Melatonin Lotion
Health Benefits

Melatonin Lotion for Pain Relief: Recipe + Success Stories

The comments below reflect the personal experiences and opinions of readers and do not represent medical advice or the views of this website. The information shared has not been evaluated by the FDA and is not intended to diagnose, treat, or prevent any disease or health condition. Always consult a qualified healthcare professional for medical concerns.
Varicose Vein Pain
Posted by Art (California) on 09/09/2025 2715 posts
★★★★★

About seven months ago, a friend told me he was having pain in his legs so he went to the doctor and his doctor told him he had varicose veins and suggested he wear the stockings designed for this purpose. My friend wears shorts very often so he said he didn't really want to wear the stockings and asked if I would suggest something else. I told him, you already have melatonin lotion (ML) that I had given him for a previous issue, so you might as well see if it helps and I asked him to let me know what happens and he said he would.

That was 7 months ago, and after just having made a reply to an EC member with varicose veins last night, I decided to call him to find out if the ML had helped at all since I had no previous feedback on ML for varicose veins. At first he said he didn't know if it had helped or not because he had run out of ML after applying it for about one month and had not made any more. I asked him if he noticed any pain relief while he was using it since he had previously told me his legs were quite painful, and he said, yes, he did notice pain relief. So I asked him how long the pain relief lasted after he stopped using ML and he said, it hasn't come back. That's over 6 month's of being pain free! I was excited with his results, but he was not.

I asked him why he didn't let me know about his great results and he told me because I wasn't sure that it was because of the ML or something else. I then asked him if he had used anything else that was new during the period when he was using ML and he thought about it for quite awhile before saying, no, he hadn't used anything else.

I reminded him that the nature of untreated varicose veins is that they just continue to worsen. I asked him if he thought the pain went away on its own? He said no, I guess it was the melatonin lotion. I suggested that he make a new batch and continue using it since it appeared to be keeping him pain free. He agreed and said he would, but he wasn't even a bit excited about his results.

I'm going to go ahead and call this another win for ML, but there is no science that I am aware of to support that melatonin can help varicose veins and this one instance only shows that it can potentially relieve the pain caused by varicose veins, but given that I have heard how bad that pain can be, I think my friends experience is important and possibly helpful for many others with varicose veins.

I also feel that the fact that the pain did not come back immediately after stopping ML applications and has still not come back after at least 6 months of no ML, suggests to me that there were some potential reparative effects going on in my friends veins? I asked him if he didn't think it was significant that he had had no more pain in his legs for the past 6 months since previously it had been pain everyday to varying degrees? He had to think about it for quite awhile and he finally grudgingly agreed that 6 months of no pain was very significant. I was pretty dumfounded by his responses, but ML appears to be useful for pain caused by varicose veins!

Art


Q&A
Posted by Lola (Ontario) on 09/28/2024
★★★★★

Hello Art, I live in Ontario, Canada and only melatonin tablets/capsules or drops are available to purchase. Is it possible to use any of them? Maybe drops? Many Thanks

Ankle and Foot Swelling
Posted by Art (California) on 07/19/2024 2715 posts
★★★★★

Melatonin Lotion Helped Reduce Ankle And Foot Swelling From An Unknown Cause

Recently I was talking with a friend who has ongoing ankle swelling that their doctor is trying to determine the cause of and has narrowed it down to heart or liver, but can't determine a treatment until that cause is pinpointed. I suggested to my friend that they try melatonin lotion on their feet and ankles in the meantime to try and reduce the inflammation, pain and swelling that is making it difficult and painful for them to stand or walk.

After 2.5 days they showed me that their ankle swelling had reduced significantly and one ankle and foot looked almost normal while the other was noticeably reduced using two applications sparingly applied per day. This is the most relief they have gotten for their swollen ankles and feet and my friend is very happy to finally get some relief!

Art


Q&A
Posted by Helen B (British Columbia, Canada) on 06/24/2024

Thank you so much for your response!

I am hoping this lotion will help with my fibromyalgia pain.


Q&A
Posted by Helen B (British Columbia, Canada) on 06/25/2024

Thanks for all your help so far Art!

I have an additional question about the melatonin recipe. It calls for 1 gram of melatonin powder. I have purchased a bottle of 90 capsules of 10mg strength melatonin which if I understand correctly is 900mg, 10 capsules short of 1 gram. Am I correct in my math and will it still be strong enough for the pain relief benefits?

(I found a store with 50 ml bottles of gin!! :o) )

Thank you so so much for all the help you have given me!

Helen


Q&A
Posted by Art (California) on 09/02/2024 2715 posts

Hi Cfitz.

The amount of melatonin to dissolve in 1.5 oz of gin is a one quarter measuring teaspoon that is level full.

Art


Q&A
Posted by Art (California) on 09/02/2024 2715 posts

Hi again, Cfitz,

I misunderstood your question. The only way I know of to get an accurate measure of 100 mg of melatonin powder is to use a digital milligram scale. The quarter teaspoon that I mentioned in my previous reply will be approximately 750 milligrams so you would need about one eight of that 1/4 teaspoon to get in the area of 100 mg.

I don't think 100 mg of melatonin in the 3 oz. bottle of melatonin lotion would have much effect as it will be a very weak mix.

Art


Migraines
Posted by Art (California) on 11/11/2024 2715 posts

Hi Sherry,

My friend who used it for migraines told me she applied it sparingly to the back of her neck, temples and scalp. She said she applied from just below the lowest part of the neck to the top of the neck, which is above the hairline at the base of the skull and then applied it to the scalp and temples. She said her migraines would always last about a week and the ML would have them gone in less than a day with significant symptom reduction while the migraine was active. which she said was the best relief she had ever gotten.

Please let us know how it works for your daughter, whether it is helpful or not.

Art


Q&A
Posted by Dawna (Naples, FL) on 03/29/2024
★★★★★

Hi Art, Does it have to be used with Cetaphil or can I use any lotion?

