Melatonin Gel: Health Benefits and Recipe

| Modified on Apr 27, 2026
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Enlarged Prostate
Posted by Art (California) on 09/19/2025 2891 posts
★★★★★

Enlarged Prostate / Benign Prostatic Hyperplasia Rapid Relief With Melatonin Gel (MG)

Recently a friend mentioned to me that his urine flow had slowed down noticeably over the past 2 months and he asked me what might be causing it. I told him that because he is in his 70's it could be a couple of things possibly related to his prostate gland and I told him he should have his doctor check his prostate and explain the reduced urine flow rate at the same time. He told me he has that scheduled, but it is two months until that appointment. I told him that once we pass our mid 40's the prostate starts to enlarge and that this enlarging process can continue as we age. This is called Benign Prostatic Hyperplasia or BPH and is extremely common in men over 70. He asked if there was anything he could do while he waited for his prostate exam.

I suggested that he could try applying Melatonin Gel (MG) to the perineum area once in the morning and once at bedtime. This is the area between the scrotum and the anus. I made him a small bottle of melatonin gel and asked him to let me know if it helped improve his urine flow.

I talked with him yesterday and he told me that his urine flow is now back to normal and he no longer has to get up during the night to urinate. He said that since this started, he was having to urinate 2 to 3 times during the night, whereas before he almost never had to urinate during the night.

I thanked him for the feedback and told him to still keep his appointment for the prostate exam to determine what the problem is or was and to see what his doctor recommends. I don't know if this will work the same for someone with long standing BPH, but it is so simple, fast acting and easy to do, it seems worth consideration for a problem that affects many men as they age.

This brings the number of uses for melatonin gel or melatonin lotion to 49, up from the original 40 that I mentioned in the original post.

Art


Reader Q&A
Posted by Renee (NC) on 07/02/2025
★★★★★

Thanks so much, Art. I successfully made a batch using vodka. I didn't adjust the amounts and it seemed to work out fine. It seemed to take a while for the melatonin to dissolve, but I just added the aloe gel and the melatonin all seemed to disperse evenly and then disappear/dissolve. I used an old hand sanitizer flip-cap bottle, and it worked well. Too soon to tell about the health benefits.


Reader Q&A
Posted by Confused (Somewhere) on 02/04/2025

These studies seem off. "99% of the gel is water.4 Additionally, mucopolysaccharides along with amino acids and zinc present in Aloe vera can lead to skin integrity, moisture retention, erythema" That teeny 1% of "mucopolysaccharides along with amino acids and zinc" must be quite powerful? UV light causing immunosuppression? I had read the opposite, it is the UV which boosts the immune system. No disrespect, Art. Just scratching my head.

Reader Q&A
Posted by Vince (Maryborough Queensland) on 12/31/2025

Hi all,

Does MG need to be refrigerated and how long does it keep please.

Reader Q&A
Posted by Renee (Bergen Co, NJ) on 06/21/2025

I'm planning to make Melatonin Gel, and I'm wondering if I can substitute vodka for the gin. I don't care to buy a bottle of gin if I don't need to. Thanks!

Reader Q&A
Posted by Alan (Hawaii) on 11/06/2025

I've spent a good deal of time over the years, digging into Earth Clinic, researching alternative strategies for healing various problems. But I only just now discovered these posts regarding the use of topical melatonin. I have a couple of metal rods, either titanium or stainless steel, in my left ankle, surgically implanted to repair a broken ankle, the result of a hiking fall a decade ago. I've had continuing problems for years with that ankle/foot; discolored skin and slight swelling in the area, and more recently add to that now I've developed achilles tendonitis too. Studies I've read indicate some folks have negative reactions to metal implants, so I could be one of those individuals. Looks like melatonin has "strong scavenging abilities", and I'm wondering if it might be able to remedy my problem with my body's apparent chronic reaction to the ankle implants, and save me from ultimately having to get surgery to remove those implants.


Reader Q&A
Posted by Alan (Hawaii) on 11/10/2025

Hi Art, You are correct, and I had forgotten, "retrograde ejaculation" is the medical term for this condition. And it seems most of the statistics for guys who end up with this problem post-prostate resectioning have had TURP. But I myself didn't have TURP. I had GreenLight Laser. I thought this technology was supposed to be a tad less invasive but it still caused the same damage a bunch of men end up with. I like your idea about trying melatonin lotion to find out if it can heal this surgically-generated condition. I had mentioned that I planned on using DMSO/aloe to make melatonin lotion for this. I'm thinking now though to experiment instead with emu oil instead of DMSO. Some parts of my body will tolerate DMSO while other parts not so much! And apparently emu oil has skin penetration (carrier) ability perhaps similar to DMSO.