★★★★★
This new review article (July 2025) goes into detail of why Melatonin is an important molecule to help fight cancer through multiple methods of action. It details much of what is known about how melatonin fights cancer and interacts well with standard of care :
https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2025.1617508/full
Here is a relevant quote from the article :
' Melatonin (MLT), a naturally occurring hormone produced by the pineal gland, exhibits significant anticancer effects. It has superior antioxidant, inhibit tumor cell proliferation, migration, angiogenesis-inhibiting, and tumor cell apoptosis-inducing functions. Mechanistically, melatonin inhibits tumor development through epigenetic regulation, metabolic reprogramming, immune micro-environment, and regulation of important signaling pathways (PI3K/AKT). In addition, MLT significantly enhances anticancer efficacy in combination with other anticancer drugs, such as cisplatin, 5-fluorouracil, and paclitaxel. However, the shortcomings of melatonin, such as its low bioavailability, rapid metabolism, and significant individual variation in secretion, have limited its clinical application in anticancer therapy. This limitation has been mitigated by targeted delivery and individualized therapy. Therefore, MLT may be a promising candidate for natural hormone therapy in the future. '
I would like to add that melatonin lotion and melatonin gel may also offer a way to help overcome the poor bioavailability of oral melatonin as well as the rapid metabolism of the molecule.
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