Thanks,

Dawna

Q&A
Posted by Hollyhock (America ) on 03/31/2024

Thanks Art! I would say it only has helped a little, but it does have a relaxing effect (I only use it at night before bed). I also apply some on my neck, which gives me trouble, and it relaxes that area. I will continue using it for such benefit! I never thought about applying to my face, I will give that a try as well! Thank you for the idea and the recipe!


Q&A
Posted by whitebeach (Auchterarder) on 02/22/2024

Hi Art, you say use a small amount of topical melatonin but can you describe what a small amount may be?

Q&A
Posted by Art (California) on 02/27/2024 2715 posts

Hi Peter,

Two reasons why applying sparingly is a good idea is that applying sparingly will be effective and some people are very sensitive to melatonin and applying generously can cause varying degrees of tiredness during the day in those who are sensitive. Applying sparingly helps avoid this issue and also makes your bottle of lotion last much longer.

I am not particularly sensitive to melatonin and can apply the lotion heavily without problem, but to me that is just wasteful unless you are trying to fight something systemically such as cancer because topically applied melatonin can definitely go systemic.

If the generous application you are using does not cause you to feel tired during the day, that is a very good indication for you for the future should you ever need to reach high systemic levels of melatonin for another reason not related to pain, but in the meantime, probably a little wasteful.

Peter, I have a few questions for you as your feedback is very helpful.

1. How effective are you finding melatonin lotion as a pain reliever?

2. What areas of your body have you used it on so far?

3. Is your wife also using it and what is she using it for?

The reason for question number 3 is since topically applied melatonin goes systemic in a way that oral melatonin can not, it can help protect the kidneys from multiple insults as discussed here :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10047594/#:~:text=Melatonin also plays a direct, ATP production and protects mitochondria.

Here is a relevant quote from the link :

' The process of kidney degeneration is often an implication of the frequent prevalence of arterial hypertension, diabetes mellitus, atherosclerosis, and obesity. Melatonin has been proven to have beneficial effects in all of these complications. Melatonin also plays a direct renoprotective role. Moreover, it can be helpful in almost every type of kidney injury because inflammation, apoptosis, and oxidative stress occur without regard to the mechanism. Melatonin regulates mitochondrial metabolism and ATP production and protects mitochondria. It inactivates free radicals by attaching one or more electrons and thus reduces oxidative stress. Due to these mechanisms, melatonin enables normal mitochondrial functions and protects patients from subsequent apoptotic implications and the death of kidney cells. '

In addition melatonin has also shown the ability to protect pancreatic beta cells which is important in diabetes as discussed here :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9189213/#:~:text=Melatonin succeeded in protecting β, for diabetes management and treatment.

Here is a relevant quote from the link :

' Melatonin acted as an anti-inflammatory agent that reduced pro-inflammatory cytokines (IL-1β and IL-12) and oxidative stress biomarkers (MDA). Melatonin succeeded in protecting β cells under severe inflammatory situations, which was apparent by the regeneration of islets of Langerhans in treated diabetic rats. Moreover, these results can open a gate for diabetes management and treatment.'

Diabetes is well known to increase the risk for cardiovascular diseases (CVD) and melatonin works to help reduce this risk as discussed here :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8929360/

Here is a relevant quote :

' Diabetic cardiovascular complications and impaired cardiac function are considered to be the main causes of death in diabetic patients worldwide, especially patients with type 2 diabetes mellitus (T2DM). An increasing number of studies have shown that melatonin, as the main product secreted by the pineal gland, plays a vital role in the occurrence and development of diabetes. Melatonin improves myocardial cell metabolism, reduces vascular endothelial cell death, reverses microcirculation disorders, reduces myocardial fibrosis, reduces oxidative and endoplasmic reticulum stress, regulates cell autophagy and apoptosis, and improves mitochondrial function, all of which are the characteristics of diabetic cardiomyopathy (DCM). This review focuses on the role of melatonin in DCM. We also discuss new molecular findings that might facilitate a better understanding of the underlying mechanism.'

Art


Trigger Finger
Posted by Art (California) on 02/09/2024 2715 posts

Hi Gary,

I am very happy that your wife was able to relieve her trigger finger issue and pain so quickly! Please tell your wife she is welcome! Thank you, Gary, for coming back to let us know about another benefit from melatonin lotion as the list is growing fairly quickly!

Art


Where to Buy: UK
Posted by Art (California) on 02/05/2024 2715 posts
★★★★★

How To Get Melatonin Powder In The UK To Use For Melatonin Lotion

Recently I came across a bulk supplier in the UK that sells melatonin powder. Here is a link to that supplier:

https://rawpowders.co.uk/melatonin-powder

I'm not sure why, but it takes a long time for their website to load and open.

I had recommended this supplier to an acquaintance in the UK and they said they received quick service and would buy from them again, so I thought I would share the link since melatonin powder seems harder to obtain in the UK compared to the US.

Art


Alleviates Nerve and Muscular Issues
Posted by Art (California) on 08/04/2025 2715 posts

Hi Marshagail,

If you read past my friends experience with melatonin lotion (ML), you will see the directions on how to make the lotion. Here is a rewrite of how to make it :

Here are simplified instructions for making a three-ounce batch of melatonin lotion without the need for a milligram scale:

1. Prepare Your Ingredients and Container

  • Melatonin powder
  • Gin
  • Cetaphil Moisturizing Lotion
  • A three ounce jar or bottle

2. Measure Melatonin Powder

  • Use a baker's one quarter teaspoon measuring spoon to add 1/4 teaspoon that is level full of melatonin powder into the three or four-ounce jar.

3. Add Gin

  • Pour one ounce of gin over the melatonin powder in the jar.

4. Mix Melatonin and Gin

  • Secure the lid on the jar and shake it well until the gin appears clear, indicating the melatonin has dissolved.

5. Add Cetaphil Lotion

  • Add two ounces of Cetaphil lotion to the jar.

6. Final Mixing

  • Replace the lid and shake the jar again until the mixture is thoroughly blended.

7. Usage

  • Apply the lotion sparingly up to two times a day or to tolerance. The three-ounce batch should last a long time.

