Does MG need to be refrigerated and how long does it keep please.
Reader Q&A
Reader Q&A
I believe that that condition is called retrograde ejaculation and is very common after having TURP. There are several medications that can help in only some cases such as imipramine or pseudoephedrine, but that might be worth asking your doctor or urologist about.
This is often caused by nerve, muscle or damage to the sphincter at the bladder neck that can occur during various prostate surgeries or procedures. Since you are going to be using melatonin lotion (ML) on your ankle, you might also try applying to you perineum, rear portion of the scrotum and leg creases adjacent to the scrotum since melatonin has shown potential nerve, muscle and sphincter reparative effects. It seems like a long shot, but it might be worth discussing with your doctor and or urologist to see if they would consider a 3 month trial of twice daily applications.
Art
Reader Q&A
Here's another question. You're talking about using melatonin applied topically for enlarged prostate. Too late for me. Over a few years, I'd ended up in ER several times for blocked urine flow. Terrifying experience every time! Finally had to be on a urinary catheter 24/7. So I had the surgery in 2019. It was a success in terms of I don't have to end up in ER these days or wear a catheter anymore. However, the procedure did create a new problem. And my research suggests that at least half of the guys who get prostate "resectioning" end up with what I've got. I can still have an erection, and orgasm, however, I don't have semen ejaculating upon orgasm. Instead the ejaculate comes out later during urination. Apparently there's a valve in the bladder that controls this action and that valve must have been either destroyed, damaged, or traumatized during the prostate resectioning procedure. Do you know anything about this problem and could topical melatonin possibly remedy or heal this damage?
Reader Q&A
Melatonin does not scavenge or chelate titanium, which may be the metal used in your ankle. Melatonin does however offer anti inflammatory effects that may apply against inflammation caused by titanium as discussed here :
Here are two very relevant quotes from the link :
' In this study, we examined the potential inhibitory effects of melatonin on titanium particle-induced inflammatory osteolysis (the destruction of bone tissue through bone resorption) in a murine calvarial model and on RANKL-induced osteoclastic formation in bone marrow-derived macrophages. We found that the exogenous administration of melatonin significantly inhibited wear debris-induced bone resorption and the expression of inflammatory cytokines in vivo. Additionally, melatonin inhibited RANKL-induced osteoclast differentiation, F-actin ring formation, and osteoclastic resorption in a concentration-dependent manner in vitro. We also showed that melatonin blocked the phosphorylation of IκB-α and p65, but not IKKα, and significantly inhibited the expression of NFATc1 and c-Fos. However, melatonin had no effect on MAPK or PI3K/AKT signaling pathways. These results provide novel mechanistic insight into the anti-inflammatory and anti-bone resorptive effects of melatonin on wear debris-induced bone loss and provide an evidence-based rationale for the protective effects of melatonin as a treatment for peri-implant osteolysis. '
' Wear debris-induced chronic inflammation, osteoclastic activation and osteoblastic inhibition have been identified as critical factors of peri-implant bone loss. We previously demonstrated that melatonin, a bioactive indolamine secreted mainly by the pineal gland, activates Wnt/β-catenin signaling pathway and enhances bone regeneration at osteolytic site in vivo. In the current study, we further demonstrated that melatonin significantly suppresses wear debris-induced bone resorption and inflammatory cytokine expression in vivo. In addition, melatonin inhibits receptor activator of nuclear factor kappa-B ligand induced osteoclast formation and osteoclastic bone resorption in vitro. Meanwhile, we found that melatonin mediates its anti-inflammation and anti-bone resorption effects by abrogating nuclear factor kappa-B activation. These results further support the protective effects of melatonin on wear debris-induced peri-implant bone loss, and strongly suggest that melatonin could be considered as a potential candidate for the prevention and treatment of wear debris-induced osteolysis and subsequent aseptic loosening.
Based on this, it seems worth discussing with your doctor whether testing topical melatonin lotion or melatonin gel on your ankle area will be a good option for you to reduce the swelling, inflammation and bone destruction you are experiencing while offering potential bone repair effects as discussed in other studies. If your doctor agrees, here is how to make melatonin lotion :
https://www.earthclinic.com/supplements/melatonin-lotion.html
And how to make melatonin gel :
https://www.earthclinic.com/supplements/melatonin-gel.html
Keep us posted on your progress!
