Reader Q&A
Melatonin does not scavenge or chelate titanium, which may be the metal used in your ankle. Melatonin does however offer anti inflammatory effects that may apply against inflammation caused by titanium as discussed here :
Here are two very relevant quotes from the link :
' In this study, we examined the potential inhibitory effects of melatonin on titanium particle-induced inflammatory osteolysis (the destruction of bone tissue through bone resorption) in a murine calvarial model and on RANKL-induced osteoclastic formation in bone marrow-derived macrophages. We found that the exogenous administration of melatonin significantly inhibited wear debris-induced bone resorption and the expression of inflammatory cytokines in vivo. Additionally, melatonin inhibited RANKL-induced osteoclast differentiation, F-actin ring formation, and osteoclastic resorption in a concentration-dependent manner in vitro. We also showed that melatonin blocked the phosphorylation of IκB-α and p65, but not IKKα, and significantly inhibited the expression of NFATc1 and c-Fos. However, melatonin had no effect on MAPK or PI3K/AKT signaling pathways. These results provide novel mechanistic insight into the anti-inflammatory and anti-bone resorptive effects of melatonin on wear debris-induced bone loss and provide an evidence-based rationale for the protective effects of melatonin as a treatment for peri-implant osteolysis. '
' Wear debris-induced chronic inflammation, osteoclastic activation and osteoblastic inhibition have been identified as critical factors of peri-implant bone loss. We previously demonstrated that melatonin, a bioactive indolamine secreted mainly by the pineal gland, activates Wnt/β-catenin signaling pathway and enhances bone regeneration at osteolytic site in vivo. In the current study, we further demonstrated that melatonin significantly suppresses wear debris-induced bone resorption and inflammatory cytokine expression in vivo. In addition, melatonin inhibits receptor activator of nuclear factor kappa-B ligand induced osteoclast formation and osteoclastic bone resorption in vitro. Meanwhile, we found that melatonin mediates its anti-inflammation and anti-bone resorption effects by abrogating nuclear factor kappa-B activation. These results further support the protective effects of melatonin on wear debris-induced peri-implant bone loss, and strongly suggest that melatonin could be considered as a potential candidate for the prevention and treatment of wear debris-induced osteolysis and subsequent aseptic loosening.
Based on this, it seems worth discussing with your doctor whether testing topical melatonin lotion or melatonin gel on your ankle area will be a good option for you to reduce the swelling, inflammation and bone destruction you are experiencing while offering potential bone repair effects as discussed in other studies. If your doctor agrees, here is how to make melatonin lotion :
https://www.earthclinic.com/supplements/melatonin-lotion.html
And how to make melatonin gel :
https://www.earthclinic.com/supplements/melatonin-gel.html
Keep us posted on your progress!
Art
Enlarged Prostate
★★★★★
Recently a friend mentioned to me that his urine flow had slowed down noticeably over the past 2 months and he asked me what might be causing it. I told him that because he is in his 70's it could be a couple of things possibly related to his prostate gland and I told him he should have his doctor check his prostate and explain the reduced urine flow rate at the same time. He told me he has that scheduled, but it is two months until that appointment. I told him that once we pass our mid 40's the prostate starts to enlarge and that this enlarging process can continue as we age. This is called Benign Prostatic Hyperplasia or BPH and is extremely common in men over 70. He asked if there was anything he could do while he waited for his prostate exam.
I suggested that he could try applying Melatonin Gel (MG) to the perineum area once in the morning and once at bedtime. This is the area between the scrotum and the anus. I made him a small bottle of melatonin gel and asked him to let me know if it helped improve his urine flow.
I talked with him yesterday and he told me that his urine flow is now back to normal and he no longer has to get up during the night to urinate. He said that since this started, he was having to urinate 2 to 3 times during the night, whereas before he almost never had to urinate during the night.
I thanked him for the feedback and told him to still keep his appointment for the prostate exam to determine what the problem is or was and to see what his doctor recommends. I don't know if this will work the same for someone with long standing BPH, but it is so simple, fast acting and easy to do, it seems worth consideration for a problem that affects many men as they age.
This brings the number of uses for melatonin gel or melatonin lotion to 49, up from the original 40 that I mentioned in the original post.
Art
Reader Q&A
Reader Q&A