This simplified method uses readily available measuring tools and ensures a consistent, easy-to-make lotion.

Art


Back Pain Relief
Posted by lynn (pa) on 08/12/2024 7 posts

Hi Bonnie,

I made lotion without gin. First of you have to make lotion-you can use all kind oil as coconut oil, olive oil......., and you need put bee wax in it to make lotion. I use big pot with water in it, boil water at same time put glass bottle on it, put all kind oil what you like in it, then you put bee wax in it, last step is put melatonin in it. you have to wait let bee wax melt in the oil, then you have using something to mix it to let melatonin completely melted into lotion. I do not know heat will affect melatonin effecting or not. But I used lotion after I made it that the lotion made me sleepiness. I guess heat did not affect melatonin effecting.


Back Pain Relief
Posted by Carol (Michigan ) on 12/27/2023

Hi Art,

Thank you so much for your answer about the lotion. Just wondering if you could help with what supplements to take. I'm currently taking:

500 mg Berberine 3x a day.
400mg quercetin 3x a day.plus resveratrol. Not sure dosage. Vitamin C 1000 mg 3-4x a day Lysine1000 mg. 3-4x a day. One multi vitamin per day. minerals, herbal extracts with milk thistle, chaparral, dandelion root, pau de arco and others.
400 mg Oregano tablets. Grape Seed extract and the melatonin as much as I can afford. Have done the castor oil wraps and want to try ivermectin or fenben but not sure which I should try or the dosage. Trying to juice but have an old juicer that doesn't do a great job but better than nothing. Anyway, if you or anyone else has any other ideas I would greatly appreciate hearing them. Thanks again for everything you do!


Back Pain Relief
Posted by Art (California) on 09/09/2025 2715 posts

Hi again, AnnaM,

I forgot to mention that the shoulder pain and itching can be caused by nerve issues that often times originate at the spine and melatonin helps with nerve repair. I believe it is called Notalgia Paresthetica (NP) and melatonin has shown potential to help, as you have seen!

Art


Melatonin Lotion Feedback
Posted by Art (California) on 11/18/2023 2715 posts

Hi Deirdre,

I'm excited to hear your results too!

Art


Where to Buy
Posted by Art (California) on 11/16/2023 2715 posts

Hi Dave,

Melatonin powder is available in one strength, but manufacturers describe using different amounts to equal so many milligrams such as 3 mg or 10 mg. They are basically mentioning the dose they are recommending and sometimes include a scoop for the amount they are recommending.

So any bulk powder melatonin should work. Earth Clinic has posted an easier mix that requires just one, 1/4 teaspoon at level full to make a 3 ounce melatonin lotion mix. You can find that in the original article where it has been added today.

A $20 bag of melatonin powder should contain about 25 grams of melatonin and that should be enough melatonin to make at least 25 mixes of melatonin lotion.

Skip the $200 bag of melatonin. My friends used the bag of melatonin that EC linked to in the article which is around $20.

Art


Melatonin Lotion Feedback
Posted by lynn (pa) on 08/12/2024 7 posts

Hi Susan,

I am not Art, But I did melt melatonin with what I made lotion. You can make any kind lotion you want using boiling water. Put glass bottle in the water with something under glass (Provent glass break from very hot heat) all kind oils with bee wax, then put melatonin in it. after bee wax melt, melatonin mostly is melting too. you need using something mix melatonin with lotion. I did not measure how much oil and bee wax I put in and I did not measure how many grams of melatonin I put in. I used my tomato sauce glass bottle that at least is 16 oz bottle. I just put oil first, put bee wax in it as 3/4 bottle already, then put melatonin in it too. after wax melt if I think lotion is too oily, I just put more bee wax. I want strong melatonin lotion, so I put maybe almost 2 table spools of melatonin in, I thought if lotion too strong I will use less, if too weak I cannot use too much lotion on my skin. I tested my lotion after I finished, I did feel sleepiness after for a while.


Q&A
Posted by Art (California) on 10/19/2025 2715 posts

Hi Mix,

In the 3 ounce mix of melatonin lotion, the 1/4 teaspoon of pure melatonin powder is equivalent to 750 mg of pills or capsules. The downside to this approach is that those capsules or pills have a very significant amount of fillers in them so it is going to be much more than a 1/4 teaspoon of powder. The fillers may not dissolve in the gin and so the mix may feel gritty. You will need enough pills or capsules to equal 750 mg of melatonin.

This was reported to me by another EC member who I think is in Canada, who could not buy bulk melatonin powder and had to use capsules. She did say that it definitely helped her fibromyalgia pain better than her prescription medications and it didn't cause her any side effects. She also said that the lotion felt gritty.

Art


Q&A
Posted by Melvin Russel (Florida) on 09/30/2025

The recipe you're referring to calls for 1 gram. That's the amount. You won't want to use pills for that as it would take a lot of them. Get the powder from one of the wholesalers. 1 gram of bulk powder is approximately equivalent to 1/4 tsp (though a scale is much more accurate). For the metrically challenged, 1 gram is 1000 mg.


Q&A
Posted by Art (California) on 09/29/2024 2715 posts

Hi Lola,

Another poster reported that she was able to use capsules that are equivalent to 750 mg to make the lotion to ameliorate her fibromyalgia pain. Not the best way to do it, but she said it worked for her.

Art


Q&A
Posted by Julie C (Louisiana ) on 07/18/2024

Hello!

Regarding the melatonin recipe you gave - would using a coconut oil be an alternative to the lotion? Thank you!

Q&A
Posted by Art (California) on 07/18/2024 2715 posts

Hi Julie C,

I never tested coconut oil for melatonin lotion because some people don't like the smell, but if you try it, please let us know how it works for you as people who like coconut oil will definitely want to know how it works.