Art
Reader Q&A
Enlarged Prostate
★★★★★
Recently a friend mentioned to me that his urine flow had slowed down noticeably over the past 2 months and he asked me what might be causing it. I told him that because he is in his 70's it could be a couple of things possibly related to his prostate gland and I told him he should have his doctor check his prostate and explain the reduced urine flow rate at the same time. He told me he has that scheduled, but it is two months until that appointment. I told him that once we pass our mid 40's the prostate starts to enlarge and that this enlarging process can continue as we age. This is called Benign Prostatic Hyperplasia or BPH and is extremely common in men over 70. He asked if there was anything he could do while he waited for his prostate exam.
I suggested that he could try applying Melatonin Gel (MG) to the perineum area once in the morning and once at bedtime. This is the area between the scrotum and the anus. I made him a small bottle of melatonin gel and asked him to let me know if it helped improve his urine flow.
I talked with him yesterday and he told me that his urine flow is now back to normal and he no longer has to get up during the night to urinate. He said that since this started, he was having to urinate 2 to 3 times during the night, whereas before he almost never had to urinate during the night.
I thanked him for the feedback and told him to still keep his appointment for the prostate exam to determine what the problem is or was and to see what his doctor recommends. I don't know if this will work the same for someone with long standing BPH, but it is so simple, fast acting and easy to do, it seems worth consideration for a problem that affects many men as they age.
This brings the number of uses for melatonin gel or melatonin lotion to 49, up from the original 40 that I mentioned in the original post.
Art
Reader Q&A
★★★★★
Reader Q&A
I have gotten several feedbacks saying that vodka works, but it will require more vodka than gin in order to properly dissolve the melatonin powder. That has been my experience also. This results in a more watery mixture.
Art
Reader Q&A
The lotion is fine for your knees. I made the melatonin gel for more sensitive areas such as the face and the fact that melatonin and aloe vera gel are both very good for the skin as a protectant and enhancer.
A friend told me she used melatonin lotion successfully for hemorrhoids, but I suggested that she might consider melatonin gel for such a sensitive area because the lotion has a ton of other ingredients, that you may not want in such a sensitive area.
I make the gel more often now because it works similarly to the lotion, but I can also use it in more sensitive areas. The cost to make either one is also similar.
The effects for either form for osteoarthritis are also going to be similar. Are you finding it beneficial for the osteoarthritis in your knees?
I have another question for you, have you tried the borax remedy for arthritis? I ask because the people who have benefited from borax for arthritis, such as myself have found it very effective. I think because of their different methods of action, melatonin lotion or melatonin gel with borax may have synergy with each other for arthritis. Here is a link to Earth clinics page on borax which explains how it is used and is also EC's #1 remedy for arthritis :
https://www.earthclinic.com/remedies/borax.html
Here is a link discussing melatonin for osteoarthritis :
https://pubmed.ncbi.nlm.nih.gov/39228264/
Here is a relevant quote from the link :
' Recent evidence indicates that the damaged regions in osteoarthritis are accompanied by the accumulation of iron ions. Ferroptosis, as an iron-dependent form of cell death, holds significant implications in osteoarthritis. Melatonin, a natural product with strong scavenging abilities against reactive oxygen species and lipid peroxidation, plays a crucial role in the treatment of osteoarthritis. This study aims to demonstrate the existence of ferroptosis in osteoarthritis and explore the specific mechanism of melatonin in suppressing ferroptosis and alleviating osteoarthritis. Our findings reveal that melatonin reverses inflammation-induced oxidative stress and lipid peroxidation while promoting the expression of extracellular matrix components in chondrocytes, safeguarding the cells. Our research has revealed that NADPH oxidase 4 (NOX4) serves as a crucial molecule in the ferroptosis process of osteoarthritis. Specifically, NOX4 is located on mitochondria in chondrocytes, which can induce disorders in mitochondrial energy metabolism and dysfunction, thereby intensifying oxidative stress and lipid peroxidation. LC-MS analysis further uncovered that GRP78 is a downstream binding protein of NOX4. NOX4 induces ferroptosis by weakening GRP78's protective effect on GPX4 and reducing its expression. Melatonin can inhibit the upregulation of NOX4 on mitochondria and mitigate mitochondrial dysfunction, effectively suppressing ferroptosis and alleviating osteoarthritis. This suggests that melatonin therapy represents a promising new approach for the treatment of osteoarthritis. '
Art
Reader Q&A
Reader Q&A
I have mainly switched to melatonin gel because it works at least as well as the lotion, has much less "extra ingredients", has the same pain relieving effects and it can be used in sensitive areas which are questionable for the lotion. I really like the fact that I can use it around my eyes without irritation and the fact that the aloe gel, like melatonin, can help fractures heal faster.
I'm not telling people not to use the lotion, just updating as the science continues to expand and the melatonin gel seems like a natural evolution to melatonin lotion.
Art
Reader Q&A
