Yes, serrapeptase 250,000 iu at night plus progesterone cream at night works.
I used this for a couple months prior to endo surgery. I had the surgery a few years back and had severe endometriosis and all my sx had returned so I was expecting another big removal. This time- nothing! No endometriosis at all. I think this may be the reason. I also use iodine, coconut oil, and acv, all only occasionally over the past 3 years. The serrapeptase was the only treatment I did daily.
However, I am still having heavy, painful periods. Cayenne, coconut oil, acv, mag oil, castor oil packs have not helped. Haven't found a solution yet. Also, I think I may have overdone the iodine because now I sweat massively at night, a sign of hyperthyroidism. I still use 4 drops of lugol's into my farm milk to sterilize each half gallon when I get it home.
I plan to continue using the iodine for my milk because the farm has campylobacter, but I won't but pasteurized milk and I have to drink milk to help with kidney stones. The iodine has defintely helped my interstitial cystitis dramatically, though. Borax helped that also, fyi, but again, that's not a super safe sounding cure to me, although I do use it on a rare occasion.
I use serrapeptase especially when I wake up in the night from pain in my uterus or ovaries due to endo and fibroids. Serrapeptase always seems to really help with the pain and really seems to clear any congestion or heaviness from that area. You must take it on an empty stomach though.