Art


Q&A
Posted by Tim (VIC) on 07/10/2024

Melatonin 1 gram

Hi My first ever post. Yay! Art gave a fantastic post on making melatonin topical pain recipe. I only have a bottle of melatonin capsules 10mg. How many capsules would = 1 gram? I am horrible with maths, so I tried but couldn't figure it out myself. Thanks very much earthclinic community for all your advice. 🥰

Q&A
Posted by EB (England) on 07/04/2024

Art, I would like to make melatonin lotion without a scale.

What do you mean by a "quarter measuring teaspoon" of melatonin powder? Do you mean a measuring spoon which is a teaspoon measure?

Q&A
Posted by Cfitz (Georgia) on 09/02/2024

Sir: I am very melatonin tolerant. I want to use 100mg strength to mix with gin and lotion. I have a bag of Melatonin from Bulk Supplements. The bag says 100g (3.5 oz). That's just the weight. The strength is only 3mg. How many teaspoons or tablespoons would I need to get 100 milligrams to mix in the 1.5 oz of gin, please? Thank you, Sir! Colleen


Where to Buy: Canada

Where to Buy: Canada
Posted by susanmaria (buffalo) on 05/08/2024

Do you know anyone in Ontario, Canada? They can drive over the border and purchase it in the US at most large grocery stores or health food stores for you. I get a bad case of sleeplessness starting in February due to lack of sunshine. What works for me is tanning/a vacation in Florida getting lots of natural sunshine or a valerian tinture. Also taking progesterone/biest if you are a woman and menopausal.


Back, Neck & Knee Pain
Posted by Art (California) on 02/09/2024 2715 posts

Hi Peter,

Thank you for adding your results with melatonin lotion for your wife to this thread. Always good to hear how it is working for people.

I think in the long run, you will get a better total effect by substituting melatonin lotion for topical naproxen because melatonin has shown potential reparative effects compared to naproxen which only has pain relieving effects. I also am seeing that the melatonin lotion has cumulative effects with regular use that may ultimately exceed naproxen's pain relieving effects. A very important point about melatonin lotion that I have not discussed yet on EC is that it goes systemic in such a way that it may be more beneficial than high dose oral melatonin for our health. I will discuss that point more in a future post, but this feature of melatonin lotion is very important for our health in many ways.

If you want to continue using naproxen anyway, then gin will also work as the solvent, but I would take melatonin lotion any day over naproxen topical mix that I mentioned to you months ago.

Continued improved health to you and your wife!

Art


Skin Cancer
Posted by Koys (Sofia) on 02/01/2024

Hi Art, Thank you for your melatonin article and report of the results.

I wonder, if the melatonin, applied locally to the skin could help for skin cancer also. Thank you for your insights.

Alleviates Nerve and Muscular Issues
Posted by Cindy (iowa) on 08/16/2025

Did you buy the melatonin powder in bulk or open capsules? Is there a safe source to purchase the powder from (ie non gmo/organic?)


Melatonin Lotion Feedback
Posted by Debra (USA) on 04/29/2025

I'm curious about the melatonin strength in the lotion? On Amazon I found PURE (brand name) and it's 20 mg and advertised as - NOT FOR SLEEP, but cellular healing. Your thoughts, experience or recommendation? TY


Melatonin Lotion Feedback
Posted by Art (California) on 04/29/2025 2715 posts

Hi Debra,

For the easy mix that I described, each ounce contains approximately 250 mg of melatonin and the breakdown looks somewhat like this :

3 oz. = 750 mg melatonin

2 oz. = 500 mg

1 oz. = 250 mg

3/4 oz. = 187.5 mg

1/2 oz. = 125 mg

1/4 oz. = 62.5 mg

1/8 oz. = 31.25 mg

1/16 oz. = 15.625 mg

You are trying to compare a 20 mg capsule of melatonin to the lotion and they are not really comparable because with oral melatonin only about 3% is bioavailable to the body and it is pretty much done within 5 hours in the body. Whereas topically applied melatonin lotion (ML) or melatonin gel (MG) accumulate in the stratum corneum layers and then release over an approximate 24 hour period, somewhat similar to a patch. ML and MG also reach much higher local tissue levels. As an example of how this makes a significant difference between ML and oral melatonin, a friend who had liver cancer would get pain in the area of his liver that 360 mg of oral melatonin could not touch, but ML applied directly over the liver area could stop the pain very effectively in less than 5 minutes.

I have written a lot about the health value of melatonin on EC and you can find much of it by searching the index. Melatonin is protective of the major organs while be anti inflammatory and a potent scavenger of reactive oxygen species. It helps fight the toxicity of heavy metals as well as helping to protect against ionizing radiation among many other health benefits that it offers to humans, animals and plant life. It also is a cancer fighter through multiple methods of action.

Art


Back Pain Relief
Posted by Bonnie (Los Angeles) on 07/16/2024

Hello,

Could the melatonin recipe be made without the gin? I don't drink alcohol and would prefer not to put in on my body topically. Or is there a substitute product for the gin? Thank you!


Back Pain Relief
Posted by Art (California) on 12/04/2023 2715 posts

Hi Yomama,

Thank you for this important feedback on how well the melatonin lotion is working out for you! I am very happy that you are finally finding some long needed relief! As to the physiatrist you saw, I have several words for that person, but I can't post them here.

You've got multiple spinal issues going on and I am glad the lotion is helping you with them. It is worth mentioning that melatonin is also useful for fighting osteoporosis, as I previously discussed here :

https://www.earthclinic.com/cures/osteoporosis-supplements-art-solbrig.html

And here :

https://www.earthclinic.com/cures/melatonin-for-osteoporosis.html

Something else I have found very useful for bulging discs and degenerative disc disease (DDD), I wrote about here :

https://www.earthclinic.com/cures/ddd-art-solbrig.html

It sounds like you are going to be having better days ahead because melatonin can be healing to the body in general and the DDD/HA/Stopain remedy is likely to be additive based on reports on EC and from my friends who have used the combination.

Btw, my friend Lydia, who was one of the three friends that I wrote about, had also used the Salonpas patches and ran into the same sensitivity issue as you after about a few weeks of use and could no longer use them, but she did say that the melatonin lotion was more effective and non-irritating.

