such as superoxide dismutase (SOD), catalase (CAT), or glutathione peroxidase (GPx), (3) the decline of pro-inflammatory cytokine tumor necrosis α (TNFα) production, accompanied by stimulation of an anti-inflammatory IL-10, (4) improvement of pancreatic blood flow and decrease of neutrophil infiltration, (5) reduction of apoptosis and necrosis in the inflamed pancreatic tissue, (6) increased production of chaperon protein (HSP60), and (7) promotion of regenerative process in the pancreas. '

https://benthamscience.com/article/57502

Here is a relevant quote :

' Both melatonin and its precursor have been demonstrated to protect the pancreas against acute pancreatitis and to attenuate pancreatic tissue damage. In the pancreas melatonin and L-tryptophan activate complex mechanisms which involve direct scavenging of the radical oxygen and nitrogen species, activation of antioxidant enzymes (catalase, superoxide dysmutase, glutation peroxidase), reduction of pro-inflammatory cytokines and prostaglandins, activation of heat shock protein, and a decrease of necrosis and increase of regeneration in the pancreas. There are several arguments for the idea that endogenous melatonin produced in the pineal gland and in the gastrointestinal system could be the part of a native mechanisms for protecting the pancreas against acute damage: 1/ the melatonin precursor L-tryptophan exerts similar protective effect as melatonin, 2/ application of the melatonin receptor antagonist, luzindole aggravates acute pancreatitis, 3/ pinealectomy results in the exacerbation of acute pancreatitis, 4/ low melatonin plasma levels are associated with an increased risk of severe acute pancreatitis. '

Based on the above and considering the very good safety profile of melatonin, melatonin certainly seems worthy of consideration when dealing with acute pancreatitis.

This does not even take into consideration the heart protective effects of melatonin, and this is very important because people with pancreatitis are at increased risk of cardiovascular disease (CVD). Here is a link to an article that I wrote about how melatonin acts as a preventative and or treatment for CVD to give you a better idea of how heart protective melatonin is :

https://www.earthclinic.com/cures/melatonin-for-cardiovascular-disease.html

Art


Melatonin
Posted by Art (California) on 03/16/2019 2164 posts
★★★★★

Pancreatitis and Some Possible Help

Pancreatitis can be a devastating disease, but there are some natural options that may help in controlling pancreatitis.

One of those natural options is melatonin which is one of my favorite supplements! Melatonin is typically thought of as a non- prescription sleep aid, but it is so much more than just a sleep aid! I would like to get into those other potential health benefits, but will stick to pancreatitis for this post to keep it simple and to the point.

Melatonin has a very good safety profile, but even so, some people do not tolerate melatonin well even though it is produced in multiple areas of the human body everyday. Fortunately the majority of people do tolerate melatonin.

In this first study from 2014, it is found that in pancreatitis patients there is a tendency toward reduced melatonin type 2 receptors suggesting that this lack of MTR2 receptors may play a role in pancreatitis especially the acute form :

https://www.ncbi.nlm.nih.gov/pubmed/25055509

In this next full study it is shown that melatonin, ghrelin, and leptin may help in controlling the inflammatory process associated with acute pancreatitis and all three are naturally produced in the body :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4258559/

This next full study (2016) illustrates how a melatonin metabolite, N(1)-acetyl-N(1)-formyl-5-methoxykynuramine (AFMK), can attenuate acute pancreatitis in a rodent model, both in vitro and in vivo:

https://www.jpp.krakow.pl/journal/archive/06_16/pdf/411_06_16_article.pdf

In this next study it is shown that melatonin is protective in a rat model of acute pancreatitis that was induced with arginine and the melatonin was said to exhibit strong therapeutic effects in the course of acute pancreatitis in this rat model of AP. :

https://www.ncbi.nlm.nih.gov/pubmed/27830885

This next study is another study of acute pancreatitis in a rat model and it is shown that melatonin induces anti-inflammatory effects via endoplasmic reticulum stress in acute pancreatitis to play a protective role.

This next full and newer study (2017) goes into multiple details about how melatonin goes about its business when it comes to pancreatitis:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454927/

This next and newer 2018 study delves further into how and what melatonin may be doing in pancreatitis to help alleviate symptoms and calm the excess inflammation associated with this condition :

https://www.ncbi.nlm.nih.gov/pubmed/2948439

This next study (2018) attempts to further elucidate the method of action of melatonin in pancreatitis and implies that these findings suggest that melatonin protects AR42J cells and Sprague-Dawley rats against AP-associated injury, probably through downregulation of IRE1α-mediated JNK/NF-κB pathways.

https://www.ncbi.nlm.nih.gov/pubmed/29912856

This next study from December 2018 continues in the search for the mechanism of action in how melatonin is working in these rodent models to modify the course of the disease:

This last study is new this month and goes a step further to try and determine how melatonin attenuates pancreatitis induced liver damage! Well I did say that melatonin was one of my favorite supplements!

https://www.ncbi.nlm.nih.gov/pubmed/30694771

So what is lacking here are the actual human studies, but there are hundreds of human studies which have more than established melatonin as having a very good safety profile at multiple dosing ranges while being highly protective of the liver which is a very important factor when it comes to pancreatitis! Based on the above it is worth discussing the use of melatonin with your doctor as a potential means of helping to deal with pancreatitis effectively.

There are several natural supplements that have shown benefit in dealing with pancreatitis and pancreatic cancer such as Inositol and inositol hexakisphosphate. If you are willing to look, you will find other supplements and herbs which are likely to be quite beneficial in dealing with pancreatitis, but melatonin is a good starting point and may be as far as you have to go! Here is a typical study suggesting as much :

https://www.ncbi.nlm.nih.gov/pubmed/28965010

Obviously because of the serious and sometimes deadly nature of pancreatitis, your doctor's permission and supervision are an absolute must if you consider melatonin or anything else and the very good safety profile of melatonin will go a long way in that conversation with your doctor!

Art


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