The following discusses how melatonin can be beneficial for the spine :

https://www.earthclinic.com/cures/melatonin-spine-health.html

Please keep us posted on your great results using melatonin lotion! Also, please update us on how it works for your shoulder pain. Lydia applies the lotion to her whole spine regularly now and I discussed why that might be a good idea here: https://www.earthclinic.com/cures/melatonin-spine-health.html

Art


Back Pain Relief
Posted by Carol (Michigan ) on 12/25/2023

Hi Art,

I have breast cancer and would like to know what dosage the melatonin would be. I was thinking of applying it directly over the breast. I am trying to get up to the 300 mg a day that is supposed to stop the metastes but can't afford the number of pills that would take. Any help would be greatly appreciated and thank you for all your informative advice on this site. God Bless!


Back Pain Relief
Posted by M-L Bloch (Zürich) on 02/05/2024

Hi Carol

Do not forget B17, that should help cancer.

rgs from sunny Zurich, Switzerland


Back Pain Relief
Posted by Anna (Texas) on 07/31/2025 15 posts

Hi Art, I have been using the melatonin lotion and it seems to help. I have breast cancer for the 2nd time in 5 years. Doing great on natural remedies according to my oncologist. Tumor has only grown by .5cm in 2 years and has not spread. I also have a degenerative brain disease, spinal degeneration, arthritis in the neck and Thalassemia A minor, plus several other health problems. I had been looking into dissolving melatonin in DMSO. I have used DMSO for over 20 years but would really like to dissolve melatonin in it specifically for my breast tumor. I usually apply DMSO right after I shower so as to have the area as clean as possible. Can you please assist as to how much of each, will it keep or should I just make it as I use it. Thanks, my brain doesn't work as well as it used to, to do calculations.


Back Pain Relief
Posted by AnnaM (Tx) on 09/09/2025 15 posts

1. I do not believe, or remember talking previously on EC.

2. Currently taking Astaxanthin, Vitamin D-3 & K2, DIM, Zinc Bis-Glycinate, Gamma E mixed tocopherols and tocotrienols, Selenium, R-ALA, Milk Thistle, Trans Resveratrol and 6 bitter apricot kernels. Mind you, I have had to get off my supplements 2 or 3 times because my doctor said my liver enzymes were very high, which they never had been before. Finally figured out that it was probably the creosote and maybe the serrapeptase that were causing liver enzymes to elevate because they came back down. I had just started taking those recently but was not taking liver supplements like the Milk Thistle. I have changed my regimen several times but the one thing that has been consistent throughout is that I use my frequency generator every night with scans and also different frequencies during the day like detox. I also have done nebulized colloidal silver, I have 2 ozone generators but I'm on and off on that and I use red light therapy. I also have a vibration board and Chi machine but also I forget or get lazy. I have a lot of trouble staying focused and I have no help.

4. I had been having itching (middle of back) and pain in my left shoulder blade but no one, Oncologist, general practitioner, and I had 2 CT scans done, could tell me what it was. When I started applying the melatonin lotion the pain and itching subsided drastically. I also apply it pretty much to all my body, legs because I have bad vericose veins which I have had all my life and had neuropathy so bad around 10 years ago that I had couldn't even wear any clothes, went to the ER twice within 5 days and they couldn't do anything. Turns out I had disc problems and had several MRI's, won't get into that fiacso, and the neurologist ended up telling me I had been having mini seizures for over 10 years. Fast forward to 2020 when, long story but we ended up moving out in the middle of nowhere Texas, away from all our family and I down and couldn't undertand how or why. Went to the doctor, and had an MRI and he yelled at me and asked if I smoke. Well no, and he said I have microvascular brain disease (white brain matter) and have been having mini strokes for the last 10 years. So that makes it over 20 years I have been having seizures or strokes. So which is it, seizures or strokes? No one will confirm, and I have asked. I also have Thalassemia A minor. which I found out after my first breast cancer full body scan in 2021. Would've been nice to have known that when I was having children. OK, that's my brain and my legs, I also have the degenerative back also found out in 2021 and arthritis in the neck and the idiot oncologist, who I refuse to see anymore, took 4 lymph nodes out of my left arm even though I told him not to and they tested 4 times and said they were not "involved". So I just slather, lightly, the melatonin lotion every night and sometimes when I remember in the mornings.

5. I do not know how bad the microvascular brain disease is because the first doctor yelled at me which I took as it's pretty bad, and another doctor told me that everybody has mini strokes. I assume it's hereditary because my aunt told me my grandmother passed with dementia and my uncle found out he had microvascular brain disease the same time I did and he passed a few months later, of course he was older than me and an alcoholic.

6. Yes, from my research because my hematologist won't tell me more, is that it is manageable but I do get anemia and cold feet every so often but doctor said I do not have anemia.

My balance is very bad but I do not know what the reason is because no doctor knows. When I was using DMSO consistently on my vericose veins, I did notice they were diminishing and then winter came, our OLD house is very cold, and I quit using it. I have used DMSO as a mouth rinse because I also have a few bad teeth that a dental school really messed me us but red light therapy works really well but unfortunately my device broke and I do not have the money to buy a new one. COVID really drained us both financially and physically. I did try hydrogen peroxide protocol, The One Minute Cure by Madison Cavanaugh but halfway through our refrigerator broke :( BUT my blood pressure was normal for awhile!!!! Need to do that again but I forget and it's doesn't taste very appealing.

I was taking liposomal vitamin C several times a day which I make my own; melatonin 180 mg, L-Theanine 500 mg and niacin (I forget how much) and CBD/CBG/CBN at night but again, that is so much to keep up with and I forget. I did try Borax, Methylene Blue, Lugols Iodine and so many other things, not all at the same time and I still have most of the supplements in case I get to thinking or learn something new that motivates me to take them. Sorry it is so long. I'm sure I am missing some things, oh and I do have SIBO and H Pylori which I got so sick after having a colonoscopy, I kid you not, right after I left the hospital was so sick and they found out I have H Pylori and SIBO. I refuse to take their pills but I am going to try making the SIBO yogurt by Dr. Davis. I have taken and made my own Kefir, kombucha and and microgreens/sprouts in the past but our house is so cold in winter and hot in the summer and very dusty that it doesn't survive for long. And again, money is tight, so I can't afford to keep buying the grains all the time which are hard to find in my part of the world. I also use DMSO in my eyes and now I can't see with my contacts and use my glasses only for reading when I have to. I also have minor macular degeneration, glaucoma and cataracts but very minor and have not changed for the past 20 years or so, because I keep records. So I must be doing something right. Have been doing natural remedies for over 20 years. I also have a portable FIR sauna that I use when I remember. Luckily I had acquired/bought most of the big/more expensive items before I got cancer and so sick but our house is not grounded so it's hard to use the red light therapy because they told me it is not adviseable to use it ungrounded. And we only have 1 or 2 outlets per room. But I am still alive! Thank God. I do believe he was guiding me to acquire the expensive items before we went broke.


Back Pain Relief
Posted by Art (California) on 09/09/2025 2715 posts

Hi AnnaM,

Yes, I realized it was someone else that I was thinking of who had breast cancer, after I came across our conversation after I had replied to you.

That is a very useful group of supplements you are working with and it looks like you have done your homework!

Wow, that is a lot you are dealing with!

It's been awhile since I replied to you and I was wondering how you were doing.

As far as the peripheral neuropathy pain, melatonin lotion should help for that too. It also has nerve reparative effects with longer term daily use. If you read the original ML article and replies you are already aware of some of its many uses. A recent finding in a friend is that topically applied over the heart area, it helped calm his pounding heart arrythmia and allows him to go right to sleep. within about 15 minutes. Topically applied like that, it accumulates in the stratum corneum and is released over an approximate 24 hour period into the blood. Yes, it goes systemic when topically applied. Melatonin has also shown benefit for stroke recovery. The science is very limited (animal studies), but melatonin and Apigenin may also be helpful with seizures.

It may also be useful for the breast cancer as discussed here :

https://pmc.ncbi.nlm.nih.gov/articles/PMC12133437/

Here is a very important quote from the link that should definitely interest you:

' MLT produced by the pineal gland activates the sleep-wake cycle and exhibits a broad range of other activities, including antioxidant, immunomodulatory, anti-inflammatory, anti-metastatic, antiproliferative, antineoplastic, antiestrogenic, and anticarcinogenic effects. Indeed, there is a significant amount of data from clinical and laboratory trials that show MLT can exhibit anticarcinogenic activity against cancer, including apoptosis, oncostatic, antiproliferative, and antineoplastic properties. MLT inhibits initiation, progression, and metastasis in cancer. It is an important medication against cancer because it may trigger several anticancer mechanisms in breast cancer. The peculiar feature of MLT is the fact that it prevents entrance of cancer cells into the circulatory system and forbids them from spreading in the distant regions. '

As far as SIBO, 5 of the best supplements I am aware of are garlic extract, berberine, oregano oil soft gels, probiotics and digestive enzymes that also contain betaine HCI.

Balance issues can be a lot of different things, but one simple one you can easily test is the Epley Maneuver as discussed here to realign the ear crystals :

https://youtu.be/2NmXXPZFHnc?si=Vbtlm8ayeUjHAzrc

When you say frequency generator, are you referring to a Scenar Therapy device? I have used it, if that is what you are referring to, but it requires a lot of time and effort and it isn't cheap so I don't usually recommend it.

To help with focus, methylene blue is sometimes helpful in sharpening that up. It may have potential for gut microbiome issues, but the science isn't really there.

The pain and itching are ML regulars. It is also helpful for atopic dermatitis. Quite useful for neck pain and other spinal issues as melatonin has spinal reparative qualities including beneficial effect on spinal discs. shoulder pain sometimes originates in the neck area of the spine and if applying the ML to the neck relieves the shoulder pain, that will be a huge clue. Melatonin has also shown to cross the blood brain barrier (BBB) and reduce inflammation and oxidative stress in the brain. These are two very brain damaging components in many neurodegenerative diseases, so knocking them down is very important. In some cases melatonin has helped improve circulation in the hands and feet which may be helpful for cold feet, but low iron/anemia is a common cause of cold feet, but your doctor says that is not your problem. I don't have any experience with it yet, but melatonin has shown some benefit with certain vascular issues. Melatonin has shown some benefit with age related macular degeneration. I use melatonin gel instead of lotion as I am able to apply it on my face closer to my eyes without irritation. The gel has less other ingredient and is made the same way as the ML, just substituting aloe vera gel for the lotion in the original mix.

The astaxanthin you are taking is a very useful supplement!

If you decide to try anything that I mentioned above, because of your multiple health issues, you will need to get approval and supervision from your doctor first in order to be safe!

I tried to answer everything you mentioned, but I'm sure I missed things. Good luck and keep us posted on how your recovery goes!

Art


Where to Buy
Posted by JenE (NC) on 11/14/2023

Hya, Hyacinth!

I noted this in the links above --- maybe it was a later addition?

Am doing research for my brother and a couple of friends, and maybe for myself before too long since 69 y/o knees feeling the stresses now.

Where to Buy Melatonin Powder

Bulk Supplements sells a large bag of pure melatonin powder reasonably priced.

Melatonin Powder Bulk Supplements - $18.96 for 25 grams - 8,333 servings


Melatonin Lotion Feedback
Posted by Art (California) on 11/15/2023 2715 posts

Hi Hollyhock,

Your feedback will be very useful since I have not tried it for hip pain yet.

Thank you!

Art


Q&A
Posted by Marshagail (United States) on 08/04/2025
★★★★★

I just read Art Solberg's Xcellent article about preparing Melatonin Topical Lotion & want to make some. He lists 1gram or ¼tsp of Melatonin should be used but doesn't indicate how many milligrams. Is it 2mg, 3mg, 5mg, 10mg or?? Would absolutely appreciate any clarification! Can't wait2try it!!

Q&A
Posted by Maryb (Palm Desert CA) on 05/29/2025

Melatonin Lotion

For carotid stenosis where to apply the lotion? Thank you

Pain
Posted by Hollyhock (America ) on 01/14/2025

Art, I am curious why you would rub the melatonin on the stomach area if it was for the knee pain? Thanks!


Q&A
Posted by Art (California) on 11/05/2024 2715 posts

Hi Gerrit,

Thank you for answering the question of, "does melatonin lotion (ML) help rheumatoid arthritis (RA) pain" as I wasn't positive whether it did or not as I have never had someone test it for that purpose until now! It worked for OA and PA, but I wasn't sure about RA. Can you tell me how you use it for RA and how it helps in your experience?

To answer your question, yes it will work, but always remember that you have to dissolve the melatonin powder in the gin, before adding the lotion or the finished product will be weak or not effective enough!

I don't mean to try and talk you out of using ML for your RA, but a potentially more effective and less expensive remedy for various forms of arthritis, in my experience, is borax, which has kept my psoriatic arthritis in remission for over 16 years and is a very inexpensive remedy that also offers potential to fend off osteopenia and osteoporosis.

Here is a link to the Earth Clinic (EC) Borax page :

https://www.earthclinic.com/remedies/borax.html

The above EC link gives information on multiple uses for borax as well as dosing information for arthritis and much more!

Until you have completed a test of borax, you can use the ML simultaneously. Studies suggest that melatonin can help arthritis and even offer some joint protective effects, but for me borax was life changing keeping my joints pain free for all of these years. It doesn't work for everyone, but seems to work for the greater majority of people who test it. I gave it the full 3 to 4 months as suggested by Dr. Rex Newnham who originally discovered the use of boron or borax for various forms of arthritis back in the 1960s/1970s. My PA was severe and it took about three months for me to become pain free, but I already felt benefit within the first month.

Good luck with whatever you decide to do and thank you again for the feedback on ML for RA pain relief!

Art


Q&A
Posted by Art (California) on 11/07/2024 2715 posts

Hi again, Gerrit, Interestingly melatonin is useful for some with autism spectrum disorder (ASD) to help with sleep, but as discussed in the following link may also offer further benefit for other ASD symptoms, but I would expect those benefits would likely be most likely with extended use of both oral melatonin and ML together over an extended period of time :

Https://pmc.ncbi.nlm.nih.gov/articles/PMC6096870/#:~:text=Melatonin is used to treat, , pain, and gastrointestinal dysfunctions.

Here is a relevant quote from the link:

' Melatonin is used to treat sleep difficulties associated with autism spectrum disorder (ASD). There are growing evidence that melatonin could have an effect on other symptoms than sleep, such as anxiety, depression, pain, and gastrointestinal dysfunctions. '

I do not understand the word you used, "league, "so I wasn't quite sure what you meant with that sentence. I have found that 360 mg of oral melatonin could not come close to the pain relieving effect of melatonin lotion (ML).

Art


Q&A
Posted by Wanda (Spring, Texas) on 04/02/2025 53 posts

Thank you Sir! I appreciate it.


Q&A
Posted by Art (California) on 08/06/2024 2715 posts

Hi Lynn,

In my experience, people have reported on the internet that melatonin can worsen joint pain in people with rheumatoid arthritis (RA), but on the other hand, I have gotten reports that it helped. As with most medications and supplements for specific health issues, it usually comes down to trial and error. For RA, studies seem to reflect this conundrum also, when it comes to RA and melatonin.

As far as oral melatonin, in my testing, I have not gotten any reports of pain relief of any significance, whereas, melatonin lotion (ML) has resulted in pain relief from many various pain issues as discussed here :

https://www.earthclinic.com/supplements/topical-melatonin-advantages-pain-management-guide.html

I would also add that that list of 40 has grown to 43.

ML is relatively inexpensive to make and test and doesn't seem to have many of the severe side effects that pain relieving NSAIDS can have as discussed here :

https://www.sciencedaily.com/releases/2005/01/050111123706.htm#:~:text=Each year, the side effects, cancer in the United States.

Here is a very relevant quote from the above link :

' Each year, the side effects of long-term NSAID use cause nearly 103, 000 hospitalizations and 16, 500 deaths. More people die each year from NSAIDs-related complications than from AIDS and cervical cancer in the United States.'

Keep in mind that is just for the USA and does not include the rest of the world! By comparison, see how many deaths you can find caused by melatonin each year and I can promise you that the two are not even comparable!

I'm not saying that ML can alleviate every kind of pain, it can't, but it certainly seems worth testing considering its known safety profile, at least for most people. As with anything else used to relieve pain, it will not be agreeable with everyone, but if it is, it offers many other potential health benefits whereas NSAIDS which are also used for pain relief, mainly only help for pain management and not much else.

If you prefer NSAIDS which are readily available and also relatively inexpensive, you might keep the following in mind. Acetaminophen, an NSAID, also known as Tylenol, among other names, is often used for pain reduction and is the number one cause of liver transplants in the USA and the number two cause of liver transplants in the world as discussed here :

https://www.ncbi.nlm.nih.gov/books/NBK441917/

Here is a relevant quote from the link :

' Acetaminophen toxicity is the second most common cause of liver transplantation worldwide and the most common cause of liver transplantation in the US. It is responsible for 56, 000 emergency department visits, 2, 600 hospitalizations, and 500 deaths per year in the United States. Fifty percent of these are unintentional overdoses. More than 60 million Americans consume acetaminophen on a weekly basis, and many are unaware that it is contained in combined products. '

If melatonin did the same as the above quote about Acetaminophen, it would be banned by the FDA immediately!

To answer your question, ' if oral melatonin taking make my join pain, what about melatonin lotion? can I still use melatonin lotion even I cannot take melatonin orally. '

I would say if oral melatonin causes you pain, then you might not want to consider ML among your pain relieving options.

Art


Q&A
Posted by Art (California) on 08/08/2024 2715 posts

Hi Lynn,

Yes, I have used higher dose melatonin for many years. I have not experienced joint pain from taking melatonin, but I have seen reports on the internet that some people with rheumatoid arthritis have. On the other hand, I have seen reports that melatonin does not increase joint pain for people with RA, so that is a bit puzzling to me. I've gone as high as 180 mg, but I am now very likely higher than that amount because I take melatonin orally and topically everyday.

Art


Migraines
Posted by Sherry (Virginia ) on 11/11/2024

How was the melatonin lotion applied? My daughter has migraines and I made your lotion for her and then realized there is no instruction on how to use it for migraines. Does she rub the lotion on where she has migraine pain?


Where to Buy: Canada
Posted by Guzin (Vancouver Canada) on 05/02/2024

Hi Art,

Thank you very much.

looking forward to try your melatonin lotion for pain. I will post my results.


Where to Buy: Canada
Posted by Mike (North) on 07/07/2024

This is not quite true, melatonin is available over the counter in Canada but only in pill form up to 10mg I believe. Bulk powder does not appear to have the same freedom.


Q&A
Posted by Art (California) on 03/29/2024 2715 posts

Hi Dawna,

I just used Cetaphil because it has been around for a long time and is readily available, but I think most lotions will work. Be sure to completely dissolve the melatonin in the gin before adding the lotion to the bottle.

Art


Q&A
Posted by Hollyhock (America ) on 03/30/2024

I've been using the clear aloe vera gel available in stores. It works nicely. :)


Q&A
Posted by Peter (Chicago ) on 02/26/2024

Art, I have user generous portion for neck and. back pain. Is there problem use generous portion?


Alleviates Nerve and Muscular Issues
Posted by Marshagail (United States) on 08/04/2025

Hey!!! Please tell me what milligram of Bulk Melatonin I should use - 3mg, 5mg, 10mg, etc!!! Can't wait to try this! So Very Grateful for All of your Xcellent articles & commentsâTM¡


Alleviates Nerve and Muscular Issues
Posted by Cindy (Australia) on 09/12/2025

Melatonin Lotion

Hi

Would love to try this - having issues with muscle pain due to menopause and structural spine issues.

Melatonin recently banned in Australia (except professionally prescribed). Any Aussies know where to purchase this in powder form?

Thanks :-)


Alleviates Nerve and Muscular Issues
Posted by Art (California) on 09/12/2025 2715 posts

Hi Cindy,

I see two sellers on Ebay Australia, but both say "delivery from China".

Art


Back Pain Relief
Posted by Art (California) on 12/05/2023 2715 posts

Sharon,

I forgot to ask if you still had a problem with tiredness from the application? If so, how did you work around it?

Art


Back Pain Relief
Posted by judith (USA) on 12/10/2023

thank you, Art! she has lower back stenosis - L5


Back Pain Relief
Posted by Carol (Michigan) on 02/25/2024

Hi M-L Bloch,

Thank you so much for the suggestion regarding B17.

I will definitely try it! I wish I were in Sunny Zurich. We don't have many sunny days in Michigan in winter. Thanks again, Carol


Back Pain Relief
Posted by Art (California) on 08/04/2025 2715 posts

Hi Marshagail,

Melatonin has very poor solubility in castor oil. Not enough melatonin will dissolve in castor oil to offer the benefits discussed in the original article.

Art


Where to Buy
Posted by Dave (Ontario, Canada) on 11/16/2023

I visited the Amazon site for powdered melatonin and confused about what strength to buy. There are bags with 3mg strength, 10mg They are different price from $20. To $40. Depending on size and strength and then there was a choice of laboratory grade 99.9% pure strength for $200. + or -?

Melatonin Lotion Feedback
Posted by cy (usa) on 11/14/2023

Can castor oil be substituted for gin in pain remedy with melatonin?


Melatonin Lotion Feedback
Posted by Karen (NSW) on 11/14/2023

Yes I am questioning the use of the chemical ingredients of Cetaphil as well. I'm finding it's so hard to find ANY product that has safe ingredients??!! My skin is so dry as I've given up searching as it's a mind field of so many companies claiming their products are all natural, but they're not!!! I use a little coconut oil and olive oil sometimes but I get over the greasiness of them.


Melatonin Lotion Feedback
Posted by Mary (NEW YORK) on 11/14/2023

Hi! Can you or anyone put this recipe into spoons… I don't know grams.. 1/2 teaspoon???? Thanx I want to try it!!!!!!


Melatonin Lotion Feedback
Posted by Frances (Cabarlah, Qld.) on 11/18/2023

Karen, have you tried Aussie-grown product jojoba oil, either on its own or in various moisturising products.


Melatonin Lotion Feedback
Posted by Susan (Wake Forest, NC) on 11/28/2023

Art,

Since melatonin is both lipophilic and hydrophilic, could one just dissolve the mel powder in their moisturizer (I use tallow) and skip the alcohol step?

Thanks,

Susan


Melatonin Lotion Feedback
Posted by Diana (MA) on 11/14/2023
★★★★★

Interesting article. I make lotions including one with magnesium and Naproxen for pain. Usually I use a rate of 1st of each. Melatonin in powder is pretty expensive. Any idea what the usage rate for a lotion is? Thank you.

Melatonin Lotion Feedback
Posted by M-L Bloch (Zürich) on 02/05/2024

Hi Frances

The same in Switzerland, we get it only after 65 years old. I order it at

iherb, usa

rgs from ZUrich


Melatonin Lotion Feedback
Posted by Hollyhock (America ) on 11/15/2023

Art, thank you for the recipe! I put it together today and will try it on my back and hips before bed. I will give it a few weeks and then give feedback!


Q&A
Posted by Mix (Gauteng) on 10/19/2025

Hi Art

I am trying to make the Melatonin lotion for my dad, as you have very kindly suggested. Having difficulty getting the pure powdered melatonin in SA but am working on it, is there an interim recipe crushing 5/10 grams melatonin tablets till I can source it?

Thank you


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